Serine O-acetyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine acetyltransferase, putative

Species:

Leishmania mexicana

UniProt:

E9B576_LEIMU

TriTrypDb:

LmxM.33.2850

Length:

411

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B576

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B576

Function

Biological processes
Term	Name	Level	Count
GO:0000096	sulfur amino acid metabolic process	4	1
GO:0000097	sulfur amino acid biosynthetic process	5	1
GO:0006082	organic acid metabolic process	3	1
GO:0006520	amino acid metabolic process	3	1
GO:0006534	cysteine metabolic process	5	1
GO:0006535	cysteine biosynthetic process from serine	7	1
GO:0006563	L-serine metabolic process	6	1
GO:0006790	sulfur compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008652	amino acid biosynthetic process	4	1
GO:0009058	biosynthetic process	2	1
GO:0009069	serine family amino acid metabolic process	5	1
GO:0009070	serine family amino acid biosynthetic process	6	1
GO:0009987	cellular process	1	1
GO:0016053	organic acid biosynthetic process	4	1
GO:0019344	cysteine biosynthetic process	6	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044272	sulfur compound biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0046394	carboxylic acid biosynthetic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1
GO:1901605	alpha-amino acid metabolic process	4	1
GO:1901607	alpha-amino acid biosynthetic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0008374	O-acyltransferase activity	5	6
GO:0009001	serine O-acetyltransferase activity	7	6
GO:0016407	acetyltransferase activity	5	6
GO:0016412	serine O-acyltransferase activity	6	6
GO:0016413	O-acetyltransferase activity	6	6
GO:0016740	transferase activity	2	7
GO:0016746	acyltransferase activity	3	7
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	59	63	PF00656	0.471
CLV_NRD_NRD_1	108	110	PF00675	0.567
CLV_NRD_NRD_1	201	203	PF00675	0.491
CLV_PCSK_KEX2_1	108	110	PF00082	0.604
CLV_PCSK_KEX2_1	2	4	PF00082	0.528
CLV_PCSK_KEX2_1	200	202	PF00082	0.517
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.528
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.517
CLV_PCSK_SKI1_1	219	223	PF00082	0.362
CLV_PCSK_SKI1_1	272	276	PF00082	0.429
CLV_PCSK_SKI1_1	401	405	PF00082	0.623
CLV_PCSK_SKI1_1	8	12	PF00082	0.533
CLV_PCSK_SKI1_1	99	103	PF00082	0.762
CLV_Separin_Metazoa	152	156	PF03568	0.514
DEG_APCC_DBOX_1	28	36	PF00400	0.575
DEG_APCC_DBOX_1	7	15	PF00400	0.593
DEG_Nend_UBRbox_1	1	4	PF02207	0.535
DOC_CYCLIN_RxL_1	214	225	PF00134	0.366
DOC_MAPK_gen_1	160	169	PF00069	0.508
DOC_PP2B_LxvP_1	264	267	PF13499	0.431
DOC_USP7_MATH_1	100	104	PF00917	0.480
DOC_USP7_UBL2_3	144	148	PF12436	0.651
DOC_WW_Pin1_4	12	17	PF00397	0.431
DOC_WW_Pin1_4	235	240	PF00397	0.500
DOC_WW_Pin1_4	54	59	PF00397	0.599
LIG_14-3-3_CanoR_1	108	114	PF00244	0.700
LIG_14-3-3_CanoR_1	162	168	PF00244	0.508
LIG_14-3-3_CanoR_1	29	33	PF00244	0.524
LIG_APCC_ABBA_1	86	91	PF00400	0.536
LIG_APCC_ABBAyCdc20_2	219	225	PF00400	0.422
LIG_CtBP_PxDLS_1	53	57	PF00389	0.359
LIG_FHA_1	182	188	PF00498	0.729
LIG_FHA_1	206	212	PF00498	0.448
LIG_FHA_1	238	244	PF00498	0.274
LIG_FHA_1	269	275	PF00498	0.463
