Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B516_LEIMU

TriTrypDb:

LmxM.33.2300

Length:

615

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B516

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B516

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	216	220	PF00656	0.522
CLV_C14_Caspase3-7	326	330	PF00656	0.675
CLV_NRD_NRD_1	34	36	PF00675	0.747
CLV_NRD_NRD_1	424	426	PF00675	0.494
CLV_NRD_NRD_1	562	564	PF00675	0.505
CLV_PCSK_KEX2_1	36	38	PF00082	0.736
CLV_PCSK_KEX2_1	424	426	PF00082	0.467
CLV_PCSK_KEX2_1	566	568	PF00082	0.536
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.736
CLV_PCSK_PC1ET2_1	566	568	PF00082	0.568
CLV_PCSK_SKI1_1	107	111	PF00082	0.644
CLV_PCSK_SKI1_1	317	321	PF00082	0.593
CLV_PCSK_SKI1_1	349	353	PF00082	0.513
CLV_PCSK_SKI1_1	396	400	PF00082	0.525
CLV_PCSK_SKI1_1	407	411	PF00082	0.459
CLV_PCSK_SKI1_1	424	428	PF00082	0.408
CLV_PCSK_SKI1_1	519	523	PF00082	0.418
CLV_PCSK_SKI1_1	65	69	PF00082	0.649
DEG_APCC_DBOX_1	518	526	PF00400	0.469
DEG_APCC_DBOX_1	601	609	PF00400	0.510
DEG_Nend_UBRbox_3	1	3	PF02207	0.732
DEG_ODPH_VHL_1	110	121	PF01847	0.294
DEG_SPOP_SBC_1	28	32	PF00917	0.716
DEG_SPOP_SBC_1	306	310	PF00917	0.725
DEG_SPOP_SBC_1	48	52	PF00917	0.613
DOC_CDC14_PxL_1	257	265	PF14671	0.588
DOC_CKS1_1	92	97	PF01111	0.571
DOC_CYCLIN_RxL_1	314	323	PF00134	0.606
DOC_CYCLIN_RxL_1	346	353	PF00134	0.542
DOC_MAPK_gen_1	424	432	PF00069	0.435
DOC_MAPK_MEF2A_6	182	190	PF00069	0.463
DOC_MAPK_MEF2A_6	425	434	PF00069	0.431
DOC_MIT_MIM_1	178	186	PF04212	0.479
DOC_PP1_RVXF_1	422	429	PF00149	0.466
DOC_PP4_FxxP_1	21	24	PF00568	0.626
DOC_PP4_FxxP_1	537	540	PF00568	0.403
DOC_USP7_MATH_1	105	109	PF00917	0.676
DOC_USP7_MATH_1	144	148	PF00917	0.599
DOC_USP7_MATH_1	22	26	PF00917	0.732
DOC_USP7_MATH_1	28	32	PF00917	0.755
DOC_USP7_MATH_1	304	308	PF00917	0.732
DOC_USP7_MATH_1	342	346	PF00917	0.431
DOC_USP7_MATH_1	347	351	PF00917	0.413
DOC_USP7_MATH_1	382	386	PF00917	0.686
DOC_USP7_MATH_1	48	52	PF00917	0.653
DOC_USP7_MATH_1	562	566	PF00917	0.511
DOC_USP7_MATH_1	569	573	PF00917	0.498
DOC_WW_Pin1_4	142	147	PF00397	0.708
DOC_WW_Pin1_4	320	325	PF00397	0.612
DOC_WW_Pin1_4	366	371	PF00397	0.598
DOC_WW_Pin1_4	37	42	PF00397	0.736
DOC_WW_Pin1_4	52	57	PF00397	0.651
DOC_WW_Pin1_4	555	560	PF00397	0.435
DOC_WW_Pin1_4	58	63	PF00397	0.633
DOC_WW_Pin1_4	91	96	PF00397	0.666
LIG_14-3-3_CanoR_1	122	128	PF00244	0.492
LIG_14-3-3_CanoR_1	173	178	PF00244	0.508
LIG_14-3-3_CanoR_1	467	471	PF00244	0.538
LIG_14-3-3_CanoR_1	87	95	PF00244	0.577
LIG_Actin_WH2_2	127	144	PF00022	0.503
LIG_Actin_WH2_2	507	525	PF00022	0.488
LIG_BIR_III_2	204	208	PF00653	0.545
LIG_BIR_III_4	532	536	PF00653	0.497
LIG_BRCT_BRCA1_1	473	477	PF00533	0.563
LIG_BRCT_BRCA1_1	557	561	PF00533	0.418
LIG_BRCT_BRCA1_1	81	85	PF00533	0.540
LIG_Clathr_ClatBox_1	544	548	PF01394	0.513
LIG_deltaCOP1_diTrp_1	280	286	PF00928	0.582
LIG_FHA_1	169	175	PF00498	0.591
LIG_FHA_1	246	252	PF00498	0.557
LIG_FHA_1	341	347	PF00498	0.393
LIG_FHA_2	173	179	PF00498	0.504
LIG_LIR_Apic_2	89	95	PF02991	0.503
LIG_LIR_Gen_1	178	188	PF02991	0.376
LIG_LIR_Gen_1	243	252	PF02991	0.576
LIG_LIR_Gen_1	358	368	PF02991	0.554
LIG_LIR_Gen_1	548	557	PF02991	0.475
LIG_LIR_Nem_3	178	183	PF02991	0.374
LIG_LIR_Nem_3	243	247	PF02991	0.531
LIG_LIR_Nem_3	358	363	PF02991	0.495
LIG_LIR_Nem_3	403	409	PF02991	0.529
LIG_LIR_Nem_3	485	490	PF02991	0.465
LIG_LIR_Nem_3	548	552	PF02991	0.444
LIG_LIR_Nem_3	568	573	PF02991	0.205
LIG_Pex14_1	282	286	PF04695	0.580
LIG_Pex14_1	414	418	PF04695	0.553
LIG_PTB_Apo_2	543	550	PF02174	0.508
LIG_Rb_pABgroove_1	346	354	PF01858	0.539
LIG_SH2_CRK	395	399	PF00017	0.307
LIG_SH2_CRK	418	422	PF00017	0.481
LIG_SH2_CRK	570	574	PF00017	0.503
LIG_SH2_CRK	92	96	PF00017	0.524
LIG_SH2_NCK_1	92	96	PF00017	0.524
LIG_SH2_SRC	435	438	PF00017	0.333
LIG_SH2_STAP1	437	441	PF00017	0.498
LIG_SH2_STAT3	437	440	PF00017	0.257
LIG_SH2_STAT3	74	77	PF00017	0.657
LIG_SH2_STAT5	140	143	PF00017	0.570
LIG_SH2_STAT5	180	183	PF00017	0.365
LIG_SH2_STAT5	265	268	PF00017	0.395
LIG_SH3_2	6	11	PF14604	0.721
LIG_SH3_3	3	9	PF00018	0.818
LIG_SH3_3	391	397	PF00018	0.600
LIG_SH3_3	53	59	PF00018	0.784
LIG_SUMO_SIM_par_1	397	403	PF11976	0.488
LIG_TRAF2_1	61	64	PF00917	0.508
LIG_TYR_ITIM	552	557	PF00017	0.323
LIG_WRC_WIRS_1	241	246	PF05994	0.585
LIG_WRC_WIRS_1	401	406	PF05994	0.271
MOD_CDK_SPxxK_3	366	373	PF00069	0.588
MOD_CDK_SPxxK_3	58	65	PF00069	0.515
MOD_CK1_1	27	33	PF00069	0.737
MOD_CK1_1	307	313	PF00069	0.652
MOD_CK1_1	323	329	PF00069	0.442
MOD_CK1_1	369	375	PF00069	0.567
MOD_CK1_1	385	391	PF00069	0.632
MOD_CK1_1	445	451	PF00069	0.666
MOD_CK1_1	51	57	PF00069	0.740
MOD_CK1_1	86	92	PF00069	0.615
MOD_CK2_1	172	178	PF00069	0.497
MOD_CK2_1	310	316	PF00069	0.544
MOD_CK2_1	562	568	PF00069	0.498
MOD_CK2_1	58	64	PF00069	0.714
MOD_CMANNOS	463	466	PF00535	0.497
MOD_DYRK1A_RPxSP_1	142	146	PF00069	0.618
MOD_DYRK1A_RPxSP_1	37	41	PF00069	0.763
MOD_GlcNHglycan	107	110	PF01048	0.576
MOD_GlcNHglycan	135	139	PF01048	0.540
MOD_GlcNHglycan	26	29	PF01048	0.774
MOD_GlcNHglycan	325	328	PF01048	0.561
MOD_GlcNHglycan	385	388	PF01048	0.701
MOD_GlcNHglycan	389	392	PF01048	0.672
MOD_GlcNHglycan	451	454	PF01048	0.649
MOD_GlcNHglycan	473	476	PF01048	0.515
MOD_GlcNHglycan	511	514	PF01048	0.584
MOD_GSK3_1	162	169	PF00069	0.644
MOD_GSK3_1	22	29	PF00069	0.733
MOD_GSK3_1	251	258	PF00069	0.585
MOD_GSK3_1	304	311	PF00069	0.746
MOD_GSK3_1	37	44	PF00069	0.686
MOD_GSK3_1	383	390	PF00069	0.680
MOD_GSK3_1	441	448	PF00069	0.604
MOD_GSK3_1	47	54	PF00069	0.768
MOD_GSK3_1	505	512	PF00069	0.327
MOD_GSK3_1	569	576	PF00069	0.487
MOD_GSK3_1	588	595	PF00069	0.349
MOD_GSK3_1	79	86	PF00069	0.590
MOD_N-GLC_1	100	105	PF02516	0.709
MOD_NEK2_1	134	139	PF00069	0.476
MOD_NEK2_1	232	237	PF00069	0.406
MOD_NEK2_1	240	245	PF00069	0.428
MOD_NEK2_1	315	320	PF00069	0.563
MOD_NEK2_1	491	496	PF00069	0.634
MOD_NEK2_1	580	585	PF00069	0.509
MOD_NEK2_2	347	352	PF00069	0.517
MOD_NEK2_2	492	497	PF00069	0.449
MOD_NEK2_2	597	602	PF00069	0.260
MOD_PIKK_1	22	28	PF00454	0.684
MOD_PIKK_1	281	287	PF00454	0.546
MOD_PK_1	505	511	PF00069	0.286
MOD_PKA_1	35	41	PF00069	0.784
MOD_PKA_2	172	178	PF00069	0.536
MOD_PKA_2	466	472	PF00069	0.495
MOD_PKA_2	562	568	PF00069	0.498
MOD_PKA_2	86	92	PF00069	0.599
MOD_Plk_1	218	224	PF00069	0.453
MOD_Plk_1	225	231	PF00069	0.389
MOD_Plk_1	232	238	PF00069	0.336
MOD_Plk_1	245	251	PF00069	0.497
MOD_Plk_1	255	261	PF00069	0.444
MOD_Plk_1	315	321	PF00069	0.592
MOD_Plk_1	547	553	PF00069	0.431
MOD_Plk_2-3	400	406	PF00069	0.563
MOD_Plk_4	123	129	PF00069	0.358
MOD_Plk_4	232	238	PF00069	0.458
MOD_Plk_4	272	278	PF00069	0.480
MOD_Plk_4	310	316	PF00069	0.565
MOD_ProDKin_1	142	148	PF00069	0.717
MOD_ProDKin_1	320	326	PF00069	0.621
MOD_ProDKin_1	366	372	PF00069	0.595
MOD_ProDKin_1	37	43	PF00069	0.735
MOD_ProDKin_1	52	58	PF00069	0.648
MOD_ProDKin_1	555	561	PF00069	0.434
MOD_ProDKin_1	91	97	PF00069	0.671
MOD_SUMO_rev_2	400	409	PF00179	0.561
MOD_SUMO_rev_2	8	18	PF00179	0.793
TRG_DiLeu_BaEn_2	13	19	PF01217	0.648
TRG_DiLeu_BaEn_4	63	69	PF01217	0.495
TRG_ENDOCYTIC_2	180	183	PF00928	0.365
TRG_ENDOCYTIC_2	395	398	PF00928	0.431
TRG_ENDOCYTIC_2	418	421	PF00928	0.469
TRG_ENDOCYTIC_2	554	557	PF00928	0.392
TRG_ENDOCYTIC_2	570	573	PF00928	0.538
TRG_ER_diArg_1	423	425	PF00400	0.455
TRG_NES_CRM1_1	123	135	PF08389	0.541
TRG_NES_CRM1_1	178	192	PF08389	0.387
TRG_NLS_MonoExtC_3	34	39	PF00514	0.739
TRG_NLS_MonoExtC_3	562	567	PF00514	0.529
TRG_NLS_MonoExtN_4	35	40	PF00514	0.744
TRG_Pf-PMV_PEXEL_1	268	272	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	349	353	PF00026	0.545
TRG_Pf-PMV_PEXEL_1	424	429	PF00026	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGH4	Leptomonas seymouri	46%	95%
A0A1X0P9M0	Trypanosomatidae	26%	100%
A0A3Q8IFL4	Leishmania donovani	90%	100%
A0A422P0J6	Trypanosoma rangeli	25%	100%
A4HAU2	Leishmania braziliensis	74%	100%
C9ZMM5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9AHT6	Leishmania infantum	89%	100%
Q4Q2X0	Leishmania major	85%	100%
V5BKG8	Trypanosoma cruzi	25%	100%