DNAj-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNAj-like protein

Gene product:

DNAj-like protein

Species:

Leishmania mexicana

UniProt:

E9B529_LEIMU

TriTrypDb:

LmxM.33.2430

Length:

808

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B529

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B529

Function

Biological processes
Term	Name	Level	Count
GO:0007154	cell communication	2	1
GO:0007267	cell-cell signaling	2	1
GO:0007268	chemical synaptic transmission	6	1
GO:0009987	cellular process	1	1
GO:0023052	signaling	1	1
GO:0098916	anterograde trans-synaptic signaling	5	1
GO:0099536	synaptic signaling	3	1
GO:0099537	trans-synaptic signaling	4	1

Molecular functions
Term	Name	Level	Count
GO:0005102	signaling receptor binding	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0030674	protein-macromolecule adaptor activity	2	1
GO:0033130	acetylcholine receptor binding	4	1
GO:0043495	protein-membrane adaptor activity	3	1
GO:0060090	molecular adaptor activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	296	300	PF00656	0.726
CLV_NRD_NRD_1	108	110	PF00675	0.795
CLV_NRD_NRD_1	201	203	PF00675	0.594
CLV_NRD_NRD_1	243	245	PF00675	0.671
CLV_NRD_NRD_1	321	323	PF00675	0.668
CLV_NRD_NRD_1	353	355	PF00675	0.557
CLV_NRD_NRD_1	548	550	PF00675	0.579
CLV_NRD_NRD_1	649	651	PF00675	0.378
CLV_NRD_NRD_1	763	765	PF00675	0.456
CLV_PCSK_FUR_1	247	251	PF00082	0.696
CLV_PCSK_KEX2_1	108	110	PF00082	0.795
CLV_PCSK_KEX2_1	201	203	PF00082	0.613
CLV_PCSK_KEX2_1	243	245	PF00082	0.675
CLV_PCSK_KEX2_1	249	251	PF00082	0.676
CLV_PCSK_KEX2_1	435	437	PF00082	0.622
CLV_PCSK_KEX2_1	649	651	PF00082	0.378
CLV_PCSK_KEX2_1	762	764	PF00082	0.391
CLV_PCSK_PC1ET2_1	249	251	PF00082	0.704
CLV_PCSK_PC1ET2_1	435	437	PF00082	0.622
CLV_PCSK_PC1ET2_1	762	764	PF00082	0.394
CLV_PCSK_SKI1_1	178	182	PF00082	0.637
CLV_PCSK_SKI1_1	202	206	PF00082	0.596
CLV_PCSK_SKI1_1	220	224	PF00082	0.382
CLV_PCSK_SKI1_1	243	247	PF00082	0.758
CLV_PCSK_SKI1_1	370	374	PF00082	0.628
CLV_PCSK_SKI1_1	665	669	PF00082	0.380
CLV_PCSK_SKI1_1	709	713	PF00082	0.390
CLV_PCSK_SKI1_1	714	718	PF00082	0.364
CLV_Separin_Metazoa	214	218	PF03568	0.746
CLV_Separin_Metazoa	221	225	PF03568	0.599
CLV_Separin_Metazoa	409	413	PF03568	0.582
DEG_APCC_DBOX_1	219	227	PF00400	0.629
DEG_SPOP_SBC_1	11	15	PF00917	0.834
DEG_SPOP_SBC_1	16	20	PF00917	0.762
DOC_CKS1_1	474	479	PF01111	0.537
DOC_MAPK_gen_1	201	207	PF00069	0.732
DOC_MAPK_gen_1	217	225	PF00069	0.426
DOC_MAPK_gen_1	243	254	PF00069	0.747
DOC_MAPK_gen_1	717	725	PF00069	0.378
DOC_MAPK_MEF2A_6	184	191	PF00069	0.684
DOC_MAPK_RevD_3	187	202	PF00069	0.611
DOC_PP2B_LxvP_1	205	208	PF13499	0.742
DOC_PP4_FxxP_1	474	477	PF00568	0.542
DOC_PP4_FxxP_1	94	97	PF00568	0.786
DOC_USP7_MATH_1	146	150	PF00917	0.770
DOC_USP7_MATH_1	151	155	PF00917	0.712
DOC_USP7_MATH_1	16	20	PF00917	0.802
DOC_USP7_MATH_1	194	198	PF00917	0.657
DOC_USP7_MATH_1	274	278	PF00917	0.750
DOC_USP7_MATH_1	311	315	PF00917	0.670
DOC_USP7_MATH_1	424	428	PF00917	0.548
DOC_USP7_MATH_1	48	52	PF00917	0.832
DOC_USP7_UBL2_3	641	645	PF12436	0.499
DOC_USP7_UBL2_3	693	697	PF12436	0.565
DOC_WW_Pin1_4	123	128	PF00397	0.760
DOC_WW_Pin1_4	272	277	PF00397	0.808
DOC_WW_Pin1_4	329	334	PF00397	0.549
DOC_WW_Pin1_4	37	42	PF00397	0.843
DOC_WW_Pin1_4	441	446	PF00397	0.622
DOC_WW_Pin1_4	473	478	PF00397	0.511
DOC_WW_Pin1_4	523	528	PF00397	0.482
DOC_WW_Pin1_4	78	83	PF00397	0.759
LIG_14-3-3_CanoR_1	128	132	PF00244	0.569
LIG_14-3-3_CanoR_1	148	156	PF00244	0.596
LIG_14-3-3_CanoR_1	423	431	PF00244	0.574
LIG_14-3-3_CanoR_1	448	457	PF00244	0.627
LIG_14-3-3_CanoR_1	497	504	PF00244	0.563
LIG_14-3-3_CanoR_1	531	539	PF00244	0.499
LIG_14-3-3_CanoR_1	709	718	PF00244	0.394
LIG_14-3-3_CanoR_1	93	97	PF00244	0.823
LIG_Actin_WH2_2	165	180	PF00022	0.737
LIG_BIR_II_1	1	5	PF00653	0.795
LIG_FHA_1	330	336	PF00498	0.501
LIG_FHA_1	367	373	PF00498	0.509
LIG_FHA_1	594	600	PF00498	0.450
LIG_FHA_1	632	638	PF00498	0.394
LIG_FHA_1	72	78	PF00498	0.834
LIG_FHA_1	79	85	PF00498	0.720
LIG_FHA_2	296	302	PF00498	0.646
LIG_FHA_2	442	448	PF00498	0.567
LIG_FHA_2	674	680	PF00498	0.622
LIG_FHA_2	708	714	PF00498	0.440
LIG_FHA_2	754	760	PF00498	0.378
LIG_LIR_Apic_2	471	477	PF02991	0.543
LIG_LIR_Gen_1	100	110	PF02991	0.748
LIG_LIR_Gen_1	540	548	PF02991	0.435
LIG_LIR_Gen_1	659	667	PF02991	0.499
LIG_LIR_Gen_1	751	761	PF02991	0.488
LIG_LIR_Nem_3	100	106	PF02991	0.809
LIG_LIR_Nem_3	480	486	PF02991	0.442
LIG_LIR_Nem_3	540	545	PF02991	0.432
LIG_LIR_Nem_3	593	597	PF02991	0.607
LIG_LIR_Nem_3	642	647	PF02991	0.499
LIG_LIR_Nem_3	659	664	PF02991	0.499
LIG_LIR_Nem_3	700	705	PF02991	0.384
LIG_LIR_Nem_3	744	750	PF02991	0.378
LIG_LIR_Nem_3	751	757	PF02991	0.378
LIG_PCNA_yPIPBox_3	605	616	PF02747	0.542
LIG_PTB_Apo_2	355	362	PF02174	0.623
LIG_PTB_Phospho_1	355	361	PF10480	0.622
LIG_SH2_CRK	483	487	PF00017	0.576
LIG_SH2_CRK	754	758	PF00017	0.486
LIG_SH2_GRB2like	356	359	PF00017	0.634
LIG_SH2_NCK_1	356	360	PF00017	0.542
LIG_SH2_SRC	356	359	PF00017	0.609
LIG_SH2_STAP1	368	372	PF00017	0.479
LIG_SH2_STAP1	400	404	PF00017	0.307
LIG_SH2_STAP1	595	599	PF00017	0.438
LIG_SH2_STAP1	647	651	PF00017	0.394
LIG_SH2_STAP1	754	758	PF00017	0.467
LIG_SH2_STAT3	395	398	PF00017	0.615
LIG_SH2_STAT5	361	364	PF00017	0.468
LIG_SH2_STAT5	368	371	PF00017	0.464
LIG_SH2_STAT5	538	541	PF00017	0.418
LIG_SH2_STAT5	544	547	PF00017	0.433
LIG_SH2_STAT5	595	598	PF00017	0.451
LIG_SH2_STAT5	613	616	PF00017	0.378
LIG_SH2_STAT5	702	705	PF00017	0.398
LIG_SH3_3	270	276	PF00018	0.818
LIG_SUMO_SIM_anti_2	188	193	PF11976	0.703
LIG_SUMO_SIM_anti_2	405	412	PF11976	0.573
LIG_TRAF2_1	266	269	PF00917	0.628
LIG_TYR_ITIM	718	723	PF00017	0.413
MOD_CDK_SPK_2	123	128	PF00069	0.569
MOD_CDK_SPK_2	441	446	PF00069	0.663
MOD_CDK_SPxxK_3	441	448	PF00069	0.590
MOD_CDK_SPxxK_3	78	85	PF00069	0.548
MOD_CK1_1	126	132	PF00069	0.715
MOD_CK1_1	14	20	PF00069	0.817
MOD_CK1_1	275	281	PF00069	0.733
MOD_CK1_1	283	289	PF00069	0.628
MOD_CK1_1	314	320	PF00069	0.653
MOD_CK1_1	427	433	PF00069	0.596
MOD_CK1_1	44	50	PF00069	0.851
MOD_CK1_1	500	506	PF00069	0.569
MOD_CK1_1	521	527	PF00069	0.531
MOD_CK1_1	785	791	PF00069	0.629
MOD_CK2_1	168	174	PF00069	0.697
MOD_CK2_1	295	301	PF00069	0.624
MOD_CK2_1	312	318	PF00069	0.599
MOD_CK2_1	448	454	PF00069	0.565
MOD_CK2_1	459	465	PF00069	0.497
MOD_CK2_1	500	506	PF00069	0.594
MOD_CK2_1	537	543	PF00069	0.435
MOD_CK2_1	673	679	PF00069	0.435
MOD_CK2_1	707	713	PF00069	0.419
MOD_GlcNHglycan	1	4	PF01048	0.811
MOD_GlcNHglycan	113	116	PF01048	0.795
MOD_GlcNHglycan	138	141	PF01048	0.857
MOD_GlcNHglycan	14	17	PF01048	0.802
MOD_GlcNHglycan	142	145	PF01048	0.830
MOD_GlcNHglycan	149	152	PF01048	0.821
MOD_GlcNHglycan	153	156	PF01048	0.757
MOD_GlcNHglycan	282	285	PF01048	0.644
MOD_GlcNHglycan	309	312	PF01048	0.638
MOD_GlcNHglycan	323	326	PF01048	0.534
MOD_GlcNHglycan	390	393	PF01048	0.441
MOD_GlcNHglycan	426	429	PF01048	0.565
MOD_GlcNHglycan	461	464	PF01048	0.502
MOD_GlcNHglycan	499	502	PF01048	0.568
MOD_GlcNHglycan	50	53	PF01048	0.833
MOD_GlcNHglycan	539	542	PF01048	0.434
MOD_GlcNHglycan	66	69	PF01048	0.763
MOD_GlcNHglycan	787	790	PF01048	0.664
MOD_GSK3_1	10	17	PF00069	0.807
MOD_GSK3_1	104	111	PF00069	0.665
MOD_GSK3_1	118	125	PF00069	0.684
MOD_GSK3_1	136	143	PF00069	0.788
MOD_GSK3_1	147	154	PF00069	0.802
MOD_GSK3_1	280	287	PF00069	0.576
MOD_GSK3_1	295	302	PF00069	0.632
MOD_GSK3_1	307	314	PF00069	0.652
MOD_GSK3_1	317	324	PF00069	0.686
MOD_GSK3_1	325	332	PF00069	0.581
MOD_GSK3_1	37	44	PF00069	0.846
MOD_GSK3_1	46	53	PF00069	0.840
MOD_GSK3_1	705	712	PF00069	0.394
MOD_GSK3_1	753	760	PF00069	0.459
MOD_GSK3_1	781	788	PF00069	0.725
MOD_N-GLC_1	136	141	PF02516	0.806
MOD_N-GLC_1	151	156	PF02516	0.836
MOD_N-GLC_1	254	259	PF02516	0.546
MOD_N-GLC_1	37	42	PF02516	0.802
MOD_N-GLC_1	388	393	PF02516	0.435
MOD_N-GLC_1	781	786	PF02516	0.705
MOD_NEK2_1	147	152	PF00069	0.837
MOD_NEK2_1	168	173	PF00069	0.627
MOD_NEK2_1	490	495	PF00069	0.483
MOD_NEK2_1	520	525	PF00069	0.590
MOD_NEK2_1	537	542	PF00069	0.284
MOD_NEK2_1	705	710	PF00069	0.378
MOD_NEK2_1	757	762	PF00069	0.507
MOD_NEK2_1	781	786	PF00069	0.699
MOD_PIKK_1	118	124	PF00454	0.851
MOD_PKA_1	108	114	PF00069	0.745
MOD_PKA_2	108	114	PF00069	0.630
MOD_PKA_2	127	133	PF00069	0.562
MOD_PKA_2	147	153	PF00069	0.800
MOD_PKA_2	321	327	PF00069	0.739
MOD_PKA_2	398	404	PF00069	0.304
MOD_PKA_2	447	453	PF00069	0.643
MOD_PKA_2	773	779	PF00069	0.590
MOD_PKA_2	92	98	PF00069	0.751
MOD_PKB_1	446	454	PF00069	0.387
MOD_Plk_1	41	47	PF00069	0.842
MOD_Plk_1	721	727	PF00069	0.386
MOD_ProDKin_1	123	129	PF00069	0.760
MOD_ProDKin_1	272	278	PF00069	0.806
MOD_ProDKin_1	329	335	PF00069	0.553
MOD_ProDKin_1	37	43	PF00069	0.844
MOD_ProDKin_1	441	447	PF00069	0.630
MOD_ProDKin_1	473	479	PF00069	0.503
MOD_ProDKin_1	523	529	PF00069	0.472
MOD_ProDKin_1	78	84	PF00069	0.756
MOD_SUMO_for_1	266	269	PF00179	0.834
MOD_SUMO_for_1	97	100	PF00179	0.784
MOD_SUMO_rev_2	713	718	PF00179	0.400
MOD_SUMO_rev_2	739	747	PF00179	0.399
TRG_ENDOCYTIC_2	483	486	PF00928	0.564
TRG_ENDOCYTIC_2	594	597	PF00928	0.601
TRG_ENDOCYTIC_2	620	623	PF00928	0.413
TRG_ENDOCYTIC_2	702	705	PF00928	0.381
TRG_ENDOCYTIC_2	720	723	PF00928	0.413
TRG_ENDOCYTIC_2	754	757	PF00928	0.486
TRG_ER_diArg_1	108	110	PF00400	0.821
TRG_ER_diArg_1	243	245	PF00400	0.690
TRG_ER_diArg_1	496	499	PF00400	0.445
TRG_ER_diArg_1	649	652	PF00400	0.378
TRG_ER_diArg_1	796	799	PF00400	0.777
TRG_NES_CRM1_1	402	414	PF08389	0.531
TRG_Pf-PMV_PEXEL_1	170	174	PF00026	0.736
TRG_Pf-PMV_PEXEL_1	217	221	PF00026	0.705
TRG_Pf-PMV_PEXEL_1	484	489	PF00026	0.593
TRG_Pf-PMV_PEXEL_1	678	683	PF00026	0.579

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFH1	Leptomonas seymouri	61%	100%
A0A0S4JUH7	Bodo saltans	42%	100%
A0A1X0P9Z7	Trypanosomatidae	50%	100%
A0A3S7X821	Leishmania donovani	93%	100%
A0A422P0G2	Trypanosoma rangeli	49%	100%
A4HAV4	Leishmania braziliensis	82%	100%
A4IA01	Leishmania infantum	94%	100%
C9ZML0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
Q4Q2V7	Leishmania major	93%	100%
V5BKG1	Trypanosoma cruzi	47%	100%