Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Aminotransferase class IV, putative

Species:

Leishmania mexicana

UniProt:

E9B527_LEIMU

TriTrypDb:

LmxM.33.2410

Length:

423

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9B527

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B527

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044281	small molecule metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008483	transaminase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016769	transferase activity, transferring nitrogenous groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	373	375	PF00675	0.489
CLV_NRD_NRD_1	77	79	PF00675	0.435
CLV_PCSK_KEX2_1	373	375	PF00082	0.489
CLV_PCSK_KEX2_1	77	79	PF00082	0.408
CLV_PCSK_SKI1_1	193	197	PF00082	0.286
CLV_PCSK_SKI1_1	341	345	PF00082	0.307
DOC_CYCLIN_yClb1_LxF_4	16	21	PF00134	0.431
DOC_CYCLIN_yCln2_LP_2	157	163	PF00134	0.448
DOC_CYCLIN_yCln2_LP_2	400	406	PF00134	0.355
DOC_MAPK_DCC_7	397	406	PF00069	0.356
DOC_MAPK_gen_1	135	143	PF00069	0.483
DOC_MAPK_gen_1	66	74	PF00069	0.555
DOC_MAPK_MEF2A_6	234	243	PF00069	0.448
DOC_MAPK_MEF2A_6	37	44	PF00069	0.500
DOC_MAPK_MEF2A_6	397	406	PF00069	0.414
DOC_MAPK_MEF2A_6	67	76	PF00069	0.509
DOC_MAPK_NFAT4_5	37	45	PF00069	0.499
DOC_MAPK_NFAT4_5	397	405	PF00069	0.313
DOC_PP1_RVXF_1	16	22	PF00149	0.433
DOC_PP1_RVXF_1	194	201	PF00149	0.434
DOC_PP2B_LxvP_1	157	160	PF13499	0.501
DOC_PP2B_LxvP_1	400	403	PF13499	0.230
DOC_PP4_FxxP_1	214	217	PF00568	0.490
DOC_USP7_MATH_1	109	113	PF00917	0.403
DOC_USP7_MATH_1	118	122	PF00917	0.597
DOC_USP7_MATH_1	204	208	PF00917	0.423
DOC_USP7_MATH_1	228	232	PF00917	0.542
DOC_USP7_MATH_1	288	292	PF00917	0.444
DOC_USP7_MATH_1	360	364	PF00917	0.537
DOC_USP7_MATH_2	165	171	PF00917	0.414
DOC_USP7_UBL2_3	337	341	PF12436	0.537
DOC_WW_Pin1_4	10	15	PF00397	0.421
DOC_WW_Pin1_4	121	126	PF00397	0.483
DOC_WW_Pin1_4	179	184	PF00397	0.448
DOC_WW_Pin1_4	22	27	PF00397	0.421
DOC_WW_Pin1_4	28	33	PF00397	0.444
DOC_WW_Pin1_4	352	357	PF00397	0.465
DOC_WW_Pin1_4	98	103	PF00397	0.400
LIG_14-3-3_CanoR_1	150	156	PF00244	0.501
LIG_14-3-3_CanoR_1	18	22	PF00244	0.677
LIG_Actin_WH2_2	326	343	PF00022	0.537
LIG_APCC_ABBA_1	364	369	PF00400	0.371
LIG_FHA_1	211	217	PF00498	0.472
LIG_FHA_2	337	343	PF00498	0.560
LIG_FHA_2	58	64	PF00498	0.408
LIG_LIR_Apic_2	212	217	PF02991	0.541
LIG_LIR_Apic_2	283	288	PF02991	0.482
LIG_LIR_Gen_1	124	134	PF02991	0.420
LIG_LIR_Gen_1	94	103	PF02991	0.435
LIG_LIR_Nem_3	124	130	PF02991	0.383
LIG_LIR_Nem_3	320	325	PF02991	0.535
LIG_LIR_Nem_3	38	44	PF02991	0.573
LIG_LIR_Nem_3	94	98	PF02991	0.393
LIG_PCNA_yPIPBox_3	193	201	PF02747	0.537
LIG_Pex14_2	88	92	PF04695	0.356
LIG_SH2_CRK	127	131	PF00017	0.388
LIG_SH2_CRK	322	326	PF00017	0.483
LIG_SH2_SRC	179	182	PF00017	0.539
LIG_SH2_SRC	186	189	PF00017	0.553
LIG_SH2_SRC	376	379	PF00017	0.494
LIG_SH2_STAP1	147	151	PF00017	0.469
LIG_SH2_STAP1	273	277	PF00017	0.537
LIG_SH2_STAP1	376	380	PF00017	0.509
LIG_SH2_STAT3	295	298	PF00017	0.537
LIG_SH2_STAT5	179	182	PF00017	0.486
LIG_SH2_STAT5	186	189	PF00017	0.483
LIG_SH2_STAT5	266	269	PF00017	0.556
LIG_SH2_STAT5	285	288	PF00017	0.464
LIG_SH2_STAT5	295	298	PF00017	0.425
LIG_SH2_STAT5	350	353	PF00017	0.560
LIG_SH2_STAT5	416	419	PF00017	0.458
LIG_SH3_3	40	46	PF00018	0.416
LIG_SH3_3	52	58	PF00018	0.409
LIG_SUMO_SIM_anti_2	274	280	PF11976	0.458
LIG_SUMO_SIM_par_1	101	107	PF11976	0.422
LIG_SUMO_SIM_par_1	218	223	PF11976	0.452
LIG_SUMO_SIM_par_1	274	280	PF11976	0.458
LIG_SxIP_EBH_1	193	207	PF03271	0.448
LIG_TRAF2_1	307	310	PF00917	0.476
LIG_UBA3_1	312	319	PF00899	0.559
LIG_WRC_WIRS_1	92	97	PF05994	0.441
MOD_CDC14_SPxK_1	15	18	PF00782	0.421
MOD_CDK_SPxK_1	12	18	PF00069	0.416
MOD_CK1_1	121	127	PF00069	0.468
MOD_CK1_1	223	229	PF00069	0.483
MOD_CK1_1	300	306	PF00069	0.554
MOD_CK2_1	143	149	PF00069	0.565
MOD_CK2_1	304	310	PF00069	0.490
MOD_CK2_1	57	63	PF00069	0.414
MOD_GlcNHglycan	111	114	PF01048	0.346
MOD_GlcNHglycan	120	123	PF01048	0.504
MOD_GlcNHglycan	306	309	PF01048	0.319
MOD_GlcNHglycan	33	36	PF01048	0.426
MOD_GlcNHglycan	51	54	PF01048	0.615
MOD_GlcNHglycan	96	101	PF01048	0.430
MOD_GSK3_1	104	111	PF00069	0.319
MOD_GSK3_1	117	124	PF00069	0.415
MOD_GSK3_1	167	174	PF00069	0.499
MOD_GSK3_1	17	24	PF00069	0.440
MOD_GSK3_1	222	229	PF00069	0.509
MOD_GSK3_1	300	307	PF00069	0.507
MOD_GSK3_1	379	386	PF00069	0.387
MOD_NEK2_1	143	148	PF00069	0.522
MOD_NEK2_1	151	156	PF00069	0.455
MOD_NEK2_1	17	22	PF00069	0.448
MOD_NEK2_1	171	176	PF00069	0.465
MOD_NEK2_1	222	227	PF00069	0.483
MOD_NEK2_1	383	388	PF00069	0.570
MOD_NEK2_2	228	233	PF00069	0.510
MOD_NEK2_2	336	341	PF00069	0.496
MOD_PIKK_1	411	417	PF00454	0.288
MOD_PKA_2	17	23	PF00069	0.677
MOD_PKA_2	367	373	PF00069	0.285
MOD_Plk_2-3	65	71	PF00069	0.328
MOD_Plk_4	167	173	PF00069	0.549
MOD_Plk_4	196	202	PF00069	0.489
MOD_Plk_4	228	234	PF00069	0.461
MOD_Plk_4	300	306	PF00069	0.515
MOD_Plk_4	317	323	PF00069	0.480
MOD_Plk_4	345	351	PF00069	0.564
MOD_Plk_4	354	360	PF00069	0.518
MOD_ProDKin_1	10	16	PF00069	0.418
MOD_ProDKin_1	121	127	PF00069	0.468
MOD_ProDKin_1	179	185	PF00069	0.448
MOD_ProDKin_1	22	28	PF00069	0.424
MOD_ProDKin_1	352	358	PF00069	0.465
MOD_ProDKin_1	98	104	PF00069	0.400
MOD_SUMO_rev_2	342	349	PF00179	0.483
MOD_SUMO_rev_2	394	398	PF00179	0.510
MOD_SUMO_rev_2	63	69	PF00179	0.346
TRG_DiLeu_BaEn_1	167	172	PF01217	0.448
TRG_DiLeu_BaEn_1	309	314	PF01217	0.476
TRG_ENDOCYTIC_2	127	130	PF00928	0.336
TRG_ENDOCYTIC_2	131	134	PF00928	0.425
TRG_ENDOCYTIC_2	273	276	PF00928	0.512
TRG_ENDOCYTIC_2	322	325	PF00928	0.537
TRG_ER_diArg_1	134	137	PF00400	0.479
TRG_ER_diArg_1	373	375	PF00400	0.391
TRG_ER_diArg_1	76	78	PF00400	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDK5	Leptomonas seymouri	64%	100%
A0A0S4INR1	Bodo saltans	26%	99%
A0A1X0PAI4	Trypanosomatidae	35%	100%
A0A3Q8IUN5	Leishmania donovani	89%	100%
A0A3R7NT31	Trypanosoma rangeli	36%	100%
A4HAV2	Leishmania braziliensis	84%	100%
A4I9Z9	Leishmania infantum	90%	100%
C9ZML4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
Q4Q2V9	Leishmania major	78%	98%
V5B0F3	Trypanosoma cruzi	32%	90%