LeishMANIAdb
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Signal recognition particle subunit SRP68

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Signal recognition particle subunit SRP68
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B570_LEIMU
TriTrypDb:
LmxM.33.2790
Length:
600

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005730 nucleolus 5 11
GO:0005786 signal recognition particle, endoplasmic reticulum targeting 4 11
GO:0032991 protein-containing complex 1 11
GO:0043226 organelle 2 11
GO:0043228 non-membrane-bounded organelle 3 11
GO:0043229 intracellular organelle 3 11
GO:0043232 intracellular non-membrane-bounded organelle 4 11
GO:0048500 signal recognition particle 3 11
GO:0110165 cellular anatomical entity 1 11
GO:1990904 ribonucleoprotein complex 2 11

Expansion

Sequence features

E9B570
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B570

Function

Biological processes
Term Name Level Count
GO:0006605 protein targeting 5 11
GO:0006612 protein targeting to membrane 5 11
GO:0006613 cotranslational protein targeting to membrane 6 11
GO:0006614 SRP-dependent cotranslational protein targeting to membrane 7 11
GO:0006810 transport 3 11
GO:0006886 intracellular protein transport 4 11
GO:0008104 protein localization 4 11
GO:0009987 cellular process 1 11
GO:0015031 protein transport 4 11
GO:0033036 macromolecule localization 2 11
GO:0033365 protein localization to organelle 5 11
GO:0045047 protein targeting to ER 6 11
GO:0045184 establishment of protein localization 3 11
GO:0046907 intracellular transport 3 11
GO:0051179 localization 1 11
GO:0051234 establishment of localization 2 11
GO:0051641 cellular localization 2 11
GO:0051649 establishment of localization in cell 3 11
GO:0051668 localization within membrane 3 11
GO:0070727 cellular macromolecule localization 3 11
GO:0070972 protein localization to endoplasmic reticulum 6 11
GO:0071702 organic substance transport 4 11
GO:0071705 nitrogen compound transport 4 11
GO:0072594 establishment of protein localization to organelle 4 11
GO:0072599 establishment of protein localization to endoplasmic reticulum 5 11
GO:0072657 protein localization to membrane 4 11
GO:0090150 establishment of protein localization to membrane 4 11
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 11
GO:0003723 RNA binding 4 11
GO:0005047 signal recognition particle binding 4 11
GO:0005048 signal sequence binding 4 11
GO:0005488 binding 1 11
GO:0008312 7S RNA binding 5 11
GO:0030942 endoplasmic reticulum signal peptide binding 5 11
GO:0033218 amide binding 2 11
GO:0042277 peptide binding 3 11
GO:0043021 ribonucleoprotein complex binding 3 11
GO:0044877 protein-containing complex binding 2 11
GO:0097159 organic cyclic compound binding 2 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 561 565 PF00656 0.714
CLV_NRD_NRD_1 113 115 PF00675 0.209
CLV_NRD_NRD_1 171 173 PF00675 0.181
CLV_NRD_NRD_1 297 299 PF00675 0.235
CLV_NRD_NRD_1 342 344 PF00675 0.257
CLV_NRD_NRD_1 353 355 PF00675 0.186
CLV_NRD_NRD_1 383 385 PF00675 0.275
CLV_NRD_NRD_1 506 508 PF00675 0.241
CLV_PCSK_FUR_1 384 388 PF00082 0.146
CLV_PCSK_KEX2_1 115 117 PF00082 0.207
CLV_PCSK_KEX2_1 297 299 PF00082 0.235
CLV_PCSK_KEX2_1 342 344 PF00082 0.257
CLV_PCSK_KEX2_1 352 354 PF00082 0.193
CLV_PCSK_KEX2_1 386 388 PF00082 0.185
CLV_PCSK_KEX2_1 506 508 PF00082 0.314
CLV_PCSK_PC1ET2_1 115 117 PF00082 0.221
CLV_PCSK_PC1ET2_1 386 388 PF00082 0.146
CLV_PCSK_SKI1_1 119 123 PF00082 0.235
CLV_PCSK_SKI1_1 162 166 PF00082 0.248
CLV_PCSK_SKI1_1 258 262 PF00082 0.249
CLV_PCSK_SKI1_1 35 39 PF00082 0.294
CLV_PCSK_SKI1_1 360 364 PF00082 0.245
CLV_PCSK_SKI1_1 467 471 PF00082 0.291
CLV_PCSK_SKI1_1 50 54 PF00082 0.170
CLV_PCSK_SKI1_1 542 546 PF00082 0.228
CLV_PCSK_SKI1_1 55 59 PF00082 0.129
CLV_Separin_Metazoa 400 404 PF03568 0.435
DEG_SPOP_SBC_1 571 575 PF00917 0.476
DOC_ANK_TNKS_1 313 320 PF00023 0.476
DOC_MAPK_MEF2A_6 262 271 PF00069 0.346
DOC_MAPK_MEF2A_6 66 73 PF00069 0.425
DOC_MAPK_NFAT4_5 66 74 PF00069 0.515
DOC_PP1_RVXF_1 117 124 PF00149 0.421
DOC_USP7_MATH_1 230 234 PF00917 0.381
DOC_USP7_MATH_1 408 412 PF00917 0.504
DOC_USP7_MATH_1 419 423 PF00917 0.439
DOC_USP7_MATH_1 432 436 PF00917 0.496
DOC_USP7_MATH_1 505 509 PF00917 0.566
DOC_USP7_MATH_1 556 560 PF00917 0.613
DOC_USP7_UBL2_3 115 119 PF12436 0.421
DOC_USP7_UBL2_3 122 126 PF12436 0.421
DOC_USP7_UBL2_3 51 55 PF12436 0.478
DOC_WW_Pin1_4 394 399 PF00397 0.432
DOC_WW_Pin1_4 506 511 PF00397 0.528
LIG_14-3-3_CanoR_1 116 122 PF00244 0.414
LIG_14-3-3_CanoR_1 153 161 PF00244 0.453
LIG_14-3-3_CanoR_1 172 176 PF00244 0.463
LIG_14-3-3_CanoR_1 179 189 PF00244 0.492
LIG_14-3-3_CanoR_1 200 204 PF00244 0.515
LIG_14-3-3_CanoR_1 35 40 PF00244 0.449
LIG_14-3-3_CanoR_1 360 368 PF00244 0.373
LIG_14-3-3_CanoR_1 506 510 PF00244 0.448
LIG_14-3-3_CanoR_1 568 576 PF00244 0.476
LIG_Actin_WH2_2 326 344 PF00022 0.515
LIG_APCC_ABBA_1 71 76 PF00400 0.453
LIG_APCC_ABBAyCdc20_2 50 56 PF00400 0.451
LIG_BIR_II_1 1 5 PF00653 0.485
LIG_deltaCOP1_diTrp_1 444 452 PF00928 0.535
LIG_FHA_1 142 148 PF00498 0.456
LIG_FHA_1 229 235 PF00498 0.449
LIG_FHA_1 247 253 PF00498 0.486
LIG_FHA_1 31 37 PF00498 0.435
LIG_FHA_1 342 348 PF00498 0.524
LIG_FHA_1 391 397 PF00498 0.560
LIG_FHA_1 511 517 PF00498 0.494
LIG_FHA_1 520 526 PF00498 0.457
LIG_FHA_1 571 577 PF00498 0.750
LIG_FHA_1 6 12 PF00498 0.424
LIG_FHA_2 313 319 PF00498 0.355
LIG_FHA_2 549 555 PF00498 0.528
LIG_FHA_2 89 95 PF00498 0.346
LIG_Integrin_isoDGR_2 246 248 PF01839 0.236
LIG_LIR_Apic_2 365 371 PF02991 0.389
LIG_LIR_Apic_2 393 398 PF02991 0.419
LIG_LIR_Gen_1 184 194 PF02991 0.394
LIG_LIR_Gen_1 323 333 PF02991 0.519
LIG_LIR_Nem_3 174 178 PF02991 0.447
LIG_LIR_Nem_3 184 190 PF02991 0.448
LIG_LIR_Nem_3 23 28 PF02991 0.452
LIG_LIR_Nem_3 323 328 PF02991 0.519
LIG_LIR_Nem_3 550 555 PF02991 0.430
LIG_SH2_CRK 175 179 PF00017 0.518
LIG_SH2_CRK 325 329 PF00017 0.424
LIG_SH2_CRK 368 372 PF00017 0.377
LIG_SH2_GRB2like 301 304 PF00017 0.515
LIG_SH2_NCK_1 368 372 PF00017 0.346
LIG_SH2_PTP2 395 398 PF00017 0.389
LIG_SH2_STAP1 253 257 PF00017 0.476
LIG_SH2_STAT3 203 206 PF00017 0.515
LIG_SH2_STAT5 146 149 PF00017 0.478
LIG_SH2_STAT5 203 206 PF00017 0.438
LIG_SH2_STAT5 25 28 PF00017 0.454
LIG_SH2_STAT5 31 34 PF00017 0.446
LIG_SH2_STAT5 331 334 PF00017 0.388
LIG_SH2_STAT5 395 398 PF00017 0.389
LIG_SH2_STAT5 459 462 PF00017 0.571
LIG_SH2_STAT5 514 517 PF00017 0.435
LIG_SH3_3 527 533 PF00018 0.464
LIG_SH3_3 537 543 PF00018 0.386
LIG_SH3_3 574 580 PF00018 0.511
LIG_SUMO_SIM_anti_2 397 403 PF11976 0.435
LIG_SUMO_SIM_anti_2 461 468 PF11976 0.505
LIG_SUMO_SIM_par_1 290 296 PF11976 0.435
LIG_TRAF2_1 476 479 PF00917 0.493
LIG_TRAF2_1 518 521 PF00917 0.441
LIG_TYR_ITSM 321 328 PF00017 0.424
LIG_WW_1 533 536 PF00397 0.421
MOD_CK1_1 180 186 PF00069 0.461
MOD_CK1_1 238 244 PF00069 0.565
MOD_CK1_1 369 375 PF00069 0.467
MOD_CK1_1 495 501 PF00069 0.490
MOD_CK1_1 570 576 PF00069 0.604
MOD_CK1_1 95 101 PF00069 0.441
MOD_CK2_1 312 318 PF00069 0.464
MOD_CK2_1 394 400 PF00069 0.436
MOD_CK2_1 408 414 PF00069 0.444
MOD_CK2_1 419 425 PF00069 0.457
MOD_CK2_1 473 479 PF00069 0.531
MOD_CK2_1 556 562 PF00069 0.661
MOD_CK2_1 88 94 PF00069 0.374
MOD_GlcNHglycan 224 227 PF01048 0.315
MOD_GlcNHglycan 237 240 PF01048 0.349
MOD_GlcNHglycan 368 371 PF01048 0.160
MOD_GlcNHglycan 421 424 PF01048 0.285
MOD_GlcNHglycan 434 437 PF01048 0.285
MOD_GlcNHglycan 494 497 PF01048 0.227
MOD_GlcNHglycan 569 572 PF01048 0.653
MOD_GlcNHglycan 581 584 PF01048 0.595
MOD_GSK3_1 337 344 PF00069 0.421
MOD_GSK3_1 358 365 PF00069 0.472
MOD_GSK3_1 366 373 PF00069 0.435
MOD_GSK3_1 390 397 PF00069 0.419
MOD_GSK3_1 442 449 PF00069 0.466
