LeishMANIAdb
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Major Facilitator Superfamily

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Major Facilitator Superfamily
Gene product:
major facilitator superfamily, putative
Species:
Leishmania mexicana
UniProt:
E9B562_LEIMU
TriTrypDb:
LmxM.33.2720
Length:
686

Annotations

LeishMANIAdb annotations

A family with high similarity to plant sugar transporters.. Might be an extensive family that already diverged in free-living Kinetoplastids

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

E9B562
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B562

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 10
GO:0022857 transmembrane transporter activity 2 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 316 320 PF00656 0.609
CLV_NRD_NRD_1 241 243 PF00675 0.416
CLV_NRD_NRD_1 422 424 PF00675 0.390
CLV_NRD_NRD_1 8 10 PF00675 0.347
CLV_PCSK_KEX2_1 241 243 PF00082 0.416
CLV_PCSK_KEX2_1 421 423 PF00082 0.385
CLV_PCSK_KEX2_1 493 495 PF00082 0.309
CLV_PCSK_KEX2_1 8 10 PF00082 0.347
CLV_PCSK_PC1ET2_1 241 243 PF00082 0.409
CLV_PCSK_PC1ET2_1 493 495 PF00082 0.309
CLV_PCSK_SKI1_1 32 36 PF00082 0.390
CLV_PCSK_SKI1_1 536 540 PF00082 0.416
CLV_PCSK_SKI1_1 9 13 PF00082 0.394
DEG_APCC_DBOX_1 170 178 PF00400 0.509
DEG_Nend_UBRbox_1 1 4 PF02207 0.591
DOC_CDC14_PxL_1 34 42 PF14671 0.588
DOC_CYCLIN_yClb5_NLxxxL_5 470 479 PF00134 0.213
DOC_CYCLIN_yCln2_LP_2 619 625 PF00134 0.615
DOC_MAPK_gen_1 171 179 PF00069 0.509
DOC_MAPK_gen_1 421 430 PF00069 0.552
DOC_MAPK_MEF2A_6 119 127 PF00069 0.348
DOC_MAPK_MEF2A_6 423 432 PF00069 0.514
DOC_PP1_RVXF_1 110 117 PF00149 0.472
DOC_PP4_FxxP_1 35 38 PF00568 0.533
DOC_USP7_MATH_1 233 237 PF00917 0.517
DOC_USP7_MATH_1 324 328 PF00917 0.715
DOC_USP7_MATH_1 343 347 PF00917 0.643
DOC_USP7_MATH_1 565 569 PF00917 0.413
DOC_USP7_MATH_1 631 635 PF00917 0.743
DOC_USP7_MATH_1 97 101 PF00917 0.351
DOC_WW_Pin1_4 319 324 PF00397 0.708
DOC_WW_Pin1_4 643 648 PF00397 0.824
LIG_14-3-3_CanoR_1 173 178 PF00244 0.517
LIG_14-3-3_CanoR_1 25 35 PF00244 0.672
LIG_14-3-3_CanoR_1 337 344 PF00244 0.752
LIG_14-3-3_CanoR_1 345 355 PF00244 0.719
LIG_14-3-3_CanoR_1 497 503 PF00244 0.406
LIG_14-3-3_CanoR_1 659 665 PF00244 0.692
LIG_14-3-3_CanoR_1 674 681 PF00244 0.674
LIG_Actin_WH2_2 151 169 PF00022 0.357
LIG_BRCT_BRCA1_1 175 179 PF00533 0.509
LIG_BRCT_BRCA1_1 227 231 PF00533 0.357
LIG_CSL_BTD_1 66 69 PF09270 0.309
LIG_DLG_GKlike_1 173 181 PF00625 0.504
LIG_EH1_1 219 227 PF00400 0.357
LIG_EH1_1 432 440 PF00400 0.213
LIG_eIF4E_1 454 460 PF01652 0.304
LIG_FHA_1 212 218 PF00498 0.458
LIG_FHA_1 246 252 PF00498 0.606
LIG_FHA_1 268 274 PF00498 0.766
LIG_FHA_1 380 386 PF00498 0.680
