Thioredoxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

thioredoxin, putative

Species:

Leishmania mexicana

UniProt:

E9B506_LEIMU

TriTrypDb:

LmxM.33.2200

Length:

433

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 1
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005788	endoplasmic reticulum lumen	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B506

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B506

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	1
GO:0009987	cellular process	1	1
GO:0033554	cellular response to stress	3	1
GO:0034976	response to endoplasmic reticulum stress	4	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1

Molecular functions
Term	Name	Level	Count
GO:0003756	protein disulfide isomerase activity	3	11
GO:0003824	catalytic activity	1	11
GO:0016853	isomerase activity	2	11
GO:0016860	intramolecular oxidoreductase activity	3	11
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	4	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:0015035	protein-disulfide reductase activity	3	1
GO:0015036	disulfide oxidoreductase activity	4	1
GO:0016491	oxidoreductase activity	2	1
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	403	407	PF00656	0.556
CLV_NRD_NRD_1	316	318	PF00675	0.623
CLV_PCSK_SKI1_1	146	150	PF00082	0.497
CLV_PCSK_SKI1_1	253	257	PF00082	0.443
CLV_PCSK_SKI1_1	398	402	PF00082	0.536
DEG_Nend_UBRbox_4	1	3	PF02207	0.596
DOC_MAPK_gen_1	165	172	PF00069	0.476
DOC_MAPK_gen_1	190	198	PF00069	0.572
DOC_MAPK_gen_1	317	327	PF00069	0.562
DOC_MAPK_MEF2A_6	165	172	PF00069	0.588
DOC_MAPK_MEF2A_6	190	198	PF00069	0.604
DOC_MAPK_MEF2A_6	290	298	PF00069	0.687
DOC_MAPK_MEF2A_6	344	351	PF00069	0.575
DOC_PP4_FxxP_1	311	314	PF00568	0.501
DOC_PP4_FxxP_1	58	61	PF00568	0.385
DOC_PP4_MxPP_1	372	375	PF00568	0.507
DOC_USP7_MATH_1	133	137	PF00917	0.458
DOC_USP7_MATH_1	270	274	PF00917	0.684
DOC_USP7_MATH_1	378	382	PF00917	0.622
DOC_USP7_UBL2_3	206	210	PF12436	0.461
DOC_WW_Pin1_4	185	190	PF00397	0.492
DOC_WW_Pin1_4	200	205	PF00397	0.498
DOC_WW_Pin1_4	223	228	PF00397	0.633
DOC_WW_Pin1_4	301	306	PF00397	0.564
DOC_WW_Pin1_4	320	325	PF00397	0.589
DOC_WW_Pin1_4	37	42	PF00397	0.345
LIG_14-3-3_CanoR_1	290	298	PF00244	0.741
LIG_14-3-3_CanoR_1	3	12	PF00244	0.618
LIG_14-3-3_CanoR_1	32	39	PF00244	0.588
LIG_Actin_WH2_2	210	226	PF00022	0.614
LIG_Clathr_ClatBox_1	348	352	PF01394	0.479
LIG_FHA_1	114	120	PF00498	0.482
LIG_FHA_1	302	308	PF00498	0.527
LIG_FHA_1	314	320	PF00498	0.561
LIG_FHA_1	377	383	PF00498	0.623
LIG_FHA_1	81	87	PF00498	0.404
LIG_FHA_2	149	155	PF00498	0.643
LIG_FHA_2	224	230	PF00498	0.537
LIG_HP1_1	53	57	PF01393	0.497
LIG_LIR_Apic_2	309	314	PF02991	0.537
LIG_LIR_Gen_1	396	405	PF02991	0.453
LIG_LIR_Gen_1	72	80	PF02991	0.370
LIG_LIR_Nem_3	245	251	PF02991	0.486
LIG_LIR_Nem_3	396	402	PF02991	0.446
LIG_LIR_Nem_3	72	76	PF02991	0.370
LIG_PCNA_yPIPBox_3	210	223	PF02747	0.586
LIG_Pex14_2	58	62	PF04695	0.385
LIG_SH2_CRK	248	252	PF00017	0.369
LIG_SH2_NCK_1	225	229	PF00017	0.628
LIG_SH2_NCK_1	248	252	PF00017	0.437
LIG_SH2_SRC	248	251	PF00017	0.433
LIG_SH2_STAP1	73	77	PF00017	0.446
LIG_SH2_STAT3	125	128	PF00017	0.497
LIG_SH2_STAT5	225	228	PF00017	0.614
LIG_SH2_STAT5	303	306	PF00017	0.621
LIG_SH2_STAT5	342	345	PF00017	0.642
LIG_SH3_3	294	300	PF00018	0.540
LIG_SUMO_SIM_anti_2	385	390	PF11976	0.555
LIG_TYR_ITIM	246	251	PF00017	0.451
LIG_TYR_ITIM	397	402	PF00017	0.483
LIG_UBA3_1	167	175	PF00899	0.592
LIG_UBA3_1	181	190	PF00899	0.573
LIG_WRC_WIRS_1	308	313	PF05994	0.337
MOD_CDC14_SPxK_1	203	206	PF00782	0.473
MOD_CDK_SPK_2	185	190	PF00069	0.516
MOD_CDK_SPK_2	301	306	PF00069	0.594
MOD_CDK_SPxK_1	200	206	PF00069	0.463
MOD_CDK_SPxxK_3	185	192	PF00069	0.516
MOD_CK1_1	118	124	PF00069	0.497
MOD_CK1_1	264	270	PF00069	0.723
MOD_CK1_1	289	295	PF00069	0.513
MOD_CK1_1	34	40	PF00069	0.501
MOD_CK1_1	392	398	PF00069	0.599
MOD_CK1_1	4	10	PF00069	0.753
MOD_CK2_1	148	154	PF00069	0.604
MOD_CK2_1	223	229	PF00069	0.520
MOD_CK2_1	262	268	PF00069	0.601
MOD_CK2_1	326	332	PF00069	0.571
MOD_GlcNHglycan	113	116	PF01048	0.537
MOD_GlcNHglycan	172	175	PF01048	0.496
MOD_GlcNHglycan	264	267	PF01048	0.715
MOD_GlcNHglycan	33	36	PF01048	0.486
MOD_GlcNHglycan	6	9	PF01048	0.742
MOD_GSK3_1	111	118	PF00069	0.529
MOD_GSK3_1	142	149	PF00069	0.532
MOD_GSK3_1	282	289	PF00069	0.623
MOD_GSK3_1	30	37	PF00069	0.614
MOD_GSK3_1	378	385	PF00069	0.635
MOD_GSK3_1	389	396	PF00069	0.534
MOD_GSK3_1	76	83	PF00069	0.428
MOD_LATS_1	391	397	PF00433	0.457
MOD_NEK2_1	1	6	PF00069	0.713
MOD_NEK2_1	148	153	PF00069	0.590
MOD_NEK2_1	198	203	PF00069	0.539
MOD_NEK2_1	21	26	PF00069	0.633
MOD_NEK2_1	212	217	PF00069	0.486
MOD_NEK2_1	351	356	PF00069	0.534
MOD_NEK2_1	382	387	PF00069	0.586
MOD_NEK2_1	389	394	PF00069	0.533
MOD_NEK2_1	47	52	PF00069	0.364
MOD_NEK2_1	76	81	PF00069	0.404
MOD_PIKK_1	119	125	PF00454	0.541
MOD_PIKK_1	212	218	PF00454	0.626
MOD_PIKK_1	351	357	PF00454	0.607
MOD_PK_1	290	296	PF00069	0.692
MOD_PKA_2	2	8	PF00069	0.692
MOD_PKA_2	289	295	PF00069	0.775
MOD_PKA_2	31	37	PF00069	0.553
MOD_PKA_2	389	395	PF00069	0.517
MOD_Plk_4	133	139	PF00069	0.465
MOD_Plk_4	382	388	PF00069	0.625
MOD_ProDKin_1	185	191	PF00069	0.486
MOD_ProDKin_1	200	206	PF00069	0.504
MOD_ProDKin_1	223	229	PF00069	0.642
MOD_ProDKin_1	301	307	PF00069	0.558
MOD_ProDKin_1	320	326	PF00069	0.580
MOD_ProDKin_1	37	43	PF00069	0.345
MOD_SUMO_rev_2	229	236	PF00179	0.568
TRG_DiLeu_BaEn_3	233	239	PF01217	0.566
TRG_DiLeu_BaLyEn_6	344	349	PF01217	0.519
TRG_ENDOCYTIC_2	248	251	PF00928	0.433
TRG_ENDOCYTIC_2	399	402	PF00928	0.506
TRG_ENDOCYTIC_2	73	76	PF00928	0.526
TRG_NES_CRM1_1	358	371	PF08389	0.544
TRG_NLS_MonoExtN_4	314	321	PF00514	0.665
TRG_Pf-PMV_PEXEL_1	417	422	PF00026	0.599

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Y0	Leptomonas seymouri	58%	95%
A0A0S4J6N7	Bodo saltans	35%	99%
A0A1X0PAY2	Trypanosomatidae	41%	100%
A0A3Q8IL31	Leishmania donovani	93%	100%
A4HAT2	Leishmania braziliensis	75%	100%
A4I9Z2	Leishmania infantum	93%	100%
C9ZMN6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
Q4Q2Y0	Leishmania major	92%	100%
V5BFX1	Trypanosoma cruzi	40%	98%