Serine/threonine-protein phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine protein phosphatase-like protein

Species:

Leishmania mexicana

UniProt:

E9B568_LEIMU

TriTrypDb:

LmxM.33.2770

Length:

629

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B568

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B568

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004721	phosphoprotein phosphatase activity	3	10
GO:0004722	protein serine/threonine phosphatase activity	4	10
GO:0016787	hydrolase activity	2	10
GO:0016788	hydrolase activity, acting on ester bonds	3	10
GO:0016791	phosphatase activity	5	10
GO:0017018	myosin phosphatase activity	5	10
GO:0042578	phosphoric ester hydrolase activity	4	10
GO:0140096	catalytic activity, acting on a protein	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	323	327	PF00656	0.512
CLV_C14_Caspase3-7	41	45	PF00656	0.495
CLV_NRD_NRD_1	116	118	PF00675	0.624
CLV_NRD_NRD_1	363	365	PF00675	0.530
CLV_NRD_NRD_1	451	453	PF00675	0.455
CLV_NRD_NRD_1	584	586	PF00675	0.523
CLV_PCSK_FUR_1	370	374	PF00082	0.513
CLV_PCSK_KEX2_1	363	365	PF00082	0.530
CLV_PCSK_KEX2_1	372	374	PF00082	0.364
CLV_PCSK_KEX2_1	451	453	PF00082	0.483
CLV_PCSK_KEX2_1	480	482	PF00082	0.798
CLV_PCSK_PC1ET2_1	372	374	PF00082	0.511
CLV_PCSK_PC1ET2_1	480	482	PF00082	0.798
CLV_PCSK_SKI1_1	121	125	PF00082	0.703
CLV_PCSK_SKI1_1	183	187	PF00082	0.368
CLV_PCSK_SKI1_1	363	367	PF00082	0.523
CLV_PCSK_SKI1_1	451	455	PF00082	0.421
CLV_PCSK_SKI1_1	566	570	PF00082	0.408
CLV_PCSK_SKI1_1	67	71	PF00082	0.431
DEG_Nend_Nbox_1	1	3	PF02207	0.422
DEG_SCF_FBW7_1	145	152	PF00400	0.642
DEG_SCF_TRCP1_1	135	141	PF00400	0.589
DEG_SPOP_SBC_1	157	161	PF00917	0.481
DOC_CYCLIN_RxL_1	180	189	PF00134	0.368
DOC_CYCLIN_yClb3_PxF_3	598	604	PF00134	0.637
DOC_CYCLIN_yCln2_LP_2	139	145	PF00134	0.515
DOC_CYCLIN_yCln2_LP_2	18	21	PF00134	0.495
DOC_MAPK_gen_1	193	203	PF00069	0.424
DOC_MAPK_HePTP_8	69	81	PF00069	0.427
DOC_MAPK_MEF2A_6	193	202	PF00069	0.420
DOC_MAPK_MEF2A_6	72	81	PF00069	0.429
DOC_PP1_RVXF_1	178	185	PF00149	0.499
DOC_PP1_RVXF_1	554	560	PF00149	0.461
DOC_PP2B_LxvP_1	18	21	PF13499	0.495
DOC_PP4_FxxP_1	526	529	PF00568	0.333
DOC_USP7_MATH_1	113	117	PF00917	0.447
DOC_USP7_MATH_1	157	161	PF00917	0.681
DOC_USP7_MATH_1	261	265	PF00917	0.751
DOC_USP7_MATH_1	301	305	PF00917	0.707
DOC_USP7_MATH_1	327	331	PF00917	0.504
DOC_USP7_MATH_1	387	391	PF00917	0.627
DOC_USP7_MATH_1	470	474	PF00917	0.765
DOC_USP7_MATH_1	548	552	PF00917	0.615
DOC_WW_Pin1_4	138	143	PF00397	0.688
DOC_WW_Pin1_4	145	150	PF00397	0.642
DOC_WW_Pin1_4	266	271	PF00397	0.671
DOC_WW_Pin1_4	356	361	PF00397	0.344
DOC_WW_Pin1_4	383	388	PF00397	0.629
DOC_WW_Pin1_4	394	399	PF00397	0.527
LIG_14-3-3_CanoR_1	111	116	PF00244	0.363
LIG_14-3-3_CanoR_1	28	37	PF00244	0.439
LIG_14-3-3_CanoR_1	308	316	PF00244	0.748
LIG_14-3-3_CanoR_1	363	371	PF00244	0.532
