ArgoN domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B561_LEIMU

TriTrypDb:

LmxM.33.2710

Length:

450

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B561

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B561

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.728
CLV_C14_Caspase3-7	235	239	PF00656	0.840
CLV_NRD_NRD_1	164	166	PF00675	0.674
CLV_NRD_NRD_1	21	23	PF00675	0.737
CLV_NRD_NRD_1	266	268	PF00675	0.600
CLV_NRD_NRD_1	382	384	PF00675	0.523
CLV_NRD_NRD_1	4	6	PF00675	0.725
CLV_NRD_NRD_1	51	53	PF00675	0.764
CLV_NRD_NRD_1	96	98	PF00675	0.837
CLV_PCSK_KEX2_1	21	23	PF00082	0.737
CLV_PCSK_KEX2_1	266	268	PF00082	0.508
CLV_PCSK_KEX2_1	381	383	PF00082	0.598
CLV_PCSK_KEX2_1	4	6	PF00082	0.725
CLV_PCSK_KEX2_1	51	53	PF00082	0.764
CLV_PCSK_KEX2_1	95	97	PF00082	0.843
CLV_PCSK_PC7_1	378	384	PF00082	0.553
CLV_PCSK_PC7_1	92	98	PF00082	0.835
CLV_PCSK_SKI1_1	249	253	PF00082	0.698
CLV_PCSK_SKI1_1	35	39	PF00082	0.589
DOC_CYCLIN_RxL_1	356	366	PF00134	0.463
DOC_MAPK_gen_1	400	410	PF00069	0.414
DOC_MAPK_gen_1	415	425	PF00069	0.442
DOC_MAPK_MEF2A_6	298	305	PF00069	0.493
DOC_PP1_SILK_1	387	392	PF00149	0.519
DOC_SPAK_OSR1_1	314	318	PF12202	0.399
DOC_USP7_MATH_1	177	181	PF00917	0.805
DOC_USP7_MATH_1	244	248	PF00917	0.721
DOC_USP7_MATH_1	71	75	PF00917	0.794
DOC_USP7_MATH_2	167	173	PF00917	0.544
DOC_WW_Pin1_4	180	185	PF00397	0.715
LIG_14-3-3_CanoR_1	153	159	PF00244	0.581
LIG_14-3-3_CanoR_1	186	194	PF00244	0.745
LIG_14-3-3_CanoR_1	249	259	PF00244	0.668
LIG_14-3-3_CanoR_1	351	359	PF00244	0.593
LIG_14-3-3_CanoR_1	381	386	PF00244	0.599
LIG_14-3-3_CanoR_1	51	55	PF00244	0.672
LIG_Actin_WH2_2	289	306	PF00022	0.583
LIG_BIR_III_2	196	200	PF00653	0.812
LIG_BIR_III_4	238	242	PF00653	0.547
LIG_FHA_1	222	228	PF00498	0.680
LIG_FHA_1	260	266	PF00498	0.574
LIG_FHA_1	32	38	PF00498	0.638
LIG_FHA_1	397	403	PF00498	0.584
LIG_FHA_1	420	426	PF00498	0.414
LIG_FHA_1	429	435	PF00498	0.407
LIG_FHA_2	230	236	PF00498	0.737
LIG_FHA_2	75	81	PF00498	0.654
LIG_HCF-1_HBM_1	376	379	PF13415	0.521
LIG_Integrin_RGD_1	14	16	PF01839	0.544
LIG_LIR_Apic_2	172	177	PF02991	0.564
LIG_LIR_Nem_3	58	64	PF02991	0.633
LIG_MYND_1	257	261	PF01753	0.615
LIG_Pex14_2	316	320	PF04695	0.455
LIG_Pex14_2	406	410	PF04695	0.436
LIG_REV1ctd_RIR_1	313	323	PF16727	0.473
LIG_SH2_STAP1	133	137	PF00017	0.807
LIG_SH2_STAP1	28	32	PF00017	0.640
LIG_SH2_STAP1	61	65	PF00017	0.628
LIG_SH2_STAT3	64	67	PF00017	0.663
LIG_SH2_STAT5	133	136	PF00017	0.704
LIG_SH2_STAT5	274	277	PF00017	0.339
LIG_SH2_STAT5	295	298	PF00017	0.475
LIG_SH2_STAT5	379	382	PF00017	0.537
LIG_SH2_STAT5	401	404	PF00017	0.546
LIG_SH2_STAT5	433	436	PF00017	0.540
LIG_SH3_1	276	282	PF00018	0.639
LIG_SH3_3	187	193	PF00018	0.787
LIG_SH3_3	275	281	PF00018	0.468
LIG_SUMO_SIM_anti_2	420	428	PF11976	0.576
