Putative gpi transamidase component

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GPI transamidase subunit 16, putative

Species:

Leishmania mexicana

UniProt:

E9B563_LEIMU

TriTrypDb:

LmxM.33.2730

Length:

733

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 6, no: 4
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9B563

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B563

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	446	450	PF00656	0.518
CLV_NRD_NRD_1	11	13	PF00675	0.467
CLV_NRD_NRD_1	123	125	PF00675	0.535
CLV_NRD_NRD_1	47	49	PF00675	0.568
CLV_NRD_NRD_1	710	712	PF00675	0.417
CLV_PCSK_KEX2_1	11	13	PF00082	0.506
CLV_PCSK_KEX2_1	122	124	PF00082	0.531
CLV_PCSK_KEX2_1	47	49	PF00082	0.568
CLV_PCSK_KEX2_1	648	650	PF00082	0.725
CLV_PCSK_KEX2_1	710	712	PF00082	0.398
CLV_PCSK_KEX2_1	715	717	PF00082	0.394
CLV_PCSK_PC1ET2_1	648	650	PF00082	0.623
CLV_PCSK_PC1ET2_1	715	717	PF00082	0.480
CLV_PCSK_PC7_1	711	717	PF00082	0.399
CLV_PCSK_SKI1_1	163	167	PF00082	0.638
CLV_PCSK_SKI1_1	368	372	PF00082	0.600
CLV_PCSK_SKI1_1	470	474	PF00082	0.571
CLV_PCSK_SKI1_1	710	714	PF00082	0.360
DEG_APCC_DBOX_1	367	375	PF00400	0.273
DEG_APCC_DBOX_1	480	488	PF00400	0.305
DEG_APCC_DBOX_1	648	656	PF00400	0.365
DEG_APCC_DBOX_1	715	723	PF00400	0.702
DOC_CKS1_1	386	391	PF01111	0.390
DOC_CYCLIN_yCln2_LP_2	473	479	PF00134	0.290
DOC_CYCLIN_yCln2_LP_2	78	84	PF00134	0.367
DOC_MAPK_DCC_7	368	376	PF00069	0.241
DOC_MAPK_DCC_7	470	479	PF00069	0.380
DOC_MAPK_DCC_7	579	587	PF00069	0.433
DOC_MAPK_gen_1	215	224	PF00069	0.447
DOC_MAPK_gen_1	350	358	PF00069	0.387
DOC_MAPK_gen_1	47	53	PF00069	0.307
DOC_MAPK_gen_1	546	556	PF00069	0.442
DOC_MAPK_gen_1	715	722	PF00069	0.598
DOC_MAPK_MEF2A_6	317	324	PF00069	0.368
DOC_MAPK_MEF2A_6	350	358	PF00069	0.435
DOC_MAPK_MEF2A_6	368	376	PF00069	0.239
DOC_MAPK_MEF2A_6	418	427	PF00069	0.415
DOC_MAPK_MEF2A_6	579	588	PF00069	0.336
DOC_PP1_RVXF_1	104	110	PF00149	0.269
DOC_PP1_RVXF_1	126	132	PF00149	0.351
DOC_PP2B_LxvP_1	78	81	PF13499	0.303
DOC_PP4_FxxP_1	288	291	PF00568	0.401
DOC_USP7_MATH_1	214	218	PF00917	0.508
DOC_USP7_MATH_1	280	284	PF00917	0.335
DOC_USP7_MATH_1	305	309	PF00917	0.493
DOC_USP7_MATH_1	34	38	PF00917	0.531
DOC_USP7_MATH_1	375	379	PF00917	0.418
DOC_USP7_MATH_1	393	397	PF00917	0.556
DOC_USP7_MATH_1	43	47	PF00917	0.390
DOC_USP7_MATH_1	591	595	PF00917	0.516
DOC_USP7_MATH_1	600	604	PF00917	0.476
DOC_USP7_MATH_1	94	98	PF00917	0.311
DOC_WW_Pin1_4	202	207	PF00397	0.371
DOC_WW_Pin1_4	210	215	PF00397	0.398
DOC_WW_Pin1_4	253	258	PF00397	0.436
DOC_WW_Pin1_4	376	381	PF00397	0.437
DOC_WW_Pin1_4	385	390	PF00397	0.448
DOC_WW_Pin1_4	395	400	PF00397	0.457
DOC_WW_Pin1_4	403	408	PF00397	0.374
DOC_WW_Pin1_4	63	68	PF00397	0.404
LIG_14-3-3_CanoR_1	106	110	PF00244	0.268
LIG_14-3-3_CanoR_1	11	20	PF00244	0.428
LIG_14-3-3_CanoR_1	186	194	PF00244	0.359
LIG_14-3-3_CanoR_1	323	327	PF00244	0.389
LIG_14-3-3_CanoR_1	391	399	PF00244	0.581
LIG_14-3-3_CanoR_1	47	52	PF00244	0.375
LIG_14-3-3_CanoR_1	590	597	PF00244	0.394
LIG_14-3-3_CanoR_1	649	659	PF00244	0.456
LIG_14-3-3_CanoR_1	670	674	PF00244	0.403
LIG_14-3-3_CanoR_1	710	719	PF00244	0.630
LIG_AP_GAE_1	110	116	PF02883	0.408
LIG_AP2alpha_1	109	113	PF02296	0.297
LIG_BIR_II_1	1	5	PF00653	0.577
LIG_BIR_III_2	642	646	PF00653	0.341
LIG_BRCT_BRCA1_1	155	159	PF00533	0.411
LIG_BRCT_BRCA1_1	175	179	PF00533	0.400
LIG_Clathr_ClatBox_1	431	435	PF01394	0.396
LIG_deltaCOP1_diTrp_1	130	138	PF00928	0.319
LIG_EH1_1	484	492	PF00400	0.411
LIG_eIF4E_1	485	491	PF01652	0.396
LIG_FHA_1	250	256	PF00498	0.359
LIG_FHA_1	313	319	PF00498	0.384
LIG_FHA_1	422	428	PF00498	0.302
LIG_FHA_1	469	475	PF00498	0.389
LIG_FHA_1	492	498	PF00498	0.410
LIG_FHA_1	505	511	PF00498	0.363
LIG_FHA_1	516	522	PF00498	0.368
LIG_FHA_1	55	61	PF00498	0.383
LIG_FHA_1	64	70	PF00498	0.353
LIG_FHA_1	707	713	PF00498	0.602
LIG_FHA_1	727	733	PF00498	0.648
LIG_FHA_2	106	112	PF00498	0.355
LIG_HCF-1_HBM_1	419	422	PF13415	0.429
LIG_LIR_Apic_2	286	291	PF02991	0.257
LIG_LIR_Gen_1	173	182	PF02991	0.401
LIG_LIR_Gen_1	241	250	PF02991	0.419
LIG_LIR_Gen_1	419	430	PF02991	0.369
LIG_LIR_Gen_1	46	56	PF02991	0.405
LIG_LIR_Nem_3	110	116	PF02991	0.325
LIG_LIR_Nem_3	156	162	PF02991	0.440
LIG_LIR_Nem_3	173	177	PF02991	0.422
LIG_LIR_Nem_3	236	242	PF02991	0.347
LIG_LIR_Nem_3	283	287	PF02991	0.308
LIG_LIR_Nem_3	419	425	PF02991	0.324
LIG_NRBOX	507	513	PF00104	0.333
LIG_NRBOX	718	724	PF00104	0.648
LIG_Pex14_1	194	198	PF04695	0.336
LIG_Pex14_2	109	113	PF04695	0.415
LIG_Pex14_2	277	281	PF04695	0.309
LIG_Pex14_2	284	288	PF04695	0.289
LIG_Pex14_2	559	563	PF04695	0.311
LIG_PTB_Apo_2	275	282	PF02174	0.204
LIG_SH2_CRK	174	178	PF00017	0.411
LIG_SH2_CRK	242	246	PF00017	0.396
LIG_SH2_NCK_1	174	178	PF00017	0.400
LIG_SH2_NCK_1	524	528	PF00017	0.403
LIG_SH2_SRC	528	531	PF00017	0.377
LIG_SH2_STAP1	411	415	PF00017	0.280
LIG_SH2_STAP1	49	53	PF00017	0.339
LIG_SH2_STAP1	524	528	PF00017	0.403
LIG_SH2_STAT5	119	122	PF00017	0.426
LIG_SH2_STAT5	287	290	PF00017	0.354
LIG_SH2_STAT5	422	425	PF00017	0.344
LIG_SH3_3	307	313	PF00018	0.318
LIG_SH3_3	374	380	PF00018	0.415
LIG_SH3_3	578	584	PF00018	0.417
LIG_SH3_3	78	84	PF00018	0.367
LIG_SUMO_SIM_anti_2	507	515	PF11976	0.374
LIG_SUMO_SIM_par_1	23	28	PF11976	0.334
LIG_SUMO_SIM_par_1	430	435	PF11976	0.446
LIG_TRAF2_1	299	302	PF00917	0.428
LIG_TYR_ITIM	116	121	PF00017	0.495
LIG_UBA3_1	655	660	PF00899	0.439
LIG_Vh1_VBS_1	497	515	PF01044	0.388
LIG_WRC_WIRS_1	281	286	PF05994	0.467
MOD_CDK_SPK_2	210	215	PF00069	0.516
MOD_CDK_SPK_2	376	381	PF00069	0.479
MOD_CDK_SPxK_1	385	391	PF00069	0.615
MOD_CDK_SPxxK_3	395	402	PF00069	0.625
MOD_CK1_1	175	181	PF00069	0.390
MOD_CK1_1	200	206	PF00069	0.457
MOD_CK1_1	229	235	PF00069	0.557
MOD_CK1_1	283	289	PF00069	0.577
MOD_CK1_1	398	404	PF00069	0.634
MOD_CK1_1	448	454	PF00069	0.586
MOD_CK1_1	603	609	PF00069	0.665
MOD_CK1_1	675	681	PF00069	0.645
MOD_CK2_1	229	235	PF00069	0.574
MOD_CK2_1	329	335	PF00069	0.464
MOD_CK2_1	376	382	PF00069	0.607
MOD_CK2_1	56	62	PF00069	0.542
MOD_Cter_Amidation	646	649	PF01082	0.545
MOD_GlcNHglycan	13	16	PF01048	0.593
MOD_GlcNHglycan	148	151	PF01048	0.717
MOD_GlcNHglycan	231	234	PF01048	0.564
MOD_GlcNHglycan	263	266	PF01048	0.540
MOD_GlcNHglycan	368	371	PF01048	0.508
MOD_GlcNHglycan	393	396	PF01048	0.746
MOD_GlcNHglycan	452	457	PF01048	0.668
MOD_GlcNHglycan	565	568	PF01048	0.513
MOD_GlcNHglycan	593	596	PF01048	0.568
MOD_GlcNHglycan	652	655	PF01048	0.575
MOD_GlcNHglycan	674	677	PF01048	0.620
MOD_GlcNHglycan	698	701	PF01048	0.195
MOD_GSK3_1	142	149	PF00069	0.412
MOD_GSK3_1	197	204	PF00069	0.448
MOD_GSK3_1	210	217	PF00069	0.603
MOD_GSK3_1	249	256	PF00069	0.424
MOD_GSK3_1	293	300	PF00069	0.424
MOD_GSK3_1	335	342	PF00069	0.448
MOD_GSK3_1	391	398	PF00069	0.728
MOD_GSK3_1	43	50	PF00069	0.443
MOD_GSK3_1	448	455	PF00069	0.710
MOD_GSK3_1	486	493	PF00069	0.521
MOD_GSK3_1	511	518	PF00069	0.334
MOD_GSK3_1	668	675	PF00069	0.516
MOD_GSK3_1	706	713	PF00069	0.626
MOD_N-GLC_1	153	158	PF02516	0.425
MOD_N-GLC_1	306	311	PF02516	0.533
MOD_N-GLC_1	43	48	PF02516	0.431
MOD_N-GLC_1	638	643	PF02516	0.433
MOD_NEK2_1	198	203	PF00069	0.424
MOD_NEK2_1	207	212	PF00069	0.495
MOD_NEK2_1	457	462	PF00069	0.573
MOD_NEK2_1	490	495	PF00069	0.520
