LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B567_LEIMU
TriTrypDb:
LmxM.33.2765
Length:
343

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B567
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B567

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 279 283 PF00656 0.526
CLV_NRD_NRD_1 30 32 PF00675 0.545
CLV_NRD_NRD_1 57 59 PF00675 0.742
CLV_PCSK_KEX2_1 30 32 PF00082 0.476
CLV_PCSK_KEX2_1 57 59 PF00082 0.817
CLV_PCSK_KEX2_1 69 71 PF00082 0.625
CLV_PCSK_PC1ET2_1 30 32 PF00082 0.476
CLV_PCSK_PC1ET2_1 69 71 PF00082 0.615
DEG_SPOP_SBC_1 213 217 PF00917 0.642
DOC_CKS1_1 306 311 PF01111 0.484
DOC_CKS1_1 65 70 PF01111 0.671
DOC_MAPK_gen_1 30 39 PF00069 0.523
DOC_MAPK_MEF2A_6 30 39 PF00069 0.601
DOC_PP2B_LxvP_1 11 14 PF13499 0.644
DOC_PP2B_LxvP_1 232 235 PF13499 0.574
DOC_USP7_MATH_1 120 124 PF00917 0.753
DOC_USP7_MATH_1 147 151 PF00917 0.635
DOC_USP7_MATH_1 169 173 PF00917 0.537
DOC_USP7_MATH_1 213 217 PF00917 0.533
DOC_USP7_MATH_1 225 229 PF00917 0.530
DOC_USP7_MATH_1 254 258 PF00917 0.578
DOC_WW_Pin1_4 100 105 PF00397 0.531
DOC_WW_Pin1_4 141 146 PF00397 0.671
DOC_WW_Pin1_4 288 293 PF00397 0.498
DOC_WW_Pin1_4 305 310 PF00397 0.510
DOC_WW_Pin1_4 320 325 PF00397 0.579
DOC_WW_Pin1_4 64 69 PF00397 0.672
DOC_WW_Pin1_4 85 90 PF00397 0.664
LIG_14-3-3_CanoR_1 128 136 PF00244 0.585
LIG_14-3-3_CanoR_1 140 145 PF00244 0.667
LIG_14-3-3_CanoR_1 187 195 PF00244 0.453
LIG_14-3-3_CanoR_1 201 207 PF00244 0.518
LIG_14-3-3_CanoR_1 331 335 PF00244 0.555
LIG_BIR_III_4 26 30 PF00653 0.481
LIG_FHA_1 133 139 PF00498 0.669
LIG_FHA_1 234 240 PF00498 0.600
LIG_FHA_1 306 312 PF00498 0.482
LIG_FHA_1 34 40 PF00498 0.613
LIG_FHA_2 155 161 PF00498 0.659
LIG_FHA_2 189 195 PF00498 0.522
LIG_FHA_2 207 213 PF00498 0.527
LIG_FHA_2 85 91 PF00498 0.744
LIG_Integrin_RGD_1 198 200 PF01839 0.634
LIG_LIR_Apic_2 139 145 PF02991 0.504
LIG_SH2_CRK 142 146 PF00017 0.648
LIG_SH2_CRK 177 181 PF00017 0.374
LIG_SH2_NCK_1 142 146 PF00017 0.506
LIG_SH2_STAT5 177 180 PF00017 0.629
LIG_SH2_STAT5 288 291 PF00017 0.503
LIG_SH3_3 241 247 PF00018 0.491
LIG_SH3_3 310 316 PF00018 0.592
LIG_SUMO_SIM_anti_2 157 165 PF11976 0.551
LIG_SUMO_SIM_anti_2 236 243 PF11976 0.582
LIG_SUMO_SIM_par_1 228 237 PF11976 0.589
LIG_SUMO_SIM_par_1 333 339 PF11976 0.433
LIG_TRAF2_1 270 273 PF00917 0.628
LIG_TYR_ITIM 175 180 PF00017 0.378
LIG_UBA3_1 161 168 PF00899 0.492
MOD_CDK_SPK_2 64 69 PF00069 0.672
MOD_CDK_SPxK_1 64 70 PF00069 0.619
MOD_CDK_SPxxK_3 100 107 PF00069 0.652
MOD_CK1_1 214 220 PF00069 0.612
MOD_CK1_1 286 292 PF00069 0.664
MOD_CK1_1 293 299 PF00069 0.589
MOD_CK1_1 333 339 PF00069 0.554
MOD_CK1_1 84 90 PF00069 0.716
MOD_CK2_1 147 153 PF00069 0.773
MOD_CK2_1 188 194 PF00069 0.510
MOD_CK2_1 267 273 PF00069 0.578
MOD_CK2_1 85 91 PF00069 0.742
MOD_Cter_Amidation 28 31 PF01082 0.481
MOD_GlcNHglycan 104 107 PF01048 0.607
MOD_GlcNHglycan 118 121 PF01048 0.699
MOD_GlcNHglycan 149 152 PF01048 0.511
MOD_GlcNHglycan 228 231 PF01048 0.546
MOD_GlcNHglycan 243 247 PF01048 0.493
MOD_GlcNHglycan 256 259 PF01048 0.626
MOD_GlcNHglycan 269 272 PF01048 0.565
MOD_GlcNHglycan 4 7 PF01048 0.590
MOD_GlcNHglycan 47 50 PF01048 0.664
MOD_GlcNHglycan 84 87 PF01048 0.686
MOD_GSK3_1 116 123 PF00069 0.666
MOD_GSK3_1 128 135 PF00069 0.598
MOD_GSK3_1 136 143 PF00069 0.551
MOD_GSK3_1 189 196 PF00069 0.665
MOD_GSK3_1 202 209 PF00069 0.681
MOD_GSK3_1 211 218 PF00069 0.638
MOD_GSK3_1 248 255 PF00069 0.618
MOD_GSK3_1 282 289 PF00069 0.676
MOD_GSK3_1 81 88 PF00069 0.683
MOD_NEK2_1 175 180 PF00069 0.535
MOD_NEK2_1 252 257 PF00069 0.584
MOD_NEK2_1 330 335 PF00069 0.559
MOD_NEK2_2 176 181 PF00069 0.531
MOD_NEK2_2 283 288 PF00069 0.510
MOD_PIKK_1 325 331 PF00454 0.549
MOD_PK_1 109 115 PF00069 0.696
MOD_PKA_2 200 206 PF00069 0.592
MOD_PKA_2 330 336 PF00069 0.553
MOD_PKB_1 17 25 PF00069 0.583
MOD_Plk_2-3 21 27 PF00069 0.487
MOD_Plk_4 283 289 PF00069 0.517
MOD_Plk_4 307 313 PF00069 0.513
MOD_Plk_4 330 336 PF00069 0.553
MOD_ProDKin_1 100 106 PF00069 0.530
MOD_ProDKin_1 141 147 PF00069 0.671
MOD_ProDKin_1 288 294 PF00069 0.497
MOD_ProDKin_1 305 311 PF00069 0.509
MOD_ProDKin_1 320 326 PF00069 0.576
MOD_ProDKin_1 64 70 PF00069 0.673
MOD_ProDKin_1 85 91 PF00069 0.662
TRG_ENDOCYTIC_2 177 180 PF00928 0.573
TRG_ER_diArg_1 16 19 PF00400 0.539
TRG_ER_diArg_1 56 58 PF00400 0.763

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S5H7X2 Leishmania donovani 78% 100%
A4HAZ3 Leishmania braziliensis 50% 99%
A4IA53 Leishmania infantum 78% 100%
Q4Q2R8 Leishmania major 74% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS