CortBP2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B522_LEIMU

TriTrypDb:

LmxM.33.2360

Length:

432

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B522

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B522

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.428
CLV_NRD_NRD_1	131	133	PF00675	0.434
CLV_NRD_NRD_1	138	140	PF00675	0.414
CLV_NRD_NRD_1	24	26	PF00675	0.497
CLV_NRD_NRD_1	310	312	PF00675	0.534
CLV_NRD_NRD_1	45	47	PF00675	0.447
CLV_NRD_NRD_1	75	77	PF00675	0.500
CLV_PCSK_FUR_1	22	26	PF00082	0.517
CLV_PCSK_KEX2_1	103	105	PF00082	0.476
CLV_PCSK_KEX2_1	24	26	PF00082	0.497
CLV_PCSK_KEX2_1	75	77	PF00082	0.500
CLV_PCSK_SKI1_1	103	107	PF00082	0.482
CLV_PCSK_SKI1_1	132	136	PF00082	0.413
CLV_PCSK_SKI1_1	416	420	PF00082	0.484
CLV_PCSK_SKI1_1	57	61	PF00082	0.506
DEG_APCC_DBOX_1	365	373	PF00400	0.521
DEG_APCC_DBOX_1	415	423	PF00400	0.548
DEG_SCF_FBW7_1	249	256	PF00400	0.525
DEG_SCF_FBW7_1	292	297	PF00400	0.682
DEG_SPOP_SBC_1	190	194	PF00917	0.613
DEG_SPOP_SBC_1	390	394	PF00917	0.736
DOC_CKS1_1	250	255	PF01111	0.524
DOC_CYCLIN_RxL_1	129	136	PF00134	0.411
DOC_CYCLIN_RxL_1	412	421	PF00134	0.532
DOC_MAPK_gen_1	152	160	PF00069	0.473
DOC_MAPK_gen_1	22	30	PF00069	0.503
DOC_MAPK_gen_1	259	267	PF00069	0.548
DOC_MAPK_gen_1	311	318	PF00069	0.541
DOC_MAPK_MEF2A_6	152	160	PF00069	0.490
DOC_MIT_MIM_1	157	167	PF04212	0.479
DOC_PP4_FxxP_1	385	388	PF00568	0.450
DOC_USP7_MATH_1	294	298	PF00917	0.650
DOC_USP7_MATH_1	353	357	PF00917	0.517
DOC_USP7_MATH_1	374	378	PF00917	0.471
DOC_USP7_MATH_1	381	385	PF00917	0.504
DOC_USP7_MATH_1	6	10	PF00917	0.663
DOC_WW_Pin1_4	183	188	PF00397	0.697
DOC_WW_Pin1_4	210	215	PF00397	0.656
DOC_WW_Pin1_4	249	254	PF00397	0.666
DOC_WW_Pin1_4	283	288	PF00397	0.624
DOC_WW_Pin1_4	290	295	PF00397	0.652
DOC_WW_Pin1_4	8	13	PF00397	0.574
LIG_14-3-3_CanoR_1	109	119	PF00244	0.516
LIG_14-3-3_CanoR_1	139	148	PF00244	0.432
LIG_14-3-3_CanoR_1	280	287	PF00244	0.713
LIG_14-3-3_CanoR_1	326	336	PF00244	0.481
LIG_14-3-3_CanoR_1	86	91	PF00244	0.422
LIG_Actin_WH2_2	16	33	PF00022	0.509
LIG_BIR_II_1	1	5	PF00653	0.640
LIG_FHA_1	190	196	PF00498	0.638
LIG_FHA_1	211	217	PF00498	0.663
LIG_FHA_1	250	256	PF00498	0.611
LIG_FHA_1	336	342	PF00498	0.512
LIG_FHA_1	413	419	PF00498	0.494
LIG_FHA_2	111	117	PF00498	0.518
LIG_FHA_2	140	146	PF00498	0.638
LIG_FHA_2	191	197	PF00498	0.478
LIG_FHA_2	239	245	PF00498	0.471
LIG_FHA_2	346	352	PF00498	0.444
LIG_FHA_2	36	42	PF00498	0.618
