Tr-type G domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Elongation factor Tu GTP binding domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B532_LEIMU

TriTrypDb:

LmxM.33.2460

Length:

876

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B532

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B532

Function

Biological processes
Term	Name	Level	Count
GO:0006414	translational elongation	5	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0003924	GTPase activity	7	10
GO:0005488	binding	1	10
GO:0005525	GTP binding	5	10
GO:0016462	pyrophosphatase activity	5	10
GO:0016787	hydrolase activity	2	10
GO:0016817	hydrolase activity, acting on acid anhydrides	3	10
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	10
GO:0017076	purine nucleotide binding	4	10
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	10
GO:0019001	guanyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032561	guanyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10
GO:0003676	nucleic acid binding	3	2
GO:0003746	translation elongation factor activity	4	2
GO:0008135	translation factor activity, RNA binding	3	2
GO:0045182	translation regulator activity	1	2
GO:0090079	translation regulator activity, nucleic acid binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	176	180	PF00656	0.655
CLV_C14_Caspase3-7	502	506	PF00656	0.580
CLV_C14_Caspase3-7	588	592	PF00656	0.596
CLV_C14_Caspase3-7	820	824	PF00656	0.760
CLV_C14_Caspase3-7	848	852	PF00656	0.593
CLV_NRD_NRD_1	10	12	PF00675	0.792
CLV_NRD_NRD_1	119	121	PF00675	0.771
CLV_NRD_NRD_1	128	130	PF00675	0.800
CLV_NRD_NRD_1	287	289	PF00675	0.611
CLV_NRD_NRD_1	316	318	PF00675	0.571
CLV_NRD_NRD_1	371	373	PF00675	0.615
CLV_NRD_NRD_1	520	522	PF00675	0.333
CLV_PCSK_KEX2_1	119	121	PF00082	0.771
CLV_PCSK_KEX2_1	287	289	PF00082	0.611
CLV_PCSK_KEX2_1	371	373	PF00082	0.615
CLV_PCSK_PC7_1	283	289	PF00082	0.603
CLV_PCSK_SKI1_1	283	287	PF00082	0.514
CLV_PCSK_SKI1_1	499	503	PF00082	0.316
CLV_PCSK_SKI1_1	512	516	PF00082	0.258
CLV_PCSK_SKI1_1	839	843	PF00082	0.545
DEG_APCC_DBOX_1	656	664	PF00400	0.560
DEG_APCC_KENBOX_2	355	359	PF00400	0.701
DEG_Nend_Nbox_1	1	3	PF02207	0.758
DEG_SCF_FBW7_1	621	628	PF00400	0.611
DEG_SPOP_SBC_1	29	33	PF00917	0.767
DEG_SPOP_SBC_1	616	620	PF00917	0.614
DEG_SPOP_SBC_1	68	72	PF00917	0.816
DEG_SPOP_SBC_1	75	79	PF00917	0.716
DOC_CKS1_1	550	555	PF01111	0.587
DOC_CKS1_1	622	627	PF01111	0.611
DOC_CYCLIN_RxL_1	836	845	PF00134	0.525
DOC_MAPK_gen_1	521	528	PF00069	0.587
DOC_MAPK_gen_1	633	641	PF00069	0.555
DOC_MAPK_gen_1	703	711	PF00069	0.550
