Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B546_LEIMU

TriTrypDb:

LmxM.33.2550

Length:

617

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B546

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B546

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	143	147	PF00656	0.468
CLV_C14_Caspase3-7	395	399	PF00656	0.791
CLV_C14_Caspase3-7	424	428	PF00656	0.566
CLV_NRD_NRD_1	100	102	PF00675	0.471
CLV_NRD_NRD_1	242	244	PF00675	0.436
CLV_NRD_NRD_1	28	30	PF00675	0.400
CLV_NRD_NRD_1	302	304	PF00675	0.392
CLV_NRD_NRD_1	418	420	PF00675	0.753
CLV_NRD_NRD_1	52	54	PF00675	0.459
CLV_NRD_NRD_1	567	569	PF00675	0.609
CLV_PCSK_FUR_1	240	244	PF00082	0.437
CLV_PCSK_KEX2_1	100	102	PF00082	0.340
CLV_PCSK_KEX2_1	242	244	PF00082	0.436
CLV_PCSK_KEX2_1	28	30	PF00082	0.362
CLV_PCSK_KEX2_1	414	416	PF00082	0.621
CLV_PCSK_KEX2_1	418	420	PF00082	0.592
CLV_PCSK_KEX2_1	567	569	PF00082	0.583
CLV_PCSK_KEX2_1	92	94	PF00082	0.524
CLV_PCSK_PC1ET2_1	414	416	PF00082	0.621
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.540
CLV_PCSK_SKI1_1	204	208	PF00082	0.423
CLV_PCSK_SKI1_1	411	415	PF00082	0.729
CLV_PCSK_SKI1_1	49	53	PF00082	0.446
CLV_PCSK_SKI1_1	518	522	PF00082	0.471
CLV_PCSK_SKI1_1	544	548	PF00082	0.560
CLV_PCSK_SKI1_1	92	96	PF00082	0.500
DEG_APCC_DBOX_1	291	299	PF00400	0.501
DEG_APCC_DBOX_1	48	56	PF00400	0.465
DEG_Nend_UBRbox_3	1	3	PF02207	0.494
DEG_SPOP_SBC_1	435	439	PF00917	0.605
DOC_CYCLIN_RxL_1	515	525	PF00134	0.453
DOC_CYCLIN_RxL_1	541	549	PF00134	0.489
DOC_MAPK_gen_1	149	159	PF00069	0.464
DOC_MAPK_gen_1	28	36	PF00069	0.401
DOC_MAPK_MEF2A_6	152	161	PF00069	0.430
DOC_MAPK_MEF2A_6	29	38	PF00069	0.417
DOC_MIT_MIM_1	64	72	PF04212	0.460
DOC_PP1_RVXF_1	5	12	PF00149	0.309
DOC_PP1_RVXF_1	577	583	PF00149	0.474
DOC_PP1_RVXF_1	91	98	PF00149	0.409
DOC_PP4_FxxP_1	11	14	PF00568	0.331
DOC_USP7_MATH_1	111	115	PF00917	0.375
DOC_USP7_MATH_1	121	125	PF00917	0.440
DOC_USP7_MATH_1	231	235	PF00917	0.349
DOC_USP7_MATH_1	294	298	PF00917	0.437
DOC_USP7_MATH_1	392	396	PF00917	0.660
DOC_USP7_MATH_1	47	51	PF00917	0.461
DOC_USP7_MATH_1	472	476	PF00917	0.657
DOC_USP7_MATH_1	60	64	PF00917	0.313
DOC_USP7_UBL2_3	486	490	PF12436	0.559
DOC_WW_Pin1_4	341	346	PF00397	0.639
DOC_WW_Pin1_4	350	355	PF00397	0.605
DOC_WW_Pin1_4	550	555	PF00397	0.519
LIG_14-3-3_CanoR_1	242	247	PF00244	0.447
LIG_14-3-3_CanoR_1	261	266	PF00244	0.521
LIG_14-3-3_CanoR_1	303	307	PF00244	0.423
LIG_14-3-3_CanoR_1	322	327	PF00244	0.662
LIG_14-3-3_CanoR_1	374	383	PF00244	0.660
LIG_14-3-3_CanoR_1	46	52	PF00244	0.507
LIG_14-3-3_CanoR_1	53	62	PF00244	0.398
LIG_14-3-3_CanoR_1	68	73	PF00244	0.592
LIG_Clathr_ClatBox_1	276	280	PF01394	0.285
LIG_FHA_1	260	266	PF00498	0.429
LIG_FHA_1	3	9	PF00498	0.502
LIG_FHA_1	31	37	PF00498	0.419
LIG_FHA_1	441	447	PF00498	0.634
LIG_FHA_1	452	458	PF00498	0.720
LIG_FHA_2	141	147	PF00498	0.548
LIG_FHA_2	206	212	PF00498	0.240
LIG_FHA_2	332	338	PF00498	0.544
LIG_FHA_2	521	527	PF00498	0.542
LIG_Integrin_isoDGR_2	366	368	PF01839	0.534
LIG_LIR_Gen_1	172	182	PF02991	0.430
LIG_LIR_Gen_1	186	197	PF02991	0.386
LIG_LIR_Gen_1	211	218	PF02991	0.272
LIG_LIR_Gen_1	278	287	PF02991	0.348
LIG_LIR_Gen_1	501	510	PF02991	0.450
LIG_LIR_Gen_1	66	77	PF02991	0.404
LIG_LIR_Nem_3	172	177	PF02991	0.424
LIG_LIR_Nem_3	186	192	PF02991	0.384
LIG_LIR_Nem_3	207	212	PF02991	0.425
LIG_LIR_Nem_3	278	282	PF02991	0.340
LIG_LIR_Nem_3	325	331	PF02991	0.581
LIG_LIR_Nem_3	501	506	PF02991	0.448
LIG_LIR_Nem_3	66	72	PF02991	0.433
LIG_Pex14_1	205	209	PF04695	0.532
LIG_PTAP_UEV_1	468	473	PF05743	0.572
LIG_Rb_LxCxE_1	494	515	PF01857	0.538
LIG_SH2_CRK	174	178	PF00017	0.333
LIG_SH2_CRK	189	193	PF00017	0.381
LIG_SH2_CRK	212	216	PF00017	0.264
LIG_SH2_GRB2like	510	513	PF00017	0.561
LIG_SH2_NCK_1	174	178	PF00017	0.466
LIG_SH2_STAP1	189	193	PF00017	0.295
LIG_SH2_STAP1	510	514	PF00017	0.478
LIG_SH2_STAT5	181	184	PF00017	0.406
LIG_SH2_STAT5	275	278	PF00017	0.527
LIG_SH2_STAT5	287	290	PF00017	0.321
LIG_SH2_STAT5	599	602	PF00017	0.684
LIG_SH3_3	323	329	PF00018	0.584
LIG_SH3_3	332	338	PF00018	0.605
LIG_SH3_3	466	472	PF00018	0.683
LIG_SH3_3	548	554	PF00018	0.508
LIG_TRAF2_1	297	300	PF00917	0.503
LIG_TRAF2_1	523	526	PF00917	0.541
LIG_TYR_ITIM	187	192	PF00017	0.378
LIG_WRC_WIRS_1	206	211	PF05994	0.239
LIG_WRC_WIRS_1	276	281	PF05994	0.288
MOD_CK1_1	138	144	PF00069	0.612
MOD_CK1_1	183	189	PF00069	0.459
MOD_CK1_1	235	241	PF00069	0.478
MOD_CK1_1	324	330	PF00069	0.554
MOD_CK1_1	358	364	PF00069	0.615
MOD_CK1_1	421	427	PF00069	0.770
MOD_CK1_1	449	455	PF00069	0.685
MOD_CK1_1	463	469	PF00069	0.703
MOD_CK1_1	470	476	PF00069	0.563
MOD_CK1_1	539	545	PF00069	0.493
MOD_CK2_1	129	135	PF00069	0.286
MOD_CK2_1	150	156	PF00069	0.382
MOD_CK2_1	173	179	PF00069	0.402
MOD_CK2_1	235	241	PF00069	0.410
MOD_CK2_1	294	300	PF00069	0.608
MOD_CK2_1	331	337	PF00069	0.646
MOD_CK2_1	520	526	PF00069	0.639
MOD_CK2_1	60	66	PF00069	0.472
MOD_DYRK1A_RPxSP_1	550	554	PF00069	0.419
MOD_GlcNHglycan	119	122	PF01048	0.423
MOD_GlcNHglycan	152	155	PF01048	0.492
MOD_GlcNHglycan	237	240	PF01048	0.421
MOD_GlcNHglycan	310	313	PF01048	0.729
MOD_GlcNHglycan	357	360	PF01048	0.628
MOD_GlcNHglycan	395	398	PF01048	0.541
MOD_GlcNHglycan	420	423	PF01048	0.652
MOD_GlcNHglycan	468	472	PF01048	0.682
MOD_GlcNHglycan	474	477	PF01048	0.664
MOD_GlcNHglycan	563	566	PF01048	0.662
MOD_GlcNHglycan	585	588	PF01048	0.625
MOD_GSK3_1	117	124	PF00069	0.505
MOD_GSK3_1	135	142	PF00069	0.461
