Regulatory subunit of protein kinase a-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

regulatory subunit of protein kinase a-like protein

Species:

Leishmania mexicana

UniProt:

E9B573_LEIMU

TriTrypDb:

LmxM.33.2820

Length:

646

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B573

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B573

Function

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Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	5
GO:0006796	phosphate-containing compound metabolic process	4	5
GO:0008152	metabolic process	1	5
GO:0009987	cellular process	1	5
GO:0016310	phosphorylation	5	5
GO:0044237	cellular metabolic process	2	5

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0016301	kinase activity	4	5
GO:0016740	transferase activity	2	5
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	5

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	286	290	PF00656	0.715
CLV_C14_Caspase3-7	33	37	PF00656	0.476
CLV_NRD_NRD_1	169	171	PF00675	0.672
CLV_NRD_NRD_1	314	316	PF00675	0.613
CLV_NRD_NRD_1	459	461	PF00675	0.388
CLV_NRD_NRD_1	473	475	PF00675	0.435
CLV_NRD_NRD_1	49	51	PF00675	0.541
CLV_NRD_NRD_1	584	586	PF00675	0.365
CLV_NRD_NRD_1	59	61	PF00675	0.590
CLV_NRD_NRD_1	63	65	PF00675	0.514

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC94	Leptomonas seymouri	46%	93%
A0A3S7X836	Leishmania donovani	83%	100%
A4HB05	Leishmania braziliensis	61%	99%
A4IA61	Leishmania infantum	83%	100%
Q4Q2R2	Leishmania major	82%	100%

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