Endo/exonuclease/phosphatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Endonuclease/Exonuclease/phosphatase family, putative

Species:

Leishmania mexicana

UniProt:

E9B508_LEIMU

TriTrypDb:

LmxM.33.2220

Length:

704

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B508

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B508

Function

Biological processes
Term	Name	Level	Count
GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	6	1
GO:0000956	nuclear-transcribed mRNA catabolic process	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006401	RNA catabolic process	5	1
GO:0006402	mRNA catabolic process	6	1
GO:0006417	regulation of translation	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009890	negative regulation of biosynthetic process	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009894	regulation of catabolic process	4	1
GO:0009896	positive regulation of catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010558	negative regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0010629	negative regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0017148	negative regulation of translation	7	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031327	negative regulation of cellular biosynthetic process	6	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0031331	positive regulation of cellular catabolic process	6	1
GO:0034248	regulation of amide metabolic process	5	1
GO:0034249	negative regulation of amide metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043487	regulation of RNA stability	3	1
GO:0043488	regulation of mRNA stability	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0048518	positive regulation of biological process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050779	RNA destabilization	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051248	negative regulation of protein metabolic process	6	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051254	positive regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0061013	regulation of mRNA catabolic process	6	1
GO:0061014	positive regulation of mRNA catabolic process	7	1
GO:0061157	mRNA destabilization	5	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1903311	regulation of mRNA metabolic process	6	1
GO:1903313	positive regulation of mRNA metabolic process	7	1
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	1
GO:2000113	obsolete negative regulation of cellular macromolecule biosynthetic process	7	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0000175	3'-5'-RNA exonuclease activity	7	1
GO:0004518	nuclease activity	4	2
GO:0004527	exonuclease activity	5	2
GO:0004532	RNA exonuclease activity	5	1
GO:0004540	RNA nuclease activity	4	1
GO:0008408	3'-5' exonuclease activity	6	1
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1
GO:0004519	endonuclease activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	406	412	PF00089	0.316
CLV_NRD_NRD_1	320	322	PF00675	0.316
CLV_NRD_NRD_1	496	498	PF00675	0.381
CLV_NRD_NRD_1	565	567	PF00675	0.392
CLV_PCSK_FUR_1	492	496	PF00082	0.275
CLV_PCSK_KEX2_1	494	496	PF00082	0.382
CLV_PCSK_KEX2_1	570	572	PF00082	0.396
CLV_PCSK_KEX2_1	80	82	PF00082	0.548
CLV_PCSK_PC1ET2_1	570	572	PF00082	0.381
CLV_PCSK_PC1ET2_1	80	82	PF00082	0.536
CLV_PCSK_PC7_1	492	498	PF00082	0.290
CLV_PCSK_PC7_1	566	572	PF00082	0.409
CLV_PCSK_SKI1_1	286	290	PF00082	0.274
CLV_PCSK_SKI1_1	344	348	PF00082	0.322
CLV_PCSK_SKI1_1	417	421	PF00082	0.260
CLV_PCSK_SKI1_1	429	433	PF00082	0.292
CLV_PCSK_SKI1_1	515	519	PF00082	0.256
CLV_PCSK_SKI1_1	612	616	PF00082	0.325
CLV_PCSK_SKI1_1	66	70	PF00082	0.480
CLV_Separin_Metazoa	664	668	PF03568	0.398
DEG_Nend_UBRbox_3	1	3	PF02207	0.597
DEG_SCF_FBW7_2	228	235	PF00400	0.274
DOC_MAPK_MEF2A_6	239	247	PF00069	0.486
DOC_MAPK_MEF2A_6	60	69	PF00069	0.436
DOC_PP1_RVXF_1	531	537	PF00149	0.376
DOC_PP1_RVXF_1	64	70	PF00149	0.458
DOC_PP2B_LxvP_1	113	116	PF13499	0.521
DOC_PP2B_LxvP_1	266	269	PF13499	0.553
DOC_PP2B_LxvP_1	638	641	PF13499	0.434
DOC_PP2B_LxvP_1	68	71	PF13499	0.533
DOC_PP4_FxxP_1	681	684	PF00568	0.398
DOC_PP4_FxxP_1	69	72	PF00568	0.553
DOC_USP7_MATH_1	12	16	PF00917	0.453
DOC_USP7_MATH_1	185	189	PF00917	0.380
DOC_USP7_MATH_1	193	197	PF00917	0.417
DOC_USP7_MATH_1	422	426	PF00917	0.420
DOC_USP7_MATH_1	670	674	PF00917	0.393
DOC_USP7_MATH_1	72	76	PF00917	0.582
DOC_USP7_UBL2_3	570	574	PF12436	0.290
DOC_USP7_UBL2_3	80	84	PF12436	0.634
DOC_WW_Pin1_4	169	174	PF00397	0.511
DOC_WW_Pin1_4	228	233	PF00397	0.356
DOC_WW_Pin1_4	473	478	PF00397	0.342
DOC_WW_Pin1_4	578	583	PF00397	0.407
LIG_14-3-3_CanoR_1	131	139	PF00244	0.455
LIG_14-3-3_CanoR_1	244	248	PF00244	0.476
LIG_14-3-3_CanoR_1	286	291	PF00244	0.278
LIG_14-3-3_CanoR_1	515	522	PF00244	0.398
LIG_14-3-3_CanoR_1	99	106	PF00244	0.492
LIG_Actin_WH2_2	403	419	PF00022	0.314
LIG_APCC_ABBA_1	8	13	PF00400	0.469
LIG_APCC_ABBAyCdc20_2	602	608	PF00400	0.147
LIG_APCC_ABBAyCdc20_2	84	90	PF00400	0.503
LIG_BIR_III_2	478	482	PF00653	0.147
LIG_BRCT_BRCA1_1	187	191	PF00533	0.462
LIG_BRCT_BRCA1_1	399	403	PF00533	0.367
LIG_CtBP_PxDLS_1	486	490	PF00389	0.147
LIG_FHA_1	117	123	PF00498	0.540
LIG_FHA_1	17	23	PF00498	0.395
LIG_FHA_1	231	237	PF00498	0.405
LIG_FHA_1	274	280	PF00498	0.376
LIG_FHA_1	287	293	PF00498	0.272
LIG_FHA_1	310	316	PF00498	0.235
LIG_FHA_1	396	402	PF00498	0.194
LIG_FHA_1	41	47	PF00498	0.571
LIG_FHA_1	517	523	PF00498	0.374
LIG_FHA_1	582	588	PF00498	0.225
LIG_FHA_1	666	672	PF00498	0.263
LIG_FHA_2	581	587	PF00498	0.332
LIG_FHA_2	646	652	PF00498	0.296
LIG_FHA_2	80	86	PF00498	0.382
LIG_GBD_Chelix_1	695	703	PF00786	0.256
LIG_LIR_Apic_2	349	353	PF02991	0.381
LIG_LIR_Apic_2	678	684	PF02991	0.400
LIG_LIR_Gen_1	129	140	PF02991	0.547
LIG_LIR_Gen_1	200	209	PF02991	0.459
LIG_LIR_Gen_1	251	262	PF02991	0.394
LIG_LIR_Gen_1	289	297	PF02991	0.256
LIG_LIR_Gen_1	381	392	PF02991	0.319
LIG_LIR_Gen_1	639	649	PF02991	0.365
LIG_LIR_Gen_1	654	663	PF02991	0.212
LIG_LIR_Nem_3	129	135	PF02991	0.466
LIG_LIR_Nem_3	200	204	PF02991	0.375
LIG_LIR_Nem_3	289	293	PF02991	0.273
LIG_LIR_Nem_3	345	350	PF02991	0.318
LIG_LIR_Nem_3	381	387	PF02991	0.319
LIG_LIR_Nem_3	400	406	PF02991	0.462
LIG_LIR_Nem_3	511	517	PF02991	0.275
LIG_LIR_Nem_3	551	556	PF02991	0.147
LIG_LIR_Nem_3	639	645	PF02991	0.284
LIG_LIR_Nem_3	646	652	PF02991	0.271
LIG_LIR_Nem_3	654	658	PF02991	0.263
LIG_PCNA_yPIPBox_3	149	161	PF02747	0.357
LIG_Pex14_2	347	351	PF04695	0.387
LIG_Pex14_2	645	649	PF04695	0.398
LIG_PTB_Apo_2	138	145	PF02174	0.324
LIG_PTB_Apo_2	682	689	PF02174	0.272
LIG_PTB_Phospho_1	682	688	PF10480	0.272
LIG_SH2_CRK	162	166	PF00017	0.371
LIG_SH2_CRK	290	294	PF00017	0.256
LIG_SH2_CRK	360	364	PF00017	0.350
LIG_SH2_CRK	389	393	PF00017	0.210
LIG_SH2_CRK	463	467	PF00017	0.272
LIG_SH2_CRK	514	518	PF00017	0.272
LIG_SH2_NCK_1	162	166	PF00017	0.359
LIG_SH2_NCK_1	389	393	PF00017	0.252
LIG_SH2_PTP2	177	180	PF00017	0.337
LIG_SH2_STAP1	199	203	PF00017	0.273
LIG_SH2_STAP1	545	549	PF00017	0.147
LIG_SH2_STAT3	623	626	PF00017	0.342
LIG_SH2_STAT5	177	180	PF00017	0.303
LIG_SH2_STAT5	350	353	PF00017	0.321
LIG_SH2_STAT5	364	367	PF00017	0.195
LIG_SH2_STAT5	655	658	PF00017	0.303
LIG_SH3_3	118	124	PF00018	0.436
LIG_SH3_3	134	140	PF00018	0.383
LIG_SH3_3	170	176	PF00018	0.336
LIG_SH3_3	265	271	PF00018	0.468
LIG_SH3_3	277	283	PF00018	0.311
LIG_SH3_3	33	39	PF00018	0.693
LIG_SH3_3	478	484	PF00018	0.354
LIG_SH3_3	6	12	PF00018	0.367
LIG_SH3_3	666	672	PF00018	0.273
LIG_SH3_CIN85_PxpxPR_1	267	272	PF14604	0.400
LIG_SUMO_SIM_anti_2	186	191	PF11976	0.429
LIG_SUMO_SIM_anti_2	398	403	PF11976	0.147
LIG_SUMO_SIM_anti_2	659	668	PF11976	0.279
LIG_SUMO_SIM_anti_2	690	698	PF11976	0.301
LIG_SUMO_SIM_par_1	15	21	PF11976	0.388
LIG_SUMO_SIM_par_1	166	172	PF11976	0.545
LIG_SUMO_SIM_par_1	312	319	PF11976	0.261
LIG_TRAF2_1	51	54	PF00917	0.555
LIG_TYR_ITIM	175	180	PF00017	0.440
LIG_TYR_ITIM	288	293	PF00017	0.272
LIG_TYR_ITIM	387	392	PF00017	0.277
LIG_UBA3_1	315	322	PF00899	0.328
LIG_WW_3	70	74	PF00397	0.595
MOD_CK1_1	169	175	PF00069	0.528
MOD_CK1_1	205	211	PF00069	0.531
MOD_CK1_1	300	306	PF00069	0.295
MOD_CK1_1	421	427	PF00069	0.358
MOD_CK1_1	659	665	PF00069	0.357
MOD_CK1_1	75	81	PF00069	0.721
MOD_CK2_1	367	373	PF00069	0.401
MOD_CK2_1	434	440	PF00069	0.291
MOD_CK2_1	645	651	PF00069	0.297
MOD_CK2_1	670	676	PF00069	0.381
MOD_CK2_1	79	85	PF00069	0.415
MOD_GlcNHglycan	206	210	PF01048	0.640
MOD_GlcNHglycan	367	370	PF01048	0.330
MOD_GlcNHglycan	420	423	PF01048	0.404
MOD_GlcNHglycan	74	77	PF01048	0.592
MOD_GSK3_1	12	19	PF00069	0.411
MOD_GSK3_1	126	133	PF00069	0.615
MOD_GSK3_1	226	233	PF00069	0.515
MOD_GSK3_1	248	255	PF00069	0.414
MOD_GSK3_1	296	303	PF00069	0.363
MOD_GSK3_1	40	47	PF00069	0.630
MOD_GSK3_1	418	425	PF00069	0.366
MOD_GSK3_1	469	476	PF00069	0.282
MOD_GSK3_1	54	61	PF00069	0.484
MOD_GSK3_1	576	583	PF00069	0.378
MOD_GSK3_1	636	643	PF00069	0.414
MOD_GSK3_1	71	78	PF00069	0.686
MOD_N-GLC_1	126	131	PF02516	0.361
MOD_N-GLC_1	153	158	PF02516	0.468
MOD_N-GLC_1	365	370	PF02516	0.350
MOD_N-GLC_1	469	474	PF02516	0.147
MOD_N-GLC_1	505	510	PF02516	0.256
MOD_N-GLC_1	643	648	PF02516	0.291
MOD_N-GLC_2	453	455	PF02516	0.256
MOD_NEK2_1	297	302	PF00069	0.305
MOD_NEK2_1	379	384	PF00069	0.352
MOD_NEK2_1	432	437	PF00069	0.454
MOD_NEK2_1	469	474	PF00069	0.171
MOD_NEK2_1	505	510	PF00069	0.289
MOD_NEK2_1	516	521	PF00069	0.272
MOD_NEK2_1	645	650	PF00069	0.377
MOD_NEK2_1	699	704	PF00069	0.432
MOD_PIKK_1	12	18	PF00454	0.485
MOD_PK_1	258	264	PF00069	0.311
MOD_PK_1	367	373	PF00069	0.398
MOD_PKA_1	80	86	PF00069	0.496
MOD_PKA_2	130	136	PF00069	0.458
MOD_PKA_2	211	217	PF00069	0.419
MOD_PKA_2	243	249	PF00069	0.472
MOD_PKA_2	379	385	PF00069	0.318
MOD_PKA_2	432	438	PF00069	0.434
MOD_PKA_2	72	78	PF00069	0.603
MOD_PKA_2	80	86	PF00069	0.547
MOD_PKA_2	98	104	PF00069	0.519
MOD_PKB_1	610	618	PF00069	0.147
MOD_Plk_1	153	159	PF00069	0.395
MOD_Plk_1	185	191	PF00069	0.437
MOD_Plk_1	20	26	PF00069	0.447
MOD_Plk_1	274	280	PF00069	0.240
MOD_Plk_1	469	475	PF00069	0.468
MOD_Plk_1	636	642	PF00069	0.333
MOD_Plk_1	643	649	PF00069	0.274
MOD_Plk_1	659	665	PF00069	0.291
MOD_Plk_2-3	434	440	PF00069	0.277
MOD_Plk_2-3	525	531	PF00069	0.290
MOD_Plk_4	117	123	PF00069	0.407
MOD_Plk_4	153	159	PF00069	0.356
MOD_Plk_4	163	169	PF00069	0.393
MOD_Plk_4	185	191	PF00069	0.370
MOD_Plk_4	258	264	PF00069	0.311
MOD_Plk_4	275	281	PF00069	0.216
MOD_Plk_4	346	352	PF00069	0.299
MOD_Plk_4	397	403	PF00069	0.436
MOD_Plk_4	470	476	PF00069	0.383
MOD_ProDKin_1	169	175	PF00069	0.508
MOD_ProDKin_1	228	234	PF00069	0.360
MOD_ProDKin_1	473	479	PF00069	0.342
MOD_ProDKin_1	578	584	PF00069	0.407
MOD_SUMO_rev_2	47	57	PF00179	0.497
TRG_DiLeu_BaEn_2	372	378	PF01217	0.398
TRG_DiLeu_BaEn_4	108	114	PF01217	0.472
TRG_DiLeu_BaLyEn_6	121	126	PF01217	0.304
TRG_DiLeu_BaLyEn_6	512	517	PF01217	0.398
TRG_DiLeu_BaLyEn_6	538	543	PF01217	0.350
TRG_DiLeu_BaLyEn_6	63	68	PF01217	0.454
TRG_ENDOCYTIC_2	177	180	PF00928	0.356
TRG_ENDOCYTIC_2	282	285	PF00928	0.364
TRG_ENDOCYTIC_2	290	293	PF00928	0.256
TRG_ENDOCYTIC_2	294	297	PF00928	0.261
TRG_ENDOCYTIC_2	360	363	PF00928	0.350
TRG_ENDOCYTIC_2	389	392	PF00928	0.201
TRG_ENDOCYTIC_2	463	466	PF00928	0.272
TRG_ENDOCYTIC_2	514	517	PF00928	0.256
TRG_ENDOCYTIC_2	655	658	PF00928	0.272
TRG_ER_diArg_1	492	495	PF00400	0.290
TRG_ER_diArg_1	496	498	PF00400	0.256
TRG_ER_diArg_1	64	67	PF00400	0.432
TRG_NES_CRM1_1	328	341	PF08389	0.212
TRG_NES_CRM1_1	661	674	PF08389	0.342
TRG_Pf-PMV_PEXEL_1	541	546	PF00026	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IC26	Leptomonas seymouri	62%	99%
A0A0S4J452	Bodo saltans	32%	100%
A0A1X0PAG3	Trypanosomatidae	44%	100%
A0A3R7LBT2	Trypanosoma rangeli	44%	100%
A0A3S7X813	Leishmania donovani	91%	100%
A4HAT4	Leishmania braziliensis	79%	100%
A4I9Z4	Leishmania infantum	90%	85%
C9ZMN4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
Q08DF7	Bos taurus	24%	100%
Q3TIU4	Mus musculus	25%	100%
Q4Q2X8	Leishmania major	90%	100%
Q6AXQ5	Rattus norvegicus	24%	100%
Q8W0Z9	Arabidopsis thaliana	25%	100%
V5DGT6	Trypanosoma cruzi	41%	100%