Regulatory subunit of protein kinase a-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

regulatory subunit of protein kinase a-like protein

Species:

Leishmania mexicana

UniProt:

E9B573_LEIMU

TriTrypDb:

LmxM.33.2820

Length:

646

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B573

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B573

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	5
GO:0006796	phosphate-containing compound metabolic process	4	5
GO:0008152	metabolic process	1	5
GO:0009987	cellular process	1	5
GO:0016310	phosphorylation	5	5
GO:0044237	cellular metabolic process	2	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0016301	kinase activity	4	5
GO:0016740	transferase activity	2	5
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	286	290	PF00656	0.715
CLV_C14_Caspase3-7	33	37	PF00656	0.476
CLV_NRD_NRD_1	169	171	PF00675	0.672
CLV_NRD_NRD_1	314	316	PF00675	0.613
CLV_NRD_NRD_1	459	461	PF00675	0.388
CLV_NRD_NRD_1	473	475	PF00675	0.435
CLV_NRD_NRD_1	49	51	PF00675	0.541
CLV_NRD_NRD_1	584	586	PF00675	0.365
CLV_NRD_NRD_1	59	61	PF00675	0.590
CLV_NRD_NRD_1	63	65	PF00675	0.514
CLV_NRD_NRD_1	73	75	PF00675	0.711
CLV_PCSK_FUR_1	71	75	PF00082	0.617
CLV_PCSK_KEX2_1	169	171	PF00082	0.739
CLV_PCSK_KEX2_1	21	23	PF00082	0.536
CLV_PCSK_KEX2_1	216	218	PF00082	0.688
CLV_PCSK_KEX2_1	313	315	PF00082	0.611
CLV_PCSK_KEX2_1	459	461	PF00082	0.388
CLV_PCSK_KEX2_1	473	475	PF00082	0.435
CLV_PCSK_KEX2_1	58	60	PF00082	0.574
CLV_PCSK_KEX2_1	584	586	PF00082	0.365
CLV_PCSK_KEX2_1	71	73	PF00082	0.497
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.461
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.593
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.618
CLV_PCSK_SKI1_1	108	112	PF00082	0.597
CLV_PCSK_SKI1_1	298	302	PF00082	0.575
CLV_PCSK_SKI1_1	361	365	PF00082	0.440
CLV_PCSK_SKI1_1	463	467	PF00082	0.442
CLV_PCSK_SKI1_1	478	482	PF00082	0.428
CLV_PCSK_SKI1_1	512	516	PF00082	0.258
CLV_PCSK_SKI1_1	578	582	PF00082	0.365
CLV_PCSK_SKI1_1	64	68	PF00082	0.623
DEG_Kelch_Keap1_1	537	542	PF01344	0.258
DEG_SPOP_SBC_1	119	123	PF00917	0.636
DOC_CKS1_1	343	348	PF01111	0.525
DOC_CYCLIN_yCln2_LP_2	41	47	PF00134	0.571
DOC_MAPK_gen_1	142	150	PF00069	0.667
DOC_MAPK_gen_1	21	31	PF00069	0.580
DOC_MAPK_gen_1	351	360	PF00069	0.464
DOC_MAPK_HePTP_8	19	31	PF00069	0.441
DOC_MAPK_MEF2A_6	22	31	PF00069	0.565
DOC_MAPK_NFAT4_5	24	32	PF00069	0.575
DOC_PP1_RVXF_1	149	156	PF00149	0.620
DOC_PP4_FxxP_1	629	632	PF00568	0.606
DOC_PP4_MxPP_1	227	230	PF00568	0.722
DOC_USP7_MATH_1	119	123	PF00917	0.663
DOC_USP7_MATH_1	448	452	PF00917	0.458
DOC_USP7_MATH_1	488	492	PF00917	0.484
DOC_USP7_MATH_1	83	87	PF00917	0.624
DOC_USP7_MATH_1	97	101	PF00917	0.651
DOC_USP7_UBL2_3	347	351	PF12436	0.504
DOC_WW_Pin1_4	120	125	PF00397	0.620
DOC_WW_Pin1_4	168	173	PF00397	0.576
DOC_WW_Pin1_4	192	197	PF00397	0.717
DOC_WW_Pin1_4	219	224	PF00397	0.710