LIG_TRAF2_1	147	150	PF00917	0.741
LIG_WRC_WIRS_1	439	444	PF05994	0.428
MOD_CDC14_SPxK_1	183	186	PF00782	0.687
MOD_CDK_SPxK_1	180	186	PF00069	0.696
MOD_CK1_1	100	106	PF00069	0.840
MOD_CK1_1	126	132	PF00069	0.756
MOD_CK1_1	180	186	PF00069	0.729
MOD_CK1_1	297	303	PF00069	0.527
MOD_CK1_1	414	420	PF00069	0.540
MOD_CK1_1	441	447	PF00069	0.423
MOD_CK1_1	47	53	PF00069	0.723
MOD_CK1_1	74	80	PF00069	0.526
MOD_CK2_1	143	149	PF00069	0.734
MOD_CK2_1	414	420	PF00069	0.540
MOD_Cter_Amidation	93	96	PF01082	0.615
MOD_GlcNHglycan	102	105	PF01048	0.833
MOD_GlcNHglycan	113	116	PF01048	0.736
MOD_GlcNHglycan	137	140	PF01048	0.816
MOD_GlcNHglycan	179	182	PF01048	0.742
MOD_GlcNHglycan	23	27	PF01048	0.699
MOD_GlcNHglycan	252	255	PF01048	0.692
MOD_GlcNHglycan	394	397	PF01048	0.704
MOD_GlcNHglycan	71	74	PF01048	0.660
MOD_GSK3_1	122	129	PF00069	0.734
MOD_GSK3_1	131	138	PF00069	0.644
MOD_GSK3_1	139	146	PF00069	0.716
MOD_GSK3_1	22	29	PF00069	0.733
MOD_GSK3_1	221	228	PF00069	0.818
MOD_GSK3_1	255	262	PF00069	0.600
MOD_GSK3_1	392	399	PF00069	0.587
MOD_GSK3_1	50	57	PF00069	0.732
MOD_N-GLC_1	351	356	PF02516	0.387
MOD_N-GLC_1	428	433	PF02516	0.456
MOD_N-GLC_1	47	52	PF02516	0.685
MOD_NEK2_1	127	132	PF00069	0.513
MOD_NEK2_1	185	190	PF00069	0.653
MOD_NEK2_1	303	308	PF00069	0.329
MOD_NEK2_2	154	159	PF00069	0.544
MOD_PIKK_1	428	434	PF00454	0.464
MOD_PIKK_1	441	447	PF00454	0.479
MOD_PKA_1	21	27	PF00069	0.766
MOD_PKA_1	381	387	PF00069	0.606
MOD_PKA_2	100	106	PF00069	0.840
MOD_PKA_2	154	160	PF00069	0.588
MOD_PKA_2	177	183	PF00069	0.575
MOD_PKA_2	185	191	PF00069	0.618
MOD_PKA_2	21	27	PF00069	0.764
MOD_PKA_2	297	303	PF00069	0.432
MOD_PKA_2	381	387	PF00069	0.553
MOD_PKA_2	414	420	PF00069	0.540
MOD_PKA_2	50	56	PF00069	0.793
MOD_PKB_1	95	103	PF00069	0.837
MOD_Plk_1	122	128	PF00069	0.601
MOD_Plk_1	419	425	PF00069	0.482
MOD_Plk_1	428	434	PF00069	0.481
MOD_Plk_2-3	145	151	PF00069	0.744
MOD_Plk_4	123	129	PF00069	0.565
MOD_Plk_4	154	160	PF00069	0.544
MOD_Plk_4	297	303	PF00069	0.588
MOD_Plk_4	345	351	PF00069	0.456
MOD_Plk_4	438	444	PF00069	0.384
MOD_ProDKin_1	180	186	PF00069	0.718
MOD_SUMO_rev_2	168	173	PF00179	0.550
MOD_SUMO_rev_2	219	224	PF00179	0.767
MOD_SUMO_rev_2	366	372	PF00179	0.445
TRG_DiLeu_BaLyEn_6	247	252	PF01217	0.726
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.508
TRG_ENDOCYTIC_2	60	63	PF00928	0.699
TRG_ER_diArg_1	20	22	PF00400	0.757
TRG_ER_diArg_1	265	267	PF00400	0.545
TRG_ER_diArg_1	380	383	PF00400	0.581
TRG_ER_diArg_1	4	7	PF00400	0.707
TRG_ER_diArg_1	90	93	PF00400	0.766
TRG_ER_diArg_1	95	97	PF00400	0.832

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ09	Leptomonas seymouri	49%	92%
A0A3Q8IIN3	Leishmania donovani	83%	100%
A4HAY8	Leishmania braziliensis	66%	100%
A4IA47	Leishmania infantum	83%	100%