LIG_FHA_1 450 456 PF00498 0.351
LIG_FHA_1 467 473 PF00498 0.304
LIG_FHA_1 507 513 PF00498 0.513
LIG_FHA_1 541 547 PF00498 0.470
LIG_FHA_1 603 609 PF00498 0.397
LIG_FHA_1 667 673 PF00498 0.600
LIG_FHA_2 154 160 PF00498 0.416
LIG_FHA_2 18 24 PF00498 0.498
LIG_FHA_2 314 320 PF00498 0.610
LIG_FHA_2 661 667 PF00498 0.580
LIG_LIR_Gen_1 193 200 PF02991 0.344
LIG_LIR_Gen_1 509 518 PF02991 0.351
LIG_LIR_Gen_1 561 569 PF02991 0.509
LIG_LIR_Gen_1 593 603 PF02991 0.360
LIG_LIR_Gen_1 93 103 PF02991 0.232
LIG_LIR_Nem_3 193 198 PF02991 0.361
LIG_LIR_Nem_3 28 34 PF02991 0.542
LIG_LIR_Nem_3 452 457 PF02991 0.339
LIG_LIR_Nem_3 509 513 PF02991 0.351
LIG_LIR_Nem_3 561 566 PF02991 0.509
LIG_LIR_Nem_3 593 599 PF02991 0.360
LIG_LIR_Nem_3 64 70 PF02991 0.334
LIG_LIR_Nem_3 93 98 PF02991 0.232
LIG_Pex14_2 227 231 PF04695 0.414
LIG_Pex14_2 31 35 PF04695 0.500
LIG_Pex14_2 594 598 PF04695 0.357
LIG_Pex14_2 91 95 PF04695 0.213
LIG_PTAP_UEV_1 263 268 PF05743 0.698
LIG_SH2_CRK 495 499 PF00017 0.488
LIG_SH2_CRK 514 518 PF00017 0.351
LIG_SH2_CRK 626 630 PF00017 0.673
LIG_SH2_NCK_1 414 418 PF00017 0.590
LIG_SH2_SRC 414 417 PF00017 0.565
LIG_SH2_STAP1 175 179 PF00017 0.509
LIG_SH2_STAP1 27 31 PF00017 0.602
LIG_SH2_STAT5 197 200 PF00017 0.389
LIG_SH2_STAT5 27 30 PF00017 0.601
LIG_SH2_STAT5 409 412 PF00017 0.603
LIG_SH2_STAT5 454 457 PF00017 0.343
LIG_SH2_STAT5 533 536 PF00017 0.295
LIG_SH2_STAT5 72 75 PF00017 0.304
LIG_SH3_2 264 269 PF14604 0.703
LIG_SH3_3 104 110 PF00018 0.504
LIG_SH3_3 261 267 PF00018 0.754
LIG_SH3_3 270 276 PF00018 0.777
LIG_SH3_3 648 654 PF00018 0.829
LIG_SUMO_SIM_anti_2 248 255 PF11976 0.619
LIG_SUMO_SIM_anti_2 441 448 PF11976 0.357
LIG_SUMO_SIM_par_1 248 255 PF11976 0.703
LIG_SUMO_SIM_par_1 441 448 PF11976 0.442
LIG_SUMO_SIM_par_1 621 627 PF11976 0.695
LIG_SxIP_EBH_1 378 388 PF03271 0.626
LIG_TRAF2_1 20 23 PF00917 0.496
LIG_TYR_ITIM 512 517 PF00017 0.351
LIG_TYR_ITIM 624 629 PF00017 0.588
LIG_UBA3_1 221 229 PF00899 0.382
LIG_UBA3_1 457 461 PF00899 0.309
LIG_UBA3_1 511 520 PF00899 0.351
LIG_UBA3_1 579 587 PF00899 0.351
LIG_WRC_WIRS_1 507 512 PF05994 0.351
LIG_WRC_WIRS_1 595 600 PF05994 0.357
MOD_CK1_1 180 186 PF00069 0.357
MOD_CK1_1 346 352 PF00069 0.666
MOD_CK1_1 466 472 PF00069 0.304
MOD_CK1_1 56 62 PF00069 0.375
MOD_CK1_1 568 574 PF00069 0.352
MOD_CK1_1 677 683 PF00069 0.672
MOD_CK2_1 153 159 PF00069 0.416
MOD_CK2_1 17 23 PF00069 0.500
MOD_CK2_1 360 366 PF00069 0.677
MOD_CK2_1 631 637 PF00069 0.724
MOD_CK2_1 660 666 PF00069 0.588
MOD_Cter_Amidation 491 494 PF01082 0.309
MOD_GlcNHglycan 264 267 PF01048 0.578
MOD_GlcNHglycan 349 352 PF01048 0.454
MOD_GlcNHglycan 362 365 PF01048 0.485
MOD_GlcNHglycan 415 420 PF01048 0.441
MOD_GlcNHglycan 447 450 PF01048 0.357
