EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flagellum attachment zone protein 8

Species:

Leishmania mexicana

UniProt:

E9B548_LEIMU

TriTrypDb:

LmxM.33.2570

Length:

557

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B548

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B548

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.475
CLV_NRD_NRD_1	206	208	PF00675	0.575
CLV_NRD_NRD_1	220	222	PF00675	0.534
CLV_NRD_NRD_1	379	381	PF00675	0.551
CLV_PCSK_KEX2_1	379	381	PF00082	0.525
CLV_PCSK_SKI1_1	222	226	PF00082	0.475
CLV_PCSK_SKI1_1	257	261	PF00082	0.616
CLV_PCSK_SKI1_1	379	383	PF00082	0.641
CLV_PCSK_SKI1_1	443	447	PF00082	0.462
CLV_PCSK_SKI1_1	529	533	PF00082	0.479
DEG_APCC_DBOX_1	528	536	PF00400	0.554
DEG_APCC_KENBOX_2	396	400	PF00400	0.601
DOC_CYCLIN_RxL_1	525	534	PF00134	0.502
DOC_MAPK_gen_1	145	153	PF00069	0.578
DOC_MAPK_MEF2A_6	495	504	PF00069	0.443
DOC_MAPK_MEF2A_6	92	100	PF00069	0.411
DOC_PP1_RVXF_1	467	473	PF00149	0.464
DOC_PP2B_LxvP_1	79	82	PF13499	0.523
DOC_USP7_MATH_1	235	239	PF00917	0.448
DOC_USP7_MATH_1	28	32	PF00917	0.620
DOC_USP7_MATH_1	292	296	PF00917	0.736
DOC_USP7_MATH_1	437	441	PF00917	0.571
DOC_USP7_MATH_1	488	492	PF00917	0.444
DOC_USP7_MATH_1	493	497	PF00917	0.395
DOC_USP7_UBL2_3	25	29	PF12436	0.525
DOC_WW_Pin1_4	288	293	PF00397	0.728
LIG_14-3-3_CanoR_1	404	414	PF00244	0.548
LIG_14-3-3_CanoR_1	457	461	PF00244	0.490
LIG_BIR_II_1	1	5	PF00653	0.617
LIG_CaM_IQ_9	247	262	PF13499	0.501
LIG_FHA_1	360	366	PF00498	0.561
LIG_FHA_1	405	411	PF00498	0.564
LIG_FHA_1	97	103	PF00498	0.386
LIG_FHA_2	101	107	PF00498	0.560
LIG_FHA_2	406	412	PF00498	0.422
LIG_Integrin_RGD_1	164	166	PF01839	0.618
LIG_LIR_Gen_1	302	312	PF02991	0.507
LIG_LIR_Gen_1	5	12	PF02991	0.661
LIG_LIR_Gen_1	95	102	PF02991	0.384
LIG_LIR_Nem_3	124	129	PF02991	0.547
LIG_LIR_Nem_3	302	308	PF02991	0.508
LIG_LIR_Nem_3	425	431	PF02991	0.448
LIG_LIR_Nem_3	5	11	PF02991	0.645
LIG_LIR_Nem_3	54	59	PF02991	0.428
LIG_LIR_Nem_3	95	100	PF02991	0.383
LIG_NRBOX	335	341	PF00104	0.617
LIG_PCNA_PIPBox_1	90	99	PF02747	0.532
LIG_PDZ_Class_1	552	557	PF00595	0.613
LIG_Pex14_2	122	126	PF04695	0.544
LIG_SH2_GRB2like	354	357	PF00017	0.460
LIG_SH2_STAP1	354	358	PF00017	0.474
LIG_SH2_STAP1	406	410	PF00017	0.439
LIG_SH2_STAT5	273	276	PF00017	0.600
LIG_SH2_STAT5	406	409	PF00017	0.562
LIG_SH2_STAT5	431	434	PF00017	0.561
LIG_SH2_STAT5	97	100	PF00017	0.375
LIG_SUMO_SIM_anti_2	7	13	PF11976	0.657
LIG_SUMO_SIM_par_1	295	300	PF11976	0.648
LIG_SUMO_SIM_par_1	413	419	PF11976	0.505
LIG_TRAF2_1	109	112	PF00917	0.601
LIG_TRAF2_1	180	183	PF00917	0.585
LIG_UBA3_1	196	202	PF00899	0.566
LIG_UBA3_1	245	254	PF00899	0.515
LIG_UBA3_1	274	279	PF00899	0.623
LIG_WRC_WIRS_1	97	102	PF05994	0.379
MOD_CDK_SPK_2	288	293	PF00069	0.726
MOD_CK1_1	41	47	PF00069	0.517
MOD_CK1_1	453	459	PF00069	0.529
MOD_CK1_1	62	68	PF00069	0.471
MOD_CK1_1	7	13	PF00069	0.658
MOD_CK2_1	100	106	PF00069	0.545
MOD_CK2_1	388	394	PF00069	0.579
MOD_CK2_1	405	411	PF00069	0.550
MOD_CK2_1	488	494	PF00069	0.585
MOD_GlcNHglycan	1	4	PF01048	0.558
MOD_GlcNHglycan	15	18	PF01048	0.696
MOD_GlcNHglycan	236	240	PF01048	0.537
MOD_GlcNHglycan	288	291	PF01048	0.679
MOD_GlcNHglycan	30	33	PF01048	0.489
MOD_GlcNHglycan	496	499	PF01048	0.543
MOD_GSK3_1	277	284	PF00069	0.543
MOD_GSK3_1	28	35	PF00069	0.482
MOD_GSK3_1	288	295	PF00069	0.633
MOD_GSK3_1	364	371	PF00069	0.567
MOD_GSK3_1	38	45	PF00069	0.536
MOD_GSK3_1	456	463	PF00069	0.478
MOD_GSK3_1	92	99	PF00069	0.413
MOD_N-GLC_1	286	291	PF02516	0.739
MOD_N-GLC_1	398	403	PF02516	0.495
MOD_NEK2_1	39	44	PF00069	0.535
MOD_NEK2_1	4	9	PF00069	0.651
MOD_NEK2_1	413	418	PF00069	0.548
MOD_NEK2_1	460	465	PF00069	0.507
MOD_NEK2_1	506	511	PF00069	0.408
MOD_NEK2_1	531	536	PF00069	0.445
MOD_NEK2_1	59	64	PF00069	0.359
MOD_NEK2_1	67	72	PF00069	0.386
MOD_NEK2_1	96	101	PF00069	0.377
MOD_PIKK_1	106	112	PF00454	0.605
MOD_PIKK_1	209	215	PF00454	0.607
MOD_PIKK_1	277	283	PF00454	0.609
MOD_PIKK_1	319	325	PF00454	0.495
MOD_PIKK_1	359	365	PF00454	0.596
MOD_PK_1	461	467	PF00069	0.569
MOD_PKA_2	292	298	PF00069	0.726
MOD_PKA_2	334	340	PF00069	0.482
MOD_PKA_2	368	374	PF00069	0.521
MOD_PKA_2	388	394	PF00069	0.573
MOD_PKA_2	45	51	PF00069	0.436
MOD_PKA_2	456	462	PF00069	0.471
MOD_Plk_1	192	198	PF00069	0.612
MOD_Plk_1	398	404	PF00069	0.474
MOD_Plk_1	4	10	PF00069	0.603
MOD_Plk_1	73	79	PF00069	0.479
MOD_Plk_2-3	350	356	PF00069	0.589
MOD_Plk_4	192	198	PF00069	0.553
MOD_Plk_4	292	298	PF00069	0.728
MOD_Plk_4	398	404	PF00069	0.474
MOD_Plk_4	4	10	PF00069	0.616
MOD_Plk_4	62	68	PF00069	0.450
MOD_Plk_4	92	98	PF00069	0.422
MOD_ProDKin_1	288	294	PF00069	0.730
MOD_SUMO_for_1	228	231	PF00179	0.507
MOD_SUMO_rev_2	163	171	PF00179	0.599
MOD_SUMO_rev_2	218	224	PF00179	0.475
MOD_SUMO_rev_2	367	374	PF00179	0.555
MOD_SUMO_rev_2	447	456	PF00179	0.589
TRG_DiLeu_BaEn_1	220	225	PF01217	0.608
TRG_DiLeu_BaEn_1	304	309	PF01217	0.497
TRG_DiLeu_BaLyEn_6	35	40	PF01217	0.418
TRG_ENDOCYTIC_2	97	100	PF00928	0.375
TRG_ER_diArg_1	282	285	PF00400	0.529
TRG_Pf-PMV_PEXEL_1	158	163	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	536	540	PF00026	0.566
TRG_Pf-PMV_PEXEL_1	547	551	PF00026	0.605

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P612	Leptomonas seymouri	70%	98%
A0A1X0P9R7	Trypanosomatidae	47%	96%
A0A3S7X860	Leishmania donovani	95%	100%
A0A422N8F5	Trypanosoma rangeli	47%	96%
A4HAX4	Leishmania braziliensis	84%	100%
A4IA33	Leishmania infantum	95%	100%
C9ZMJ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	95%
Q4Q2T8	Leishmania major	96%	100%
V5BUY7	Trypanosoma cruzi	46%	96%