Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B559_LEIMU

TriTrypDb:

LmxM.33.2690

Length:

573

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B559

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B559

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	459	463	PF00656	0.468
CLV_C14_Caspase3-7	472	476	PF00656	0.611
CLV_NRD_NRD_1	119	121	PF00675	0.559
CLV_NRD_NRD_1	212	214	PF00675	0.564
CLV_NRD_NRD_1	329	331	PF00675	0.510
CLV_NRD_NRD_1	447	449	PF00675	0.526
CLV_PCSK_FUR_1	324	328	PF00082	0.548
CLV_PCSK_FUR_1	330	334	PF00082	0.578
CLV_PCSK_KEX2_1	119	121	PF00082	0.602
CLV_PCSK_KEX2_1	211	213	PF00082	0.570
CLV_PCSK_KEX2_1	326	328	PF00082	0.561
CLV_PCSK_KEX2_1	329	331	PF00082	0.597
CLV_PCSK_KEX2_1	332	334	PF00082	0.607
CLV_PCSK_KEX2_1	447	449	PF00082	0.541
CLV_PCSK_PC1ET2_1	326	328	PF00082	0.614
CLV_PCSK_PC1ET2_1	332	334	PF00082	0.606
CLV_PCSK_PC7_1	322	328	PF00082	0.544
CLV_PCSK_PC7_1	443	449	PF00082	0.531
CLV_PCSK_SKI1_1	144	148	PF00082	0.485
CLV_PCSK_SKI1_1	431	435	PF00082	0.594
DEG_APCC_DBOX_1	174	182	PF00400	0.616
DEG_SCF_FBW7_1	65	72	PF00400	0.581
DEG_SPOP_SBC_1	106	110	PF00917	0.565
DEG_SPOP_SBC_1	455	459	PF00917	0.497
DOC_CKS1_1	66	71	PF01111	0.556
DOC_MAPK_FxFP_2	84	87	PF00069	0.467
DOC_PP4_FxxP_1	242	245	PF00568	0.486
DOC_PP4_FxxP_1	409	412	PF00568	0.509
DOC_PP4_FxxP_1	53	56	PF00568	0.689
DOC_PP4_FxxP_1	84	87	PF00568	0.580
DOC_USP7_MATH_1	159	163	PF00917	0.656
DOC_USP7_MATH_1	183	187	PF00917	0.784
DOC_USP7_MATH_1	281	285	PF00917	0.714
DOC_USP7_MATH_1	348	352	PF00917	0.713
DOC_USP7_MATH_1	353	357	PF00917	0.811
DOC_USP7_MATH_1	370	374	PF00917	0.557
DOC_USP7_MATH_1	393	397	PF00917	0.664
DOC_USP7_MATH_1	413	417	PF00917	0.509
DOC_USP7_MATH_1	455	459	PF00917	0.588
DOC_USP7_MATH_1	482	486	PF00917	0.674
DOC_WW_Pin1_4	102	107	PF00397	0.644
DOC_WW_Pin1_4	145	150	PF00397	0.624
DOC_WW_Pin1_4	223	228	PF00397	0.726
DOC_WW_Pin1_4	257	262	PF00397	0.604
DOC_WW_Pin1_4	270	275	PF00397	0.618
DOC_WW_Pin1_4	277	282	PF00397	0.574
DOC_WW_Pin1_4	335	340	PF00397	0.576
DOC_WW_Pin1_4	408	413	PF00397	0.641
DOC_WW_Pin1_4	421	426	PF00397	0.597
DOC_WW_Pin1_4	497	502	PF00397	0.583
DOC_WW_Pin1_4	557	562	PF00397	0.604
DOC_WW_Pin1_4	61	66	PF00397	0.615
DOC_WW_Pin1_4	79	84	PF00397	0.493
LIG_14-3-3_CanoR_1	169	177	PF00244	0.793
LIG_14-3-3_CanoR_1	182	188	PF00244	0.582
LIG_14-3-3_CanoR_1	552	561	PF00244	0.584
LIG_BIR_III_2	519	523	PF00653	0.576
LIG_BRCT_BRCA1_1	555	559	PF00533	0.528
LIG_CaM_IQ_9	314	329	PF13499	0.570
LIG_CSL_BTD_1	498	501	PF09270	0.585
LIG_FHA_1	10	16	PF00498	0.496
LIG_FHA_1	107	113	PF00498	0.657
LIG_FHA_1	182	188	PF00498	0.640