MOD_GlcNHglycan 570 573 PF01048 0.400
MOD_GlcNHglycan 574 577 PF01048 0.395
MOD_GlcNHglycan 605 608 PF01048 0.357
MOD_GlcNHglycan 99 102 PF01048 0.387
MOD_GSK3_1 153 160 PF00069 0.405
MOD_GSK3_1 173 180 PF00069 0.388
MOD_GSK3_1 299 306 PF00069 0.822
MOD_GSK3_1 309 316 PF00069 0.680
MOD_GSK3_1 329 336 PF00069 0.690
MOD_GSK3_1 343 350 PF00069 0.761
MOD_GSK3_1 380 387 PF00069 0.743
MOD_GSK3_1 445 452 PF00069 0.348
MOD_GSK3_1 459 466 PF00069 0.273
MOD_GSK3_1 53 60 PF00069 0.351
MOD_GSK3_1 540 547 PF00069 0.341
MOD_GSK3_1 568 575 PF00069 0.388
MOD_GSK3_1 590 597 PF00069 0.206
MOD_GSK3_1 643 650 PF00069 0.751
MOD_N-GLC_1 153 158 PF02516 0.288
MOD_N-GLC_1 319 324 PF02516 0.482
MOD_N-GLC_1 463 468 PF02516 0.504
MOD_N-GLC_1 540 545 PF02516 0.357
MOD_N-GLC_1 75 80 PF02516 0.509
MOD_NEK2_1 153 158 PF00069 0.402
MOD_NEK2_1 190 195 PF00069 0.408
MOD_NEK2_1 40 45 PF00069 0.570
MOD_NEK2_1 459 464 PF00069 0.215
MOD_NEK2_1 475 480 PF00069 0.363
MOD_NEK2_1 527 532 PF00069 0.372
MOD_NEK2_1 53 58 PF00069 0.359
MOD_NEK2_1 540 545 PF00069 0.395
MOD_NEK2_1 594 599 PF00069 0.416
MOD_NEK2_1 602 607 PF00069 0.416
MOD_NEK2_1 75 80 PF00069 0.424
MOD_NEK2_2 157 162 PF00069 0.509
MOD_NEK2_2 27 32 PF00069 0.505
MOD_PIKK_1 645 651 PF00454 0.648
MOD_PKA_2 233 239 PF00069 0.540
MOD_PKA_2 299 305 PF00069 0.614
MOD_PKA_2 309 315 PF00069 0.725
MOD_PKA_2 336 342 PF00069 0.725
MOD_PKA_2 498 504 PF00069 0.406
MOD_PKA_2 558 564 PF00069 0.500
MOD_PKB_1 171 179 PF00069 0.509
MOD_Plk_1 153 159 PF00069 0.288
MOD_Plk_1 463 469 PF00069 0.304
MOD_Plk_1 540 546 PF00069 0.424
MOD_Plk_1 9 15 PF00069 0.525
MOD_Plk_4 157 163 PF00069 0.509
MOD_Plk_4 190 196 PF00069 0.364
MOD_Plk_4 220 226 PF00069 0.466
MOD_Plk_4 380 386 PF00069 0.725
MOD_Plk_4 391 397 PF00069 0.687
MOD_Plk_4 475 481 PF00069 0.513
MOD_Plk_4 506 512 PF00069 0.351
MOD_Plk_4 57 63 PF00069 0.406
MOD_Plk_4 590 596 PF00069 0.322
MOD_ProDKin_1 319 325 PF00069 0.711
MOD_ProDKin_1 643 649 PF00069 0.824
TRG_ENDOCYTIC_2 150 153 PF00928 0.416
TRG_ENDOCYTIC_2 197 200 PF00928 0.357
TRG_ENDOCYTIC_2 454 457 PF00928 0.351
TRG_ENDOCYTIC_2 495 498 PF00928 0.488
TRG_ENDOCYTIC_2 514 517 PF00928 0.351
TRG_ENDOCYTIC_2 626 629 PF00928 0.611
TRG_ENDOCYTIC_2 72 75 PF00928 0.304
TRG_ER_diArg_1 421 423 PF00400 0.589
TRG_Pf-PMV_PEXEL_1 548 553 PF00026 0.309

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I5K5 Leptomonas seymouri 56% 100%
A0A3Q8IIA5 Leishmania donovani 85% 100%
A0A3S7WTH9 Leishmania donovani 26% 100%
A4HWI5 Leishmania infantum 26% 100%
A4IA48 Leishmania infantum 85% 100%
E9AQ86 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
Q4Q2S3 Leishmania major 84% 100%
Q4QF97 Leishmania major 26% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS