LeishMANIAdb
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Cytosolic carboxypeptidase-like protein 5

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Cytosolic carboxypeptidase-like protein 5
Gene product:
Carboxypeptidase-like protein
Species:
Leishmania mexicana
UniProt:
E9B572_LEIMU
TriTrypDb:
LmxM.33.2810
Length:
884

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 10
GO:0005819 spindle 5 10
GO:0030496 midbody 2 10
GO:0043226 organelle 2 10
GO:0043227 membrane-bounded organelle 3 10
GO:0043228 non-membrane-bounded organelle 3 10
GO:0043229 intracellular organelle 3 10
GO:0043231 intracellular membrane-bounded organelle 4 10
GO:0043232 intracellular non-membrane-bounded organelle 4 10
GO:0110165 cellular anatomical entity 1 10
GO:0005737 cytoplasm 2 1

Expansion

Sequence features

E9B572
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B572

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 10
GO:0006807 nitrogen compound metabolic process 2 10
GO:0008152 metabolic process 1 10
GO:0018193 peptidyl-amino acid modification 5 10
GO:0018200 peptidyl-glutamic acid modification 6 10
GO:0019538 protein metabolic process 3 10
GO:0035608 protein deglutamylation 7 10
GO:0036211 protein modification process 4 10
GO:0043170 macromolecule metabolic process 3 10
GO:0043412 macromolecule modification 4 10
GO:0044238 primary metabolic process 2 10
GO:0071704 organic substance metabolic process 2 10
GO:1901564 organonitrogen compound metabolic process 3 10
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 10
GO:0004180 carboxypeptidase activity 5 10
GO:0004181 metallocarboxypeptidase activity 6 10
GO:0005488 binding 1 10
GO:0008233 peptidase activity 3 10
GO:0008235 metalloexopeptidase activity 5 10
GO:0008237 metallopeptidase activity 4 10
GO:0008238 exopeptidase activity 4 10
GO:0008270 zinc ion binding 6 10
GO:0016787 hydrolase activity 2 10
GO:0043167 ion binding 2 10
GO:0043169 cation binding 3 10
GO:0046872 metal ion binding 4 10
GO:0046914 transition metal ion binding 5 10
GO:0140096 catalytic activity, acting on a protein 2 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 221 225 PF00656 0.666
CLV_C14_Caspase3-7 230 234 PF00656 0.682
CLV_C14_Caspase3-7 357 361 PF00656 0.706
CLV_C14_Caspase3-7 520 524 PF00656 0.444
CLV_NRD_NRD_1 27 29 PF00675 0.554
CLV_NRD_NRD_1 331 333 PF00675 0.542
CLV_NRD_NRD_1 349 351 PF00675 0.506
CLV_NRD_NRD_1 537 539 PF00675 0.397
CLV_NRD_NRD_1 622 624 PF00675 0.550
CLV_NRD_NRD_1 845 847 PF00675 0.708
CLV_NRD_NRD_1 869 871 PF00675 0.664
CLV_PCSK_KEX2_1 331 333 PF00082 0.573
CLV_PCSK_KEX2_1 349 351 PF00082 0.506
CLV_PCSK_KEX2_1 570 572 PF00082 0.443
CLV_PCSK_KEX2_1 622 624 PF00082 0.550
CLV_PCSK_KEX2_1 845 847 PF00082 0.731
CLV_PCSK_KEX2_1 868 870 PF00082 0.701
CLV_PCSK_PC1ET2_1 570 572 PF00082 0.475
CLV_PCSK_PC1ET2_1 622 624 PF00082 0.616
CLV_PCSK_SKI1_1 269 273 PF00082 0.708
CLV_PCSK_SKI1_1 405 409 PF00082 0.428
CLV_PCSK_SKI1_1 415 419 PF00082 0.401
CLV_PCSK_SKI1_1 557 561 PF00082 0.311
CLV_PCSK_SKI1_1 690 694 PF00082 0.379
CLV_PCSK_SKI1_1 814 818 PF00082 0.569
CLV_PCSK_SKI1_1 872 876 PF00082 0.738
DEG_APCC_DBOX_1 689 697 PF00400 0.474
DOC_CDC14_PxL_1 430 438 PF14671 0.310
DOC_CDC14_PxL_1 504 512 PF14671 0.401
DOC_CKS1_1 205 210 PF01111 0.587
DOC_CKS1_1 597 602 PF01111 0.376
DOC_CYCLIN_RxL_1 811 820 PF00134 0.552
DOC_MAPK_DCC_7 778 788 PF00069 0.359
DOC_MAPK_gen_1 268 280 PF00069 0.620
DOC_MAPK_gen_1 778 788 PF00069 0.310
DOC_MAPK_gen_1 868 876 PF00069 0.707
DOC_MAPK_MEF2A_6 155 163 PF00069 0.591
DOC_MAPK_MEF2A_6 273 282 PF00069 0.542
DOC_MAPK_MEF2A_6 557 564 PF00069 0.326
DOC_MAPK_MEF2A_6 781 788 PF00069 0.292
DOC_PP1_RVXF_1 627 634 PF00149 0.538
DOC_PP1_RVXF_1 783 789 PF00149 0.238
DOC_PP2B_LxvP_1 673 676 PF13499 0.508
DOC_PP4_FxxP_1 86 89 PF00568 0.502
DOC_USP7_MATH_1 236 240 PF00917 0.537
DOC_USP7_MATH_1 330 334 PF00917 0.566
DOC_USP7_MATH_1 348 352 PF00917 0.596
DOC_USP7_MATH_1 372 376 PF00917 0.616
DOC_USP7_MATH_1 443 447 PF00917 0.344
DOC_USP7_MATH_1 62 66 PF00917 0.775
DOC_USP7_MATH_1 747 751 PF00917 0.518
DOC_USP7_MATH_2 14 20 PF00917 0.773
DOC_USP7_UBL2_3 216 220 PF12436 0.659
DOC_USP7_UBL2_3 268 272 PF12436 0.653
DOC_USP7_UBL2_3 741 745 PF12436 0.550
DOC_WW_Pin1_4 10 15 PF00397 0.702
DOC_WW_Pin1_4 204 209 PF00397 0.583
DOC_WW_Pin1_4 254 259 PF00397 0.788
DOC_WW_Pin1_4 292 297 PF00397 0.570
DOC_WW_Pin1_4 596 601 PF00397 0.375
DOC_WW_Pin1_4 671 676 PF00397 0.588
DOC_WW_Pin1_4 678 683 PF00397 0.495
DOC_WW_Pin1_4 846 851 PF00397 0.763
LIG_14-3-3_CanoR_1 32 42 PF00244 0.609
LIG_14-3-3_CanoR_1 453 458 PF00244 0.388
LIG_14-3-3_CanoR_1 785 789 PF00244 0.531
LIG_APCC_ABBA_1 558 563 PF00400 0.344
LIG_APCC_ABBAyCdc20_2 557 563 PF00400 0.321
LIG_BRCT_BRCA1_1 105 109 PF00533 0.499
LIG_BRCT_BRCA1_1 168 172 PF00533 0.561
LIG_BRCT_BRCA1_1 605 609 PF00533 0.371
LIG_Clathr_ClatBox_1 114 118 PF01394 0.490
LIG_deltaCOP1_diTrp_1 80 86 PF00928 0.622
LIG_EH1_1 544 552 PF00400 0.369
LIG_eIF4E_1 545 551 PF01652 0.401
LIG_FHA_1 247 253 PF00498 0.685
LIG_FHA_1 464 470 PF00498 0.356
LIG_FHA_1 597 603 PF00498 0.424
LIG_FHA_1 644 650 PF00498 0.435
LIG_FHA_1 668 674 PF00498 0.642
LIG_FHA_1 714 720 PF00498 0.460
LIG_FHA_1 797 803 PF00498 0.527
LIG_FHA_2 127 133 PF00498 0.508