DOC_WW_Pin1_4	225	230	PF00397	0.693
DOC_WW_Pin1_4	342	347	PF00397	0.522
DOC_WW_Pin1_4	623	628	PF00397	0.615
LIG_14-3-3_CanoR_1	324	334	PF00244	0.538
LIG_14-3-3_CanoR_1	338	343	PF00244	0.532
LIG_14-3-3_CanoR_1	427	432	PF00244	0.445
LIG_14-3-3_CanoR_1	449	453	PF00244	0.425
LIG_14-3-3_CanoR_1	459	463	PF00244	0.314
LIG_14-3-3_CanoR_1	512	519	PF00244	0.258
LIG_14-3-3_CanoR_1	584	588	PF00244	0.365
LIG_14-3-3_CanoR_1	637	641	PF00244	0.564
LIG_Actin_WH2_2	154	171	PF00022	0.523
LIG_BIR_II_1	1	5	PF00653	0.557
LIG_BIR_III_2	630	634	PF00653	0.683
LIG_BRCT_BRCA1_1	585	589	PF00533	0.395
LIG_EVH1_1	81	85	PF00568	0.690
LIG_FHA_1	192	198	PF00498	0.680
LIG_FHA_1	24	30	PF00498	0.512
LIG_FHA_1	398	404	PF00498	0.322
LIG_FHA_1	409	415	PF00498	0.414
LIG_FHA_1	513	519	PF00498	0.338
LIG_FHA_1	577	583	PF00498	0.365
LIG_FHA_2	102	108	PF00498	0.667
LIG_FHA_2	202	208	PF00498	0.656
LIG_FHA_2	365	371	PF00498	0.453
LIG_FHA_2	428	434	PF00498	0.369
LIG_LIR_Apic_2	626	632	PF02991	0.600
LIG_LIR_Gen_1	152	163	PF02991	0.582
LIG_LIR_Gen_1	36	45	PF02991	0.594
LIG_LIR_Gen_1	399	409	PF02991	0.365
LIG_LIR_Gen_1	586	594	PF02991	0.455
LIG_LIR_Nem_3	152	158	PF02991	0.600
LIG_LIR_Nem_3	2	7	PF02991	0.531
LIG_LIR_Nem_3	266	271	PF02991	0.732
LIG_LIR_Nem_3	36	41	PF02991	0.591
LIG_LIR_Nem_3	399	405	PF02991	0.365
LIG_LIR_Nem_3	429	434	PF02991	0.558
LIG_LIR_Nem_3	461	465	PF02991	0.431
LIG_LIR_Nem_3	586	592	PF02991	0.458
LIG_LIR_Nem_3	605	611	PF02991	0.517
LIG_PDZ_Class_3	641	646	PF00595	0.676
LIG_SH2_CRK	38	42	PF00017	0.641
LIG_SH2_CRK	462	466	PF00017	0.432
LIG_SH2_SRC	507	510	PF00017	0.370
LIG_SH2_STAT3	7	10	PF00017	0.515
LIG_SH2_STAT5	507	510	PF00017	0.546
LIG_SH2_STAT5	7	10	PF00017	0.515
LIG_SH3_3	137	143	PF00018	0.668
LIG_SH3_3	340	346	PF00018	0.552
LIG_SH3_3	418	424	PF00018	0.445
LIG_SH3_3	530	536	PF00018	0.365
LIG_SH3_3	79	85	PF00018	0.631
LIG_SUMO_SIM_anti_2	545	551	PF11976	0.365
LIG_SUMO_SIM_par_1	569	574	PF11976	0.395
LIG_TRAF2_1	263	266	PF00917	0.654
LIG_TRAF2_1	601	604	PF00917	0.573
LIG_TRAF2_1	610	613	PF00917	0.514
LIG_TRAF2_1	66	69	PF00917	0.577
LIG_UBA3_1	27	32	PF00899	0.579
LIG_WRC_WIRS_1	1	6	PF05994	0.638
LIG_WRC_WIRS_1	268	273	PF05994	0.648
LIG_WW_2	82	85	PF00397	0.636
MOD_CDC14_SPxK_1	123	126	PF00782	0.593
MOD_CDK_SPK_2	342	347	PF00069	0.522
MOD_CDK_SPxK_1	120	126	PF00069	0.612
MOD_CDK_SPxK_1	168	174	PF00069	0.572
MOD_CDK_SPxxK_3	219	226	PF00069	0.661
MOD_CK1_1	109	115	PF00069	0.670
MOD_CK1_1	188	194	PF00069	0.585
MOD_CK1_1	201	207	PF00069	0.702
MOD_CK1_1	328	334	PF00069	0.524
MOD_CK1_1	341	347	PF00069	0.527
MOD_CK1_1	583	589	PF00069	0.365
MOD_CK2_1	101	107	PF00069	0.796
MOD_CK2_1	119	125	PF00069	0.711
MOD_CK2_1	201	207	PF00069	0.710
MOD_CK2_1	260	266	PF00069	0.640
MOD_CK2_1	281	287	PF00069	0.803
MOD_CK2_1	488	494	PF00069	0.372
MOD_CK2_1	503	509	PF00069	0.434
MOD_DYRK1A_RPxSP_1	219	223	PF00069	0.595