LIG_FHA_2	48	54	PF00498	0.499
LIG_LIR_Apic_2	383	388	PF02991	0.446
LIG_LIR_Gen_1	124	130	PF02991	0.471
LIG_LIR_Gen_1	196	207	PF02991	0.468
LIG_LIR_Gen_1	26	35	PF02991	0.482
LIG_LIR_LC3C_4	246	251	PF02991	0.467
LIG_LIR_Nem_3	196	202	PF02991	0.471
LIG_LIR_Nem_3	26	30	PF02991	0.487
LIG_NRBOX	312	318	PF00104	0.490
LIG_PTB_Apo_2	68	75	PF02174	0.486
LIG_SH2_CRK	87	91	PF00017	0.531
LIG_SH2_PTP2	27	30	PF00017	0.486
LIG_SH2_SRC	155	158	PF00017	0.489
LIG_SH2_STAP1	35	39	PF00017	0.473
LIG_SH2_STAT5	125	128	PF00017	0.475
LIG_SH2_STAT5	155	158	PF00017	0.413
LIG_SH2_STAT5	27	30	PF00017	0.466
LIG_SH3_3	198	204	PF00018	0.649
LIG_SH3_3	247	253	PF00018	0.661
LIG_SH3_3	419	425	PF00018	0.581
LIG_SUMO_SIM_par_1	246	252	PF11976	0.583
LIG_TRAF2_1	118	121	PF00917	0.461
LIG_TRAF2_1	343	346	PF00917	0.487
LIG_TRAF2_1	38	41	PF00917	0.473
LIG_UBA3_1	126	133	PF00899	0.468
LIG_UBA3_1	134	141	PF00899	0.482
LIG_UBA3_1	73	82	PF00899	0.455
LIG_WRC_WIRS_1	382	387	PF05994	0.454
MOD_CDK_SPK_2	283	288	PF00069	0.646
MOD_CDK_SPK_2	290	295	PF00069	0.610
MOD_CDK_SPxxK_3	210	217	PF00069	0.616
MOD_CK1_1	110	116	PF00069	0.517
MOD_CK1_1	174	180	PF00069	0.664
MOD_CK1_1	183	189	PF00069	0.731
MOD_CK1_1	209	215	PF00069	0.544
MOD_CK1_1	282	288	PF00069	0.672
MOD_CK1_1	29	35	PF00069	0.479
MOD_CK1_1	296	302	PF00069	0.499
MOD_CK1_1	375	381	PF00069	0.497
MOD_CK1_1	389	395	PF00069	0.569
MOD_CK1_1	407	413	PF00069	0.406
MOD_CK2_1	110	116	PF00069	0.343
MOD_CK2_1	139	145	PF00069	0.430
MOD_CK2_1	170	176	PF00069	0.639
MOD_CK2_1	183	189	PF00069	0.545
MOD_CK2_1	190	196	PF00069	0.458
MOD_CK2_1	325	331	PF00069	0.513
MOD_CK2_1	35	41	PF00069	0.471
MOD_CK2_1	407	413	PF00069	0.522
MOD_CK2_1	47	53	PF00069	0.416
MOD_CK2_1	93	99	PF00069	0.525
MOD_DYRK1A_RPxSP_1	8	12	PF00069	0.637
MOD_GlcNHglycan	277	280	PF01048	0.789
MOD_GlcNHglycan	281	284	PF01048	0.759
MOD_GlcNHglycan	288	291	PF01048	0.567
MOD_GlcNHglycan	327	330	PF01048	0.504
MOD_GlcNHglycan	376	380	PF01048	0.489
MOD_GSK3_1	170	177	PF00069	0.628
MOD_GSK3_1	202	209	PF00069	0.626
MOD_GSK3_1	224	231	PF00069	0.500
MOD_GSK3_1	249	256	PF00069	0.595
MOD_GSK3_1	26	33	PF00069	0.460
MOD_GSK3_1	263	270	PF00069	0.727
MOD_GSK3_1	271	278	PF00069	0.667
MOD_GSK3_1	279	286	PF00069	0.538
MOD_GSK3_1	290	297	PF00069	0.560
MOD_GSK3_1	35	42	PF00069	0.410
MOD_GSK3_1	386	393	PF00069	0.679
MOD_GSK3_1	394	401	PF00069	0.602
MOD_GSK3_1	4	11	PF00069	0.681
MOD_GSK3_1	93	100	PF00069	0.524
MOD_N-GLC_1	190	195	PF02516	0.505
MOD_N-GLC_1	224	229	PF02516	0.791
MOD_N-GLC_1	267	272	PF02516	0.643
MOD_N-GLC_1	274	279	PF02516	0.569
MOD_N-GLC_1	394	399	PF02516	0.627
MOD_N-GLC_1	407	412	PF02516	0.460
MOD_NEK2_1	215	220	PF00069	0.650
MOD_NEK2_1	281	286	PF00069	0.758
MOD_NEK2_1	30	35	PF00069	0.480
MOD_NEK2_1	324	329	PF00069	0.512
MOD_NEK2_1	391	396	PF00069	0.659
MOD_NEK2_1	398	403	PF00069	0.706
MOD_NEK2_1	4	9	PF00069	0.642
MOD_NEK2_1	418	423	PF00069	0.374
MOD_PIKK_1	107	113	PF00454	0.518
MOD_PIKK_1	180	186	PF00454	0.633
MOD_PK_1	52	58	PF00069	0.483
MOD_PKA_1	139	145	PF00069	0.489
MOD_PKA_2	279	285	PF00069	0.728
MOD_PKA_2	294	300	PF00069	0.525
MOD_PKA_2	325	331	PF00069	0.513
MOD_PKA_2	353	359	PF00069	0.649
MOD_Plk_1	16	22	PF00069	0.530
MOD_Plk_1	190	196	PF00069	0.672
MOD_Plk_1	224	230	PF00069	0.565
MOD_Plk_1	243	249	PF00069	0.557
MOD_Plk_1	345	351	PF00069	0.494
MOD_Plk_1	39	45	PF00069	0.427
MOD_Plk_1	394	400	PF00069	0.579
MOD_Plk_1	407	413	PF00069	0.453
MOD_Plk_1	52	58	PF00069	0.472
MOD_Plk_2-3	238	244	PF00069	0.474
MOD_Plk_2-3	93	99	PF00069	0.509
MOD_Plk_4	224	230	PF00069	0.565
MOD_Plk_4	345	351	PF00069	0.445
MOD_Plk_4	386	392	PF00069	0.572
MOD_Plk_4	400	406	PF00069	0.636
MOD_Plk_4	86	92	PF00069	0.469
MOD_ProDKin_1	183	189	PF00069	0.698
MOD_ProDKin_1	210	216	PF00069	0.656
MOD_ProDKin_1	249	255	PF00069	0.667
MOD_ProDKin_1	283	289	PF00069	0.622
MOD_ProDKin_1	290	296	PF00069	0.647
MOD_ProDKin_1	8	14	PF00069	0.569
MOD_SUMO_for_1	358	361	PF00179	0.530
MOD_SUMO_for_1	64	67	PF00179	0.445
MOD_SUMO_for_1	91	94	PF00179	0.466
MOD_SUMO_rev_2	370	375	PF00179	0.536
TRG_DiLeu_BaEn_1	40	45	PF01217	0.491
TRG_DiLeu_BaLyEn_6	211	216	PF01217	0.616
TRG_ENDOCYTIC_2	125	128	PF00928	0.475
TRG_ENDOCYTIC_2	155	158	PF00928	0.413
TRG_ENDOCYTIC_2	27	30	PF00928	0.486
TRG_ENDOCYTIC_2	87	90	PF00928	0.514
TRG_ER_diArg_1	103	105	PF00400	0.428
TRG_ER_diArg_1	152	155	PF00400	0.500
TRG_ER_diArg_1	166	169	PF00400	0.528
TRG_ER_diArg_1	22	25	PF00400	0.508
TRG_ER_diArg_1	74	76	PF00400	0.498
TRG_Pf-PMV_PEXEL_1	103	107	PF00026	0.424
TRG_Pf-PMV_PEXEL_1	132	136	PF00026	0.413
TRG_Pf-PMV_PEXEL_1	233	237	PF00026	0.605
TRG_Pf-PMV_PEXEL_1	311	315	PF00026	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Y4	Leptomonas seymouri	54%	99%
A0A0S4JG85	Bodo saltans	30%	83%
A0A3Q8IL47	Leishmania donovani	90%	100%
A4IA15	Leishmania infantum	90%	100%
E9AI69	Leishmania braziliensis	80%	100%
Q4Q2W4	Leishmania major	89%	100%