Leucine_Rich_repeat_-_putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B538_LEIMU

TriTrypDb:

LmxM.33.2485

Length:

359

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12
GO:0005634	nucleus	5	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9B538

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B538

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	14	16	PF00675	0.623
CLV_NRD_NRD_1	154	156	PF00675	0.384
CLV_NRD_NRD_1	251	253	PF00675	0.467
CLV_NRD_NRD_1	279	281	PF00675	0.399
CLV_NRD_NRD_1	346	348	PF00675	0.666
CLV_NRD_NRD_1	88	90	PF00675	0.524
CLV_PCSK_KEX2_1	154	156	PF00082	0.384
CLV_PCSK_KEX2_1	251	253	PF00082	0.480
CLV_PCSK_KEX2_1	279	281	PF00082	0.399
CLV_PCSK_KEX2_1	348	350	PF00082	0.680
CLV_PCSK_PC1ET2_1	348	350	PF00082	0.693
CLV_PCSK_SKI1_1	16	20	PF00082	0.687
CLV_PCSK_SKI1_1	298	302	PF00082	0.524
CLV_PCSK_SKI1_1	85	89	PF00082	0.456
CLV_Separin_Metazoa	107	111	PF03568	0.512
DEG_APCC_DBOX_1	159	167	PF00400	0.343
DEG_SPOP_SBC_1	46	50	PF00917	0.645
DEG_SPOP_SBC_1	62	66	PF00917	0.516
DOC_CYCLIN_yCln2_LP_2	296	302	PF00134	0.526
DOC_PP1_RVXF_1	162	169	PF00149	0.385
DOC_PP4_FxxP_1	113	116	PF00568	0.500
DOC_USP7_MATH_1	200	204	PF00917	0.634
DOC_USP7_MATH_1	208	212	PF00917	0.636
DOC_USP7_MATH_1	217	221	PF00917	0.591
DOC_USP7_MATH_1	223	227	PF00917	0.383
DOC_USP7_MATH_1	37	41	PF00917	0.705
DOC_USP7_MATH_1	42	46	PF00917	0.742
DOC_USP7_MATH_1	47	51	PF00917	0.720
DOC_USP7_MATH_1	81	85	PF00917	0.568
DOC_USP7_MATH_1	9	13	PF00917	0.507
DOC_USP7_UBL2_3	16	20	PF12436	0.690
DOC_WW_Pin1_4	289	294	PF00397	0.651
DOC_WW_Pin1_4	49	54	PF00397	0.476
LIG_14-3-3_CanoR_1	15	19	PF00244	0.724
LIG_14-3-3_CanoR_1	160	164	PF00244	0.385
LIG_14-3-3_CanoR_1	170	180	PF00244	0.342
LIG_14-3-3_CanoR_1	298	307	PF00244	0.583
LIG_14-3-3_CanoR_1	36	46	PF00244	0.501
LIG_Actin_WH2_2	149	166	PF00022	0.389
LIG_Actin_WH2_2	246	264	PF00022	0.406
LIG_FHA_1	160	166	PF00498	0.394
LIG_FHA_1	319	325	PF00498	0.455
LIG_LIR_Apic_2	111	116	PF02991	0.504
LIG_LIR_Gen_1	147	158	PF02991	0.480
LIG_LIR_Gen_1	305	316	PF02991	0.349
LIG_LIR_Nem_3	147	153	PF02991	0.445
LIG_LIR_Nem_3	305	311	PF02991	0.380
LIG_NRP_CendR_1	358	359	PF00754	0.645
LIG_REV1ctd_RIR_1	150	159	PF16727	0.418
LIG_RPA_C_Fungi	167	179	PF08784	0.343
LIG_SH2_GRB2like	308	311	PF00017	0.459
LIG_SH2_STAT3	234	237	PF00017	0.167
LIG_SH2_STAT5	124	127	PF00017	0.326
LIG_SH2_STAT5	150	153	PF00017	0.433
LIG_SH2_STAT5	308	311	PF00017	0.459
LIG_SH2_STAT5	315	318	PF00017	0.471
LIG_SUMO_SIM_anti_2	103	111	PF11976	0.368
LIG_SUMO_SIM_anti_2	224	231	PF11976	0.267
LIG_SUMO_SIM_par_1	228	233	PF11976	0.276
LIG_SUMO_SIM_par_1	59	67	PF11976	0.446
LIG_TRAF2_1	66	69	PF00917	0.489
MOD_CK1_1	211	217	PF00069	0.615
MOD_CK1_1	40	46	PF00069	0.679
MOD_CK1_1	49	55	PF00069	0.703
MOD_CK2_1	108	114	PF00069	0.429
MOD_CK2_1	222	228	PF00069	0.281
MOD_CK2_1	61	67	PF00069	0.552
MOD_GlcNHglycan	173	176	PF01048	0.355
MOD_GlcNHglycan	203	206	PF01048	0.723
MOD_GlcNHglycan	219	222	PF01048	0.581
MOD_GlcNHglycan	289	292	PF01048	0.646
MOD_GlcNHglycan	302	305	PF01048	0.558
MOD_GlcNHglycan	39	42	PF01048	0.698
MOD_GlcNHglycan	49	52	PF01048	0.748
MOD_GlcNHglycan	81	84	PF01048	0.582
MOD_GSK3_1	14	21	PF00069	0.611
MOD_GSK3_1	192	199	PF00069	0.554
MOD_GSK3_1	217	224	PF00069	0.655
MOD_GSK3_1	298	305	PF00069	0.576
MOD_GSK3_1	42	49	PF00069	0.657
MOD_GSK3_1	75	82	PF00069	0.514
MOD_NEK2_1	125	130	PF00069	0.382
MOD_NEK2_1	181	186	PF00069	0.423
MOD_NEK2_1	230	235	PF00069	0.276
MOD_NEK2_2	14	19	PF00069	0.579
MOD_PK_1	252	258	PF00069	0.442
MOD_PKA_1	347	353	PF00069	0.624
MOD_PKA_2	14	20	PF00069	0.605
MOD_PKA_2	159	165	PF00069	0.477
MOD_PKA_2	171	177	PF00069	0.388
MOD_PKA_2	318	324	PF00069	0.506
MOD_PKA_2	35	41	PF00069	0.516
MOD_Plk_1	125	131	PF00069	0.412
MOD_Plk_1	209	215	PF00069	0.750
MOD_Plk_1	230	236	PF00069	0.288
MOD_Plk_4	125	131	PF00069	0.465
MOD_Plk_4	292	298	PF00069	0.429
MOD_ProDKin_1	289	295	PF00069	0.647
MOD_ProDKin_1	49	55	PF00069	0.474
MOD_SUMO_rev_2	342	350	PF00179	0.527
TRG_ENDOCYTIC_2	124	127	PF00928	0.419
TRG_ENDOCYTIC_2	150	153	PF00928	0.433
TRG_ENDOCYTIC_2	308	311	PF00928	0.459
TRG_ENDOCYTIC_2	94	97	PF00928	0.347
TRG_ER_diArg_1	109	112	PF00400	0.559
TRG_ER_diArg_1	153	155	PF00400	0.543
TRG_ER_diArg_1	170	173	PF00400	0.369
TRG_ER_diArg_1	250	252	PF00400	0.470
TRG_ER_diArg_1	278	280	PF00400	0.399
TRG_Pf-PMV_PEXEL_1	135	140	PF00026	0.346

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAC4	Leptomonas seymouri	65%	97%
A0A0S4JWU2	Bodo saltans	35%	100%
A0A1X0P9N6	Trypanosomatidae	47%	100%
A0A3Q8INF5	Leishmania donovani	91%	100%
A0A3R7NT18	Trypanosoma rangeli	46%	100%
A4HAW3	Leishmania braziliensis	78%	100%
A4IA23	Leishmania infantum	91%	100%
C9ZMJ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
Q4Q2U8	Leishmania major	88%	100%
V5B0E5	Trypanosoma cruzi	51%	97%