DOC_MAPK_gen_1	802	810	PF00069	0.523
DOC_MAPK_HePTP_8	518	530	PF00069	0.587
DOC_MAPK_MEF2A_6	393	401	PF00069	0.508
DOC_MAPK_MEF2A_6	521	530	PF00069	0.587
DOC_MAPK_MEF2A_6	633	641	PF00069	0.555
DOC_PP2B_LxvP_1	49	52	PF13499	0.654
DOC_PP2B_LxvP_1	637	640	PF13499	0.587
DOC_PP2B_LxvP_1	672	675	PF13499	0.689
DOC_PP4_FxxP_1	43	46	PF00568	0.503
DOC_USP7_MATH_1	111	115	PF00917	0.736
DOC_USP7_MATH_1	133	137	PF00917	0.795
DOC_USP7_MATH_1	16	20	PF00917	0.830
DOC_USP7_MATH_1	211	215	PF00917	0.688
DOC_USP7_MATH_1	225	229	PF00917	0.705
DOC_USP7_MATH_1	324	328	PF00917	0.772
DOC_USP7_MATH_1	388	392	PF00917	0.553
DOC_USP7_MATH_1	468	472	PF00917	0.503
DOC_USP7_MATH_1	52	56	PF00917	0.681
DOC_USP7_MATH_1	535	539	PF00917	0.578
DOC_USP7_MATH_1	67	71	PF00917	0.817
DOC_USP7_MATH_1	75	79	PF00917	0.665
DOC_USP7_MATH_1	782	786	PF00917	0.566
DOC_WW_Pin1_4	135	140	PF00397	0.818
DOC_WW_Pin1_4	145	150	PF00397	0.726
DOC_WW_Pin1_4	196	201	PF00397	0.808
DOC_WW_Pin1_4	213	218	PF00397	0.774
DOC_WW_Pin1_4	245	250	PF00397	0.574
DOC_WW_Pin1_4	278	283	PF00397	0.513
DOC_WW_Pin1_4	31	36	PF00397	0.654
DOC_WW_Pin1_4	319	324	PF00397	0.665
DOC_WW_Pin1_4	327	332	PF00397	0.707
DOC_WW_Pin1_4	443	448	PF00397	0.569
DOC_WW_Pin1_4	457	462	PF00397	0.505
DOC_WW_Pin1_4	478	483	PF00397	0.594
DOC_WW_Pin1_4	494	499	PF00397	0.422
DOC_WW_Pin1_4	549	554	PF00397	0.587
DOC_WW_Pin1_4	617	622	PF00397	0.592
DOC_WW_Pin1_4	666	671	PF00397	0.609
DOC_WW_Pin1_4	71	76	PF00397	0.619
LIG_14-3-3_CanoR_1	110	116	PF00244	0.773
LIG_14-3-3_CanoR_1	129	135	PF00244	0.655
LIG_14-3-3_CanoR_1	184	189	PF00244	0.676
LIG_14-3-3_CanoR_1	317	323	PF00244	0.656
LIG_14-3-3_CanoR_1	413	417	PF00244	0.571
LIG_14-3-3_CanoR_1	427	432	PF00244	0.578
LIG_14-3-3_CanoR_1	434	439	PF00244	0.560
LIG_14-3-3_CanoR_1	451	459	PF00244	0.516
LIG_14-3-3_CanoR_1	470	474	PF00244	0.387
LIG_14-3-3_CanoR_1	499	504	PF00244	0.542
LIG_14-3-3_CanoR_1	657	667	PF00244	0.561
LIG_14-3-3_CanoR_1	866	871	PF00244	0.605
LIG_BIR_III_2	132	136	PF00653	0.545
LIG_BIR_III_4	505	509	PF00653	0.587
LIG_BRCT_BRCA1_1	381	385	PF00533	0.472
LIG_CSL_BTD_1	602	605	PF09270	0.555
LIG_FHA_1	129	135	PF00498	0.853
LIG_FHA_1	219	225	PF00498	0.724
LIG_FHA_1	400	406	PF00498	0.538
LIG_FHA_1	426	432	PF00498	0.500
LIG_FHA_1	448	454	PF00498	0.547
LIG_FHA_1	532	538	PF00498	0.587
LIG_FHA_1	550	556	PF00498	0.587
LIG_FHA_1	56	62	PF00498	0.742
LIG_FHA_1	617	623	PF00498	0.597
LIG_FHA_1	748	754	PF00498	0.442
LIG_FHA_2	228	234	PF00498	0.628
LIG_FHA_2	284	290	PF00498	0.547
LIG_FHA_2	336	342	PF00498	0.581
LIG_FHA_2	443	449	PF00498	0.559
