Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B535_LEIMU

TriTrypDb:

LmxM.33.2476

Length:

375

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

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Expansion

Sequence features

E9B535

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B535

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	326	332	PF00089	0.496
CLV_NRD_NRD_1	167	169	PF00675	0.627
CLV_NRD_NRD_1	206	208	PF00675	0.422
CLV_NRD_NRD_1	267	269	PF00675	0.330
CLV_NRD_NRD_1	280	282	PF00675	0.425
CLV_NRD_NRD_1	358	360	PF00675	0.514
CLV_NRD_NRD_1	372	374	PF00675	0.411
CLV_PCSK_KEX2_1	167	169	PF00082	0.627
CLV_PCSK_KEX2_1	205	207	PF00082	0.430
CLV_PCSK_KEX2_1	267	269	PF00082	0.330

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X7Z9	Leishmania donovani	83%	99%
A4IA20	Leishmania infantum	83%	99%
Q4Q2V1	Leishmania major	80%	100%

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