LIG_FHA_1	300	306	PF00498	0.419
LIG_FHA_1	307	313	PF00498	0.407
LIG_FHA_1	55	61	PF00498	0.552
LIG_FHA_1	77	83	PF00498	0.265
LIG_FHA_2	108	114	PF00498	0.687
LIG_FHA_2	222	228	PF00498	0.401
LIG_FHA_2	280	286	PF00498	0.443
LIG_FHA_2	363	369	PF00498	0.525
LIG_FHA_2	57	63	PF00498	0.560
LIG_LIR_Gen_1	80	88	PF02991	0.548
LIG_LIR_Nem_3	317	322	PF02991	0.402
LIG_LIR_Nem_3	40	46	PF02991	0.405
LIG_LIR_Nem_3	80	86	PF02991	0.469
LIG_LIR_Nem_3	98	104	PF02991	0.690
LIG_LYPXL_yS_3	246	249	PF13949	0.408
LIG_MYND_3	122	126	PF01753	0.519
LIG_PDZ_Class_1	406	411	PF00595	0.600
LIG_Pex14_2	43	47	PF04695	0.447
LIG_SH2_CRK	319	323	PF00017	0.420
LIG_SH2_GRB2like	355	358	PF00017	0.512
LIG_SH2_SRC	355	358	PF00017	0.509
LIG_SH2_STAP1	355	359	PF00017	0.509
LIG_SH2_STAT5	44	47	PF00017	0.431
LIG_SH2_STAT5	83	86	PF00017	0.471
LIG_SH3_1	340	346	PF00018	0.556
LIG_SH3_3	340	346	PF00018	0.556
LIG_SH3_3	42	48	PF00018	0.451
LIG_TYR_ITIM	244	249	PF00017	0.429
LIG_WRC_WIRS_1	23	28	PF05994	0.694
MOD_CDC14_SPxK_1	15	18	PF00782	0.520
MOD_CDK_SPxK_1	12	18	PF00069	0.498
MOD_CK1_1	103	109	PF00069	0.647
MOD_CK1_1	129	135	PF00069	0.781
MOD_CK1_1	170	176	PF00069	0.776
MOD_CK1_1	237	243	PF00069	0.482
MOD_CK1_1	328	334	PF00069	0.602
MOD_CK2_1	107	113	PF00069	0.739
MOD_CK2_1	162	168	PF00069	0.515
MOD_CK2_1	221	227	PF00069	0.398
MOD_CK2_1	235	241	PF00069	0.444
MOD_CK2_1	362	368	PF00069	0.525
MOD_GlcNHglycan	118	121	PF01048	0.736
MOD_GlcNHglycan	172	175	PF01048	0.651
MOD_GlcNHglycan	188	191	PF01048	0.533
MOD_GlcNHglycan	407	411	PF01048	0.569
MOD_GSK3_1	100	107	PF00069	0.642
MOD_GSK3_1	163	170	PF00069	0.774
MOD_GSK3_1	18	25	PF00069	0.737
MOD_GSK3_1	268	275	PF00069	0.435
MOD_GSK3_1	328	335	PF00069	0.602
MOD_GSK3_1	48	55	PF00069	0.483
MOD_N-GLC_1	104	109	PF02516	0.696
MOD_N-GLC_1	268	273	PF02516	0.442
MOD_NEK2_1	104	109	PF00069	0.678
MOD_NEK2_1	154	159	PF00069	0.785
MOD_NEK2_1	194	199	PF00069	0.349
MOD_NEK2_2	28	33	PF00069	0.591
MOD_PIKK_1	107	113	PF00454	0.687
MOD_PIKK_1	129	135	PF00454	0.506
MOD_PIKK_1	77	83	PF00454	0.409
MOD_PKA_2	107	113	PF00069	0.580
MOD_PKA_2	126	132	PF00069	0.568
MOD_PKA_2	154	160	PF00069	0.659
MOD_PKA_2	28	34	PF00069	0.587
MOD_PKA_2	362	368	PF00069	0.550
MOD_PKB_1	160	168	PF00069	0.781
MOD_Plk_1	19	25	PF00069	0.627
MOD_Plk_1	268	274	PF00069	0.437
MOD_Plk_1	367	373	PF00069	0.550
MOD_Plk_4	314	320	PF00069	0.398
MOD_Plk_4	350	356	PF00069	0.509
MOD_Plk_4	384	390	PF00069	0.421
MOD_ProDKin_1	12	18	PF00069	0.438
MOD_ProDKin_1	235	241	PF00069	0.497
MOD_ProDKin_1	54	60	PF00069	0.600
MOD_SUMO_rev_2	328	335	PF00179	0.548
MOD_SUMO_rev_2	91	101	PF00179	0.720
TRG_DiLeu_BaLyEn_6	120	125	PF01217	0.513
TRG_ENDOCYTIC_2	246	249	PF00928	0.408
TRG_ENDOCYTIC_2	319	322	PF00928	0.484
TRG_ENDOCYTIC_2	44	47	PF00928	0.394
TRG_ENDOCYTIC_2	83	86	PF00928	0.471
TRG_ER_diArg_1	160	163	PF00400	0.780
TRG_NES_CRM1_1	76	91	PF08389	0.427
TRG_Pf-PMV_PEXEL_1	272	276	PF00026	0.440
TRG_Pf-PMV_PEXEL_1	36	40	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3B6	Leptomonas seymouri	67%	100%
A0A1X0P9S3	Trypanosomatidae	47%	100%
A0A3Q8IFQ2	Leishmania donovani	90%	100%
A4IA64	Leishmania infantum	90%	100%
Q4Q2Q9	Leishmania major	89%	100%