MOD_GlcNHglycan	107	111	PF01048	0.745
MOD_GlcNHglycan	200	203	PF01048	0.738
MOD_GlcNHglycan	204	207	PF01048	0.694
MOD_GlcNHglycan	219	222	PF01048	0.738
MOD_GlcNHglycan	573	576	PF01048	0.446
MOD_GlcNHglycan	616	619	PF01048	0.586
MOD_GSK3_1	174	181	PF00069	0.678
MOD_GSK3_1	188	195	PF00069	0.644
MOD_GSK3_1	197	204	PF00069	0.669
MOD_GSK3_1	215	222	PF00069	0.704
MOD_GSK3_1	260	267	PF00069	0.735
MOD_GSK3_1	338	345	PF00069	0.539
MOD_GSK3_1	364	371	PF00069	0.448
MOD_GSK3_1	576	583	PF00069	0.365
MOD_GSK3_1	97	104	PF00069	0.774
MOD_N-GLC_1	188	193	PF02516	0.629
MOD_N-GLC_1	243	248	PF02516	0.702
MOD_N-GLC_1	279	284	PF02516	0.724
MOD_N-GLC_1	397	402	PF02516	0.365
MOD_N-GLC_1	90	95	PF02516	0.665
MOD_NEK2_1	15	20	PF00069	0.591
MOD_NEK2_1	178	183	PF00069	0.720
MOD_NEK2_1	23	28	PF00069	0.507
MOD_NEK2_1	232	237	PF00069	0.784
MOD_NEK2_1	363	368	PF00069	0.444
MOD_NEK2_1	464	469	PF00069	0.447
MOD_NEK2_1	480	485	PF00069	0.431
MOD_NEK2_1	636	641	PF00069	0.692
MOD_NEK2_2	264	269	PF00069	0.740
MOD_PIKK_1	178	184	PF00454	0.714
MOD_PIKK_1	345	351	PF00454	0.512
MOD_PIKK_1	90	96	PF00454	0.666
MOD_PK_1	375	381	PF00069	0.436
MOD_PKA_1	313	319	PF00069	0.616
MOD_PKA_2	23	29	PF00069	0.511
MOD_PKA_2	287	293	PF00069	0.603
MOD_PKA_2	313	319	PF00069	0.616
MOD_PKA_2	320	326	PF00069	0.594
MOD_PKA_2	426	432	PF00069	0.445
MOD_PKA_2	448	454	PF00069	0.425
MOD_PKA_2	458	464	PF00069	0.314
MOD_PKA_2	583	589	PF00069	0.365
MOD_PKA_2	636	642	PF00069	0.582
MOD_Plk_1	232	238	PF00069	0.784
MOD_Plk_1	242	248	PF00069	0.658
MOD_Plk_1	250	256	PF00069	0.584
MOD_Plk_1	328	334	PF00069	0.547
MOD_Plk_1	397	403	PF00069	0.365
MOD_Plk_1	409	415	PF00069	0.365
MOD_Plk_1	503	509	PF00069	0.445
MOD_Plk_1	604	610	PF00069	0.527
MOD_Plk_4	23	29	PF00069	0.511
MOD_Plk_4	375	381	PF00069	0.436
MOD_Plk_4	397	403	PF00069	0.365
MOD_Plk_4	409	415	PF00069	0.365
MOD_Plk_4	503	509	PF00069	0.445
MOD_ProDKin_1	120	126	PF00069	0.622
MOD_ProDKin_1	168	174	PF00069	0.580
MOD_ProDKin_1	192	198	PF00069	0.718
MOD_ProDKin_1	219	225	PF00069	0.712
MOD_ProDKin_1	342	348	PF00069	0.521
MOD_ProDKin_1	623	629	PF00069	0.624
MOD_SUMO_for_1	66	69	PF00179	0.608
MOD_SUMO_rev_2	537	546	PF00179	0.445
TRG_AP2beta_CARGO_1	266	275	PF09066	0.748
TRG_ENDOCYTIC_2	38	41	PF00928	0.604
TRG_ENDOCYTIC_2	462	465	PF00928	0.430
TRG_ENDOCYTIC_2	477	480	PF00928	0.426
TRG_ER_diArg_1	168	170	PF00400	0.693
TRG_ER_diArg_1	313	315	PF00400	0.612
TRG_ER_diArg_1	473	476	PF00400	0.443
TRG_ER_diArg_1	71	74	PF00400	0.564
TRG_NES_CRM1_1	372	386	PF08389	0.477
TRG_NLS_Bipartite_1	50	68	PF00514	0.471
TRG_NLS_MonoCore_2	56	61	PF00514	0.606
TRG_NLS_MonoExtC_3	63	69	PF00514	0.472
TRG_NLS_MonoExtN_4	57	62	PF00514	0.609

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC94	Leptomonas seymouri	46%	93%
A0A3S7X836	Leishmania donovani	83%	100%
A4HB05	Leishmania braziliensis	61%	99%
A4IA61	Leishmania infantum	83%	100%
Q4Q2R2	Leishmania major	82%	100%