Protein phosphatase 2C-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein phosphatase 2C-like protein

Species:

Leishmania mexicana

UniProt:

E9B541_LEIMU

TriTrypDb:

LmxM.33.2510

Length:

277

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B541

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B541

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016311	dephosphorylation	5	11
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004721	phosphoprotein phosphatase activity	3	11
GO:0004722	protein serine/threonine phosphatase activity	4	11
GO:0005488	binding	1	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0016791	phosphatase activity	5	11
GO:0017018	myosin phosphatase activity	5	9
GO:0042578	phosphoric ester hydrolase activity	4	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	250	252	PF00675	0.626
CLV_PCSK_KEX2_1	250	252	PF00082	0.556
CLV_PCSK_SKI1_1	161	165	PF00082	0.349
CLV_PCSK_SKI1_1	61	65	PF00082	0.365
DEG_APCC_DBOX_1	30	38	PF00400	0.413
DEG_COP1_1	256	264	PF00400	0.452
DEG_Nend_UBRbox_2	1	3	PF02207	0.277
DEG_SPOP_SBC_1	265	269	PF00917	0.421
DOC_MAPK_JIP1_4	105	111	PF00069	0.334
DOC_USP7_MATH_1	145	149	PF00917	0.290
DOC_USP7_MATH_1	177	181	PF00917	0.465
DOC_USP7_MATH_1	264	268	PF00917	0.449
LIG_14-3-3_CanoR_1	124	129	PF00244	0.360
LIG_14-3-3_CanoR_1	183	191	PF00244	0.360
LIG_FHA_1	150	156	PF00498	0.256
LIG_FHA_1	236	242	PF00498	0.281
LIG_FHA_1	268	274	PF00498	0.465
LIG_FHA_2	183	189	PF00498	0.244
LIG_FHA_2	201	207	PF00498	0.244
LIG_FHA_2	247	253	PF00498	0.435
LIG_FHA_2	44	50	PF00498	0.266
LIG_GBD_Chelix_1	80	88	PF00786	0.290
LIG_LIR_Gen_1	187	198	PF02991	0.308
LIG_LIR_Gen_1	203	210	PF02991	0.301
LIG_LIR_LC3C_4	85	90	PF02991	0.290
LIG_LIR_Nem_3	187	193	PF02991	0.308
LIG_LIR_Nem_3	203	207	PF02991	0.301
LIG_SH2_SRC	204	207	PF00017	0.413
LIG_SH2_STAP1	204	208	PF00017	0.306
LIG_SH2_STAT5	165	168	PF00017	0.331
LIG_SH2_STAT5	29	32	PF00017	0.413
LIG_SH3_3	134	140	PF00018	0.331
LIG_SUMO_SIM_par_1	105	110	PF11976	0.306
LIG_SUMO_SIM_par_1	171	180	PF11976	0.465
LIG_TRAF2_1	119	122	PF00917	0.290
MOD_CK1_1	117	123	PF00069	0.370
MOD_CK1_1	267	273	PF00069	0.469
MOD_CK2_1	117	123	PF00069	0.300
MOD_CK2_1	200	206	PF00069	0.394
MOD_CK2_1	246	252	PF00069	0.417
MOD_CK2_1	253	259	PF00069	0.613
MOD_CK2_1	43	49	PF00069	0.266
MOD_CK2_1	64	70	PF00069	0.290
MOD_GlcNHglycan	170	173	PF01048	0.306
MOD_GlcNHglycan	73	76	PF01048	0.305
MOD_GSK3_1	145	152	PF00069	0.306
MOD_GSK3_1	231	238	PF00069	0.281
MOD_GSK3_1	267	274	PF00069	0.525
MOD_GSK3_1	64	71	PF00069	0.456
MOD_N-GLC_1	239	244	PF02516	0.374
MOD_N-GLC_1	271	276	PF02516	0.697
MOD_N-GLC_1	71	76	PF02516	0.323
