Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Component of motile flagella 8, putative

Species:

Leishmania mexicana

UniProt:

E9B537_LEIMU

TriTrypDb:

LmxM.33.2480

Length:

1073

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005856	cytoskeleton	5	1
GO:0005930	axoneme	2	1
GO:0043226	organelle	2	3
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	3
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

E9B537

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B537

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.565
CLV_C14_Caspase3-7	754	758	PF00656	0.547
CLV_C14_Caspase3-7	789	793	PF00656	0.456
CLV_C14_Caspase3-7	838	842	PF00656	0.411
CLV_C14_Caspase3-7	90	94	PF00656	0.446
CLV_MEL_PAP_1	832	838	PF00089	0.512
CLV_NRD_NRD_1	1071	1073	PF00675	0.671
CLV_NRD_NRD_1	135	137	PF00675	0.354
CLV_NRD_NRD_1	288	290	PF00675	0.547
CLV_NRD_NRD_1	359	361	PF00675	0.503
CLV_NRD_NRD_1	393	395	PF00675	0.482
CLV_NRD_NRD_1	443	445	PF00675	0.487
CLV_NRD_NRD_1	486	488	PF00675	0.424
CLV_NRD_NRD_1	50	52	PF00675	0.563
CLV_NRD_NRD_1	575	577	PF00675	0.427
CLV_NRD_NRD_1	594	596	PF00675	0.353
CLV_NRD_NRD_1	65	67	PF00675	0.358
CLV_PCSK_KEX2_1	106	108	PF00082	0.513
CLV_PCSK_KEX2_1	1071	1073	PF00082	0.646
CLV_PCSK_KEX2_1	135	137	PF00082	0.498
CLV_PCSK_KEX2_1	276	278	PF00082	0.507
CLV_PCSK_KEX2_1	288	290	PF00082	0.414
CLV_PCSK_KEX2_1	359	361	PF00082	0.612
CLV_PCSK_KEX2_1	442	444	PF00082	0.463
CLV_PCSK_KEX2_1	452	454	PF00082	0.419
CLV_PCSK_KEX2_1	486	488	PF00082	0.407
CLV_PCSK_KEX2_1	493	495	PF00082	0.435
CLV_PCSK_KEX2_1	50	52	PF00082	0.465
CLV_PCSK_KEX2_1	594	596	PF00082	0.391
CLV_PCSK_KEX2_1	65	67	PF00082	0.315
CLV_PCSK_PC1ET2_1	106	108	PF00082	0.513
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.465
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.391
CLV_PCSK_PC1ET2_1	442	444	PF00082	0.434
CLV_PCSK_PC1ET2_1	452	454	PF00082	0.409
CLV_PCSK_PC1ET2_1	493	495	PF00082	0.379
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.478
CLV_PCSK_SKI1_1	324	328	PF00082	0.493
CLV_PCSK_SKI1_1	388	392	PF00082	0.558
CLV_PCSK_SKI1_1	402	406	PF00082	0.538
CLV_PCSK_SKI1_1	477	481	PF00082	0.576
CLV_PCSK_SKI1_1	51	55	PF00082	0.578
CLV_PCSK_SKI1_1	587	591	PF00082	0.394
CLV_PCSK_SKI1_1	664	668	PF00082	0.473
CLV_PCSK_SKI1_1	987	991	PF00082	0.644
DEG_APCC_DBOX_1	211	219	PF00400	0.605
DEG_APCC_DBOX_1	288	296	PF00400	0.463
DEG_APCC_DBOX_1	442	450	PF00400	0.557
DEG_SPOP_SBC_1	730	734	PF00917	0.465
DOC_CKS1_1	1043	1048	PF01111	0.554
DOC_CYCLIN_RxL_1	224	235	PF00134	0.495
DOC_CYCLIN_RxL_1	399	407	PF00134	0.610
DOC_CYCLIN_RxL_1	818	830	PF00134	0.443
DOC_CYCLIN_yCln2_LP_2	970	976	PF00134	0.633
DOC_MAPK_gen_1	135	142	PF00069	0.367
DOC_MAPK_gen_1	224	231	PF00069	0.483
DOC_MAPK_gen_1	339	347	PF00069	0.530
DOC_MAPK_gen_1	359	365	PF00069	0.293
DOC_MAPK_gen_1	442	451	PF00069	0.415
DOC_MAPK_gen_1	493	501	PF00069	0.537
DOC_MAPK_gen_1	723	731	PF00069	0.648
DOC_MAPK_gen_1	75	83	PF00069	0.477
DOC_MAPK_gen_1	818	826	PF00069	0.383
DOC_MAPK_MEF2A_6	122	130	PF00069	0.399
DOC_MAPK_MEF2A_6	686	694	PF00069	0.551
DOC_MAPK_MEF2A_6	723	731	PF00069	0.648
DOC_MAPK_MEF2A_6	981	990	PF00069	0.555
DOC_MIT_MIM_1	807	815	PF04212	0.329
DOC_PP2B_LxvP_1	968	971	PF13499	0.509
DOC_PP2B_LxvP_1	990	993	PF13499	0.473
DOC_USP7_MATH_1	1009	1013	PF00917	0.663
DOC_USP7_MATH_1	1030	1034	PF00917	0.757
DOC_USP7_MATH_1	582	586	PF00917	0.509
DOC_USP7_MATH_1	685	689	PF00917	0.547
DOC_USP7_MATH_1	8	12	PF00917	0.703
DOC_USP7_MATH_1	938	942	PF00917	0.604
DOC_USP7_MATH_1	979	983	PF00917	0.684
DOC_USP7_UBL2_3	412	416	PF12436	0.598
DOC_USP7_UBL2_3	493	497	PF12436	0.483
DOC_USP7_UBL2_3	50	54	PF12436	0.359
DOC_USP7_UBL2_3	531	535	PF12436	0.397
DOC_USP7_UBL2_3	577	581	PF12436	0.414
DOC_USP7_UBL2_3	814	818	PF12436	0.532
DOC_WW_Pin1_4	1004	1009	PF00397	0.749
DOC_WW_Pin1_4	1025	1030	PF00397	0.687
DOC_WW_Pin1_4	1042	1047	PF00397	0.732
DOC_WW_Pin1_4	765	770	PF00397	0.616
LIG_14-3-3_CanoR_1	1017	1022	PF00244	0.642
LIG_14-3-3_CanoR_1	182	191	PF00244	0.391
LIG_14-3-3_CanoR_1	256	261	PF00244	0.568
LIG_14-3-3_CanoR_1	277	282	PF00244	0.520
LIG_14-3-3_CanoR_1	289	293	PF00244	0.427
LIG_14-3-3_CanoR_1	306	313	PF00244	0.557
LIG_14-3-3_CanoR_1	466	470	PF00244	0.496
LIG_14-3-3_CanoR_1	486	495	PF00244	0.435
LIG_14-3-3_CanoR_1	594	603	PF00244	0.378
LIG_14-3-3_CanoR_1	87	92	PF00244	0.407
LIG_Actin_WH2_2	56	74	PF00022	0.350
LIG_Actin_WH2_2	596	613	PF00022	0.323
LIG_BRCT_BRCA1_1	410	414	PF00533	0.626
LIG_BRCT_BRCA1_2	410	416	PF00533	0.514
LIG_FHA_1	25	31	PF00498	0.426
LIG_FHA_1	320	326	PF00498	0.438
LIG_FHA_1	381	387	PF00498	0.549
LIG_FHA_1	399	405	PF00498	0.529
LIG_FHA_1	429	435	PF00498	0.598
LIG_FHA_1	528	534	PF00498	0.553
LIG_FHA_1	706	712	PF00498	0.486
LIG_FHA_1	758	764	PF00498	0.437
LIG_FHA_1	845	851	PF00498	0.357
LIG_FHA_1	950	956	PF00498	0.659
LIG_FHA_2	183	189	PF00498	0.533
LIG_FHA_2	295	301	PF00498	0.464
LIG_FHA_2	335	341	PF00498	0.464
LIG_FHA_2	604	610	PF00498	0.387
LIG_FHA_2	752	758	PF00498	0.656
LIG_FHA_2	787	793	PF00498	0.585
LIG_FHA_2	869	875	PF00498	0.321
LIG_FHA_2	88	94	PF00498	0.533
LIG_HP1_1	986	990	PF01393	0.477
LIG_LIR_Gen_1	26	36	PF02991	0.446
LIG_LIR_Gen_1	500	510	PF02991	0.358
LIG_LIR_Nem_3	26	32	PF02991	0.478
LIG_LIR_Nem_3	500	505	PF02991	0.356
LIG_LIR_Nem_3	795	801	PF02991	0.437
LIG_NRBOX	669	675	PF00104	0.371
LIG_RPA_C_Fungi	636	648	PF08784	0.461
LIG_SH2_NCK_1	910	914	PF00017	0.415
LIG_SH2_PTP2	29	32	PF00017	0.348
LIG_SH2_PTP2	798	801	PF00017	0.537
LIG_SH2_SRC	910	913	PF00017	0.412
LIG_SH2_STAP1	614	618	PF00017	0.437
LIG_SH2_STAT3	961	964	PF00017	0.538
LIG_SH2_STAT5	29	32	PF00017	0.379
LIG_SH2_STAT5	48	51	PF00017	0.381
LIG_SH2_STAT5	798	801	PF00017	0.537
LIG_SH2_STAT5	89	92	PF00017	0.408
LIG_SH2_STAT5	961	964	PF00017	0.536
LIG_SH3_2	718	723	PF14604	0.487
LIG_SH3_2	976	981	PF14604	0.531
LIG_SH3_3	1040	1046	PF00018	0.611
LIG_SH3_3	715	721	PF00018	0.477
LIG_SH3_3	732	738	PF00018	0.455
LIG_SH3_3	788	794	PF00018	0.524
LIG_SH3_3	952	958	PF00018	0.539
LIG_SH3_3	970	976	PF00018	0.516
LIG_SUMO_SIM_anti_2	536	541	PF11976	0.360
LIG_SUMO_SIM_par_1	727	734	PF11976	0.411
LIG_TRAF2_1	149	152	PF00917	0.381
LIG_TRAF2_1	245	248	PF00917	0.542
LIG_TRAF2_1	308	311	PF00917	0.547
LIG_TRAF2_1	461	464	PF00917	0.495
LIG_UBA3_1	101	106	PF00899	0.281
LIG_UBA3_1	347	355	PF00899	0.331
LIG_WRC_WIRS_1	88	93	PF05994	0.407
LIG_WW_3	991	995	PF00397	0.524
MOD_CDK_SPxxK_3	1004	1011	PF00069	0.533
MOD_CK1_1	1007	1013	PF00069	0.548
MOD_CK1_1	1024	1030	PF00069	0.750
MOD_CK1_1	1050	1056	PF00069	0.670
MOD_CK1_1	1063	1069	PF00069	0.714
MOD_CK1_1	21	27	PF00069	0.375
MOD_CK1_1	457	463	PF00069	0.577
MOD_CK1_1	538	544	PF00069	0.528
MOD_CK1_1	764	770	PF00069	0.705
MOD_CK1_1	941	947	PF00069	0.619
MOD_CK2_1	241	247	PF00069	0.544
MOD_CK2_1	263	269	PF00069	0.526
MOD_CK2_1	294	300	PF00069	0.451
MOD_CK2_1	305	311	PF00069	0.496
MOD_CK2_1	334	340	PF00069	0.592
MOD_CK2_1	346	352	PF00069	0.495
MOD_CK2_1	355	361	PF00069	0.416
MOD_CK2_1	457	463	PF00069	0.568
