Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B566_LEIMU

TriTrypDb:

LmxM.33.2760

Length:

300

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B566

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B566

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	82	86	PF00656	0.606
CLV_C14_Caspase3-7	98	102	PF00656	0.678
CLV_NRD_NRD_1	131	133	PF00675	0.463
CLV_NRD_NRD_1	275	277	PF00675	0.520
CLV_NRD_NRD_1	279	281	PF00675	0.545
CLV_NRD_NRD_1	57	59	PF00675	0.495
CLV_PCSK_KEX2_1	131	133	PF00082	0.463
CLV_PCSK_KEX2_1	275	277	PF00082	0.516
CLV_PCSK_KEX2_1	279	281	PF00082	0.520
CLV_PCSK_KEX2_1	57	59	PF00082	0.495
CLV_PCSK_PC7_1	271	277	PF00082	0.497
CLV_PCSK_SKI1_1	183	187	PF00082	0.445
CLV_PCSK_SKI1_1	222	226	PF00082	0.609
CLV_Separin_Metazoa	254	258	PF03568	0.556
DEG_Nend_UBRbox_3	1	3	PF02207	0.649
DOC_CYCLIN_RxL_1	177	190	PF00134	0.412
DOC_USP7_MATH_1	104	108	PF00917	0.723
DOC_WW_Pin1_4	191	196	PF00397	0.451
LIG_14-3-3_CanoR_1	207	215	PF00244	0.445
LIG_Actin_WH2_2	194	209	PF00022	0.444
LIG_BIR_III_4	85	89	PF00653	0.581
LIG_BRCT_BRCA1_1	195	199	PF00533	0.427
LIG_FHA_1	20	26	PF00498	0.411
LIG_FHA_1	226	232	PF00498	0.546
LIG_FHA_1	45	51	PF00498	0.439
LIG_FHA_2	145	151	PF00498	0.379
LIG_FHA_2	165	171	PF00498	0.318
LIG_LIR_Gen_1	156	166	PF02991	0.447
LIG_LIR_Nem_3	134	139	PF02991	0.406
LIG_LIR_Nem_3	156	162	PF02991	0.440
LIG_NRBOX	181	187	PF00104	0.402
LIG_PALB2_WD40_1	237	245	PF16756	0.537
LIG_Pex14_1	238	242	PF04695	0.546
LIG_SH2_CRK	159	163	PF00017	0.459
LIG_SH2_NCK_1	215	219	PF00017	0.489
LIG_SH2_STAP1	208	212	PF00017	0.564
LIG_SH2_STAT5	200	203	PF00017	0.417
LIG_SUMO_SIM_anti_2	170	175	PF11976	0.359
LIG_SUMO_SIM_par_1	187	194	PF11976	0.435
LIG_TRAF2_1	288	291	PF00917	0.559
MOD_CDK_SPxxK_3	191	198	PF00069	0.511
MOD_CK1_1	193	199	PF00069	0.567
MOD_CK1_1	258	264	PF00069	0.525
MOD_CK2_1	164	170	PF00069	0.444
MOD_CK2_1	76	82	PF00069	0.703
MOD_CK2_1	8	14	PF00069	0.621
MOD_CMANNOS	238	241	PF00535	0.546
MOD_GlcNHglycan	106	109	PF01048	0.556
MOD_GlcNHglycan	208	211	PF01048	0.597
MOD_GlcNHglycan	233	236	PF01048	0.671
MOD_GSK3_1	206	213	PF00069	0.523
MOD_GSK3_1	4	11	PF00069	0.633
MOD_N-GLC_2	40	42	PF02516	0.385
MOD_NEK2_1	199	204	PF00069	0.437
MOD_NEK2_1	206	211	PF00069	0.504
MOD_NEK2_1	231	236	PF00069	0.583
MOD_NEK2_1	45	50	PF00069	0.421
MOD_OFUCOSY	142	148	PF10250	0.383
MOD_PIKK_1	95	101	PF00454	0.695
MOD_PKA_1	131	137	PF00069	0.446
MOD_PKA_2	131	137	PF00069	0.432
MOD_PKA_2	206	212	PF00069	0.517
MOD_Plk_1	144	150	PF00069	0.379
MOD_Plk_2-3	8	14	PF00069	0.621
MOD_Plk_4	157	163	PF00069	0.519
MOD_ProDKin_1	191	197	PF00069	0.448
TRG_DiLeu_BaEn_1	184	189	PF01217	0.391
TRG_ENDOCYTIC_2	114	117	PF00928	0.462
TRG_ENDOCYTIC_2	159	162	PF00928	0.450
TRG_ENDOCYTIC_2	208	211	PF00928	0.533
TRG_ER_diArg_1	279	282	PF00400	0.528
TRG_ER_diArg_1	56	58	PF00400	0.488
TRG_NLS_MonoExtN_4	279	286	PF00514	0.464
TRG_Pf-PMV_PEXEL_1	115	119	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P606	Leptomonas seymouri	58%	100%
A0A3S7X837	Leishmania donovani	93%	100%
A4HAZ2	Leishmania braziliensis	81%	100%
A4IA52	Leishmania infantum	92%	100%
Q4Q2R9	Leishmania major	92%	100%