LIG_FHA_2 419 425 PF00498 0.369
LIG_FHA_2 682 688 PF00498 0.482
LIG_FHA_2 774 780 PF00498 0.501
LIG_FHA_2 878 884 PF00498 0.785
LIG_GBD_Chelix_1 719 727 PF00786 0.535
LIG_HOMEOBOX 174 177 PF00046 0.561
LIG_IRF3_LxIS_1 417 423 PF10401 0.444
LIG_LIR_Apic_2 293 297 PF02991 0.671
LIG_LIR_Gen_1 173 182 PF02991 0.577
LIG_LIR_Gen_1 397 403 PF02991 0.470
LIG_LIR_Gen_1 599 609 PF02991 0.463
LIG_LIR_Nem_3 122 128 PF02991 0.526
LIG_LIR_Nem_3 173 179 PF02991 0.516
LIG_LIR_Nem_3 207 213 PF02991 0.591
LIG_LIR_Nem_3 315 319 PF02991 0.431
LIG_LIR_Nem_3 397 401 PF02991 0.536
LIG_LIR_Nem_3 599 604 PF02991 0.405
LIG_LIR_Nem_3 787 791 PF02991 0.397
LIG_LIR_Nem_3 793 797 PF02991 0.382
LIG_LYPXL_yS_3 210 213 PF13949 0.616
LIG_MYND_1 508 512 PF01753 0.401
LIG_NRBOX 692 698 PF00104 0.369
LIG_Pex14_2 105 109 PF04695 0.490
LIG_Pex14_2 172 176 PF04695 0.508
LIG_Pex14_2 736 740 PF04695 0.433
LIG_PTB_Apo_2 585 592 PF02174 0.425
LIG_PTB_Phospho_1 585 591 PF10480 0.427
LIG_SH2_CRK 189 193 PF00017 0.472
LIG_SH2_CRK 294 298 PF00017 0.672
LIG_SH2_CRK 545 549 PF00017 0.412
LIG_SH2_CRK 591 595 PF00017 0.387
LIG_SH2_NCK_1 189 193 PF00017 0.603
LIG_SH2_NCK_1 294 298 PF00017 0.677
LIG_SH2_PTP2 462 465 PF00017 0.401
LIG_SH2_STAP1 189 193 PF00017 0.513
LIG_SH2_STAP1 545 549 PF00017 0.444
LIG_SH2_STAP1 591 595 PF00017 0.387
LIG_SH2_STAT3 317 320 PF00017 0.484
LIG_SH2_STAT5 128 131 PF00017 0.511
LIG_SH2_STAT5 189 192 PF00017 0.436
LIG_SH2_STAT5 294 297 PF00017 0.672
LIG_SH2_STAT5 307 310 PF00017 0.324
LIG_SH2_STAT5 314 317 PF00017 0.422
LIG_SH2_STAT5 394 397 PF00017 0.567
LIG_SH2_STAT5 402 405 PF00017 0.410
LIG_SH2_STAT5 462 465 PF00017 0.401
LIG_SH2_STAT5 601 604 PF00017 0.420
LIG_SH2_STAT5 642 645 PF00017 0.384
LIG_SH2_STAT5 97 100 PF00017 0.508
LIG_SH3_2 809 814 PF14604 0.483
LIG_SH3_3 181 187 PF00018 0.427
LIG_SH3_3 202 208 PF00018 0.562
LIG_SH3_3 211 217 PF00018 0.592
LIG_SH3_3 71 77 PF00018 0.680
LIG_SH3_3 806 812 PF00018 0.496
LIG_SH3_4 216 223 PF00018 0.659
LIG_SUMO_SIM_anti_2 416 421 PF11976 0.401
LIG_SUMO_SIM_anti_2 798 805 PF11976 0.520
LIG_SUMO_SIM_par_1 418 424 PF11976 0.337
LIG_SUMO_SIM_par_1 593 599 PF11976 0.368
LIG_SUMO_SIM_par_1 655 661 PF11976 0.443
LIG_SUMO_SIM_par_1 798 805 PF11976 0.550
LIG_SUMO_SIM_par_1 861 867 PF11976 0.655
LIG_SUMO_SIM_par_1 871 881 PF11976 0.740
LIG_TRAF2_1 767 770 PF00917 0.626
LIG_TYR_ITIM 589 594 PF00017 0.389
LIG_UBA3_1 692 700 PF00899 0.400
LIG_WRC_WIRS_1 120 125 PF05994 0.291
LIG_WRC_WIRS_1 791 796 PF05994 0.501
LIG_WW_3 811 815 PF00397 0.484
MOD_CDK_SPK_2 10 15 PF00069 0.707
MOD_CDK_SPxxK_3 254 261 PF00069 0.789
MOD_CK1_1 262 268 PF00069 0.763
MOD_CK1_1 31 37 PF00069 0.735
MOD_CK1_1 375 381 PF00069 0.725
MOD_CK1_1 423 429 PF00069 0.403
MOD_CK1_1 553 559 PF00069 0.463
MOD_CK1_1 596 602 PF00069 0.393
MOD_CK1_1 6 12 PF00069 0.723
MOD_CK1_1 65 71 PF00069 0.571
MOD_CK1_1 681 687 PF00069 0.544
MOD_CK1_1 731 737 PF00069 0.447
MOD_CK1_1 849 855 PF00069 0.707
MOD_CK1_1 878 884 PF00069 0.702
MOD_CK2_1 10 16 PF00069 0.679
MOD_CK2_1 348 354 PF00069 0.799
MOD_CK2_1 747 753 PF00069 0.620
MOD_CK2_1 773 779 PF00069 0.522
MOD_CK2_1 877 883 PF00069 0.788
MOD_Cter_Amidation 620 623 PF01082 0.652
MOD_GlcNHglycan 110 113 PF01048 0.344
MOD_GlcNHglycan 237 241 PF01048 0.739
MOD_GlcNHglycan 262 265 PF01048 0.719
MOD_GlcNHglycan 302 305 PF01048 0.300
MOD_GlcNHglycan 356 359 PF01048 0.742
MOD_GlcNHglycan 374 377 PF01048 0.514
MOD_GlcNHglycan 445 448 PF01048 0.375
MOD_GlcNHglycan 457 460 PF01048 0.385
MOD_GlcNHglycan 5 8 PF01048 0.681
MOD_GlcNHglycan 59 62 PF01048 0.585
MOD_GlcNHglycan 619 622 PF01048 0.623
MOD_GlcNHglycan 67 70 PF01048 0.605
MOD_GlcNHglycan 730 733 PF01048 0.482
MOD_GlcNHglycan 788 791 PF01048 0.486
MOD_GlcNHglycan 819 822 PF01048 0.680
MOD_GlcNHglycan 826 829 PF01048 0.658
MOD_GlcNHglycan 841 844 PF01048 0.590
MOD_GlcNHglycan 851 854 PF01048 0.709
MOD_GSK3_1 104 111 PF00069 0.344
MOD_GSK3_1 16 23 PF00069 0.672
MOD_GSK3_1 166 173 PF00069 0.418
MOD_GSK3_1 252 259 PF00069 0.757
MOD_GSK3_1 30 37 PF00069 0.491
MOD_GSK3_1 350 357 PF00069 0.762
MOD_GSK3_1 371 378 PF00069 0.680
MOD_GSK3_1 420 427 PF00069 0.206
MOD_GSK3_1 517 524 PF00069 0.369
MOD_GSK3_1 6 13 PF00069 0.688
MOD_GSK3_1 603 610 PF00069 0.404
MOD_GSK3_1 640 647 PF00069 0.459
MOD_GSK3_1 667 674 PF00069 0.642
MOD_GSK3_1 681 688 PF00069 0.417
MOD_GSK3_1 708 715 PF00069 0.501
MOD_GSK3_1 758 765 PF00069 0.488
MOD_GSK3_1 786 793 PF00069 0.547
MOD_GSK3_1 845 852 PF00069 0.742
MOD_GSK3_1 864 871 PF00069 0.757
MOD_GSK3_1 874 881 PF00069 0.626
MOD_LATS_1 124 130 PF00433 0.310
MOD_LATS_1 519 525 PF00433 0.369
MOD_N-GLC_1 278 283 PF02516 0.422
MOD_N-GLC_1 488 493 PF02516 0.401
MOD_N-GLC_1 607 612 PF02516 0.388
MOD_N-GLC_2 854 856 PF02516 0.729
MOD_NEK2_1 103 108 PF00069 0.369
MOD_NEK2_1 146 151 PF00069 0.412
MOD_NEK2_1 166 171 PF00069 0.373
MOD_NEK2_1 278 283 PF00069 0.577
MOD_NEK2_1 3 8 PF00069 0.709
MOD_NEK2_1 448 453 PF00069 0.458
MOD_NEK2_1 550 555 PF00069 0.375
MOD_NEK2_1 615 620 PF00069 0.543
MOD_NEK2_1 650 655 PF00069 0.426
MOD_NEK2_1 685 690 PF00069 0.490
MOD_NEK2_1 713 718 PF00069 0.479
MOD_NEK2_1 758 763 PF00069 0.489
MOD_NEK2_1 804 809 PF00069 0.511
MOD_NEK2_1 817 822 PF00069 0.502
MOD_NMyristoyl 1 7 PF02799 0.616
MOD_PIKK_1 104 110 PF00454 0.444