MOD_NEK2_1	149	154	PF00069	0.306
MOD_PIKK_1	209	215	PF00454	0.247
MOD_PIKK_1	21	27	PF00454	0.266
MOD_PK_1	124	130	PF00069	0.290
MOD_PKA_2	182	188	PF00069	0.315
MOD_Plk_1	177	183	PF00069	0.403
MOD_Plk_1	239	245	PF00069	0.373
MOD_Plk_2-3	200	206	PF00069	0.306
MOD_Plk_4	3	9	PF00069	0.498
TRG_DiLeu_BaEn_1	187	192	PF01217	0.331
TRG_ENDOCYTIC_2	204	207	PF00928	0.300
TRG_NES_CRM1_1	28	43	PF08389	0.300
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.266
TRG_Pf-PMV_PEXEL_1	271	275	PF00026	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5C7	Leptomonas seymouri	31%	70%
A0A0N0P8F8	Leptomonas seymouri	30%	94%
A0A0N1I0H9	Leptomonas seymouri	29%	94%
A0A0N1IHU6	Leptomonas seymouri	32%	68%
A0A0N1PAL8	Leptomonas seymouri	29%	72%
A0A0N1PEL9	Leptomonas seymouri	53%	74%
A0A0S4IY95	Bodo saltans	28%	77%
A0A0S4J0A6	Bodo saltans	31%	68%
A0A0S4JHB4	Bodo saltans	31%	72%
A0A0S4JPC3	Bodo saltans	29%	94%
A0A0S4JPM8	Bodo saltans	30%	73%
A0A1X0NRG3	Trypanosomatidae	30%	87%
A0A1X0NVC4	Trypanosomatidae	31%	67%
A0A1X0P2A0	Trypanosomatidae	30%	73%
A0A1X0P568	Trypanosomatidae	31%	68%
A0A1X0P991	Trypanosomatidae	31%	96%
A0A1X0PAN4	Trypanosomatidae	59%	87%
A0A3Q8IEK6	Leishmania donovani	33%	88%
A0A3Q8IFG7	Leishmania donovani	29%	72%
A0A3Q8IK65	Leishmania donovani	30%	93%
A0A3Q8IL63	Leishmania donovani	50%	71%
A0A3S7WTA2	Leishmania donovani	28%	69%
A0A3S7WZ14	Leishmania donovani	32%	68%
A0A422N8D7	Trypanosoma rangeli	59%	88%
A0A422NAJ1	Trypanosoma rangeli	28%	87%
A0A422NBV9	Trypanosoma rangeli	30%	68%
A0A422NML6	Trypanosoma rangeli	31%	73%
A0A422NS77	Trypanosoma rangeli	28%	67%
A0A422P293	Trypanosoma rangeli	30%	95%
A0BLX0	Paramecium tetraurelia	28%	92%
A0BQL0	Paramecium tetraurelia	28%	92%
A0CUB5	Paramecium tetraurelia	29%	94%
A0DSB3	Paramecium tetraurelia	27%	94%
A0DTY1	Paramecium tetraurelia	26%	92%
A3A8W2	Oryza sativa subsp. japonica	32%	81%
A4H7Y6	Leishmania braziliensis	31%	69%
A4HAW5	Leishmania braziliensis	51%	70%
A4HE10	Leishmania braziliensis	32%	68%
A4HG10	Leishmania braziliensis	31%	100%
A4HHY5	Leishmania braziliensis	29%	100%
A4HNR1	Leishmania braziliensis	31%	100%
A4HWB4	Leishmania infantum	28%	69%
A4I1B7	Leishmania infantum	32%	68%
A4I329	Leishmania infantum	33%	88%
A4I565	Leishmania infantum	29%	72%
A4IA25	Leishmania infantum	50%	71%
A4ICT4	Leishmania infantum	30%	93%
A5PJZ2	Bos taurus	28%	77%
C9ZJK2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	87%
C9ZMJ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	88%
C9ZQJ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	73%
D0A2L9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	95%
D0A5L0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	68%
