Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B526_LEIMU

TriTrypDb:

LmxM.33.2400

Length:

334

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B526

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B526

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	305	309	PF00656	0.577
CLV_NRD_NRD_1	125	127	PF00675	0.675
CLV_NRD_NRD_1	2	4	PF00675	0.637
CLV_NRD_NRD_1	208	210	PF00675	0.474
CLV_NRD_NRD_1	219	221	PF00675	0.344
CLV_NRD_NRD_1	225	227	PF00675	0.367
CLV_NRD_NRD_1	328	330	PF00675	0.581
CLV_NRD_NRD_1	7	9	PF00675	0.608
CLV_PCSK_KEX2_1	125	127	PF00082	0.636
CLV_PCSK_KEX2_1	207	209	PF00082	0.470
CLV_PCSK_KEX2_1	219	221	PF00082	0.343
CLV_PCSK_KEX2_1	225	227	PF00082	0.365
CLV_PCSK_KEX2_1	328	330	PF00082	0.528
CLV_PCSK_KEX2_1	7	9	PF00082	0.621
CLV_PCSK_PC1ET2_1	207	209	PF00082	0.484
CLV_PCSK_PC7_1	3	9	PF00082	0.693
CLV_PCSK_SKI1_1	15	19	PF00082	0.660
CLV_PCSK_SKI1_1	209	213	PF00082	0.472
CLV_PCSK_SKI1_1	219	223	PF00082	0.418
CLV_PCSK_SKI1_1	299	303	PF00082	0.488
CLV_PCSK_SKI1_1	8	12	PF00082	0.634
DEG_Nend_Nbox_1	1	3	PF02207	0.664
DOC_CYCLIN_RxL_1	3	14	PF00134	0.502
DOC_MAPK_DCC_7	126	136	PF00069	0.586
DOC_MAPK_gen_1	207	215	PF00069	0.438
DOC_MAPK_gen_1	3	11	PF00069	0.712
DOC_PP1_RVXF_1	194	201	PF00149	0.487
DOC_PP4_FxxP_1	17	20	PF00568	0.666
DOC_USP7_MATH_1	24	28	PF00917	0.635
DOC_USP7_MATH_1	307	311	PF00917	0.606
DOC_WW_Pin1_4	20	25	PF00397	0.628
DOC_WW_Pin1_4	253	258	PF00397	0.455
DOC_WW_Pin1_4	99	104	PF00397	0.583
LIG_14-3-3_CanoR_1	133	139	PF00244	0.655
LIG_14-3-3_CanoR_1	241	247	PF00244	0.259
LIG_14-3-3_CanoR_1	299	304	PF00244	0.491
LIG_14-3-3_CanoR_1	315	321	PF00244	0.346
LIG_APCC_ABBA_1	151	156	PF00400	0.578
LIG_Clathr_ClatBox_1	148	152	PF01394	0.536
LIG_Clathr_ClatBox_1	57	61	PF01394	0.713
LIG_eIF4E_1	138	144	PF01652	0.460
LIG_eIF4E_1	95	101	PF01652	0.509
LIG_FHA_1	26	32	PF00498	0.597
LIG_FHA_1	315	321	PF00498	0.397
LIG_FHA_2	243	249	PF00498	0.440
LIG_FHA_2	276	282	PF00498	0.453
LIG_FHA_2	300	306	PF00498	0.516
LIG_FHA_2	322	328	PF00498	0.537
LIG_KLC1_Yacidic_2	92	97	PF13176	0.582
LIG_LIR_Apic_2	14	20	PF02991	0.637
LIG_LIR_Apic_2	181	187	PF02991	0.537
LIG_LIR_Apic_2	44	50	PF02991	0.564
LIG_LIR_Apic_2	63	68	PF02991	0.621
LIG_LIR_Apic_2	92	98	PF02991	0.481
LIG_LIR_Gen_1	118	128	PF02991	0.692
LIG_LIR_Gen_1	248	257	PF02991	0.511
LIG_LIR_Gen_1	266	274	PF02991	0.439
LIG_LIR_Gen_1	283	294	PF02991	0.270
LIG_LIR_Nem_3	118	123	PF02991	0.534
LIG_LIR_Nem_3	199	203	PF02991	0.540
LIG_LIR_Nem_3	248	252	PF02991	0.419
LIG_LIR_Nem_3	266	270	PF02991	0.313
LIG_LIR_Nem_3	282	288	PF02991	0.353
LIG_LIR_Nem_3	76	82	PF02991	0.546
LIG_MAD2	196	204	PF02301	0.606
LIG_PCNA_yPIPBox_3	261	275	PF02747	0.484
LIG_Pex14_1	180	184	PF04695	0.520
LIG_SH2_CRK	34	38	PF00017	0.519
LIG_SH2_PTP2	267	270	PF00017	0.516
LIG_SH2_PTP2	47	50	PF00017	0.599
LIG_SH2_SRC	184	187	PF00017	0.540
LIG_SH2_SRC	265	268	PF00017	0.502
LIG_SH2_SRC	47	50	PF00017	0.601
LIG_SH2_SRC	95	98	PF00017	0.506
LIG_SH2_STAP1	117	121	PF00017	0.490
LIG_SH2_STAP1	316	320	PF00017	0.389
LIG_SH2_STAT3	258	261	PF00017	0.395
LIG_SH2_STAT5	184	187	PF00017	0.540
LIG_SH2_STAT5	267	270	PF00017	0.525
LIG_SH2_STAT5	285	288	PF00017	0.273
LIG_SH2_STAT5	316	319	PF00017	0.392
LIG_SH2_STAT5	47	50	PF00017	0.601
LIG_SH2_STAT5	79	82	PF00017	0.469
LIG_SH2_STAT5	95	98	PF00017	0.506
LIG_SH3_3	200	206	PF00018	0.598
LIG_SH3_CIN85_PxpxPR_1	128	133	PF14604	0.654
LIG_Sin3_3	211	218	PF02671	0.401
LIG_SUMO_SIM_anti_2	232	239	PF11976	0.525
LIG_SUMO_SIM_par_1	107	113	PF11976	0.437
LIG_SUMO_SIM_par_1	316	322	PF11976	0.396
LIG_SUMO_SIM_par_1	55	61	PF11976	0.717
LIG_TRAF2_1	102	105	PF00917	0.444
LIG_UBA3_1	214	222	PF00899	0.506
LIG_WRC_WIRS_1	320	325	PF05994	0.284
LIG_WW_3	48	52	PF00397	0.687
MOD_CK1_1	310	316	PF00069	0.557
MOD_CK2_1	99	105	PF00069	0.464
MOD_Cter_Amidation	5	8	PF01082	0.757
MOD_GlcNHglycan	181	184	PF01048	0.558
MOD_GlcNHglycan	193	196	PF01048	0.413
MOD_GlcNHglycan	258	261	PF01048	0.473
MOD_GlcNHglycan	299	302	PF01048	0.607
MOD_GlcNHglycan	54	57	PF01048	0.582
MOD_GSK3_1	134	141	PF00069	0.622
MOD_GSK3_1	20	27	PF00069	0.636
MOD_GSK3_1	297	304	PF00069	0.538
MOD_GSK3_1	310	317	PF00069	0.356
MOD_NEK2_1	110	115	PF00069	0.446
MOD_NEK2_1	134	139	PF00069	0.651
MOD_NEK2_1	179	184	PF00069	0.608
MOD_NEK2_1	2	7	PF00069	0.640
MOD_NEK2_1	25	30	PF00069	0.728
MOD_NEK2_1	270	275	PF00069	0.499
MOD_NEK2_2	242	247	PF00069	0.488
MOD_PIKK_1	41	47	PF00454	0.595
MOD_PKA_2	134	140	PF00069	0.645
MOD_PKA_2	2	8	PF00069	0.622
MOD_PKA_2	314	320	PF00069	0.401
MOD_Plk_1	167	173	PF00069	0.480
MOD_Plk_1	281	287	PF00069	0.447
MOD_Plk_1	60	66	PF00069	0.585
MOD_Plk_2-3	281	287	PF00069	0.452
MOD_Plk_4	168	174	PF00069	0.488
MOD_Plk_4	242	248	PF00069	0.449
MOD_Plk_4	281	287	PF00069	0.437
MOD_Plk_4	60	66	PF00069	0.615
MOD_ProDKin_1	20	26	PF00069	0.628
MOD_ProDKin_1	253	259	PF00069	0.454
MOD_ProDKin_1	99	105	PF00069	0.577
MOD_SUMO_for_1	161	164	PF00179	0.571
MOD_SUMO_for_1	279	282	PF00179	0.471
TRG_DiLeu_BaEn_1	104	109	PF01217	0.409
TRG_DiLeu_BaEn_1	146	151	PF01217	0.454
TRG_ENDOCYTIC_2	265	268	PF00928	0.518
TRG_ENDOCYTIC_2	34	37	PF00928	0.522
TRG_ENDOCYTIC_2	79	82	PF00928	0.469
TRG_ER_diArg_1	125	127	PF00400	0.675
TRG_ER_diArg_1	132	135	PF00400	0.565
TRG_ER_diArg_1	218	220	PF00400	0.386
TRG_ER_diArg_1	328	330	PF00400	0.621
TRG_ER_diArg_1	7	9	PF00400	0.622
TRG_NLS_MonoCore_2	206	211	PF00514	0.396
TRG_NLS_MonoExtN_4	204	211	PF00514	0.565
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	7	12	PF00026	0.690

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3R0	Leptomonas seymouri	81%	100%
A0A0S4INW7	Bodo saltans	54%	99%
A0A1X0P9M5	Trypanosomatidae	63%	100%
A0A3S7X7Z6	Leishmania donovani	98%	100%
A4HAV1	Leishmania braziliensis	93%	100%
A4I9Z8	Leishmania infantum	98%	100%
C9ZML5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
Q4Q2W0	Leishmania major	98%	100%
V5DGS2	Trypanosoma cruzi	61%	100%