Putative dual specificity protein phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinatase, putative

Species:

Leishmania mexicana

UniProt:

E9B505_LEIMU

TriTrypDb:

LmxM.33.2190

Length:

1382

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7

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Expansion

Sequence features

E9B505

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006470	protein dephosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009966	regulation of signal transduction	4	1
GO:0009968	negative regulation of signal transduction	5	1
GO:0009987	cellular process	1	7
GO:0010646	regulation of cell communication	4	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0004721	phosphoprotein phosphatase activity	3	7
GO:0004725	protein tyrosine phosphatase activity	4	6
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	4	7
GO:0008330	protein tyrosine/threonine phosphatase activity	4	1
GO:0016301	kinase activity	4	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1054	1058	PF00656	0.472
CLV_C14_Caspase3-7	1066	1070	PF00656	0.333
CLV_C14_Caspase3-7	1100	1104	PF00656	0.467
CLV_C14_Caspase3-7	3	7	PF00656	0.414
CLV_C14_Caspase3-7	41	45	PF00656	0.461
CLV_C14_Caspase3-7	616	620	PF00656	0.487
CLV_C14_Caspase3-7	724	728	PF00656	0.580
CLV_NRD_NRD_1	1042	1044	PF00675	0.411
CLV_NRD_NRD_1	106	108	PF00675	0.372
CLV_NRD_NRD_1	1247	1249	PF00675	0.411

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9A1	Leptomonas seymouri	68%	85%
A0A3Q8IH90	Leishmania donovani	93%	100%
A4HAT1	Leishmania braziliensis	79%	100%
A4I9Z1	Leishmania infantum	92%	100%
Q4Q2Y1	Leishmania major	91%	100%

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