MOD_PIKK_1 16 22 PF00454 0.717
MOD_PIKK_1 448 454 PF00454 0.408
MOD_PIKK_1 6 12 PF00454 0.695
MOD_PIKK_1 62 68 PF00454 0.744
MOD_PIKK_1 708 714 PF00454 0.577
MOD_PIKK_1 802 808 PF00454 0.510
MOD_PK_1 272 278 PF00069 0.538
MOD_PKA_1 272 278 PF00069 0.609
MOD_PKA_1 28 34 PF00069 0.625
MOD_PKA_1 349 355 PF00069 0.632
MOD_PKA_1 570 576 PF00069 0.498
MOD_PKA_1 623 629 PF00069 0.561
MOD_PKA_1 845 851 PF00069 0.810
MOD_PKA_1 868 874 PF00069 0.783
MOD_PKA_2 20 26 PF00069 0.726
MOD_PKA_2 31 37 PF00069 0.716
MOD_PKA_2 330 336 PF00069 0.614
MOD_PKA_2 348 354 PF00069 0.772
MOD_PKA_2 570 576 PF00069 0.498
MOD_PKA_2 784 790 PF00069 0.530
MOD_PKA_2 845 851 PF00069 0.778
MOD_PKA_2 868 874 PF00069 0.741
MOD_PKB_1 26 34 PF00069 0.498
MOD_Plk_1 278 284 PF00069 0.424
MOD_Plk_1 415 421 PF00069 0.444
MOD_Plk_1 423 429 PF00069 0.444
MOD_Plk_1 48 54 PF00069 0.707
MOD_Plk_1 644 650 PF00069 0.429
MOD_Plk_1 878 884 PF00069 0.706
MOD_Plk_2-3 773 779 PF00069 0.533
MOD_Plk_4 312 318 PF00069 0.478
MOD_Plk_4 415 421 PF00069 0.429
MOD_Plk_4 570 576 PF00069 0.488
MOD_Plk_4 731 737 PF00069 0.491
MOD_Plk_4 758 764 PF00069 0.400
MOD_ProDKin_1 10 16 PF00069 0.705
MOD_ProDKin_1 204 210 PF00069 0.577
MOD_ProDKin_1 254 260 PF00069 0.786
MOD_ProDKin_1 292 298 PF00069 0.573
MOD_ProDKin_1 596 602 PF00069 0.374
MOD_ProDKin_1 671 677 PF00069 0.583
MOD_ProDKin_1 678 684 PF00069 0.484
MOD_ProDKin_1 846 852 PF00069 0.765
MOD_SUMO_for_1 284 287 PF00179 0.564
TRG_DiLeu_BaLyEn_6 208 213 PF01217 0.668
TRG_DiLeu_BaLyEn_6 778 783 PF01217 0.555
TRG_DiLeu_LyEn_5 431 436 PF01217 0.408
TRG_ENDOCYTIC_2 128 131 PF00928 0.423
TRG_ENDOCYTIC_2 174 177 PF00928 0.389
TRG_ENDOCYTIC_2 189 192 PF00928 0.362
TRG_ENDOCYTIC_2 210 213 PF00928 0.545
TRG_ENDOCYTIC_2 316 319 PF00928 0.436
TRG_ENDOCYTIC_2 462 465 PF00928 0.361
TRG_ENDOCYTIC_2 545 548 PF00928 0.421
TRG_ENDOCYTIC_2 591 594 PF00928 0.365
TRG_ENDOCYTIC_2 601 604 PF00928 0.381
TRG_ER_diArg_1 868 870 PF00400 0.744
TRG_NLS_MonoCore_2 266 271 PF00514 0.685
TRG_NLS_MonoExtC_3 267 272 PF00514 0.710
TRG_NLS_MonoExtC_3 27 32 PF00514 0.495
TRG_NLS_MonoExtN_4 26 33 PF00514 0.498
TRG_NLS_MonoExtN_4 267 273 PF00514 0.747
TRG_Pf-PMV_PEXEL_1 725 730 PF00026 0.388

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HSB1 Leptomonas seymouri 65% 70%
A0A0S4J4P7 Bodo saltans 38% 100%
A0A1X0PB49 Trypanosomatidae 47% 100%
A0A3S7X873 Leishmania donovani 91% 100%
A4HB04 Leishmania braziliensis 74% 100%
A4IA60 Leishmania infantum 91% 100%
C9ZM45 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 49% 100%
Q4Q2R3 Leishmania major 89% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS