Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B514_LEIMU

TriTrypDb:

LmxM.33.2280

Length:

746

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B514

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B514

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	205	209	PF00656	0.559
CLV_C14_Caspase3-7	282	286	PF00656	0.706
CLV_C14_Caspase3-7	60	64	PF00656	0.726
CLV_C14_Caspase3-7	686	690	PF00656	0.716
CLV_NRD_NRD_1	181	183	PF00675	0.646
CLV_NRD_NRD_1	214	216	PF00675	0.654
CLV_NRD_NRD_1	248	250	PF00675	0.696
CLV_NRD_NRD_1	257	259	PF00675	0.717
CLV_NRD_NRD_1	507	509	PF00675	0.756
CLV_NRD_NRD_1	510	512	PF00675	0.681
CLV_NRD_NRD_1	669	671	PF00675	0.759
CLV_PCSK_FUR_1	508	512	PF00082	0.737
CLV_PCSK_KEX2_1	181	183	PF00082	0.646
CLV_PCSK_KEX2_1	257	259	PF00082	0.691
CLV_PCSK_KEX2_1	297	299	PF00082	0.690
CLV_PCSK_KEX2_1	507	509	PF00082	0.756
CLV_PCSK_KEX2_1	510	512	PF00082	0.681
CLV_PCSK_KEX2_1	669	671	PF00082	0.759
CLV_PCSK_PC1ET2_1	297	299	PF00082	0.671
CLV_PCSK_PC7_1	293	299	PF00082	0.676
CLV_PCSK_PC7_1	665	671	PF00082	0.741
CLV_PCSK_SKI1_1	167	171	PF00082	0.572
CLV_PCSK_SKI1_1	200	204	PF00082	0.644
CLV_PCSK_SKI1_1	275	279	PF00082	0.661
CLV_PCSK_SKI1_1	398	402	PF00082	0.453
CLV_PCSK_SKI1_1	498	502	PF00082	0.587
CLV_PCSK_SKI1_1	616	620	PF00082	0.454
CLV_PCSK_SKI1_1	665	669	PF00082	0.750
CLV_Separin_Metazoa	105	109	PF03568	0.548
CLV_Separin_Metazoa	487	491	PF03568	0.518
DEG_APCC_DBOX_1	46	54	PF00400	0.611
DEG_APCC_DBOX_1	497	505	PF00400	0.384
DEG_Kelch_Keap1_1	715	720	PF01344	0.511
DEG_SPOP_SBC_1	469	473	PF00917	0.648
DEG_SPOP_SBC_1	56	60	PF00917	0.496
DEG_SPOP_SBC_1	586	590	PF00917	0.780
DEG_SPOP_SBC_1	651	655	PF00917	0.735
DOC_CKS1_1	609	614	PF01111	0.585
DOC_CYCLIN_RxL_1	394	403	PF00134	0.511
DOC_CYCLIN_RxL_1	493	503	PF00134	0.573
DOC_CYCLIN_yCln2_LP_2	592	598	PF00134	0.490
DOC_CYCLIN_yCln2_LP_2	668	674	PF00134	0.641
DOC_MAPK_MEF2A_6	108	117	PF00069	0.538
DOC_MAPK_MEF2A_6	351	358	PF00069	0.506
DOC_PP1_RVXF_1	396	402	PF00149	0.493
DOC_PP4_FxxP_1	602	605	PF00568	0.707
DOC_PP4_FxxP_1	609	612	PF00568	0.629
DOC_USP7_MATH_1	251	255	PF00917	0.619
DOC_USP7_MATH_1	331	335	PF00917	0.615
DOC_USP7_MATH_1	38	42	PF00917	0.683
DOC_USP7_MATH_1	380	384	PF00917	0.612
DOC_USP7_MATH_1	462	466	PF00917	0.585
DOC_USP7_MATH_1	469	473	PF00917	0.466
DOC_USP7_MATH_1	651	655	PF00917	0.622
DOC_USP7_MATH_1	714	718	PF00917	0.724
DOC_WW_Pin1_4	231	236	PF00397	0.689
DOC_WW_Pin1_4	264	269	PF00397	0.584
DOC_WW_Pin1_4	291	296	PF00397	0.781
DOC_WW_Pin1_4	309	314	PF00397	0.304
DOC_WW_Pin1_4	41	46	PF00397	0.737
DOC_WW_Pin1_4	572	577	PF00397	0.684
DOC_WW_Pin1_4	591	596	PF00397	0.466
DOC_WW_Pin1_4	608	613	PF00397	0.493
DOC_WW_Pin1_4	66	71	PF00397	0.793
DOC_WW_Pin1_4	77	82	PF00397	0.618
LIG_14-3-3_CanoR_1	200	210	PF00244	0.610
LIG_14-3-3_CanoR_1	215	221	PF00244	0.479
LIG_14-3-3_CanoR_1	257	266	PF00244	0.642
LIG_14-3-3_CanoR_1	351	355	PF00244	0.485
LIG_14-3-3_CanoR_1	37	46	PF00244	0.539
LIG_14-3-3_CanoR_1	387	392	PF00244	0.563
LIG_14-3-3_CanoR_1	398	406	PF00244	0.502
LIG_14-3-3_CanoR_1	47	57	PF00244	0.691
LIG_14-3-3_CanoR_1	691	697	PF00244	0.624
LIG_14-3-3_CanoR_1	698	703	PF00244	0.583
LIG_Actin_WH2_2	92	110	PF00022	0.590
LIG_BIR_III_2	419	423	PF00653	0.400
LIG_BIR_III_4	737	741	PF00653	0.410
LIG_BRCT_BRCA1_1	474	478	PF00533	0.694
LIG_BRCT_BRCA1_1	587	591	PF00533	0.769
LIG_FHA_1	129	135	PF00498	0.418
LIG_FHA_1	154	160	PF00498	0.697
LIG_FHA_1	163	169	PF00498	0.532
LIG_FHA_1	274	280	PF00498	0.664
LIG_FHA_1	400	406	PF00498	0.536
LIG_FHA_1	459	465	PF00498	0.537
LIG_FHA_1	495	501	PF00498	0.566
LIG_FHA_1	662	668	PF00498	0.631
LIG_FHA_1	8	14	PF00498	0.601
LIG_FHA_2	673	679	PF00498	0.779
LIG_FHA_2	78	84	PF00498	0.769
LIG_Integrin_RGD_1	578	580	PF01839	0.718
LIG_IRF3_LxIS_1	306	312	PF10401	0.614
LIG_LIR_Apic_2	608	612	PF02991	0.663
LIG_LIR_Apic_2	9	14	PF02991	0.641
LIG_LIR_Gen_1	196	206	PF02991	0.402
LIG_LIR_Gen_1	243	253	PF02991	0.674
LIG_LIR_Gen_1	386	396	PF02991	0.406
LIG_LIR_Nem_3	196	201	PF02991	0.566
LIG_LIR_Nem_3	243	248	PF02991	0.678
LIG_LIR_Nem_3	386	391	PF02991	0.520
LIG_LIR_Nem_3	6	11	PF02991	0.631
LIG_LIR_Nem_3	737	742	PF02991	0.571
LIG_NRBOX	142	148	PF00104	0.533
LIG_NRBOX	92	98	PF00104	0.711
LIG_PCNA_yPIPBox_3	136	147	PF02747	0.566
LIG_PCNA_yPIPBox_3	387	400	PF02747	0.607
LIG_PDZ_Class_3	741	746	PF00595	0.674
LIG_Pex14_2	117	121	PF04695	0.443
LIG_SH2_STAP1	438	442	PF00017	0.509
LIG_SH2_STAT3	544	547	PF00017	0.711
LIG_SH2_STAT5	11	14	PF00017	0.717
LIG_SH2_STAT5	544	547	PF00017	0.666
LIG_SH2_STAT5	625	628	PF00017	0.599
LIG_SH3_2	265	270	PF14604	0.656
LIG_SH3_3	262	268	PF00018	0.681
LIG_SH3_3	592	598	PF00018	0.687
LIG_SH3_3	631	637	PF00018	0.589
LIG_Sin3_3	426	433	PF02671	0.495
LIG_SUMO_SIM_anti_2	446	451	PF11976	0.444
LIG_SUMO_SIM_par_1	144	150	PF11976	0.592
LIG_SUMO_SIM_par_1	305	310	PF11976	0.512
LIG_SUMO_SIM_par_1	582	590	PF11976	0.767
LIG_SUMO_SIM_par_1	95	101	PF11976	0.597
LIG_TRAF2_1	339	342	PF00917	0.559
LIG_TRAF2_1	549	552	PF00917	0.778
MOD_CDC14_SPxK_1	234	237	PF00782	0.684
MOD_CDC14_SPxK_1	267	270	PF00782	0.645
MOD_CDC14_SPxK_1	294	297	PF00782	0.773
MOD_CDC14_SPxK_1	44	47	PF00782	0.692
MOD_CDC14_SPxK_1	575	578	PF00782	0.768
MOD_CDK_SPxK_1	231	237	PF00069	0.688
MOD_CDK_SPxK_1	264	270	PF00069	0.660
MOD_CDK_SPxK_1	291	297	PF00069	0.781
MOD_CDK_SPxK_1	41	47	PF00069	0.696
MOD_CDK_SPxK_1	572	578	PF00069	0.775
MOD_CDK_SPxxK_3	291	298	PF00069	0.779
MOD_CK1_1	162	168	PF00069	0.514
MOD_CK1_1	287	293	PF00069	0.683
MOD_CK1_1	296	302	PF00069	0.696
MOD_CK1_1	312	318	PF00069	0.372
MOD_CK1_1	334	340	PF00069	0.519
MOD_CK1_1	41	47	PF00069	0.774
MOD_CK1_1	465	471	PF00069	0.703
MOD_CK1_1	472	478	PF00069	0.631
MOD_CK1_1	563	569	PF00069	0.656
MOD_CK1_1	582	588	PF00069	0.707
MOD_CK1_1	594	600	PF00069	0.601
MOD_CK1_1	653	659	PF00069	0.814
MOD_CK1_1	683	689	PF00069	0.770
MOD_CK1_1	69	75	PF00069	0.819
MOD_CK1_1	693	699	PF00069	0.721
MOD_CK1_1	7	13	PF00069	0.630
MOD_CK1_1	715	721	PF00069	0.513
MOD_CK1_1	77	83	PF00069	0.745
MOD_CK1_1	89	95	PF00069	0.652
MOD_CK2_1	142	148	PF00069	0.586
MOD_CK2_1	335	341	PF00069	0.572
MOD_CK2_1	672	678	PF00069	0.780
MOD_CK2_1	714	720	PF00069	0.781
MOD_GlcNHglycan	161	164	PF01048	0.573
MOD_GlcNHglycan	204	207	PF01048	0.542
MOD_GlcNHglycan	24	27	PF01048	0.738
MOD_GlcNHglycan	285	289	PF01048	0.673
MOD_GlcNHglycan	301	304	PF01048	0.635
MOD_GlcNHglycan	314	317	PF01048	0.410
MOD_GlcNHglycan	324	327	PF01048	0.473
MOD_GlcNHglycan	337	340	PF01048	0.506
MOD_GlcNHglycan	464	467	PF01048	0.716
MOD_GlcNHglycan	474	477	PF01048	0.604
MOD_GlcNHglycan	524	527	PF01048	0.632
MOD_GlcNHglycan	547	550	PF01048	0.783
MOD_GlcNHglycan	672	675	PF01048	0.739
MOD_GlcNHglycan	700	703	PF01048	0.717
MOD_GlcNHglycan	705	708	PF01048	0.649
MOD_GlcNHglycan	714	717	PF01048	0.698
MOD_GlcNHglycan	72	75	PF01048	0.843
MOD_GSK3_1	124	131	PF00069	0.494
MOD_GSK3_1	18	25	PF00069	0.748
MOD_GSK3_1	273	280	PF00069	0.554
MOD_GSK3_1	287	294	PF00069	0.597
MOD_GSK3_1	331	338	PF00069	0.574
MOD_GSK3_1	454	461	PF00069	0.573
MOD_GSK3_1	465	472	PF00069	0.632
MOD_GSK3_1	478	485	PF00069	0.348
MOD_GSK3_1	560	567	PF00069	0.702
MOD_GSK3_1	568	575	PF00069	0.726
MOD_GSK3_1	57	64	PF00069	0.777
MOD_GSK3_1	582	589	PF00069	0.756
MOD_GSK3_1	646	653	PF00069	0.809
MOD_GSK3_1	66	73	PF00069	0.801
MOD_GSK3_1	670	677	PF00069	0.730
MOD_GSK3_1	693	700	PF00069	0.728
MOD_GSK3_1	84	91	PF00069	0.541
MOD_N-GLC_1	75	80	PF02516	0.726
MOD_NEK2_1	124	129	PF00069	0.542
MOD_NEK2_1	147	152	PF00069	0.423
MOD_NEK2_1	18	23	PF00069	0.658
MOD_NEK2_1	194	199	PF00069	0.521
MOD_NEK2_1	201	206	PF00069	0.500
MOD_NEK2_1	347	352	PF00069	0.525
MOD_NEK2_1	400	405	PF00069	0.485
MOD_NEK2_1	478	483	PF00069	0.572
MOD_NEK2_1	500	505	PF00069	0.574
MOD_NEK2_1	543	548	PF00069	0.697
MOD_NEK2_1	57	62	PF00069	0.623
MOD_NEK2_1	697	702	PF00069	0.692
MOD_NEK2_1	88	93	PF00069	0.641
MOD_NEK2_2	273	278	PF00069	0.594
MOD_NEK2_2	380	385	PF00069	0.643
MOD_PIKK_1	13	19	PF00454	0.472
MOD_PIKK_1	296	302	PF00454	0.636
MOD_PIKK_1	324	330	PF00454	0.661
MOD_PIKK_1	478	484	PF00454	0.634
MOD_PIKK_1	543	549	PF00454	0.664
MOD_PKA_2	350	356	PF00069	0.479
MOD_PKA_2	690	696	PF00069	0.621
MOD_PKA_2	697	703	PF00069	0.585
MOD_PKA_2	712	718	PF00069	0.753
MOD_PKB_1	385	393	PF00069	0.368
MOD_Plk_1	240	246	PF00069	0.662
MOD_Plk_1	579	585	PF00069	0.768
MOD_Plk_1	680	686	PF00069	0.783
MOD_Plk_1	727	733	PF00069	0.649
MOD_Plk_4	142	148	PF00069	0.573
MOD_Plk_4	350	356	PF00069	0.479
MOD_Plk_4	514	520	PF00069	0.752
MOD_Plk_4	579	585	PF00069	0.768
MOD_Plk_4	587	593	PF00069	0.631
MOD_Plk_4	7	13	PF00069	0.640
MOD_Plk_4	730	736	PF00069	0.671
MOD_Plk_4	89	95	PF00069	0.643
MOD_ProDKin_1	231	237	PF00069	0.688
MOD_ProDKin_1	264	270	PF00069	0.579
MOD_ProDKin_1	291	297	PF00069	0.778
MOD_ProDKin_1	309	315	PF00069	0.308
MOD_ProDKin_1	41	47	PF00069	0.738
MOD_ProDKin_1	572	578	PF00069	0.686
MOD_ProDKin_1	591	597	PF00069	0.464
MOD_ProDKin_1	608	614	PF00069	0.483
MOD_ProDKin_1	66	72	PF00069	0.795
MOD_ProDKin_1	77	83	PF00069	0.616
TRG_DiLeu_BaEn_1	629	634	PF01217	0.706
TRG_ER_diArg_1	135	138	PF00400	0.516
TRG_ER_diArg_1	256	258	PF00400	0.609
TRG_ER_diArg_1	507	510	PF00400	0.742
TRG_ER_diArg_1	668	670	PF00400	0.785
TRG_Pf-PMV_PEXEL_1	498	502	PF00026	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8V5	Leptomonas seymouri	54%	99%
A0A3S7X7X6	Leishmania donovani	89%	99%
A4HAU0	Leishmania braziliensis	73%	100%
A4IA08	Leishmania infantum	89%	99%
Q4Q2X2	Leishmania major	89%	100%
V5B0G0	Trypanosoma cruzi	34%	100%