Protein phosphatase 2C-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein phosphatase 2C-like protein

Species:

Leishmania mexicana

UniProt:

E9B540_LEIMU

TriTrypDb:

LmxM.33.2500

Length:

391

Annotations

LeishMANIAdb annotations

This large family encompasses many diverse protein phosphatases. Some appear to have evolved transmembrane segments. Very tentatively they might regulate transmembrane receptor kinases.. The TM and non-TM groups diverged early in Eukaryota and appear to be distinct enough that they probably should not be part of the same cluster. This latter group has not expanded.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B540

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B540

Function

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Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	16
GO:0006793	phosphorus metabolic process	3	16
GO:0006796	phosphate-containing compound metabolic process	4	16
GO:0006807	nitrogen compound metabolic process	2	16
GO:0008152	metabolic process	1	16
GO:0009987	cellular process	1	16
GO:0016311	dephosphorylation	5	16
GO:0019538	protein metabolic process	3	16
GO:0036211	protein modification process	4	16
GO:0043170	macromolecule metabolic process	3	16

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	16
GO:0004721	phosphoprotein phosphatase activity	3	16
GO:0004722	protein serine/threonine phosphatase activity	4	16
GO:0005488	binding	1	16
GO:0016787	hydrolase activity	2	16
GO:0016788	hydrolase activity, acting on ester bonds	3	16
GO:0016791	phosphatase activity	5	16
GO:0017018	myosin phosphatase activity	5	13
GO:0042578	phosphoric ester hydrolase activity	4	16
GO:0043167	ion binding	2	16

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	246	250	PF00656	0.351
CLV_C14_Caspase3-7	347	351	PF00656	0.304
CLV_C14_Caspase3-7	89	93	PF00656	0.501
CLV_NRD_NRD_1	178	180	PF00675	0.264
CLV_NRD_NRD_1	364	366	PF00675	0.474
CLV_PCSK_KEX2_1	364	366	PF00082	0.460
CLV_PCSK_SKI1_1	191	195	PF00082	0.390
DEG_APCC_DBOX_1	160	168	PF00400	0.441
DOC_CKS1_1	78	83	PF01111	0.687
DOC_CKS1_1	85	90	PF01111	0.704

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8F8	Leptomonas seymouri	29%	100%
A0A0N1I0H9	Leptomonas seymouri	31%	100%
A0A0N1I8W9	Leptomonas seymouri	48%	90%
A0A0N1IHU6	Leptomonas seymouri	31%	96%
A0A0N1PAL8	Leptomonas seymouri	31%	100%
A0A0N1PEL9	Leptomonas seymouri	63%	100%
A0A0S4ILP4	Bodo saltans	26%	75%
A0A0S4IY95	Bodo saltans	29%	100%
A0A0S4J0A6	Bodo saltans	32%	96%
A0A0S4J8Y7	Bodo saltans	31%	76%

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