Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania mexicana

UniProt:

E9B558_LEIMU

TriTrypDb:

LmxM.33.2680

Length:

540

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9B558

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B558

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	319	323	PF00656	0.553
CLV_MEL_PAP_1	232	238	PF00089	0.537
CLV_NRD_NRD_1	276	278	PF00675	0.551
CLV_NRD_NRD_1	414	416	PF00675	0.726
CLV_NRD_NRD_1	469	471	PF00675	0.558
CLV_NRD_NRD_1	516	518	PF00675	0.600
CLV_PCSK_KEX2_1	276	278	PF00082	0.668
CLV_PCSK_KEX2_1	469	471	PF00082	0.558
CLV_PCSK_KEX2_1	516	518	PF00082	0.600
CLV_PCSK_SKI1_1	197	201	PF00082	0.449
CLV_PCSK_SKI1_1	22	26	PF00082	0.582
CLV_PCSK_SKI1_1	27	31	PF00082	0.553
CLV_PCSK_SKI1_1	425	429	PF00082	0.602
CLV_PCSK_SKI1_1	469	473	PF00082	0.583
DEG_APCC_DBOX_1	39	47	PF00400	0.530
DEG_APCC_DBOX_1	424	432	PF00400	0.594
DEG_SPOP_SBC_1	294	298	PF00917	0.766
DOC_CKS1_1	64	69	PF01111	0.566
DOC_CYCLIN_yCln2_LP_2	64	70	PF00134	0.542
DOC_MAPK_gen_1	226	234	PF00069	0.427
DOC_MAPK_gen_1	415	423	PF00069	0.672
DOC_MAPK_gen_1	444	454	PF00069	0.661
DOC_MAPK_MEF2A_6	228	236	PF00069	0.437
DOC_MAPK_MEF2A_6	447	456	PF00069	0.684
DOC_MAPK_MEF2A_6	56	64	PF00069	0.579
DOC_PP4_FxxP_1	518	521	PF00568	0.348
DOC_USP7_MATH_1	15	19	PF00917	0.524
DOC_USP7_MATH_1	285	289	PF00917	0.657
DOC_USP7_MATH_1	294	298	PF00917	0.703
DOC_USP7_MATH_1	348	352	PF00917	0.664
DOC_USP7_MATH_1	524	528	PF00917	0.504
DOC_WW_Pin1_4	295	300	PF00397	0.798
DOC_WW_Pin1_4	321	326	PF00397	0.756
DOC_WW_Pin1_4	336	341	PF00397	0.711
DOC_WW_Pin1_4	371	376	PF00397	0.511
DOC_WW_Pin1_4	63	68	PF00397	0.568
DOC_WW_Pin1_4	93	98	PF00397	0.700
DOC_WW_Pin1_4	99	104	PF00397	0.696
LIG_14-3-3_CanoR_1	226	234	PF00244	0.428
LIG_14-3-3_CanoR_1	248	253	PF00244	0.464
LIG_14-3-3_CanoR_1	363	371	PF00244	0.529
LIG_14-3-3_CanoR_1	373	379	PF00244	0.423
LIG_14-3-3_CanoR_1	469	478	PF00244	0.506
LIG_APCC_ABBA_1	452	457	PF00400	0.679
LIG_BIR_II_1	1	5	PF00653	0.682
LIG_BIR_III_2	322	326	PF00653	0.726
LIG_BRCT_BRCA1_1	452	456	PF00533	0.584
LIG_CSL_BTD_1	534	537	PF09270	0.442
LIG_EH1_1	43	51	PF00400	0.576
LIG_eIF4E_1	44	50	PF01652	0.488
LIG_FHA_1	118	124	PF00498	0.432
LIG_FHA_1	182	188	PF00498	0.330
LIG_FHA_1	227	233	PF00498	0.405
LIG_FHA_1	337	343	PF00498	0.722
LIG_FHA_1	386	392	PF00498	0.518
LIG_FHA_1	483	489	PF00498	0.445
LIG_FHA_1	529	535	PF00498	0.477
LIG_FHA_1	57	63	PF00498	0.573
LIG_FHA_1	73	79	PF00498	0.629
LIG_FHA_2	157	163	PF00498	0.449
LIG_FHA_2	193	199	PF00498	0.475
LIG_FHA_2	317	323	PF00498	0.685
LIG_FHA_2	326	332	PF00498	0.825
LIG_FHA_2	363	369	PF00498	0.622
LIG_FHA_2	46	52	PF00498	0.569
LIG_FHA_2	470	476	PF00498	0.539
LIG_FHA_2	64	70	PF00498	0.628
LIG_HCF-1_HBM_1	244	247	PF13415	0.577
LIG_MLH1_MIPbox_1	452	456	PF16413	0.584
LIG_Pex14_2	378	382	PF04695	0.566
LIG_SH2_CRK	90	94	PF00017	0.721
LIG_SH2_GRB2like	181	184	PF00017	0.449
LIG_SH2_NCK_1	254	258	PF00017	0.585
LIG_SH2_NCK_1	90	94	PF00017	0.683
LIG_SH2_STAP1	181	185	PF00017	0.449
LIG_SH2_STAP1	254	258	PF00017	0.546
LIG_SH2_STAT5	149	152	PF00017	0.475
LIG_SH2_STAT5	203	206	PF00017	0.511
LIG_SH2_STAT5	422	425	PF00017	0.581
LIG_SH3_3	211	217	PF00018	0.489
LIG_SH3_3	296	302	PF00018	0.760
LIG_SH3_3	352	358	PF00018	0.674
LIG_SH3_3	461	467	PF00018	0.693
LIG_SUMO_SIM_par_1	268	274	PF11976	0.453
LIG_TRAF2_1	160	163	PF00917	0.449
LIG_UBA3_1	49	56	PF00899	0.476
LIG_WW_3	357	361	PF00397	0.729
LIG_WW_3	466	470	PF00397	0.697
MOD_CK1_1	283	289	PF00069	0.572
MOD_CK1_1	351	357	PF00069	0.695
MOD_CK1_1	374	380	PF00069	0.476
MOD_CK1_1	408	414	PF00069	0.710
MOD_CK1_1	527	533	PF00069	0.512
MOD_CK1_1	63	69	PF00069	0.652
MOD_CK1_1	8	14	PF00069	0.650
MOD_CK1_1	96	102	PF00069	0.690
MOD_CK2_1	126	132	PF00069	0.449
MOD_CK2_1	156	162	PF00069	0.430
MOD_CK2_1	362	368	PF00069	0.537
MOD_Cter_Amidation	413	416	PF01082	0.732
MOD_GlcNHglycan	15	18	PF01048	0.523
MOD_GlcNHglycan	150	153	PF01048	0.475
MOD_GlcNHglycan	177	180	PF01048	0.335
MOD_GlcNHglycan	210	213	PF01048	0.446
MOD_GlcNHglycan	343	346	PF01048	0.695
MOD_GlcNHglycan	348	351	PF01048	0.638
MOD_GlcNHglycan	394	397	PF01048	0.444
MOD_GlcNHglycan	407	410	PF01048	0.530
MOD_GlcNHglycan	526	529	PF01048	0.406
MOD_GlcNHglycan	7	10	PF01048	0.592
MOD_GlcNHglycan	98	101	PF01048	0.712
MOD_GSK3_1	177	184	PF00069	0.327
MOD_GSK3_1	222	229	PF00069	0.409
MOD_GSK3_1	280	287	PF00069	0.623
MOD_GSK3_1	321	328	PF00069	0.726
MOD_GSK3_1	336	343	PF00069	0.693
MOD_GSK3_1	346	353	PF00069	0.496
MOD_GSK3_1	4	11	PF00069	0.609
MOD_GSK3_1	52	59	PF00069	0.468
MOD_GSK3_1	524	531	PF00069	0.366
MOD_LATS_1	306	312	PF00433	0.738
MOD_N-GLC_1	405	410	PF02516	0.595
MOD_NEK2_1	134	139	PF00069	0.402
MOD_NEK2_1	208	213	PF00069	0.405
MOD_NEK2_1	263	268	PF00069	0.511
MOD_NEK2_1	34	39	PF00069	0.579
MOD_NEK2_1	346	351	PF00069	0.768
MOD_NEK2_1	476	481	PF00069	0.495
MOD_NEK2_2	181	186	PF00069	0.449
MOD_NEK2_2	528	533	PF00069	0.410
MOD_PIKK_1	15	21	PF00454	0.584
MOD_PIKK_1	8	14	PF00454	0.631
MOD_PK_1	308	314	PF00069	0.636
MOD_PKA_1	469	475	PF00069	0.557
MOD_PKA_2	359	365	PF00069	0.631
MOD_PKA_2	469	475	PF00069	0.535
MOD_PKA_2	508	514	PF00069	0.542
MOD_Plk_1	181	187	PF00069	0.388
MOD_Plk_1	34	40	PF00069	0.511
MOD_Plk_1	405	411	PF00069	0.648
MOD_Plk_1	450	456	PF00069	0.617
MOD_Plk_1	528	534	PF00069	0.394
MOD_Plk_4	215	221	PF00069	0.460
MOD_Plk_4	268	274	PF00069	0.518
MOD_Plk_4	34	40	PF00069	0.592
MOD_Plk_4	45	51	PF00069	0.582
MOD_Plk_4	450	456	PF00069	0.653
MOD_ProDKin_1	295	301	PF00069	0.795
MOD_ProDKin_1	321	327	PF00069	0.756
MOD_ProDKin_1	336	342	PF00069	0.711
MOD_ProDKin_1	371	377	PF00069	0.505
MOD_ProDKin_1	63	69	PF00069	0.567
MOD_ProDKin_1	93	99	PF00069	0.701
TRG_DiLeu_BaEn_1	473	478	PF01217	0.499
TRG_DiLeu_BaLyEn_6	140	145	PF01217	0.449
TRG_DiLeu_BaLyEn_6	387	392	PF01217	0.490
TRG_ENDOCYTIC_2	90	93	PF00928	0.703
TRG_ER_diArg_1	275	277	PF00400	0.636
TRG_ER_diArg_1	468	470	PF00400	0.592
TRG_ER_diArg_1	515	517	PF00400	0.523
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.527
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	469	473	PF00026	0.583
TRG_Pf-PMV_PEXEL_1	71	76	PF00026	0.650

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6E9	Leptomonas seymouri	67%	95%
A0A0S4JQH6	Bodo saltans	35%	100%
A0A1X0P9Q5	Trypanosomatidae	42%	100%
A0A3Q8IUQ4	Leishmania donovani	93%	99%
A0A3R7L5W7	Trypanosoma rangeli	42%	100%
A4HAY5	Leishmania braziliensis	85%	100%
A4IA44	Leishmania infantum	93%	99%
C9ZM56	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
Q4Q2S7	Leishmania major	94%	99%
V5BKS0	Trypanosoma cruzi	45%	100%