E9ACV0	Leishmania major	32%	100%
E9AQ14	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9ASH0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AXF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	68%
E9AZD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9B0G2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B540	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	71%
O14156	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	72%
O62829	Bos taurus	34%	73%
O64583	Arabidopsis thaliana	31%	82%
O80871	Arabidopsis thaliana	33%	70%
O81716	Arabidopsis thaliana	29%	78%
O81760	Arabidopsis thaliana	22%	73%
O82637	Arabidopsis thaliana	30%	85%
P20650	Rattus norvegicus	34%	73%
P35182	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	99%
P35813	Homo sapiens	34%	73%
P35814	Oryctolagus cuniculus	34%	73%
P35815	Rattus norvegicus	32%	71%
P36982	Leishmania chagasi	32%	68%
P36993	Mus musculus	31%	71%
P38089	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	70%
P40371	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	80%
P49443	Mus musculus	35%	73%
P49444	Paramecium tetraurelia	29%	92%
P49596	Caenorhabditis elegans	34%	78%
P49598	Arabidopsis thaliana	32%	69%
P49599	Arabidopsis thaliana	28%	71%
P93006	Arabidopsis thaliana	31%	73%
Q09172	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	75%
Q09173	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	67%
Q0D673	Oryza sativa subsp. japonica	33%	96%
Q0DBU3	Oryza sativa subsp. japonica	30%	79%
Q0IIF0	Bos taurus	29%	75%
Q0J2L7	Oryza sativa subsp. japonica	31%	77%
Q0J2R1	Oryza sativa subsp. japonica	31%	75%
Q0JAA0	Oryza sativa subsp. japonica	28%	86%
Q0JL75	Oryza sativa subsp. japonica	34%	73%
Q0WRB2	Arabidopsis thaliana	23%	74%
Q10MX1	Oryza sativa subsp. japonica	31%	71%
Q10S32	Oryza sativa subsp. japonica	25%	69%
Q2PC20	Bos taurus	34%	74%
Q2QN36	Oryza sativa subsp. japonica	27%	71%
Q3EAF9	Arabidopsis thaliana	34%	72%
Q3EAZ3	Arabidopsis thaliana	30%	100%
Q4Q225	Leishmania major	31%	100%
Q4Q2U6	Leishmania major	50%	71%
Q4Q7S1	Leishmania major	29%	100%
Q4QA19	Leishmania major	32%	68%
Q4QFG7	Leishmania major	28%	69%
Q501F9	Arabidopsis thaliana	28%	75%
Q53Q11	Oryza sativa subsp. japonica	32%	70%
Q5JKN1	Oryza sativa subsp. japonica	28%	71%
Q5MFV5	Oryza sativa subsp. indica	25%	73%
Q5N9N2	Oryza sativa subsp. japonica	29%	67%
Q5PNS9	Arabidopsis thaliana	27%	69%
Q5R522	Pongo abelii	33%	85%
Q5SGD2	Homo sapiens	28%	77%
Q5SMK6	Oryza sativa subsp. japonica	36%	77%
Q5SN75	Oryza sativa subsp. japonica	32%	69%
Q5Z6F5	Oryza sativa subsp. japonica	31%	85%
Q5Z8P0	Oryza sativa subsp. japonica	29%	71%