MOD_CK2_1	486	492	PF00069	0.418
MOD_CK2_1	582	588	PF00069	0.475
MOD_CK2_1	685	691	PF00069	0.563
MOD_CK2_1	76	82	PF00069	0.427
MOD_CK2_1	868	874	PF00069	0.341
MOD_CK2_1	891	897	PF00069	0.504
MOD_GlcNHglycan	1000	1003	PF01048	0.760
MOD_GlcNHglycan	1023	1026	PF01048	0.748
MOD_GlcNHglycan	1032	1035	PF01048	0.749
MOD_GlcNHglycan	11	14	PF01048	0.712
MOD_GlcNHglycan	250	253	PF01048	0.487
MOD_GlcNHglycan	348	351	PF01048	0.470
MOD_GlcNHglycan	459	462	PF01048	0.574
MOD_GlcNHglycan	543	546	PF01048	0.380
MOD_GlcNHglycan	757	760	PF01048	0.695
MOD_GlcNHglycan	763	766	PF01048	0.623
MOD_GlcNHglycan	778	781	PF01048	0.582
MOD_GlcNHglycan	981	984	PF01048	0.523
MOD_GSK3_1	1017	1024	PF00069	0.679
MOD_GSK3_1	1025	1032	PF00069	0.473
MOD_GSK3_1	1055	1062	PF00069	0.683
MOD_GSK3_1	1063	1070	PF00069	0.735
MOD_GSK3_1	291	298	PF00069	0.479
MOD_GSK3_1	302	309	PF00069	0.504
MOD_GSK3_1	465	472	PF00069	0.532
MOD_GSK3_1	665	672	PF00069	0.504
MOD_GSK3_1	751	758	PF00069	0.643
MOD_GSK3_1	759	766	PF00069	0.530
MOD_N-GLC_1	1059	1064	PF02516	0.474
MOD_N-GLC_1	295	300	PF02516	0.460
MOD_N-GLC_1	621	626	PF02516	0.419
MOD_NEK2_1	1023	1028	PF00069	0.772
MOD_NEK2_1	204	209	PF00069	0.549
MOD_NEK2_1	319	324	PF00069	0.378
MOD_NEK2_1	665	670	PF00069	0.489
MOD_NEK2_1	692	697	PF00069	0.435
MOD_NEK2_1	729	734	PF00069	0.407
MOD_NEK2_1	763	768	PF00069	0.571
MOD_NEK2_1	868	873	PF00069	0.339
MOD_NEK2_1	878	883	PF00069	0.388
MOD_NEK2_1	949	954	PF00069	0.733
MOD_NEK2_2	857	862	PF00069	0.387
MOD_NEK2_2	873	878	PF00069	0.381
MOD_PIKK_1	306	312	PF00454	0.439
MOD_PIKK_1	511	517	PF00454	0.394
MOD_PIKK_1	685	691	PF00454	0.532
MOD_PIKK_1	705	711	PF00454	0.315
MOD_PK_1	1017	1023	PF00069	0.527
MOD_PK_1	535	541	PF00069	0.488
MOD_PK_1	891	897	PF00069	0.365
MOD_PKA_1	288	294	PF00069	0.425
MOD_PKA_1	486	492	PF00069	0.532
MOD_PKA_2	1016	1022	PF00069	0.753
MOD_PKA_2	121	127	PF00069	0.358
MOD_PKA_2	263	269	PF00069	0.495
MOD_PKA_2	288	294	PF00069	0.428
MOD_PKA_2	305	311	PF00069	0.507
MOD_PKA_2	380	386	PF00069	0.480
MOD_PKA_2	457	463	PF00069	0.506
MOD_PKA_2	465	471	PF00069	0.536
MOD_PKA_2	486	492	PF00069	0.439
MOD_PKA_2	541	547	PF00069	0.351
MOD_PKA_2	653	659	PF00069	0.402
MOD_PKA_2	776	782	PF00069	0.472
MOD_PKA_2	938	944	PF00069	0.455
MOD_PKB_1	85	93	PF00069	0.544
MOD_Plk_1	1059	1065	PF00069	0.520
MOD_Plk_1	295	301	PF00069	0.460
MOD_Plk_1	361	367	PF00069	0.502
MOD_Plk_1	428	434	PF00069	0.573
MOD_Plk_1	462	468	PF00069	0.456
MOD_Plk_1	535	541	PF00069	0.467
MOD_Plk_1	603	609	PF00069	0.486
MOD_Plk_1	66	72	PF00069	0.357
MOD_Plk_1	692	698	PF00069	0.436
MOD_Plk_1	844	850	PF00069	0.367
MOD_Plk_1	873	879	PF00069	0.378
MOD_Plk_1	941	947	PF00069	0.651
MOD_Plk_2-3	361	367	PF00069	0.510
MOD_Plk_4	121	127	PF00069	0.351
MOD_Plk_4	232	238	PF00069	0.389
MOD_Plk_4	535	541	PF00069	0.394
MOD_Plk_4	66	72	PF00069	0.357
MOD_Plk_4	669	675	PF00069	0.455
MOD_Plk_4	786	792	PF00069	0.520
MOD_Plk_4	873	879	PF00069	0.342
MOD_Plk_4	891	897	PF00069	0.368
MOD_ProDKin_1	1004	1010	PF00069	0.750
MOD_ProDKin_1	1025	1031	PF00069	0.687
MOD_ProDKin_1	1042	1048	PF00069	0.728
MOD_ProDKin_1	765	771	PF00069	0.618
MOD_SUMO_for_1	157	160	PF00179	0.524
MOD_SUMO_for_1	191	194	PF00179	0.409
MOD_SUMO_for_1	505	508	PF00179	0.395
MOD_SUMO_rev_2	242	251	PF00179	0.430
MOD_SUMO_rev_2	584	591	PF00179	0.546
MOD_SUMO_rev_2	712	721	PF00179	0.607
TRG_DiLeu_BaEn_1	186	191	PF01217	0.406
TRG_DiLeu_BaEn_1	315	320	PF01217	0.462
TRG_DiLeu_BaEn_1	367	372	PF01217	0.523
TRG_DiLeu_BaEn_1	528	533	PF01217	0.503
TRG_DiLeu_BaEn_4	827	833	PF01217	0.369
TRG_ENDOCYTIC_2	29	32	PF00928	0.379
TRG_ENDOCYTIC_2	798	801	PF00928	0.497
TRG_ENDOCYTIC_2	974	977	PF00928	0.499
TRG_ER_diArg_1	154	157	PF00400	0.426
TRG_ER_diArg_1	593	595	PF00400	0.370
TRG_ER_diArg_1	64	66	PF00400	0.491
TRG_ER_diArg_1	77	80	PF00400	0.401
TRG_ER_diArg_1	85	88	PF00400	0.515
TRG_NLS_Bipartite_1	275	292	PF00514	0.526
TRG_NLS_MonoExtC_3	49	54	PF00514	0.353
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.387
TRG_Pf-PMV_PEXEL_1	403	407	PF00026	0.564
TRG_Pf-PMV_PEXEL_1	594	599	PF00026	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IC41	Leptomonas seymouri	63%	92%
A0A0S4JNC8	Bodo saltans	42%	100%
A0A1X0P9Q4	Trypanosomatidae	45%	100%
A0A3Q8IGJ9	Leishmania donovani	23%	100%
A0A3S7X809	Leishmania donovani	91%	100%
A0A422P0B4	Trypanosoma rangeli	44%	100%
A4HAW2	Leishmania braziliensis	80%	100%
A4IA22	Leishmania infantum	91%	100%
A4IDS5	Leishmania infantum	23%	100%
C9ZMK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
Q4Q2U9	Leishmania major	91%	100%
Q66H60	Rattus norvegicus	23%	100%
Q8IYE0	Homo sapiens	20%	100%
V5DGR4	Trypanosoma cruzi	44%	100%