MOD_NEK2_1	511	516	PF00069	0.372
MOD_NEK2_1	563	568	PF00069	0.474
MOD_NEK2_1	655	660	PF00069	0.657
MOD_NEK2_1	696	701	PF00069	0.200
MOD_NEK2_1	74	79	PF00069	0.453
MOD_PIKK_1	187	193	PF00454	0.494
MOD_PIKK_1	249	255	PF00454	0.427
MOD_PIKK_1	297	303	PF00454	0.438
MOD_PIKK_1	361	367	PF00454	0.531
MOD_PKA_1	11	17	PF00069	0.502
MOD_PKA_1	47	53	PF00069	0.403
MOD_PKA_1	648	654	PF00069	0.544
MOD_PKA_1	710	716	PF00069	0.545
MOD_PKA_2	105	111	PF00069	0.327
MOD_PKA_2	11	17	PF00069	0.610
MOD_PKA_2	214	220	PF00069	0.607
MOD_PKA_2	322	328	PF00069	0.483
MOD_PKA_2	47	53	PF00069	0.438
MOD_PKA_2	480	486	PF00069	0.367
MOD_PKA_2	591	597	PF00069	0.381
MOD_PKA_2	62	68	PF00069	0.487
MOD_PKA_2	648	654	PF00069	0.608
MOD_PKA_2	669	675	PF00069	0.431
MOD_PKA_2	706	712	PF00069	0.452
MOD_Plk_1	140	146	PF00069	0.496
MOD_Plk_1	153	159	PF00069	0.385
MOD_Plk_1	306	312	PF00069	0.392
MOD_Plk_1	512	518	PF00069	0.475
MOD_Plk_1	600	606	PF00069	0.625
MOD_Plk_1	627	633	PF00069	0.559
MOD_Plk_1	74	80	PF00069	0.359
MOD_Plk_4	153	159	PF00069	0.575
MOD_Plk_4	25	31	PF00069	0.412
MOD_Plk_4	280	286	PF00069	0.440
MOD_Plk_4	322	328	PF00069	0.482
MOD_Plk_4	457	463	PF00069	0.504
MOD_Plk_4	47	53	PF00069	0.467
MOD_Plk_4	480	486	PF00069	0.467
MOD_Plk_4	65	71	PF00069	0.321
MOD_Plk_4	727	733	PF00069	0.654
MOD_ProDKin_1	202	208	PF00069	0.463
MOD_ProDKin_1	210	216	PF00069	0.496
MOD_ProDKin_1	253	259	PF00069	0.549
MOD_ProDKin_1	376	382	PF00069	0.557
MOD_ProDKin_1	385	391	PF00069	0.571
MOD_ProDKin_1	395	401	PF00069	0.577
MOD_ProDKin_1	403	409	PF00069	0.456
MOD_ProDKin_1	63	69	PF00069	0.493
MOD_SUMO_for_1	318	321	PF00179	0.402
TRG_DiLeu_BaEn_4	452	458	PF01217	0.420
TRG_DiLeu_BaLyEn_6	254	259	PF01217	0.534
TRG_ENDOCYTIC_2	118	121	PF00928	0.525
TRG_ENDOCYTIC_2	174	177	PF00928	0.524
TRG_ENDOCYTIC_2	242	245	PF00928	0.487
TRG_ENDOCYTIC_2	422	425	PF00928	0.366
TRG_ENDOCYTIC_2	49	52	PF00928	0.516
TRG_ER_diArg_1	121	124	PF00400	0.393
TRG_ER_diArg_1	47	49	PF00400	0.455
TRG_ER_diArg_1	710	712	PF00400	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I790	Leptomonas seymouri	60%	99%
A0A1X0P9R2	Trypanosomatidae	34%	100%
A0A3R7MUC6	Trypanosoma rangeli	34%	100%
A0A3S7X824	Leishmania donovani	88%	99%
A4HAY9	Leishmania braziliensis	77%	100%
A4IA49	Leishmania infantum	88%	99%
C9ZM54	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
Q4Q2S2	Leishmania major	88%	100%
V5BV01	Trypanosoma cruzi	34%	100%