LIG_FHA_2	500	506	PF00498	0.548
LIG_FHA_2	557	563	PF00498	0.508
LIG_FHA_2	791	797	PF00498	0.314
LIG_GSK3_LRP6_1	666	671	PF00069	0.748
LIG_LIR_Apic_2	41	46	PF02991	0.508
LIG_LIR_Apic_2	714	719	PF02991	0.537
LIG_LIR_Gen_1	148	159	PF02991	0.755
LIG_LIR_Gen_1	250	259	PF02991	0.496
LIG_LIR_Gen_1	329	340	PF02991	0.768
LIG_LIR_Gen_1	513	523	PF02991	0.604
LIG_LIR_Gen_1	524	532	PF02991	0.566
LIG_LIR_Gen_1	541	550	PF02991	0.538
LIG_LIR_Gen_1	552	558	PF02991	0.538
LIG_LIR_Gen_1	88	93	PF02991	0.553
LIG_LIR_Nem_3	148	154	PF02991	0.710
LIG_LIR_Nem_3	239	245	PF02991	0.510
LIG_LIR_Nem_3	250	255	PF02991	0.493
LIG_LIR_Nem_3	329	335	PF02991	0.774
LIG_LIR_Nem_3	524	528	PF02991	0.521
LIG_LIR_Nem_3	541	546	PF02991	0.528
LIG_LIR_Nem_3	552	557	PF02991	0.509
LIG_LIR_Nem_3	722	728	PF02991	0.441
LIG_LIR_Nem_3	88	92	PF02991	0.554
LIG_MYND_1	201	205	PF01753	0.750
LIG_MYND_1	670	674	PF01753	0.768
LIG_PDZ_Class_2	871	876	PF00595	0.655
LIG_Rb_LxCxE_1	357	370	PF01857	0.501
LIG_SH2_CRK	332	336	PF00017	0.776
LIG_SH2_CRK	543	547	PF00017	0.420
LIG_SH2_CRK	726	730	PF00017	0.539
LIG_SH2_PTP2	525	528	PF00017	0.587
LIG_SH2_PTP2	716	719	PF00017	0.526
LIG_SH2_STAP1	689	693	PF00017	0.533
LIG_SH2_STAP1	726	730	PF00017	0.500
LIG_SH2_STAP1	800	804	PF00017	0.496
LIG_SH2_STAT5	525	528	PF00017	0.587
LIG_SH2_STAT5	599	602	PF00017	0.587
LIG_SH2_STAT5	658	661	PF00017	0.611
LIG_SH2_STAT5	716	719	PF00017	0.526
LIG_SH2_STAT5	800	803	PF00017	0.465
LIG_SH3_3	136	142	PF00018	0.826
LIG_SH3_3	149	155	PF00018	0.716
LIG_SH3_3	192	198	PF00018	0.733
LIG_SH3_3	446	452	PF00018	0.590
LIG_SH3_3	479	485	PF00018	0.622
LIG_SH3_3	619	625	PF00018	0.458
LIG_SH3_3	664	670	PF00018	0.575
LIG_SH3_3	675	681	PF00018	0.592
LIG_SH3_3	767	773	PF00018	0.554
LIG_SH3_3	867	873	PF00018	0.508
LIG_SUMO_SIM_anti_2	500	505	PF11976	0.560
LIG_SUMO_SIM_par_1	554	559	PF11976	0.586
LIG_TRAF2_1	818	821	PF00917	0.753
LIG_UBA3_1	514	522	PF00899	0.587
LIG_WRC_WIRS_1	777	782	PF05994	0.482
LIG_WRC_WIRS_1	86	91	PF05994	0.560
LIG_WW_3	630	634	PF00397	0.555
MOD_CDC14_SPxK_1	248	251	PF00782	0.549
MOD_CDK_SPK_2	278	283	PF00069	0.490
MOD_CDK_SPK_2	457	462	PF00069	0.611
MOD_CDK_SPK_2	494	499	PF00069	0.587
MOD_CDK_SPxK_1	245	251	PF00069	0.576
MOD_CDK_SPxxK_3	213	220	PF00069	0.619
MOD_CDK_SPxxK_3	327	334	PF00069	0.791
MOD_CK1_1	14	20	PF00069	0.817
MOD_CK1_1	162	168	PF00069	0.795
MOD_CK1_1	191	197	PF00069	0.803
MOD_CK1_1	207	213	PF00069	0.836
MOD_CK1_1	293	299	PF00069	0.462
MOD_CK1_1	327	333	PF00069	0.715
MOD_CK1_1	36	42	PF00069	0.610
MOD_CK1_1	391	397	PF00069	0.541
