Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B535_LEIMU

TriTrypDb:

LmxM.33.2476

Length:

375

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9B535

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B535

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	326	332	PF00089	0.496
CLV_NRD_NRD_1	167	169	PF00675	0.627
CLV_NRD_NRD_1	206	208	PF00675	0.422
CLV_NRD_NRD_1	267	269	PF00675	0.330
CLV_NRD_NRD_1	280	282	PF00675	0.425
CLV_NRD_NRD_1	358	360	PF00675	0.514
CLV_NRD_NRD_1	372	374	PF00675	0.411
CLV_PCSK_KEX2_1	167	169	PF00082	0.627
CLV_PCSK_KEX2_1	205	207	PF00082	0.430
CLV_PCSK_KEX2_1	267	269	PF00082	0.330
CLV_PCSK_KEX2_1	280	282	PF00082	0.425
CLV_PCSK_KEX2_1	358	360	PF00082	0.514
CLV_PCSK_KEX2_1	371	373	PF00082	0.424
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.430
CLV_PCSK_SKI1_1	171	175	PF00082	0.311
CLV_PCSK_SKI1_1	252	256	PF00082	0.284
CLV_PCSK_SKI1_1	260	264	PF00082	0.272
CLV_PCSK_SKI1_1	27	31	PF00082	0.728
DEG_APCC_DBOX_1	259	267	PF00400	0.284
DEG_Nend_Nbox_1	1	3	PF02207	0.551
DEG_SCF_FBW7_1	49	54	PF00400	0.413
DOC_CKS1_1	134	139	PF01111	0.391
DOC_CYCLIN_yCln2_LP_2	30	36	PF00134	0.478
DOC_MAPK_gen_1	167	174	PF00069	0.454
DOC_MAPK_HePTP_8	232	244	PF00069	0.399
DOC_MAPK_JIP1_4	168	174	PF00069	0.279
DOC_MAPK_MEF2A_6	167	174	PF00069	0.412
DOC_MAPK_MEF2A_6	235	244	PF00069	0.358
DOC_PP1_RVXF_1	250	256	PF00149	0.285
DOC_PP1_RVXF_1	258	265	PF00149	0.370
DOC_PP1_SILK_1	256	261	PF00149	0.311
DOC_PP2B_LxvP_1	123	126	PF13499	0.424
DOC_PP2B_LxvP_1	37	40	PF13499	0.408
DOC_USP7_MATH_1	105	109	PF00917	0.524
DOC_USP7_MATH_1	115	119	PF00917	0.443
DOC_USP7_MATH_1	163	167	PF00917	0.442
DOC_USP7_MATH_1	254	258	PF00917	0.227
DOC_USP7_MATH_1	287	291	PF00917	0.656
DOC_USP7_MATH_1	320	324	PF00917	0.605
DOC_USP7_MATH_1	6	10	PF00917	0.540
DOC_USP7_MATH_1	83	87	PF00917	0.533
DOC_WW_Pin1_4	133	138	PF00397	0.423
DOC_WW_Pin1_4	146	151	PF00397	0.396
DOC_WW_Pin1_4	161	166	PF00397	0.402
DOC_WW_Pin1_4	47	52	PF00397	0.529
DOC_WW_Pin1_4	56	61	PF00397	0.466
DOC_WW_Pin1_4	85	90	PF00397	0.520
DOC_WW_Pin1_4	98	103	PF00397	0.445
LIG_14-3-3_CanoR_1	104	114	PF00244	0.523
LIG_14-3-3_CanoR_1	154	163	PF00244	0.430
LIG_14-3-3_CanoR_1	213	223	PF00244	0.530
LIG_14-3-3_CanoR_1	235	242	PF00244	0.403
LIG_14-3-3_CanoR_1	299	304	PF00244	0.756
LIG_14-3-3_CanoR_1	307	315	PF00244	0.732
LIG_14-3-3_CanoR_1	329	339	PF00244	0.701
LIG_14-3-3_CanoR_1	358	368	PF00244	0.720
LIG_14-3-3_CanoR_1	45	50	PF00244	0.534
LIG_BRCT_BRCA1_1	117	121	PF00533	0.404
LIG_EH1_1	223	231	PF00400	0.382
LIG_eIF4E_1	224	230	PF01652	0.382
LIG_FHA_1	134	140	PF00498	0.451
LIG_FHA_1	217	223	PF00498	0.402
LIG_FHA_1	231	237	PF00498	0.347
LIG_FHA_1	48	54	PF00498	0.524
LIG_LIR_Nem_3	55	61	PF02991	0.414
LIG_NRBOX	258	264	PF00104	0.298
LIG_Pex14_2	186	190	PF04695	0.382
LIG_PTB_Apo_2	92	99	PF02174	0.522
LIG_SH2_CRK	130	134	PF00017	0.439
LIG_SH2_CRK	58	62	PF00017	0.414
LIG_SH2_SRC	224	227	PF00017	0.382
LIG_SH2_STAT5	224	227	PF00017	0.522
LIG_SH3_3	109	115	PF00018	0.476
LIG_SH3_3	131	137	PF00018	0.437
LIG_SH3_3	250	256	PF00018	0.219
LIG_SH3_3	312	318	PF00018	0.682
LIG_SUMO_SIM_par_1	228	234	PF11976	0.382
LIG_TRFH_1	98	102	PF08558	0.659
LIG_TYR_ITIM	222	227	PF00017	0.522
MOD_CDC14_SPxK_1	101	104	PF00782	0.665
MOD_CDC14_SPxK_1	164	167	PF00782	0.553
MOD_CDK_SPxK_1	161	167	PF00069	0.569
MOD_CDK_SPxK_1	98	104	PF00069	0.664
MOD_CDK_SPxxK_3	161	168	PF00069	0.562
MOD_CK1_1	141	147	PF00069	0.555
MOD_CK1_1	17	23	PF00069	0.566
MOD_CK1_1	214	220	PF00069	0.382
MOD_CK1_1	302	308	PF00069	0.453
MOD_CK1_1	361	367	PF00069	0.498
MOD_CK1_1	5	11	PF00069	0.679
MOD_CK1_1	67	73	PF00069	0.660
MOD_CK2_1	343	349	PF00069	0.643
MOD_CMANNOS	261	264	PF00535	0.382
MOD_GlcNHglycan	130	133	PF01048	0.620
MOD_GlcNHglycan	157	160	PF01048	0.597
MOD_GlcNHglycan	16	19	PF01048	0.573
MOD_GlcNHglycan	214	217	PF01048	0.373
MOD_GlcNHglycan	27	30	PF01048	0.645
MOD_GlcNHglycan	308	311	PF01048	0.570
MOD_GlcNHglycan	361	364	PF01048	0.645
MOD_GlcNHglycan	4	7	PF01048	0.675
MOD_GlcNHglycan	45	48	PF01048	0.505
MOD_GlcNHglycan	84	88	PF01048	0.652
MOD_GSK3_1	115	122	PF00069	0.600
MOD_GSK3_1	138	145	PF00069	0.580
MOD_GSK3_1	2	9	PF00069	0.677
MOD_GSK3_1	212	219	PF00069	0.318
MOD_GSK3_1	230	237	PF00069	0.302
MOD_GSK3_1	302	309	PF00069	0.580
MOD_GSK3_1	316	323	PF00069	0.503
MOD_GSK3_1	335	342	PF00069	0.568
MOD_GSK3_1	343	350	PF00069	0.533
MOD_GSK3_1	43	50	PF00069	0.667
MOD_GSK3_1	52	59	PF00069	0.571
MOD_N-GLC_1	67	72	PF02516	0.600
MOD_NEK2_1	119	124	PF00069	0.484
MOD_NEK2_1	142	147	PF00069	0.633
MOD_NEK2_1	186	191	PF00069	0.430
MOD_NEK2_1	199	204	PF00069	0.525
MOD_NEK2_1	2	7	PF00069	0.678
MOD_NEK2_1	297	302	PF00069	0.600
MOD_NEK2_1	306	311	PF00069	0.537
MOD_NEK2_1	330	335	PF00069	0.620
MOD_NEK2_1	339	344	PF00069	0.561
MOD_NEK2_1	347	352	PF00069	0.498
MOD_NEK2_1	53	58	PF00069	0.581
MOD_NEK2_1	64	69	PF00069	0.530
MOD_NEK2_2	115	120	PF00069	0.639
MOD_NEK2_2	366	371	PF00069	0.648
MOD_PIKK_1	105	111	PF00454	0.505
MOD_PIKK_1	191	197	PF00454	0.483
MOD_PIKK_1	330	336	PF00454	0.621
MOD_PIKK_1	339	345	PF00454	0.560
MOD_PIKK_1	6	12	PF00454	0.679
MOD_PK_1	235	241	PF00069	0.331
MOD_PK_1	299	305	PF00069	0.587
MOD_PKA_1	358	364	PF00069	0.489
MOD_PKA_2	103	109	PF00069	0.665
MOD_PKA_2	128	134	PF00069	0.466
MOD_PKA_2	2	8	PF00069	0.678
MOD_PKA_2	212	218	PF00069	0.298
MOD_PKA_2	234	240	PF00069	0.564
MOD_PKA_2	306	312	PF00069	0.734
MOD_PKA_2	328	334	PF00069	0.618
MOD_PKA_2	347	353	PF00069	0.482
MOD_PKA_2	358	364	PF00069	0.537
MOD_Plk_4	138	144	PF00069	0.563
MOD_Plk_4	235	241	PF00069	0.331
MOD_Plk_4	254	260	PF00069	0.311
MOD_Plk_4	38	44	PF00069	0.499
MOD_ProDKin_1	133	139	PF00069	0.514
MOD_ProDKin_1	146	152	PF00069	0.471
MOD_ProDKin_1	161	167	PF00069	0.478
MOD_ProDKin_1	47	53	PF00069	0.658
MOD_ProDKin_1	56	62	PF00069	0.572
MOD_ProDKin_1	85	91	PF00069	0.648
MOD_ProDKin_1	98	104	PF00069	0.546
TRG_DiLeu_BaEn_1	292	297	PF01217	0.426
TRG_DiLeu_BaLyEn_6	274	279	PF01217	0.509
TRG_DiLeu_BaLyEn_6	57	62	PF01217	0.656
TRG_DiLeu_BaLyEn_6	88	93	PF01217	0.491
TRG_DiLeu_LyEn_5	292	297	PF01217	0.440
TRG_ENDOCYTIC_2	130	133	PF00928	0.536
TRG_ENDOCYTIC_2	223	226	PF00928	0.515
TRG_ENDOCYTIC_2	58	61	PF00928	0.500
TRG_ER_diArg_1	167	169	PF00400	0.510
TRG_ER_diArg_1	206	208	PF00400	0.511
TRG_ER_diArg_1	266	268	PF00400	0.383
TRG_ER_diArg_1	279	281	PF00400	0.510
TRG_ER_diArg_1	358	360	PF00400	0.640
TRG_ER_diArg_1	370	373	PF00400	0.524
TRG_NES_CRM1_1	234	245	PF08389	0.330

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X7Z9	Leishmania donovani	83%	99%
A4IA20	Leishmania infantum	83%	99%
Q4Q2V1	Leishmania major	80%	100%