LeishMANIAdb
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Ubiquitin-related modifier 1 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Ubiquitin-related modifier 1 homolog
Gene product:
ubiquitin related modifier (urm1)-like protein
Species:
Leishmania mexicana
UniProt:
E9B574_LEIMU
TriTrypDb:
LmxM.33.2830
Length:
103

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005829 cytosol 2 12
GO:0110165 cellular anatomical entity 1 12
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1

Expansion

Sequence features

E9B574
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B574

Function

Biological processes
Term Name Level Count
GO:0002097 tRNA wobble base modification 7 12
GO:0002098 tRNA wobble uridine modification 8 12
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006396 RNA processing 6 12
GO:0006399 tRNA metabolic process 7 12
GO:0006400 tRNA modification 6 12
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008033 tRNA processing 8 12
GO:0008152 metabolic process 1 12
GO:0009451 RNA modification 5 12
GO:0009987 cellular process 1 12
GO:0016070 RNA metabolic process 5 12
GO:0019538 protein metabolic process 3 12
GO:0032446 protein modification by small protein conjugation 6 12
GO:0032447 protein urmylation 7 12
GO:0034227 tRNA thio-modification 7 12
GO:0034470 ncRNA processing 7 12
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0034660 ncRNA metabolic process 6 12
GO:0036211 protein modification process 4 12
GO:0043170 macromolecule metabolic process 3 12
GO:0043412 macromolecule modification 4 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0046483 heterocycle metabolic process 3 12
GO:0070647 protein modification by small protein conjugation or removal 5 12
GO:0071704 organic substance metabolic process 2 12
GO:0090304 nucleic acid metabolic process 4 12
GO:1901360 organic cyclic compound metabolic process 3 12
GO:1901564 organonitrogen compound metabolic process 3 12
Molecular functions
Term Name Level Count
GO:0031386 protein tag 1 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 5 7 PF00675 0.357
CLV_PCSK_SKI1_1 6 10 PF00082 0.382
DEG_Nend_UBRbox_3 1 3 PF02207 0.457
DOC_MAPK_gen_1 51 58 PF00069 0.459
DOC_MAPK_gen_1 6 12 PF00069 0.416
DOC_MAPK_JIP1_4 66 72 PF00069 0.444
DOC_MAPK_MEF2A_6 51 58 PF00069 0.456
DOC_MAPK_MEF2A_6 66 73 PF00069 0.469
DOC_PP2B_PxIxI_1 66 72 PF00149 0.469
LIG_Actin_WH2_2 31 48 PF00022 0.494
LIG_APCC_ABBAyCdc20_2 53 59 PF00400 0.469
LIG_BIR_III_4 59 63 PF00653 0.505
LIG_FHA_2 25 31 PF00498 0.494
LIG_SH2_STAT5 49 52 PF00017 0.448
MOD_GlcNHglycan 12 15 PF01048 0.306
MOD_N-GLC_2 74 76 PF02516 0.244
MOD_NEK2_1 1 6 PF00069 0.411
MOD_NEK2_1 96 101 PF00069 0.444
MOD_PK_1 22 28 PF00069 0.488
MOD_Plk_1 22 28 PF00069 0.521

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2X8 Leptomonas seymouri 74% 100%
A0A0S4J1Y6 Bodo saltans 68% 100%
A0A1X0P9S0 Trypanosomatidae 60% 100%
A0A3Q8IIP5 Leishmania donovani 94% 100%
A0A3R7KKF6 Trypanosoma rangeli 57% 100%
A0MDQ1 Arabidopsis thaliana 45% 100%
A3GFM6 Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) 40% 100%
A4HB06 Leishmania braziliensis 84% 100%
A4IA62 Leishmania infantum 93% 100%
A5DTV4 Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) 32% 100%
A6R989 Ajellomyces capsulatus (strain NAm1 / WU24) 38% 85%
A6S5X1 Botryotinia fuckeliana (strain B05.10) 38% 97%
A6ZVR0 Saccharomyces cerevisiae (strain YJM789) 35% 100%
A7ETU4 Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) 38% 97%
A7TQ77 Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) 39% 100%
A8IC48 Chlamydomonas reinhardtii 48% 100%
A8P008 Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003) 42% 83%
A9YUB5 Capra hircus 47% 100%
B0D4J6 Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686) 40% 84%
B0W3S2 Culex quinquefasciatus 39% 94%
B2WIC3 Pyrenophora tritici-repentis (strain Pt-1C-BFP) 41% 96%
B3H7G2 Arabidopsis thaliana 44% 100%
B3LTL7 Saccharomyces cerevisiae (strain RM11-1a) 35% 100%
B3M611 Drosophila ananassae 44% 100%
B3NFA2 Drosophila erecta 45% 100%
B4GUT1 Drosophila persimilis 44% 100%
B4HVA2 Drosophila sechellia 44% 100%
B4J272 Drosophila grimshawi 43% 99%
B4KYT0 Drosophila mojavensis 46% 99%
B4LE67 Drosophila virilis 44% 100%
B4MLV0 Drosophila willistoni 42% 100%
B4PCA1 Drosophila yakuba 45% 100%
B4QKW3 Drosophila simulans 43% 100%
B5DQK2 Drosophila pseudoobscura pseudoobscura 44% 100%
B5FVI0 Yarrowia lipolytica (strain CLIB 122 / E 150) 35% 100%
B6SXH2 Zea mays 40% 100%
C9ZM44 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 60% 100%
P0CT26 Ustilago maydis (strain 521 / FGSC 9021) 47% 96%
P40554 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 35% 100%
Q0D6M1 Oryza sativa subsp. japonica 41% 100%
Q148F0 Bos taurus 47% 100%
Q16Y28 Aedes aegypti 41% 94%
Q1E493 Coccidioides immitis (strain RS) 40% 90%
Q1HQ10 Bombyx mori 38% 94%
Q2U9H6 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 43% 86%
Q4Q2R1 Leishmania major 94% 100%
Q54QN0 Dictyostelium discoideum 47% 100%
Q59WK2 Candida albicans (strain SC5314 / ATCC MYA-2876) 39% 100%
Q5ZJU4 Gallus gallus 46% 100%
Q6CQU4 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 36% 100%
Q6FWQ3 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 35% 100%
Q75AD1 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 39% 100%
Q7GBC8 Oryza sativa subsp. indica 41% 100%
Q7KU86 Drosophila melanogaster 44% 100%
Q7Q6I6 Anopheles gambiae 40% 94%
Q9BTM9 Homo sapiens 46% 100%
Q9C245 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 38% 94%
Q9D2P4 Mus musculus 45% 100%
Q9P3U9 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 46% 100%
V5BV79 Trypanosoma cruzi 59% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS