Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B502_LEIMU

TriTrypDb:

LmxM.33.2160

Length:

491

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B502

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B502

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	162	166	PF00656	0.650
CLV_MEL_PAP_1	407	413	PF00089	0.535
CLV_NRD_NRD_1	120	122	PF00675	0.700
CLV_NRD_NRD_1	425	427	PF00675	0.466
CLV_NRD_NRD_1	63	65	PF00675	0.469
CLV_NRD_NRD_1	80	82	PF00675	0.543
CLV_NRD_NRD_1	86	88	PF00675	0.585
CLV_PCSK_FUR_1	61	65	PF00082	0.566
CLV_PCSK_KEX2_1	120	122	PF00082	0.756
CLV_PCSK_KEX2_1	425	427	PF00082	0.614
CLV_PCSK_KEX2_1	63	65	PF00082	0.469
CLV_PCSK_KEX2_1	79	81	PF00082	0.530
CLV_PCSK_KEX2_1	86	88	PF00082	0.542
CLV_PCSK_KEX2_1	99	101	PF00082	0.428
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.699
CLV_PCSK_SKI1_1	404	408	PF00082	0.545
CLV_PCSK_SKI1_1	426	430	PF00082	0.502
CLV_PCSK_SKI1_1	432	436	PF00082	0.505
DEG_APCC_DBOX_1	186	194	PF00400	0.587
DEG_APCC_DBOX_1	340	348	PF00400	0.638
DEG_SCF_FBW7_1	470	475	PF00400	0.553
DEG_SPOP_SBC_1	152	156	PF00917	0.564
DEG_SPOP_SBC_1	472	476	PF00917	0.709
DOC_CYCLIN_RxL_1	11	19	PF00134	0.413
DOC_CYCLIN_RxL_1	183	194	PF00134	0.629
DOC_CYCLIN_RxL_1	401	408	PF00134	0.580
DOC_MAPK_FxFP_2	216	219	PF00069	0.589
DOC_MAPK_gen_1	120	128	PF00069	0.598
DOC_MAPK_gen_1	173	181	PF00069	0.533
DOC_MAPK_gen_1	251	260	PF00069	0.659
DOC_MAPK_gen_1	79	85	PF00069	0.588
DOC_MAPK_MEF2A_6	121	130	PF00069	0.606
DOC_MAPK_MEF2A_6	14	22	PF00069	0.608
DOC_PP4_FxxP_1	216	219	PF00568	0.574
DOC_USP7_MATH_1	152	156	PF00917	0.733
DOC_USP7_MATH_1	229	233	PF00917	0.562
DOC_USP7_MATH_1	297	301	PF00917	0.640
DOC_USP7_MATH_2	122	128	PF00917	0.692
DOC_USP7_UBL2_3	197	201	PF12436	0.550
DOC_WW_Pin1_4	103	108	PF00397	0.650
DOC_WW_Pin1_4	115	120	PF00397	0.666
DOC_WW_Pin1_4	2	7	PF00397	0.514
DOC_WW_Pin1_4	405	410	PF00397	0.572
DOC_WW_Pin1_4	451	456	PF00397	0.403
DOC_WW_Pin1_4	468	473	PF00397	0.663
LIG_14-3-3_CanoR_1	100	107	PF00244	0.661
LIG_14-3-3_CanoR_1	110	115	PF00244	0.767
LIG_14-3-3_CanoR_1	125	129	PF00244	0.722
LIG_14-3-3_CanoR_1	183	187	PF00244	0.556
LIG_14-3-3_CanoR_1	353	357	PF00244	0.606
LIG_14-3-3_CanoR_1	410	414	PF00244	0.537
LIG_14-3-3_CanoR_1	86	90	PF00244	0.589
LIG_AP2alpha_2	214	216	PF02296	0.578
LIG_APCC_ABBA_1	20	25	PF00400	0.607
LIG_BRCT_BRCA1_1	407	411	PF00533	0.619
LIG_Clathr_ClatBox_1	190	194	PF01394	0.637
LIG_DLG_GKlike_1	110	118	PF00625	0.664