LIG_FHA_1	285	291	PF00498	0.767
LIG_FHA_1	422	428	PF00498	0.636
LIG_FHA_2	169	175	PF00498	0.611
LIG_FHA_2	470	476	PF00498	0.657
LIG_LIR_Apic_2	240	245	PF02991	0.570
LIG_LIR_Apic_2	246	251	PF02991	0.633
LIG_LIR_Apic_2	63	69	PF02991	0.577
LIG_LIR_Apic_2	82	87	PF02991	0.562
LIG_LIR_Gen_1	299	308	PF02991	0.486
LIG_LIR_Gen_1	364	370	PF02991	0.590
LIG_LIR_Gen_1	450	461	PF02991	0.594
LIG_LIR_Gen_1	533	540	PF02991	0.569
LIG_LIR_Gen_1	68	78	PF02991	0.521
LIG_LIR_Nem_3	294	300	PF02991	0.528
LIG_LIR_Nem_3	364	369	PF02991	0.577
LIG_LIR_Nem_3	450	456	PF02991	0.577
LIG_LIR_Nem_3	533	538	PF02991	0.564
LIG_LIR_Nem_3	68	74	PF02991	0.530
LIG_MYND_1	83	87	PF01753	0.466
LIG_Pex14_1	297	301	PF04695	0.495
LIG_Pex14_1	304	308	PF04695	0.481
LIG_SH2_CRK	115	119	PF00017	0.611
LIG_SH2_CRK	308	312	PF00017	0.498
LIG_SH2_CRK	453	457	PF00017	0.590
LIG_SH2_CRK	66	70	PF00017	0.625
LIG_SH2_NCK_1	366	370	PF00017	0.522
LIG_SH2_SRC	366	369	PF00017	0.594
LIG_SH2_STAP1	298	302	PF00017	0.527
LIG_SH2_STAP1	312	316	PF00017	0.520
LIG_SH2_STAT3	307	310	PF00017	0.498
LIG_SH2_STAT3	312	315	PF00017	0.522
LIG_SH2_STAT5	302	305	PF00017	0.565
LIG_SH3_3	202	208	PF00018	0.530
LIG_SH3_3	258	264	PF00018	0.669
LIG_SH3_3	287	293	PF00018	0.579
LIG_SH3_3	409	415	PF00018	0.652
LIG_SH3_3	422	428	PF00018	0.535
LIG_SH3_3	500	506	PF00018	0.660
LIG_TRAF2_1	171	174	PF00917	0.580
LIG_TRAF2_1	195	198	PF00917	0.517
LIG_TRAF2_1	463	466	PF00917	0.482
LIG_TYR_ITIM	306	311	PF00017	0.461
LIG_TYR_ITSM	362	369	PF00017	0.595
LIG_WW_3	262	266	PF00397	0.655
MOD_CDC14_SPxK_1	411	414	PF00782	0.665
MOD_CDC14_SPxK_1	64	67	PF00782	0.605
MOD_CDK_SPK_2	421	426	PF00069	0.681
MOD_CDK_SPxK_1	408	414	PF00069	0.672
MOD_CDK_SPxK_1	61	67	PF00069	0.619
MOD_CDK_SPxxK_3	335	342	PF00069	0.578
MOD_CK1_1	105	111	PF00069	0.721
MOD_CK1_1	125	131	PF00069	0.566
MOD_CK1_1	186	192	PF00069	0.796
MOD_CK1_1	284	290	PF00069	0.685
MOD_CK1_1	335	341	PF00069	0.628
MOD_CK1_1	396	402	PF00069	0.682
MOD_CK1_1	416	422	PF00069	0.616
MOD_CK1_1	513	519	PF00069	0.590
MOD_CK2_1	167	173	PF00069	0.609
MOD_CK2_1	231	237	PF00069	0.562
MOD_CK2_1	348	354	PF00069	0.820
MOD_CK2_1	94	100	PF00069	0.641
MOD_Cter_Amidation	327	330	PF01082	0.622
MOD_DYRK1A_RPxSP_1	223	227	PF00069	0.629
MOD_GlcNHglycan	161	164	PF01048	0.689
MOD_GlcNHglycan	189	192	PF01048	0.736
MOD_GlcNHglycan	2	5	PF01048	0.608
MOD_GlcNHglycan	233	236	PF01048	0.677
MOD_GlcNHglycan	350	353	PF01048	0.696
MOD_GlcNHglycan	399	402	PF01048	0.653
MOD_GlcNHglycan	480	483	PF01048	0.742
MOD_GlcNHglycan	485	488	PF01048	0.686
MOD_GlcNHglycan	9	12	PF01048	0.623
MOD_GSK3_1	100	107	PF00069	0.645
MOD_GSK3_1	182	189	PF00069	0.787
MOD_GSK3_1	219	226	PF00069	0.640
MOD_GSK3_1	266	273	PF00069	0.751
MOD_GSK3_1	277	284	PF00069	0.653
MOD_GSK3_1	343	350	PF00069	0.648
MOD_GSK3_1	393	400	PF00069	0.670
MOD_GSK3_1	478	485	PF00069	0.555
MOD_GSK3_1	521	528	PF00069	0.695
MOD_GSK3_1	553	560	PF00069	0.789
MOD_GSK3_1	61	68	PF00069	0.732
MOD_N-GLC_1	219	224	PF02516	0.527
MOD_N-GLC_1	543	548	PF02516	0.609
MOD_NEK2_1	17	22	PF00069	0.619
MOD_NEK2_1	24	29	PF00069	0.566
MOD_NEK2_1	456	461	PF00069	0.625
MOD_PIKK_1	122	128	PF00454	0.539
MOD_PIKK_1	419	425	PF00454	0.623
MOD_PIKK_1	505	511	PF00454	0.537
MOD_PKA_1	332	338	PF00069	0.656
MOD_PKA_2	168	174	PF00069	0.608
MOD_PKA_2	181	187	PF00069	0.579
MOD_PKA_2	332	338	PF00069	0.656
MOD_PKA_2	370	376	PF00069	0.551
MOD_PKA_2	478	484	PF00069	0.631
MOD_PKA_2	525	531	PF00069	0.613
MOD_PKA_2	553	559	PF00069	0.723
MOD_PKB_1	180	188	PF00069	0.637
MOD_PKB_1	541	549	PF00069	0.565
MOD_Plk_1	393	399	PF00069	0.606
MOD_Plk_2-3	168	174	PF00069	0.636
MOD_Plk_4	456	462	PF00069	0.458
MOD_ProDKin_1	102	108	PF00069	0.642
MOD_ProDKin_1	145	151	PF00069	0.625
MOD_ProDKin_1	223	229	PF00069	0.725
MOD_ProDKin_1	257	263	PF00069	0.604
MOD_ProDKin_1	270	276	PF00069	0.619
MOD_ProDKin_1	277	283	PF00069	0.573
MOD_ProDKin_1	335	341	PF00069	0.574
MOD_ProDKin_1	408	414	PF00069	0.641
MOD_ProDKin_1	421	427	PF00069	0.592
MOD_ProDKin_1	497	503	PF00069	0.584
MOD_ProDKin_1	557	563	PF00069	0.602
MOD_ProDKin_1	61	67	PF00069	0.612
MOD_ProDKin_1	79	85	PF00069	0.497
MOD_SUMO_rev_2	445	454	PF00179	0.408
TRG_DiLeu_BaEn_2	79	85	PF01217	0.447
TRG_DiLeu_BaEn_4	173	179	PF01217	0.580
TRG_DiLeu_BaEn_4	466	472	PF01217	0.493
TRG_ENDOCYTIC_2	115	118	PF00928	0.606
TRG_ENDOCYTIC_2	302	305	PF00928	0.481
TRG_ENDOCYTIC_2	308	311	PF00928	0.494
TRG_ENDOCYTIC_2	366	369	PF00928	0.579
TRG_ENDOCYTIC_2	453	456	PF00928	0.589
TRG_ER_diArg_1	118	120	PF00400	0.577
TRG_ER_diArg_1	211	213	PF00400	0.537
TRG_ER_diArg_1	327	330	PF00400	0.477
TRG_ER_diArg_1	404	407	PF00400	0.523
TRG_ER_diArg_1	446	448	PF00400	0.696
TRG_ER_diArg_1	494	497	PF00400	0.529
TRG_ER_diArg_1	566	569	PF00400	0.685
TRG_ER_FFAT_2	411	422	PF00635	0.514
TRG_NLS_MonoExtC_3	325	330	PF00514	0.533
TRG_NLS_MonoExtN_4	324	330	PF00514	0.534
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.584
TRG_Pf-PMV_PEXEL_1	223	228	PF00026	0.604
TRG_Pf-PMV_PEXEL_1	39	44	PF00026	0.663
TRG_Pf-PMV_PEXEL_1	447	451	PF00026	0.568

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P607	Leptomonas seymouri	30%	100%
A0A3Q8IEH1	Leishmania donovani	80%	100%
A4HAY6	Leishmania braziliensis	59%	97%
A4IA45	Leishmania infantum	80%	100%
Q4Q2S6	Leishmania major	80%	100%