Q652Z7	Oryza sativa subsp. japonica	31%	73%
Q653S3	Oryza sativa subsp. japonica	28%	77%
Q65XG6	Oryza sativa subsp. japonica	31%	67%
Q65XK7	Oryza sativa subsp. japonica	31%	73%
Q67UP9	Oryza sativa subsp. japonica	27%	75%
Q67UX7	Oryza sativa subsp. japonica	34%	80%
Q69QZ0	Oryza sativa subsp. japonica	35%	78%
Q69VD9	Oryza sativa subsp. japonica	35%	75%
Q6AUQ4	Oryza sativa subsp. japonica	32%	71%
Q6EN45	Oryza sativa subsp. japonica	32%	76%
Q6ETK3	Oryza sativa subsp. japonica	28%	77%
Q6ING9	Xenopus laevis	34%	74%
Q6L482	Oryza sativa subsp. japonica	30%	78%
Q6L5H6	Oryza sativa subsp. japonica	30%	72%
Q6NKS1	Arabidopsis thaliana	27%	73%
Q6ZHC8	Oryza sativa subsp. japonica	25%	72%
Q7XCJ7	Oryza sativa subsp. japonica	26%	70%
Q7XHN8	Oryza sativa subsp. japonica	29%	73%
Q7XJ53	Arabidopsis thaliana	27%	80%
Q7XQU7	Oryza sativa subsp. japonica	31%	98%
Q7XR06	Oryza sativa subsp. japonica	33%	98%
Q7XU84	Oryza sativa subsp. japonica	33%	79%
Q7XUC5	Oryza sativa subsp. japonica	26%	71%
Q7Y138	Oryza sativa subsp. japonica	24%	72%
Q84JD5	Arabidopsis thaliana	26%	70%
Q84JI0	Oryza sativa subsp. japonica	31%	69%
Q8BGL1	Mus musculus	32%	69%
Q8BHN0	Mus musculus	28%	77%
Q8BXN7	Mus musculus	34%	74%
Q8H063	Oryza sativa subsp. japonica	26%	71%
Q8L7I4	Arabidopsis thaliana	29%	98%
Q8LAY8	Arabidopsis thaliana	32%	78%
Q8N3J5	Homo sapiens	34%	74%
Q8R0F6	Mus musculus	29%	71%
Q8RX37	Arabidopsis thaliana	35%	73%
Q8RXV3	Arabidopsis thaliana	31%	89%
Q8VZN9	Arabidopsis thaliana	34%	75%
Q93YW5	Arabidopsis thaliana	31%	98%
Q94CL8	Arabidopsis thaliana	28%	72%
Q94H98	Oryza sativa subsp. japonica	25%	73%
Q9FIF5	Arabidopsis thaliana	33%	67%
Q9FKX4	Arabidopsis thaliana	27%	72%
Q9FLI3	Arabidopsis thaliana	26%	67%
Q9FYN7	Oryza sativa subsp. japonica	33%	73%
Q9H0C8	Homo sapiens	29%	71%
Q9LDA7	Arabidopsis thaliana	32%	96%
Q9LHJ9	Arabidopsis thaliana	28%	72%
Q9LME4	Arabidopsis thaliana	30%	99%
Q9LMT1	Arabidopsis thaliana	32%	79%
Q9LNF4	Arabidopsis thaliana	32%	72%
Q9LRZ4	Arabidopsis thaliana	29%	79%
Q9M9W9	Arabidopsis thaliana	25%	77%
Q9S9Z7	Arabidopsis thaliana	29%	98%
Q9SD02	Arabidopsis thaliana	33%	77%
Q9SD12	Arabidopsis thaliana	25%	73%
Q9SIU8	Arabidopsis thaliana	32%	96%
Q9SLA1	Arabidopsis thaliana	38%	71%
Q9SUF4	Arabidopsis thaliana	31%	100%
Q9SZ53	Arabidopsis thaliana	30%	78%
Q9XEE8	Arabidopsis thaliana	34%	71%
Q9XGZ9	Arabidopsis thaliana	32%	84%
Q9Z1Z6	Rattus norvegicus	29%	71%
Q9ZW21	Arabidopsis thaliana	32%	77%
V5AZJ4	Trypanosoma cruzi	32%	70%
V5BA03	Trypanosoma cruzi	32%	96%
V5BCX6	Trypanosoma cruzi	31%	92%
V5BH00	Trypanosoma cruzi	31%	78%
V5BSS7	Trypanosoma cruzi	32%	68%
V5DCR6	Trypanosoma cruzi	30%	67%