MOD_GSK3_1 450 457 PF00069 0.445
MOD_GSK3_1 506 513 PF00069 0.525
MOD_GSK3_1 562 569 PF00069 0.732
MOD_GSK3_1 88 95 PF00069 0.376
MOD_N-GLC_1 117 122 PF02516 0.235
MOD_N-GLC_1 180 185 PF02516 0.168
MOD_N-GLC_1 60 65 PF02516 0.249
MOD_NEK2_1 117 122 PF00069 0.435
MOD_NEK2_1 147 152 PF00069 0.476
MOD_NEK2_1 341 346 PF00069 0.421
MOD_NEK2_1 362 367 PF00069 0.478
MOD_NEK2_1 494 499 PF00069 0.474
MOD_NEK2_1 5 10 PF00069 0.305
MOD_NEK2_2 337 342 PF00069 0.515
MOD_PIKK_1 11 17 PF00454 0.427
MOD_PIKK_1 182 188 PF00454 0.474
MOD_PIKK_1 238 244 PF00454 0.515
MOD_PIKK_1 390 396 PF00454 0.419
MOD_PIKK_1 520 526 PF00454 0.549
MOD_PK_1 581 587 PF00069 0.464
MOD_PKA_1 92 98 PF00069 0.476
MOD_PKA_2 171 177 PF00069 0.464
MOD_PKA_2 199 205 PF00069 0.511
MOD_PKA_2 341 347 PF00069 0.491
MOD_PKA_2 446 452 PF00069 0.435
MOD_PKA_2 505 511 PF00069 0.448
MOD_PKA_2 567 573 PF00069 0.489
MOD_PKA_2 95 101 PF00069 0.441
MOD_Plk_1 117 123 PF00069 0.435
MOD_Plk_1 141 147 PF00069 0.478
MOD_Plk_1 358 364 PF00069 0.478
MOD_Plk_1 5 11 PF00069 0.326
MOD_Plk_1 520 526 PF00069 0.471
MOD_Plk_2-3 562 568 PF00069 0.593
MOD_Plk_4 230 236 PF00069 0.407
MOD_Plk_4 454 460 PF00069 0.472
MOD_Plk_4 5 11 PF00069 0.362
MOD_Plk_4 510 516 PF00069 0.515
MOD_Plk_4 548 554 PF00069 0.533
MOD_ProDKin_1 394 400 PF00069 0.432
MOD_ProDKin_1 506 512 PF00069 0.528
MOD_SUMO_for_1 139 142 PF00179 0.456
MOD_SUMO_rev_2 157 167 PF00179 0.478
MOD_SUMO_rev_2 268 276 PF00179 0.502
MOD_SUMO_rev_2 44 52 PF00179 0.480
TRG_ENDOCYTIC_2 175 178 PF00928 0.450
TRG_ENDOCYTIC_2 325 328 PF00928 0.430
TRG_ENDOCYTIC_2 331 334 PF00928 0.391
TRG_ER_diArg_1 113 116 PF00400 0.421
TRG_ER_diArg_1 297 299 PF00400 0.442
TRG_ER_diArg_1 341 343 PF00400 0.459
TRG_ER_diArg_1 351 354 PF00400 0.394
TRG_NLS_MonoCore_2 383 388 PF00514 0.398
TRG_NLS_MonoExtC_3 383 389 PF00514 0.398
TRG_Pf-PMV_PEXEL_1 345 349 PF00026 0.146
TRG_PTS2 1 43 PF00400 0.263

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IH42 Leptomonas seymouri 68% 99%
A0A0S4J2Z5 Bodo saltans 45% 100%
A0A1X0PAR6 Trypanosomatidae 48% 100%
A0A3S7X839 Leishmania donovani 89% 100%
A4HAZ6 Leishmania braziliensis 82% 100%
A4IA56 Leishmania infantum 90% 100%
C9ZM46 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 100%
Q00004 Canis lupus familiaris 25% 96%
Q20822 Caenorhabditis elegans 20% 96%
Q4Q2R5 Leishmania major 90% 100%
Q8BMA6 Mus musculus 25% 96%
Q9UHB9 Homo sapiens 24% 96%
Q9VSS2 Drosophila melanogaster 24% 99%
V5BV06 Trypanosoma cruzi 48% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS