C2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Coiled-coil and C2 domain-containing protein

Species:

Leishmania mexicana

UniProt:

E9B545_LEIMU

TriTrypDb:

LmxM.33.2540

Length:

869

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0044297	cell body	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B545

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B545

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0044782	cilium organization	5	1
GO:0060271	cilium assembly	6	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	266	270	PF00656	0.666
CLV_C14_Caspase3-7	342	346	PF00656	0.562
CLV_C14_Caspase3-7	486	490	PF00656	0.584
CLV_C14_Caspase3-7	570	574	PF00656	0.552
CLV_NRD_NRD_1	104	106	PF00675	0.635
CLV_NRD_NRD_1	134	136	PF00675	0.592
CLV_NRD_NRD_1	434	436	PF00675	0.334
CLV_NRD_NRD_1	524	526	PF00675	0.493
CLV_NRD_NRD_1	578	580	PF00675	0.534
CLV_NRD_NRD_1	582	584	PF00675	0.420
CLV_NRD_NRD_1	592	594	PF00675	0.511
CLV_NRD_NRD_1	619	621	PF00675	0.627
CLV_NRD_NRD_1	638	640	PF00675	0.499
CLV_NRD_NRD_1	668	670	PF00675	0.649
CLV_NRD_NRD_1	688	690	PF00675	0.452
CLV_NRD_NRD_1	810	812	PF00675	0.416
CLV_PCSK_KEX2_1	104	106	PF00082	0.470
CLV_PCSK_KEX2_1	122	124	PF00082	0.372
CLV_PCSK_KEX2_1	157	159	PF00082	0.529
CLV_PCSK_KEX2_1	192	194	PF00082	0.572
CLV_PCSK_KEX2_1	434	436	PF00082	0.334
CLV_PCSK_KEX2_1	498	500	PF00082	0.573
CLV_PCSK_KEX2_1	524	526	PF00082	0.468
CLV_PCSK_KEX2_1	582	584	PF00082	0.667
CLV_PCSK_KEX2_1	618	620	PF00082	0.564
CLV_PCSK_KEX2_1	667	669	PF00082	0.682
CLV_PCSK_KEX2_1	688	690	PF00082	0.620
CLV_PCSK_KEX2_1	810	812	PF00082	0.452
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.514
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.536
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.572
CLV_PCSK_PC1ET2_1	498	500	PF00082	0.573
CLV_PCSK_PC1ET2_1	618	620	PF00082	0.539
CLV_PCSK_PC7_1	663	669	PF00082	0.656
CLV_PCSK_SKI1_1	11	15	PF00082	0.514
CLV_PCSK_SKI1_1	167	171	PF00082	0.509
CLV_PCSK_SKI1_1	228	232	PF00082	0.545
CLV_PCSK_SKI1_1	32	36	PF00082	0.473
CLV_PCSK_SKI1_1	524	528	PF00082	0.538
CLV_PCSK_SKI1_1	583	587	PF00082	0.658
CLV_PCSK_SKI1_1	713	717	PF00082	0.481
CLV_PCSK_SKI1_1	726	730	PF00082	0.387
CLV_Separin_Metazoa	460	464	PF03568	0.478
CLV_Separin_Metazoa	504	508	PF03568	0.488
CLV_Separin_Metazoa	605	609	PF03568	0.600
DEG_APCC_DBOX_1	422	430	PF00400	0.310
DOC_CKS1_1	308	313	PF01111	0.520
DOC_CYCLIN_RxL_1	422	432	PF00134	0.443
DOC_CYCLIN_RxL_1	504	515	PF00134	0.542
DOC_MAPK_gen_1	252	260	PF00069	0.510
DOC_MAPK_gen_1	729	738	PF00069	0.452
DOC_MAPK_gen_1	807	817	PF00069	0.440
DOC_MAPK_gen_1	836	844	PF00069	0.410
DOC_MAPK_MEF2A_6	810	819	PF00069	0.410
DOC_PP1_RVXF_1	505	512	PF00149	0.508
DOC_PP4_FxxP_1	766	769	PF00568	0.384
DOC_USP7_MATH_1	289	293	PF00917	0.583
DOC_USP7_MATH_1	304	308	PF00917	0.643
DOC_USP7_MATH_1	317	321	PF00917	0.590
DOC_USP7_MATH_1	380	384	PF00917	0.577
DOC_USP7_MATH_1	512	516	PF00917	0.515
DOC_USP7_MATH_1	565	569	PF00917	0.356
DOC_USP7_MATH_1	6	10	PF00917	0.424
DOC_USP7_MATH_1	662	666	PF00917	0.661
DOC_USP7_UBL2_3	236	240	PF12436	0.552
DOC_USP7_UBL2_3	452	456	PF12436	0.547
DOC_USP7_UBL2_3	591	595	PF12436	0.483
DOC_USP7_UBL2_3	67	71	PF12436	0.551
DOC_USP7_UBL2_3	729	733	PF12436	0.362
DOC_USP7_UBL2_3	83	87	PF12436	0.362
DOC_WW_Pin1_4	307	312	PF00397	0.567
DOC_WW_Pin1_4	644	649	PF00397	0.720
DOC_WW_Pin1_4	651	656	PF00397	0.669
DOC_WW_Pin1_4	658	663	PF00397	0.607
DOC_WW_Pin1_4	667	672	PF00397	0.553
DOC_WW_Pin1_4	800	805	PF00397	0.412
DOC_WW_Pin1_4	849	854	PF00397	0.450
LIG_14-3-3_CanoR_1	295	305	PF00244	0.641
LIG_14-3-3_CanoR_1	379	388	PF00244	0.644
LIG_14-3-3_CanoR_1	395	402	PF00244	0.644
LIG_14-3-3_CanoR_1	546	552	PF00244	0.545
LIG_14-3-3_CanoR_1	582	592	PF00244	0.597
LIG_14-3-3_CanoR_1	623	631	PF00244	0.346
LIG_14-3-3_CanoR_1	649	657	PF00244	0.814
LIG_14-3-3_CanoR_1	713	718	PF00244	0.499
LIG_14-3-3_CanoR_1	96	106	PF00244	0.509
LIG_Actin_WH2_2	152	169	PF00022	0.530
LIG_Actin_WH2_2	216	233	PF00022	0.491
LIG_Actin_WH2_2	355	373	PF00022	0.618
LIG_Actin_WH2_2	454	471	PF00022	0.543
LIG_Actin_WH2_2	544	561	PF00022	0.467
LIG_Actin_WH2_2	695	712	PF00022	0.487
LIG_Actin_WH2_2	82	98	PF00022	0.525
LIG_APCC_ABBAyCdc20_2	826	832	PF00400	0.368
LIG_BIR_II_1	1	5	PF00653	0.595
LIG_BIR_III_4	573	577	PF00653	0.480
LIG_Clathr_ClatBox_1	426	430	PF01394	0.295
LIG_FHA_1	146	152	PF00498	0.437
LIG_FHA_1	308	314	PF00498	0.759
LIG_FHA_1	630	636	PF00498	0.561
LIG_FHA_1	704	710	PF00498	0.396
LIG_FHA_1	760	766	PF00498	0.344
LIG_FHA_2	227	233	PF00498	0.632
LIG_FHA_2	245	251	PF00498	0.433
LIG_FHA_2	624	630	PF00498	0.599
LIG_FHA_2	699	705	PF00498	0.320
LIG_FHA_2	829	835	PF00498	0.486
LIG_FHA_2	98	104	PF00498	0.504
LIG_Integrin_isoDGR_2	711	713	PF01839	0.491
LIG_LIR_Nem_3	141	145	PF02991	0.446
LIG_LIR_Nem_3	746	752	PF02991	0.375
LIG_LIR_Nem_3	787	792	PF02991	0.430
LIG_PCNA_yPIPBox_3	177	188	PF02747	0.526
LIG_Pex14_1	326	330	PF04695	0.568
LIG_Pex14_2	745	749	PF04695	0.338
LIG_SH2_CRK	789	793	PF00017	0.501
LIG_SH2_GRB2like	528	531	PF00017	0.514
LIG_SH2_NCK_1	330	334	PF00017	0.514
LIG_SH2_SRC	528	531	PF00017	0.514
LIG_SH2_STAP1	454	458	PF00017	0.432
LIG_SH2_STAT3	454	457	PF00017	0.543
LIG_SH2_STAT3	752	755	PF00017	0.371
LIG_SH2_STAT5	752	755	PF00017	0.413
LIG_SH3_3	385	391	PF00018	0.762
LIG_SH3_3	642	648	PF00018	0.672
LIG_SH3_3	798	804	PF00018	0.485
LIG_SH3_4	640	647	PF00018	0.496
LIG_SUMO_SIM_par_1	425	430	PF11976	0.433
LIG_SUMO_SIM_par_1	701	707	PF11976	0.376
LIG_TRAF2_1	438	441	PF00917	0.480
LIG_TRAF2_1	501	504	PF00917	0.522
LIG_TRAF2_1	602	605	PF00917	0.420
LIG_TRAF2_1	831	834	PF00917	0.580
LIG_UBA3_1	272	277	PF00899	0.561
LIG_UBA3_1	722	729	PF00899	0.374
LIG_UBA3_1	78	83	PF00899	0.613
MOD_CDK_SPK_2	644	649	PF00069	0.802
MOD_CDK_SPK_2	651	656	PF00069	0.638
MOD_CDK_SPK_2	658	663	PF00069	0.641
MOD_CDK_SPxxK_3	312	319	PF00069	0.575
MOD_CDK_SPxxK_3	800	807	PF00069	0.422
MOD_CK1_1	261	267	PF00069	0.550
MOD_CK1_1	294	300	PF00069	0.498
MOD_CK1_1	306	312	PF00069	0.756
MOD_CK1_1	398	404	PF00069	0.721
MOD_CK1_1	651	657	PF00069	0.663
MOD_CK1_1	677	683	PF00069	0.657
MOD_CK1_1	784	790	PF00069	0.457
MOD_CK1_1	803	809	PF00069	0.529
MOD_CK2_1	107	113	PF00069	0.648
MOD_CK2_1	126	132	PF00069	0.335
MOD_CK2_1	15	21	PF00069	0.618
MOD_CK2_1	165	171	PF00069	0.604
MOD_CK2_1	226	232	PF00069	0.631
MOD_CK2_1	244	250	PF00069	0.442
MOD_CK2_1	435	441	PF00069	0.535
MOD_CK2_1	498	504	PF00069	0.537
MOD_CK2_1	512	518	PF00069	0.407
MOD_CK2_1	680	686	PF00069	0.720
MOD_CK2_1	698	704	PF00069	0.250
MOD_CK2_1	724	730	PF00069	0.377
MOD_CK2_1	828	834	PF00069	0.493
MOD_CK2_1	95	101	PF00069	0.632
MOD_GlcNHglycan	108	112	PF01048	0.469
MOD_GlcNHglycan	167	170	PF01048	0.603
MOD_GlcNHglycan	201	204	PF01048	0.666
MOD_GlcNHglycan	260	263	PF01048	0.590
MOD_GlcNHglycan	298	301	PF01048	0.693
MOD_GlcNHglycan	319	322	PF01048	0.520
MOD_GlcNHglycan	437	440	PF01048	0.513
MOD_GlcNHglycan	664	667	PF01048	0.691
MOD_GlcNHglycan	689	692	PF01048	0.704
MOD_GSK3_1	240	247	PF00069	0.458
MOD_GSK3_1	303	310	PF00069	0.727
MOD_GSK3_1	390	397	PF00069	0.706
MOD_GSK3_1	640	647	PF00069	0.695
MOD_GSK3_1	658	665	PF00069	0.679
MOD_GSK3_1	667	674	PF00069	0.677
MOD_GSK3_1	677	684	PF00069	0.576
MOD_GSK3_1	824	831	PF00069	0.568
MOD_N-GLC_1	58	63	PF02516	0.378
MOD_NEK2_1	145	150	PF00069	0.482
MOD_NEK2_1	226	231	PF00069	0.456
MOD_NEK2_1	258	263	PF00069	0.540
MOD_NEK2_1	547	552	PF00069	0.496
MOD_NEK2_1	698	703	PF00069	0.362
MOD_NEK2_1	745	750	PF00069	0.338
MOD_NEK2_1	824	829	PF00069	0.466
MOD_NEK2_1	95	100	PF00069	0.483
MOD_NEK2_2	6	11	PF00069	0.420
MOD_NEK2_2	732	737	PF00069	0.364
MOD_NEK2_2	825	830	PF00069	0.354
MOD_PIKK_1	380	386	PF00454	0.551
MOD_PIKK_1	640	646	PF00454	0.701
MOD_PIKK_1	674	680	PF00454	0.493
MOD_PK_1	329	335	PF00069	0.516
MOD_PK_1	390	396	PF00069	0.679
MOD_PK_1	498	504	PF00069	0.557
MOD_PK_1	724	730	PF00069	0.377
MOD_PKA_1	498	504	PF00069	0.557
MOD_PKA_2	113	119	PF00069	0.365
MOD_PKA_2	294	300	PF00069	0.612
MOD_PKA_2	378	384	PF00069	0.568
MOD_PKA_2	389	395	PF00069	0.747
MOD_PKA_2	404	410	PF00069	0.682
MOD_PKA_2	492	498	PF00069	0.582
MOD_PKA_2	648	654	PF00069	0.659
MOD_PKA_2	662	668	PF00069	0.647
MOD_PKA_2	681	687	PF00069	0.540
MOD_PKA_2	95	101	PF00069	0.480
MOD_PKB_1	105	113	PF00069	0.473
MOD_Plk_1	162	168	PF00069	0.578
MOD_Plk_1	226	232	PF00069	0.456
MOD_Plk_1	240	246	PF00069	0.423
MOD_Plk_1	398	404	PF00069	0.681
MOD_Plk_1	57	63	PF00069	0.382
MOD_Plk_1	671	677	PF00069	0.658
MOD_Plk_1	745	751	PF00069	0.379
MOD_Plk_2-3	113	119	PF00069	0.493
MOD_Plk_2-3	126	132	PF00069	0.402
MOD_Plk_2-3	15	21	PF00069	0.498
MOD_Plk_4	240	246	PF00069	0.457
MOD_Plk_4	480	486	PF00069	0.606
MOD_Plk_4	738	744	PF00069	0.386
MOD_Plk_4	745	751	PF00069	0.369
MOD_Plk_4	784	790	PF00069	0.419
MOD_ProDKin_1	307	313	PF00069	0.566
MOD_ProDKin_1	644	650	PF00069	0.722
MOD_ProDKin_1	651	657	PF00069	0.664
MOD_ProDKin_1	658	664	PF00069	0.602
MOD_ProDKin_1	667	673	PF00069	0.552
MOD_ProDKin_1	800	806	PF00069	0.415
MOD_ProDKin_1	849	855	PF00069	0.449
MOD_SUMO_for_1	219	222	PF00179	0.507
MOD_SUMO_for_1	602	605	PF00179	0.481
MOD_SUMO_rev_2	137	145	PF00179	0.536
MOD_SUMO_rev_2	33	41	PF00179	0.460
MOD_SUMO_rev_2	353	363	PF00179	0.488
MOD_SUMO_rev_2	438	445	PF00179	0.584
MOD_SUMO_rev_2	550	558	PF00179	0.497
MOD_SUMO_rev_2	567	574	PF00179	0.460
TRG_DiLeu_BaEn_1	353	358	PF01217	0.546
TRG_DiLeu_BaEn_1	504	509	PF01217	0.545
TRG_DiLeu_BaEn_1	84	89	PF01217	0.445
TRG_DiLeu_BaEn_2	836	842	PF01217	0.365
TRG_DiLeu_BaEn_4	221	227	PF01217	0.547
TRG_DiLeu_BaLyEn_6	422	427	PF01217	0.319
TRG_DiLeu_LyEn_5	504	509	PF01217	0.545
TRG_ENDOCYTIC_2	142	145	PF00928	0.446
TRG_ENDOCYTIC_2	330	333	PF00928	0.557
TRG_ENDOCYTIC_2	789	792	PF00928	0.496
TRG_ER_diArg_1	104	107	PF00400	0.469
TRG_ER_diArg_1	251	254	PF00400	0.394
TRG_ER_diArg_1	422	425	PF00400	0.529
TRG_ER_diArg_1	433	435	PF00400	0.523
TRG_ER_diArg_1	523	525	PF00400	0.515
TRG_ER_diArg_1	619	621	PF00400	0.637
TRG_ER_diArg_1	667	669	PF00400	0.701
TRG_ER_diArg_1	793	796	PF00400	0.372
TRG_NES_CRM1_1	542	555	PF08389	0.400
TRG_NLS_Bipartite_1	579	597	PF00514	0.454
TRG_NLS_MonoExtC_3	578	583	PF00514	0.489
TRG_NLS_MonoExtC_3	592	598	PF00514	0.560
TRG_NLS_MonoExtN_4	591	597	PF00514	0.523
TRG_Pf-PMV_PEXEL_1	11	15	PF00026	0.362
TRG_Pf-PMV_PEXEL_1	125	130	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	149	154	PF00026	0.454
TRG_Pf-PMV_PEXEL_1	157	161	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	228	232	PF00026	0.545
TRG_Pf-PMV_PEXEL_1	281	285	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.550
TRG_Pf-PMV_PEXEL_1	425	430	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	53	57	PF00026	0.336
TRG_Pf-PMV_PEXEL_1	583	587	PF00026	0.650
TRG_Pf-PMV_PEXEL_1	713	717	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	790	795	PF00026	0.414

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I241	Leptomonas seymouri	57%	100%
A0A1X0P9P4	Trypanosomatidae	35%	95%
A0A3Q8IEG3	Leishmania donovani	92%	100%
A0A3R7KUQ1	Trypanosoma rangeli	35%	93%
A4HAX2	Leishmania braziliensis	79%	100%
A4IA30	Leishmania infantum	92%	100%
C9ZMJ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	96%
Q4Q2U1	Leishmania major	91%	100%