MOD_GSK3_1	169	176	PF00069	0.435
MOD_GSK3_1	183	190	PF00069	0.616
MOD_GSK3_1	227	234	PF00069	0.503
MOD_GSK3_1	257	264	PF00069	0.555
MOD_GSK3_1	343	350	PF00069	0.668
MOD_GSK3_1	414	421	PF00069	0.686
MOD_GSK3_1	430	437	PF00069	0.674
MOD_GSK3_1	440	447	PF00069	0.650
MOD_GSK3_1	463	470	PF00069	0.723
MOD_GSK3_1	510	517	PF00069	0.477
MOD_GSK3_1	546	553	PF00069	0.476
MOD_N-GLC_1	341	346	PF02516	0.556
MOD_NEK2_1	122	127	PF00069	0.285
MOD_NEK2_1	139	144	PF00069	0.444
MOD_NEK2_1	150	155	PF00069	0.401
MOD_NEK2_1	169	174	PF00069	0.535
MOD_NEK2_1	182	187	PF00069	0.539
MOD_NEK2_1	193	198	PF00069	0.396
MOD_NEK2_1	302	307	PF00069	0.529
MOD_NEK2_1	436	441	PF00069	0.607
MOD_NEK2_1	450	455	PF00069	0.562
MOD_NEK2_1	546	551	PF00069	0.538
MOD_NEK2_1	560	565	PF00069	0.620
MOD_NEK2_1	580	585	PF00069	0.624
MOD_PIKK_1	111	117	PF00454	0.506
MOD_PIKK_1	259	265	PF00454	0.436
MOD_PIKK_1	451	457	PF00454	0.620
MOD_PIKK_1	536	542	PF00454	0.352
MOD_PKA_1	242	248	PF00069	0.429
MOD_PKA_1	414	420	PF00069	0.663
MOD_PKA_1	53	59	PF00069	0.393
MOD_PKA_2	117	123	PF00069	0.387
MOD_PKA_2	241	247	PF00069	0.455
MOD_PKA_2	302	308	PF00069	0.426
MOD_PKA_2	321	327	PF00069	0.699
MOD_PKA_2	373	379	PF00069	0.664
MOD_PKA_2	414	420	PF00069	0.627
MOD_PKB_1	240	248	PF00069	0.431
MOD_PKB_1	372	380	PF00069	0.614
MOD_Plk_1	169	175	PF00069	0.438
MOD_Plk_1	183	189	PF00069	0.355
MOD_Plk_1	331	337	PF00069	0.696
MOD_Plk_1	404	410	PF00069	0.593
MOD_Plk_1	601	607	PF00069	0.570
MOD_Plk_4	135	141	PF00069	0.564
MOD_Plk_4	177	183	PF00069	0.434
MOD_Plk_4	188	194	PF00069	0.338
MOD_Plk_4	205	211	PF00069	0.216
MOD_Plk_4	302	308	PF00069	0.526
MOD_Plk_4	492	498	PF00069	0.523
MOD_ProDKin_1	341	347	PF00069	0.640
MOD_ProDKin_1	350	356	PF00069	0.605
MOD_ProDKin_1	550	556	PF00069	0.521
MOD_SUMO_rev_2	132	139	PF00179	0.292
MOD_SUMO_rev_2	421	431	PF00179	0.549
MOD_SUMO_rev_2	501	511	PF00179	0.473
TRG_DiLeu_BaEn_1	135	140	PF01217	0.326
TRG_DiLeu_BaEn_4	20	26	PF01217	0.478
TRG_DiLeu_BaEn_4	501	507	PF01217	0.539
TRG_DiLeu_BaLyEn_6	146	151	PF01217	0.399
TRG_ENDOCYTIC_2	174	177	PF00928	0.389
TRG_ENDOCYTIC_2	189	192	PF00928	0.380
TRG_ENDOCYTIC_2	212	215	PF00928	0.363
TRG_ENDOCYTIC_2	503	506	PF00928	0.467
TRG_ER_diArg_1	27	29	PF00400	0.364
TRG_ER_diArg_1	371	374	PF00400	0.532
TRG_ER_diArg_1	99	101	PF00400	0.476
TRG_NLS_MonoExtN_4	84	90	PF00514	0.483
TRG_Pf-PMV_PEXEL_1	171	175	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	53	57	PF00026	0.399

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMJ7	Leptomonas seymouri	45%	98%
A0A3Q8IIM3	Leishmania donovani	83%	100%
A4HBI7	Leishmania braziliensis	64%	100%
A4IA31	Leishmania infantum	83%	100%
Q4Q2U0	Leishmania major	82%	100%