CNNM transmembrane domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function DUF21, putative

Species:

Leishmania mexicana

UniProt:

E9B555_LEIMU

TriTrypDb:

LmxM.33.2650

Length:

608

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 5
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005886	plasma membrane	3	7
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9B555

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B555

Function

Biological processes
Term	Name	Level	Count
GO:0010960	magnesium ion homeostasis	8	12
GO:0042592	homeostatic process	3	12
GO:0048878	chemical homeostasis	4	12
GO:0050801	monoatomic ion homeostasis	5	12
GO:0055065	obsolete metal ion homeostasis	7	12
GO:0055080	monoatomic cation homeostasis	6	12
GO:0065007	biological regulation	1	12
GO:0065008	regulation of biological quality	2	12
GO:0072507	obsolete divalent inorganic cation homeostasis	7	12
GO:0098771	inorganic ion homeostasis	6	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	69	73	PF00656	0.493
CLV_NRD_NRD_1	21	23	PF00675	0.649
CLV_NRD_NRD_1	347	349	PF00675	0.496
CLV_NRD_NRD_1	443	445	PF00675	0.544
CLV_NRD_NRD_1	600	602	PF00675	0.641
CLV_PCSK_KEX2_1	21	23	PF00082	0.649
CLV_PCSK_KEX2_1	347	349	PF00082	0.510
CLV_PCSK_KEX2_1	432	434	PF00082	0.645
CLV_PCSK_KEX2_1	443	445	PF00082	0.537
CLV_PCSK_PC1ET2_1	432	434	PF00082	0.645
CLV_PCSK_SKI1_1	240	244	PF00082	0.426
CLV_PCSK_SKI1_1	325	329	PF00082	0.501
CLV_PCSK_SKI1_1	337	341	PF00082	0.478
CLV_PCSK_SKI1_1	494	498	PF00082	0.553
CLV_Separin_Metazoa	577	581	PF03568	0.367
DEG_APCC_DBOX_1	11	19	PF00400	0.571
DEG_APCC_DBOX_1	234	242	PF00400	0.226
DEG_COP1_1	549	557	PF00400	0.323
DEG_Nend_Nbox_1	1	3	PF02207	0.494
DEG_SCF_FBW7_1	487	493	PF00400	0.288
DOC_CKS1_1	276	281	PF01111	0.295
DOC_CKS1_1	487	492	PF01111	0.280
DOC_MAPK_gen_1	10	17	PF00069	0.652
DOC_MAPK_gen_1	21	29	PF00069	0.464
DOC_MAPK_MEF2A_6	10	17	PF00069	0.604
DOC_MAPK_MEF2A_6	198	205	PF00069	0.305
DOC_MAPK_MEF2A_6	315	323	PF00069	0.282
DOC_MAPK_MEF2A_6	337	344	PF00069	0.319
DOC_MAPK_MEF2A_6	530	537	PF00069	0.340
DOC_MAPK_NFAT4_5	10	18	PF00069	0.575
DOC_MAPK_NFAT4_5	530	538	PF00069	0.321
DOC_PP1_RVXF_1	237	244	PF00149	0.226
DOC_PP2B_LxvP_1	13	16	PF13499	0.638
DOC_PP2B_LxvP_1	552	555	PF13499	0.336
DOC_USP7_MATH_1	16	20	PF00917	0.573
DOC_USP7_MATH_1	186	190	PF00917	0.437
DOC_USP7_MATH_1	246	250	PF00917	0.240
DOC_USP7_MATH_1	490	494	PF00917	0.496
DOC_USP7_MATH_1	547	551	PF00917	0.356
DOC_USP7_MATH_1	68	72	PF00917	0.448
DOC_USP7_UBL2_3	223	227	PF12436	0.323
DOC_WW_Pin1_4	275	280	PF00397	0.294
DOC_WW_Pin1_4	486	491	PF00397	0.266
LIG_14-3-3_CanoR_1	21	29	PF00244	0.545
LIG_14-3-3_CanoR_1	601	606	PF00244	0.429
LIG_APCC_ABBA_1	504	509	PF00400	0.403
LIG_BRCT_BRCA1_1	405	409	PF00533	0.328
LIG_BRCT_BRCA1_1	512	516	PF00533	0.281
LIG_BRCT_BRCA1_1	549	553	PF00533	0.372
LIG_Clathr_ClatBox_1	104	108	PF01394	0.523
LIG_Clathr_ClatBox_1	393	397	PF01394	0.265
LIG_Clathr_ClatBox_1	83	87	PF01394	0.387
LIG_EH1_1	387	395	PF00400	0.273
LIG_eIF4E_1	388	394	PF01652	0.270
LIG_FHA_1	107	113	PF00498	0.426
LIG_FHA_1	141	147	PF00498	0.286
LIG_FHA_1	24	30	PF00498	0.487
LIG_FHA_1	294	300	PF00498	0.345
LIG_FHA_1	334	340	PF00498	0.295
LIG_FHA_1	354	360	PF00498	0.168
LIG_FHA_1	425	431	PF00498	0.334
LIG_FHA_1	515	521	PF00498	0.267
LIG_FHA_1	543	549	PF00498	0.347
LIG_FHA_1	99	105	PF00498	0.269
LIG_FHA_2	270	276	PF00498	0.291
LIG_FHA_2	393	399	PF00498	0.261
LIG_FHA_2	487	493	PF00498	0.288
LIG_FHA_2	495	501	PF00498	0.308
LIG_FHA_2	65	71	PF00498	0.409
LIG_LIR_Gen_1	513	524	PF02991	0.268
LIG_LIR_Gen_1	539	548	PF02991	0.276
LIG_LIR_Gen_1	573	581	PF02991	0.334
LIG_LIR_Gen_1	78	86	PF02991	0.329
LIG_LIR_Gen_1	87	98	PF02991	0.307
LIG_LIR_LC3C_4	517	520	PF02991	0.350
LIG_LIR_Nem_3	385	390	PF02991	0.313
LIG_LIR_Nem_3	406	412	PF02991	0.335
LIG_LIR_Nem_3	513	519	PF02991	0.276
LIG_LIR_Nem_3	539	543	PF02991	0.276
LIG_LIR_Nem_3	78	83	PF02991	0.334
LIG_LIR_Nem_3	87	93	PF02991	0.311
LIG_NRBOX	28	34	PF00104	0.471
LIG_PCNA_yPIPBox_3	134	145	PF02747	0.426
LIG_PDZ_Class_3	603	608	PF00595	0.483
LIG_Pex14_2	206	210	PF04695	0.269
LIG_Pex14_2	553	557	PF04695	0.325
LIG_Pex14_2	93	97	PF04695	0.286
LIG_SH2_STAP1	126	130	PF00017	0.451
LIG_SH2_STAT5	364	367	PF00017	0.290
LIG_SH2_STAT5	575	578	PF00017	0.371
LIG_SH3_3	210	216	PF00018	0.330
LIG_SH3_3	273	279	PF00018	0.281
LIG_SH3_3	484	490	PF00018	0.338
LIG_SUMO_SIM_anti_2	101	106	PF11976	0.141
LIG_SUMO_SIM_anti_2	111	118	PF11976	0.426
LIG_SUMO_SIM_anti_2	258	263	PF11976	0.305
LIG_SUMO_SIM_anti_2	26	31	PF11976	0.571
LIG_SUMO_SIM_anti_2	336	342	PF11976	0.289
LIG_SUMO_SIM_anti_2	370	377	PF11976	0.281
LIG_SUMO_SIM_anti_2	82	88	PF11976	0.259
LIG_SUMO_SIM_par_1	108	113	PF11976	0.426
LIG_SUMO_SIM_par_1	281	287	PF11976	0.304
LIG_SUMO_SIM_par_1	516	521	PF11976	0.274
LIG_SUMO_SIM_par_1	82	88	PF11976	0.324
LIG_SxIP_EBH_1	303	314	PF03271	0.320
LIG_TRAF2_1	67	70	PF00917	0.408
LIG_TYR_ITIM	447	452	PF00017	0.333
LIG_UBA3_1	358	363	PF00899	0.299
LIG_WRC_WIRS_1	554	559	PF05994	0.304
MOD_CDK_SPK_2	486	491	PF00069	0.266
MOD_CK1_1	23	29	PF00069	0.310
MOD_CK1_1	249	255	PF00069	0.403
MOD_CK1_1	439	445	PF00069	0.427
MOD_CK1_1	514	520	PF00069	0.358
MOD_CK1_1	587	593	PF00069	0.455
MOD_CK2_1	115	121	PF00069	0.426
MOD_CK2_1	269	275	PF00069	0.382
MOD_CK2_1	459	465	PF00069	0.358
MOD_CK2_1	64	70	PF00069	0.518
MOD_Cter_Amidation	19	22	PF01082	0.664
MOD_DYRK1A_RPxSP_1	486	490	PF00069	0.256
MOD_GlcNHglycan	117	120	PF01048	0.226
MOD_GlcNHglycan	18	21	PF01048	0.573
MOD_GlcNHglycan	188	191	PF01048	0.231
MOD_GlcNHglycan	198	201	PF01048	0.256
MOD_GlcNHglycan	22	25	PF01048	0.497
MOD_GlcNHglycan	248	251	PF01048	0.561
MOD_GlcNHglycan	4	7	PF01048	0.650
MOD_GlcNHglycan	469	474	PF01048	0.628
MOD_GlcNHglycan	520	523	PF01048	0.529
MOD_GlcNHglycan	594	597	PF01048	0.644
MOD_GlcNHglycan	77	80	PF01048	0.616
MOD_GSK3_1	16	23	PF00069	0.396
MOD_GSK3_1	166	173	PF00069	0.269
MOD_GSK3_1	353	360	PF00069	0.290
MOD_GSK3_1	435	442	PF00069	0.418
MOD_GSK3_1	486	493	PF00069	0.334
MOD_GSK3_1	510	517	PF00069	0.290
MOD_GSK3_1	538	545	PF00069	0.374
MOD_GSK3_1	587	594	PF00069	0.447
MOD_GSK3_1	64	71	PF00069	0.512
MOD_GSK3_1	75	82	PF00069	0.414
MOD_N-GLC_1	425	430	PF02516	0.702
MOD_NEK2_1	140	145	PF00069	0.269
MOD_NEK2_1	150	155	PF00069	0.269
MOD_NEK2_1	2	7	PF00069	0.566
MOD_NEK2_1	424	429	PF00069	0.379
MOD_NEK2_1	43	48	PF00069	0.561
MOD_NEK2_1	459	464	PF00069	0.301
MOD_NEK2_1	479	484	PF00069	0.382
MOD_NEK2_1	518	523	PF00069	0.299
MOD_NEK2_2	555	560	PF00069	0.275
MOD_PKA_1	601	607	PF00069	0.434
MOD_PKA_2	20	26	PF00069	0.387
MOD_Plk_1	122	128	PF00069	0.437
MOD_Plk_1	269	275	PF00069	0.285
MOD_Plk_1	293	299	PF00069	0.323
MOD_Plk_1	464	470	PF00069	0.382
MOD_Plk_1	479	485	PF00069	0.343
MOD_Plk_1	563	569	PF00069	0.288
MOD_Plk_2-3	108	114	PF00069	0.426
MOD_Plk_2-3	117	123	PF00069	0.426
MOD_Plk_4	140	146	PF00069	0.269
MOD_Plk_4	150	156	PF00069	0.269
MOD_Plk_4	166	172	PF00069	0.269
MOD_Plk_4	215	221	PF00069	0.264
MOD_Plk_4	25	31	PF00069	0.494
MOD_Plk_4	269	275	PF00069	0.285
MOD_Plk_4	480	486	PF00069	0.360
MOD_Plk_4	511	517	PF00069	0.378
MOD_Plk_4	563	569	PF00069	0.285
MOD_Plk_4	79	85	PF00069	0.314
MOD_ProDKin_1	275	281	PF00069	0.299
MOD_ProDKin_1	486	492	PF00069	0.275
MOD_SUMO_rev_2	234	241	PF00179	0.226
MOD_SUMO_rev_2	354	359	PF00179	0.273
MOD_SUMO_rev_2	385	393	PF00179	0.288
MOD_SUMO_rev_2	594	604	PF00179	0.462
TRG_DiLeu_BaEn_1	237	242	PF01217	0.226
TRG_DiLeu_BaEn_1	295	300	PF01217	0.318
TRG_DiLeu_BaEn_1	389	394	PF01217	0.262
TRG_ENDOCYTIC_2	387	390	PF00928	0.302
TRG_ENDOCYTIC_2	449	452	PF00928	0.412
TRG_ENDOCYTIC_2	575	578	PF00928	0.317
TRG_ER_diArg_1	10	13	PF00400	0.677
TRG_ER_diArg_1	443	445	PF00400	0.337
TRG_ER_diArg_1	485	488	PF00400	0.417
TRG_NES_CRM1_1	275	290	PF08389	0.328
TRG_Pf-PMV_PEXEL_1	134	139	PF00026	0.226

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0B7P9G0	Drosophila melanogaster	33%	73%
A0A0N1PDI6	Leptomonas seymouri	83%	100%
A0A0S4JSF9	Bodo saltans	69%	100%
A0A131MCZ8	Caenorhabditis elegans	30%	76%
A0A1X0PAL3	Trypanosomatidae	75%	100%
A0A3Q8IC75	Leishmania donovani	24%	100%
A0A3Q8IL77	Leishmania donovani	95%	100%
A0A3Q8ITK0	Leishmania donovani	22%	100%
A0A422NS01	Trypanosoma rangeli	74%	100%
A0JPA0	Xenopus tropicalis	36%	79%
A3QM97	Caenorhabditis elegans	30%	75%
A4HAY2	Leishmania braziliensis	88%	99%
A4HIN7	Leishmania braziliensis	23%	100%
A4HKU5	Leishmania braziliensis	23%	100%
A4I5Y4	Leishmania infantum	24%	100%
A4I8C4	Leishmania infantum	22%	100%
A4IA41	Leishmania infantum	96%	100%
C9ZM59	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
D0A017	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	82%
E9B177	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B383	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
P0C588	Rattus norvegicus	36%	79%
Q32NY4	Mus musculus	29%	85%
Q3TWN3	Mus musculus	35%	69%
Q4Q2T0	Leishmania major	94%	100%
Q4Q4X2	Leishmania major	21%	100%
Q4Q6Y7	Leishmania major	24%	100%
Q4QE29	Leishmania major	32%	100%
Q5U2P1	Rattus norvegicus	35%	69%
Q69ZF7	Mus musculus	36%	79%
Q6P4Q7	Homo sapiens	36%	78%
Q8NE01	Homo sapiens	28%	86%
Q9GYL2	Caenorhabditis elegans	30%	80%
Q9H8M5	Homo sapiens	35%	69%
V5BKR5	Trypanosoma cruzi	74%	100%