LIG_Actin_WH2_2	39	55	PF00022	0.515
LIG_BRCT_BRCA1_1	170	174	PF00533	0.700
LIG_deltaCOP1_diTrp_1	326	335	PF00928	0.463
LIG_FHA_1	146	152	PF00498	0.631
LIG_FHA_1	225	231	PF00498	0.368
LIG_FHA_1	25	31	PF00498	0.295
LIG_FHA_1	383	389	PF00498	0.693
LIG_FHA_2	321	327	PF00498	0.603
LIG_FHA_2	73	79	PF00498	0.331
LIG_LIR_Apic_2	524	529	PF02991	0.331
LIG_LIR_Gen_1	326	335	PF02991	0.410
LIG_LIR_Gen_1	85	93	PF02991	0.478
LIG_LIR_Nem_3	326	331	PF02991	0.383
LIG_LIR_Nem_3	334	340	PF02991	0.291
LIG_LIR_Nem_3	558	562	PF02991	0.393
LIG_LIR_Nem_3	618	624	PF02991	0.672
LIG_LIR_Nem_3	8	14	PF02991	0.471
LIG_LIR_Nem_3	85	90	PF02991	0.482
LIG_MYND_1	16	20	PF01753	0.506
LIG_PCNA_yPIPBox_3	413	423	PF02747	0.510
LIG_PCNA_yPIPBox_3	607	621	PF02747	0.661
LIG_PCNA_yPIPBox_3	98	111	PF02747	0.469
LIG_Pex14_2	331	335	PF04695	0.442
LIG_Rb_pABgroove_1	8	16	PF01858	0.430
LIG_SH2_CRK	26	30	PF00017	0.289
LIG_SH2_CRK	531	535	PF00017	0.415
LIG_SH2_STAP1	26	30	PF00017	0.349
LIG_SH2_STAT5	12	15	PF00017	0.428
LIG_SH2_STAT5	190	193	PF00017	0.354
LIG_SH2_STAT5	26	29	PF00017	0.428
LIG_SH2_STAT5	42	45	PF00017	0.550
LIG_SH2_STAT5	531	534	PF00017	0.417
LIG_SH2_STAT5	620	623	PF00017	0.653
LIG_SH3_2	602	607	PF14604	0.710
LIG_SH3_3	250	256	PF00018	0.436
LIG_SH3_3	596	602	PF00018	0.646
LIG_SH3_3	609	615	PF00018	0.678
LIG_SUMO_SIM_anti_2	199	205	PF11976	0.393
LIG_SUMO_SIM_anti_2	44	50	PF11976	0.467
LIG_SUMO_SIM_par_1	521	527	PF11976	0.331
LIG_TRAF2_2	126	131	PF00917	0.672
LIG_TRAF2_2	415	420	PF00917	0.492
LIG_UBA3_1	203	208	PF00899	0.368
LIG_WW_3	487	491	PF00397	0.663
LIG_WW_3	597	601	PF00397	0.472
MOD_CDC14_SPxK_1	397	400	PF00782	0.710
MOD_CDK_SPK_2	398	403	PF00069	0.650
MOD_CDK_SPxK_1	394	400	PF00069	0.713
MOD_CDK_SPxxK_3	356	363	PF00069	0.470
MOD_CK1_1	103	109	PF00069	0.435
MOD_CK1_1	159	165	PF00069	0.682
MOD_CK1_1	306	312	PF00069	0.712
MOD_CK1_1	38	44	PF00069	0.303
MOD_CK1_1	386	392	PF00069	0.585
MOD_CK1_1	393	399	PF00069	0.635
MOD_CK1_1	408	414	PF00069	0.579
MOD_CK1_1	425	431	PF00069	0.506
MOD_CK1_1	463	469	PF00069	0.533
MOD_CK1_1	551	557	PF00069	0.602
MOD_CK1_1	575	581	PF00069	0.723
MOD_CK1_1	589	595	PF00069	0.473
MOD_CK1_1	68	74	PF00069	0.504
MOD_CK2_1	249	255	PF00069	0.641
MOD_CK2_1	287	293	PF00069	0.499
MOD_CK2_1	309	315	PF00069	0.734
MOD_CK2_1	393	399	PF00069	0.687
MOD_CK2_1	408	414	PF00069	0.610
MOD_GlcNHglycan	111	114	PF01048	0.560
MOD_GlcNHglycan	133	138	PF01048	0.785
MOD_GlcNHglycan	303	306	PF01048	0.732
MOD_GlcNHglycan	312	315	PF01048	0.712
MOD_GlcNHglycan	389	392	PF01048	0.601
MOD_GlcNHglycan	485	488	PF01048	0.623
MOD_GlcNHglycan	526	529	PF01048	0.346
MOD_GlcNHglycan	550	553	PF01048	0.522
MOD_GlcNHglycan	586	589	PF01048	0.677
MOD_GlcNHglycan	591	594	PF01048	0.687
MOD_GSK3_1	109	116	PF00069	0.537
MOD_GSK3_1	117	124	PF00069	0.737
MOD_GSK3_1	133	140	PF00069	0.774
MOD_GSK3_1	145	152	PF00069	0.746
MOD_GSK3_1	24	31	PF00069	0.264
MOD_GSK3_1	306	313	PF00069	0.716
MOD_GSK3_1	316	323	PF00069	0.560
MOD_GSK3_1	327	334	PF00069	0.449
MOD_GSK3_1	347	354	PF00069	0.195
MOD_GSK3_1	382	389	PF00069	0.662
MOD_GSK3_1	390	397	PF00069	0.717
MOD_GSK3_1	405	412	PF00069	0.574
MOD_GSK3_1	425	432	PF00069	0.307
MOD_GSK3_1	460	467	PF00069	0.706
MOD_GSK3_1	479	486	PF00069	0.568
MOD_GSK3_1	568	575	PF00069	0.498
MOD_GSK3_1	68	75	PF00069	0.564
MOD_LATS_1	584	590	PF00433	0.555
MOD_N-GLC_1	306	311	PF02516	0.727
MOD_N-GLC_1	331	336	PF02516	0.391
MOD_N-GLC_1	589	594	PF02516	0.555
MOD_N-GLC_2	530	532	PF02516	0.396
MOD_NEK2_1	100	105	PF00069	0.381
MOD_NEK2_1	109	114	PF00069	0.460
MOD_NEK2_1	151	156	PF00069	0.681
MOD_NEK2_1	331	336	PF00069	0.443
MOD_NEK2_1	351	356	PF00069	0.397
MOD_NEK2_1	380	385	PF00069	0.691
MOD_NEK2_1	447	452	PF00069	0.326
MOD_NEK2_1	521	526	PF00069	0.407
MOD_NEK2_1	569	574	PF00069	0.401
MOD_NEK2_2	347	352	PF00069	0.507
MOD_PIKK_1	121	127	PF00454	0.743
MOD_PIKK_1	363	369	PF00454	0.512
MOD_PIKK_1	460	466	PF00454	0.671
MOD_PIKK_1	494	500	PF00454	0.610
MOD_PIKK_1	514	520	PF00454	0.217
MOD_PK_1	111	117	PF00069	0.375
MOD_PKA_1	117	123	PF00069	0.654
MOD_PKA_1	363	369	PF00069	0.562
MOD_PKA_1	372	378	PF00069	0.440
MOD_PKA_2	363	369	PF00069	0.512
MOD_PKA_2	372	378	PF00069	0.523
MOD_PKA_2	584	590	PF00069	0.536
MOD_Plk_1	331	337	PF00069	0.394
MOD_Plk_1	38	44	PF00069	0.517
MOD_Plk_2-3	249	255	PF00069	0.608
MOD_Plk_4	100	106	PF00069	0.401
MOD_Plk_4	249	255	PF00069	0.706
MOD_Plk_4	261	267	PF00069	0.629
MOD_Plk_4	347	353	PF00069	0.388
MOD_Plk_4	38	44	PF00069	0.500
MOD_Plk_4	521	527	PF00069	0.331
MOD_Plk_4	65	71	PF00069	0.456
MOD_Plk_4	72	78	PF00069	0.406
MOD_ProDKin_1	138	144	PF00069	0.681
MOD_ProDKin_1	145	151	PF00069	0.643
MOD_ProDKin_1	266	272	PF00069	0.672
MOD_ProDKin_1	356	362	PF00069	0.345
MOD_ProDKin_1	383	389	PF00069	0.634
MOD_ProDKin_1	394	400	PF00069	0.527
MOD_SUMO_for_1	207	210	PF00179	0.368
MOD_SUMO_for_1	371	374	PF00179	0.504
MOD_SUMO_rev_2	473	482	PF00179	0.675
MOD_SUMO_rev_2	553	561	PF00179	0.473
MOD_SUMO_rev_2	61	69	PF00179	0.492
TRG_DiLeu_BaEn_1	199	204	PF01217	0.368
TRG_ENDOCYTIC_2	231	234	PF00928	0.338
TRG_ENDOCYTIC_2	26	29	PF00928	0.428
TRG_ENDOCYTIC_2	531	534	PF00928	0.450
TRG_ER_diArg_1	362	364	PF00400	0.518
TRG_ER_diArg_1	451	453	PF00400	0.497
TRG_NES_CRM1_1	199	210	PF08389	0.374
TRG_Pf-PMV_PEXEL_1	28	32	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	363	367	PF00026	0.567

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6E6	Leptomonas seymouri	54%	100%
A0A3S7X863	Leishmania donovani	87%	100%
A4HAZ4	Leishmania braziliensis	72%	100%
A4IA54	Leishmania infantum	87%	100%
C9ZM48	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
D0A366	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	99%
Q4Q2R7	Leishmania major	87%	100%
V5BBS3	Trypanosoma cruzi	27%	100%