MOD_CK1_1	430	436	PF00069	0.534
MOD_CK1_1	472	478	PF00069	0.623
MOD_CK1_1	497	503	PF00069	0.562
MOD_CK1_1	538	544	PF00069	0.611
MOD_CK1_1	55	61	PF00069	0.725
MOD_CK1_1	673	679	PF00069	0.713
MOD_CK1_1	71	77	PF00069	0.685
MOD_CK1_1	785	791	PF00069	0.593
MOD_CK1_1	812	818	PF00069	0.623
MOD_CK2_1	335	341	PF00069	0.769
MOD_CK2_1	442	448	PF00069	0.571
MOD_CK2_1	790	796	PF00069	0.326
MOD_CK2_1	815	821	PF00069	0.715
MOD_GlcNHglycan	18	21	PF01048	0.522
MOD_GlcNHglycan	181	184	PF01048	0.730
MOD_GlcNHglycan	206	209	PF01048	0.838
MOD_GlcNHglycan	213	216	PF01048	0.757
MOD_GlcNHglycan	326	329	PF01048	0.554
MOD_GlcNHglycan	38	41	PF01048	0.588
MOD_GlcNHglycan	390	393	PF01048	0.296
MOD_GlcNHglycan	453	456	PF01048	0.349
MOD_GlcNHglycan	46	49	PF01048	0.788
MOD_GlcNHglycan	471	474	PF01048	0.321
MOD_GlcNHglycan	79	82	PF01048	0.814
MOD_GlcNHglycan	847	850	PF01048	0.590
MOD_GSK3_1	10	17	PF00069	0.788
MOD_GSK3_1	134	141	PF00069	0.715
MOD_GSK3_1	162	169	PF00069	0.708
MOD_GSK3_1	179	186	PF00069	0.741
MOD_GSK3_1	203	210	PF00069	0.752
MOD_GSK3_1	223	230	PF00069	0.706
MOD_GSK3_1	274	281	PF00069	0.591
MOD_GSK3_1	29	36	PF00069	0.780
MOD_GSK3_1	388	395	PF00069	0.521
MOD_GSK3_1	422	429	PF00069	0.509
MOD_GSK3_1	430	437	PF00069	0.512
MOD_GSK3_1	443	450	PF00069	0.496
MOD_GSK3_1	457	464	PF00069	0.518
MOD_GSK3_1	468	475	PF00069	0.551
MOD_GSK3_1	493	500	PF00069	0.566
MOD_GSK3_1	531	538	PF00069	0.592
MOD_GSK3_1	589	596	PF00069	0.450
MOD_GSK3_1	616	623	PF00069	0.564
MOD_GSK3_1	666	673	PF00069	0.703
MOD_GSK3_1	67	74	PF00069	0.779
MOD_GSK3_1	772	779	PF00069	0.517
MOD_GSK3_1	785	792	PF00069	0.478
MOD_GSK3_1	808	815	PF00069	0.542
MOD_N-GLC_1	290	295	PF02516	0.619
MOD_N-GLC_1	52	57	PF02516	0.521
MOD_N-GLC_1	625	630	PF02516	0.401
MOD_NEK2_1	189	194	PF00069	0.815
MOD_NEK2_1	290	295	PF00069	0.547
MOD_NEK2_1	306	311	PF00069	0.491
MOD_NEK2_1	335	340	PF00069	0.687
MOD_NEK2_1	400	405	PF00069	0.604
MOD_NEK2_1	469	474	PF00069	0.622
MOD_NEK2_1	493	498	PF00069	0.432
MOD_NEK2_1	642	647	PF00069	0.508
MOD_NEK2_1	787	792	PF00069	0.525
MOD_NEK2_1	830	835	PF00069	0.552
MOD_NEK2_2	111	116	PF00069	0.739
MOD_PIKK_1	223	229	PF00454	0.497
MOD_PIKK_1	254	260	PF00454	0.479
MOD_PIKK_1	673	679	PF00454	0.619
MOD_PIKK_1	785	791	PF00454	0.528
MOD_PIKK_1	99	105	PF00454	0.748
MOD_PK_1	379	385	PF00069	0.214
MOD_PK_1	866	872	PF00069	0.500
MOD_PKA_1	11	17	PF00069	0.735
MOD_PKA_2	10	16	PF00069	0.767
MOD_PKA_2	128	134	PF00069	0.790
MOD_PKA_2	183	189	PF00069	0.726
MOD_PKA_2	261	267	PF00069	0.555
MOD_PKA_2	316	322	PF00069	0.714
MOD_PKA_2	412	418	PF00069	0.571
MOD_PKA_2	426	432	PF00069	0.581
MOD_PKA_2	469	475	PF00069	0.584
MOD_PKA_2	815	821	PF00069	0.550
MOD_PKA_2	830	836	PF00069	0.508
MOD_PKA_2	865	871	PF00069	0.567
MOD_Plk_1	290	296	PF00069	0.541
MOD_Plk_1	306	312	PF00069	0.485
MOD_Plk_1	379	385	PF00069	0.472
MOD_Plk_1	538	544	PF00069	0.535
MOD_Plk_1	590	596	PF00069	0.580
MOD_Plk_1	747	753	PF00069	0.459
MOD_Plk_4	154	160	PF00069	0.765
MOD_Plk_4	166	172	PF00069	0.760
MOD_Plk_4	184	190	PF00069	0.591
MOD_Plk_4	191	197	PF00069	0.621
MOD_Plk_4	306	312	PF00069	0.496
MOD_Plk_4	392	398	PF00069	0.508
MOD_Plk_4	412	418	PF00069	0.375
MOD_Plk_4	510	516	PF00069	0.567
MOD_Plk_4	538	544	PF00069	0.572
MOD_Plk_4	590	596	PF00069	0.597
MOD_Plk_4	782	788	PF00069	0.577
MOD_Plk_4	830	836	PF00069	0.586
MOD_ProDKin_1	135	141	PF00069	0.818
MOD_ProDKin_1	145	151	PF00069	0.727
MOD_ProDKin_1	196	202	PF00069	0.811
MOD_ProDKin_1	213	219	PF00069	0.772
MOD_ProDKin_1	245	251	PF00069	0.576
MOD_ProDKin_1	278	284	PF00069	0.508
MOD_ProDKin_1	31	37	PF00069	0.655
MOD_ProDKin_1	319	325	PF00069	0.669
MOD_ProDKin_1	327	333	PF00069	0.704
MOD_ProDKin_1	443	449	PF00069	0.569
MOD_ProDKin_1	457	463	PF00069	0.505
MOD_ProDKin_1	478	484	PF00069	0.594
MOD_ProDKin_1	494	500	PF00069	0.422
MOD_ProDKin_1	549	555	PF00069	0.587
MOD_ProDKin_1	617	623	PF00069	0.592
MOD_ProDKin_1	666	672	PF00069	0.618
MOD_ProDKin_1	71	77	PF00069	0.620
TRG_DiLeu_BaEn_1	568	573	PF01217	0.587
TRG_DiLeu_BaLyEn_6	240	245	PF01217	0.317
TRG_DiLeu_BaLyEn_6	667	672	PF01217	0.772
TRG_ENDOCYTIC_2	332	335	PF00928	0.771
TRG_ENDOCYTIC_2	525	528	PF00928	0.560
TRG_ENDOCYTIC_2	543	546	PF00928	0.508
TRG_ENDOCYTIC_2	726	729	PF00928	0.505
TRG_ER_diArg_1	119	121	PF00400	0.748
TRG_ER_diArg_1	605	608	PF00400	0.587
TRG_ER_diArg_1	636	639	PF00400	0.587
TRG_NES_CRM1_1	295	307	PF08389	0.484
TRG_NES_CRM1_1	568	581	PF08389	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Y7	Leptomonas seymouri	65%	100%
A0A0S4JNB2	Bodo saltans	34%	100%
A0A1X0PAM4	Trypanosomatidae	39%	100%
A0A3R7MTY6	Trypanosoma rangeli	39%	100%
A0A3S7X814	Leishmania donovani	91%	100%
A4HAV7	Leishmania braziliensis	79%	100%
A4IA17	Leishmania infantum	91%	100%
C9ZJA2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
C9ZMK5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
D2XV59	Rattus norvegicus	26%	100%
O00178	Homo sapiens	26%	100%
O08582	Mus musculus	26%	100%
Q18905	Caenorhabditis elegans	25%	100%
Q3UJK4	Mus musculus	26%	100%
Q4Q2V4	Leishmania major	91%	100%
Q58DC5	Bos taurus	26%	100%
Q5R8Q7	Pongo abelii	26%	100%
Q5XGS8	Xenopus laevis	26%	100%
Q9BX10	Homo sapiens	26%	100%