PNPLA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

patatin-like phospholipase, putative

Species:

Leishmania mexicana

UniProt:

E9B580_LEIMU

TriTrypDb:

LmxM.33.2910

Length:

403

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005737	cytoplasm	2	1
GO:0005811	lipid droplet	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

E9B580

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B580

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	13
GO:0008152	metabolic process	1	13
GO:0009056	catabolic process	2	13
GO:0016042	lipid catabolic process	4	13
GO:0044238	primary metabolic process	2	13
GO:0071704	organic substance metabolic process	2	13
GO:1901575	organic substance catabolic process	3	13
GO:0006638	neutral lipid metabolic process	4	1
GO:0006639	acylglycerol metabolic process	5	1
GO:0006641	triglyceride metabolic process	6	1
GO:0009987	cellular process	1	1
GO:0019433	triglyceride catabolic process	7	1
GO:0042592	homeostatic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044242	cellular lipid catabolic process	4	1
GO:0044248	cellular catabolic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0046461	neutral lipid catabolic process	5	1
GO:0046464	acylglycerol catabolic process	6	1
GO:0046486	glycerolipid metabolic process	4	1
GO:0046503	glycerolipid catabolic process	5	1
GO:0048878	chemical homeostasis	4	1
GO:0055088	lipid homeostasis	5	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0016787	hydrolase activity	2	13
GO:0004806	triglyceride lipase activity	5	1
GO:0016298	lipase activity	4	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0052689	carboxylic ester hydrolase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	277	281	PF00656	0.410
CLV_NRD_NRD_1	121	123	PF00675	0.459
CLV_NRD_NRD_1	400	402	PF00675	0.547
CLV_PCSK_KEX2_1	73	75	PF00082	0.486
CLV_PCSK_PC1ET2_1	73	75	PF00082	0.491
CLV_PCSK_SKI1_1	146	150	PF00082	0.562
CLV_PCSK_SKI1_1	283	287	PF00082	0.636
CLV_PCSK_SKI1_1	336	340	PF00082	0.361
CLV_PCSK_SKI1_1	364	368	PF00082	0.361
DEG_Nend_UBRbox_3	1	3	PF02207	0.469
DEG_SPOP_SBC_1	11	15	PF00917	0.578
DOC_MAPK_gen_1	283	291	PF00069	0.466
DOC_MAPK_gen_1	383	393	PF00069	0.582
DOC_MAPK_MEF2A_6	315	324	PF00069	0.375
DOC_PP1_RVXF_1	362	368	PF00149	0.592
DOC_PP1_RVXF_1	71	78	PF00149	0.280
DOC_PP2B_LxvP_1	247	250	PF13499	0.305
DOC_PP2B_LxvP_1	276	279	PF13499	0.401
DOC_PP2B_PxIxI_1	315	321	PF00149	0.180
DOC_USP7_MATH_1	11	15	PF00917	0.557
DOC_USP7_UBL2_3	398	402	PF12436	0.735
DOC_WW_Pin1_4	211	216	PF00397	0.294
DOC_WW_Pin1_4	3	8	PF00397	0.515
LIG_14-3-3_CanoR_1	112	116	PF00244	0.289
LIG_14-3-3_CanoR_1	167	173	PF00244	0.304
LIG_14-3-3_CanoR_1	343	347	PF00244	0.578
LIG_14-3-3_CanoR_1	354	360	PF00244	0.587
LIG_14-3-3_CanoR_1	67	75	PF00244	0.291
LIG_Actin_WH2_1	122	139	PF00022	0.259
LIG_APCC_ABBA_1	320	325	PF00400	0.368
LIG_BRCT_BRCA1_1	112	116	PF00533	0.338
LIG_BRCT_BRCA1_1	381	385	PF00533	0.596
LIG_deltaCOP1_diTrp_1	31	42	PF00928	0.447
LIG_EH1_1	303	311	PF00400	0.433
LIG_FHA_1	212	218	PF00498	0.296
LIG_FHA_1	220	226	PF00498	0.287
LIG_FHA_2	15	21	PF00498	0.567
LIG_IRF3_LxIS_1	322	329	PF10401	0.472
LIG_LIR_Gen_1	113	124	PF02991	0.286
LIG_LIR_Gen_1	173	183	PF02991	0.286
LIG_LIR_Gen_1	295	305	PF02991	0.409
LIG_LIR_Gen_1	345	353	PF02991	0.481
LIG_LIR_Gen_1	92	103	PF02991	0.333
LIG_LIR_Nem_3	113	119	PF02991	0.297
LIG_LIR_Nem_3	170	175	PF02991	0.273
LIG_LIR_Nem_3	243	247	PF02991	0.351
LIG_LIR_Nem_3	295	300	PF02991	0.426
LIG_LIR_Nem_3	303	308	PF02991	0.353
LIG_LIR_Nem_3	345	349	PF02991	0.591
LIG_LIR_Nem_3	351	356	PF02991	0.561
LIG_LIR_Nem_3	361	365	PF02991	0.534
LIG_LIR_Nem_3	382	388	PF02991	0.547
LIG_LIR_Nem_3	92	98	PF02991	0.317
LIG_PCNA_yPIPBox_3	377	388	PF02747	0.645
LIG_Pex14_1	47	51	PF04695	0.271
LIG_Pex14_2	240	244	PF04695	0.312
LIG_Pex14_2	48	52	PF04695	0.335
LIG_SH2_CRK	175	179	PF00017	0.362
LIG_SH2_CRK	255	259	PF00017	0.380
LIG_SH2_CRK	95	99	PF00017	0.362
LIG_SH2_NCK_1	57	61	PF00017	0.377
LIG_SH2_PTP2	313	316	PF00017	0.410
LIG_SH2_PTP2	323	326	PF00017	0.369
LIG_SH2_STAT5	124	127	PF00017	0.274
LIG_SH2_STAT5	229	232	PF00017	0.365
LIG_SH2_STAT5	269	272	PF00017	0.320
LIG_SH2_STAT5	313	316	PF00017	0.302
LIG_SH2_STAT5	323	326	PF00017	0.347
LIG_SH2_STAT5	51	54	PF00017	0.362
LIG_SH2_STAT5	69	72	PF00017	0.362
LIG_SH3_3	189	195	PF00018	0.280
LIG_SH3_3	236	242	PF00018	0.390
LIG_SH3_3	384	390	PF00018	0.594
LIG_SUMO_SIM_par_1	218	226	PF11976	0.325
LIG_SUMO_SIM_par_1	355	361	PF11976	0.588
LIG_TRAF2_1	373	376	PF00917	0.655
LIG_TYR_ITIM	55	60	PF00017	0.294
LIG_UBA3_1	308	315	PF00899	0.180
LIG_WRC_WIRS_1	169	174	PF05994	0.362
MOD_CDK_SPK_2	211	216	PF00069	0.320
MOD_CK1_1	138	144	PF00069	0.169
MOD_CK1_1	14	20	PF00069	0.490
MOD_CK1_1	170	176	PF00069	0.361
MOD_CK1_1	211	217	PF00069	0.340
MOD_CK1_1	358	364	PF00069	0.573
MOD_CK1_1	369	375	PF00069	0.612
MOD_CK1_1	379	385	PF00069	0.611
MOD_CK1_1	396	402	PF00069	0.662
MOD_CK2_1	197	203	PF00069	0.362
MOD_CK2_1	293	299	PF00069	0.431
MOD_CK2_1	369	375	PF00069	0.671
MOD_Cter_Amidation	399	402	PF01082	0.522
MOD_Cter_Amidation	71	74	PF01082	0.491
MOD_GlcNHglycan	104	107	PF01048	0.501
MOD_GlcNHglycan	150	153	PF01048	0.562
MOD_GlcNHglycan	225	228	PF01048	0.528
MOD_GlcNHglycan	271	274	PF01048	0.569
MOD_GlcNHglycan	61	64	PF01048	0.517
MOD_GlcNHglycan	80	83	PF01048	0.377
MOD_GlcNHglycan	91	94	PF01048	0.471
MOD_GSK3_1	10	17	PF00069	0.534
MOD_GSK3_1	131	138	PF00069	0.169
MOD_GSK3_1	163	170	PF00069	0.304
MOD_GSK3_1	178	185	PF00069	0.257
MOD_GSK3_1	219	226	PF00069	0.315
MOD_GSK3_1	36	43	PF00069	0.326
MOD_GSK3_1	366	373	PF00069	0.652
MOD_GSK3_1	85	92	PF00069	0.313
MOD_N-GLC_1	211	216	PF02516	0.562
MOD_NEK2_1	156	161	PF00069	0.292
MOD_NEK2_1	168	173	PF00069	0.324
MOD_NEK2_1	182	187	PF00069	0.210
MOD_NEK2_1	326	331	PF00069	0.413
MOD_NEK2_1	366	371	PF00069	0.557
MOD_NEK2_1	393	398	PF00069	0.673
MOD_NEK2_1	59	64	PF00069	0.318
MOD_NEK2_1	85	90	PF00069	0.317
MOD_NEK2_2	111	116	PF00069	0.362
MOD_PKA_2	111	117	PF00069	0.280
MOD_PKA_2	178	184	PF00069	0.350
MOD_PKA_2	342	348	PF00069	0.530
MOD_PKA_2	376	382	PF00069	0.581
MOD_PKA_2	75	81	PF00069	0.348
MOD_Plk_1	219	225	PF00069	0.384
MOD_Plk_1	231	237	PF00069	0.376
MOD_Plk_1	36	42	PF00069	0.298
MOD_Plk_2-3	274	280	PF00069	0.315
MOD_Plk_4	111	117	PF00069	0.280
MOD_Plk_4	156	162	PF00069	0.362
MOD_Plk_4	178	184	PF00069	0.339
MOD_Plk_4	240	246	PF00069	0.323
MOD_Plk_4	293	299	PF00069	0.425
MOD_ProDKin_1	211	217	PF00069	0.294
MOD_ProDKin_1	3	9	PF00069	0.516
MOD_SUMO_for_1	196	199	PF00179	0.362
TRG_DiLeu_BaEn_1	307	312	PF01217	0.362
TRG_DiLeu_BaLyEn_6	164	169	PF01217	0.354
TRG_DiLeu_BaLyEn_6	280	285	PF01217	0.408
TRG_ENDOCYTIC_2	175	178	PF00928	0.290
TRG_ENDOCYTIC_2	255	258	PF00928	0.320
TRG_ENDOCYTIC_2	263	266	PF00928	0.266
TRG_ENDOCYTIC_2	297	300	PF00928	0.458
TRG_ENDOCYTIC_2	323	326	PF00928	0.331
TRG_ENDOCYTIC_2	350	353	PF00928	0.552
TRG_ENDOCYTIC_2	57	60	PF00928	0.377
TRG_ENDOCYTIC_2	95	98	PF00928	0.359
TRG_ER_diArg_1	119	122	PF00400	0.221
TRG_ER_diArg_1	143	146	PF00400	0.352
TRG_ER_diArg_1	235	238	PF00400	0.395
TRG_ER_diArg_1	74	77	PF00400	0.285
TRG_Pf-PMV_PEXEL_1	283	287	PF00026	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P509	Leptomonas seymouri	73%	94%
A0A0S4IY58	Bodo saltans	35%	100%
A0A0S4J309	Bodo saltans	38%	85%
A0A1X0P9X6	Trypanosomatidae	44%	100%
A0A3S5H7X3	Leishmania donovani	91%	93%
A0A422N4J2	Trypanosoma rangeli	41%	98%
A4HB10	Leishmania braziliensis	79%	100%
A4IA67	Leishmania infantum	91%	93%
C9ZM39	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
Q4Q2Q3	Leishmania major	90%	100%
V5DLV7	Trypanosoma cruzi	41%	97%