LIG_FHA_1	144	150	PF00498	0.633
LIG_FHA_1	480	486	PF00498	0.653
LIG_FHA_2	272	278	PF00498	0.625
LIG_FHA_2	41	47	PF00498	0.588
LIG_Integrin_RGD_1	487	489	PF01839	0.446
LIG_LIR_Apic_2	214	219	PF02991	0.541
LIG_LIR_Gen_1	377	386	PF02991	0.623
LIG_LIR_Gen_1	412	419	PF02991	0.640
LIG_LIR_Nem_3	377	381	PF02991	0.661
LIG_LIR_Nem_3	412	416	PF02991	0.654
LIG_MAD2	211	219	PF02301	0.630
LIG_NRBOX	432	438	PF00104	0.464
LIG_NRBOX	54	60	PF00104	0.438
LIG_PCNA_yPIPBox_3	425	437	PF02747	0.614
LIG_Rb_pABgroove_1	342	350	PF01858	0.619
LIG_SH2_STAP1	318	322	PF00017	0.511
LIG_SH2_STAP1	348	352	PF00017	0.662
LIG_SH3_3	116	122	PF00018	0.700
LIG_SH3_3	129	135	PF00018	0.657
LIG_SH3_3	209	215	PF00018	0.574
LIG_SH3_3	435	441	PF00018	0.430
LIG_SUMO_SIM_anti_2	274	280	PF11976	0.671
LIG_SUMO_SIM_anti_2	45	52	PF11976	0.509
LIG_SUMO_SIM_anti_2	7	14	PF11976	0.624
LIG_SUMO_SIM_par_1	37	43	PF11976	0.571
LIG_TRAF2_1	135	138	PF00917	0.749
LIG_TRAF2_1	332	335	PF00917	0.391
LIG_TRAF2_1	428	431	PF00917	0.562
LIG_UBA3_1	190	197	PF00899	0.617
MOD_CDK_SPK_2	115	120	PF00069	0.744
MOD_CDK_SPK_2	405	410	PF00069	0.542
MOD_CDK_SPK_2	451	456	PF00069	0.403
MOD_CDK_SPxK_1	115	121	PF00069	0.673
MOD_CDK_SPxxK_3	103	110	PF00069	0.642
MOD_CDK_SPxxK_3	451	458	PF00069	0.397
MOD_CK1_1	108	114	PF00069	0.635
MOD_CK1_1	142	148	PF00069	0.741
MOD_CK1_1	150	156	PF00069	0.697
MOD_CK1_1	231	237	PF00069	0.650
MOD_CK1_1	249	255	PF00069	0.602
MOD_CK1_1	304	310	PF00069	0.593
MOD_CK1_1	324	330	PF00069	0.652
MOD_CK1_1	5	11	PF00069	0.679
MOD_CK2_1	352	358	PF00069	0.666
MOD_CK2_1	40	46	PF00069	0.604
MOD_CK2_1	72	78	PF00069	0.519
MOD_GlcNHglycan	110	113	PF01048	0.678
MOD_GlcNHglycan	141	144	PF01048	0.743
MOD_GlcNHglycan	251	254	PF01048	0.565
MOD_GlcNHglycan	287	290	PF01048	0.568
MOD_GlcNHglycan	305	309	PF01048	0.635
MOD_GlcNHglycan	323	327	PF01048	0.628
MOD_GlcNHglycan	7	10	PF01048	0.632
MOD_GSK3_1	1	8	PF00069	0.596
MOD_GSK3_1	101	108	PF00069	0.641
MOD_GSK3_1	139	146	PF00069	0.679
MOD_GSK3_1	147	154	PF00069	0.659
MOD_GSK3_1	159	166	PF00069	0.535
MOD_GSK3_1	228	235	PF00069	0.652
MOD_GSK3_1	252	259	PF00069	0.762
MOD_GSK3_1	262	269	PF00069	0.632
MOD_GSK3_1	297	304	PF00069	0.647
MOD_GSK3_1	321	328	PF00069	0.661
MOD_GSK3_1	385	392	PF00069	0.643
MOD_GSK3_1	405	412	PF00069	0.379
MOD_GSK3_1	468	475	PF00069	0.595
MOD_GSK3_1	85	92	PF00069	0.528
MOD_N-GLC_1	108	113	PF02516	0.789
MOD_N-GLC_1	271	276	PF02516	0.596
MOD_N-GLC_1	301	306	PF02516	0.641
MOD_NEK2_1	1	6	PF00069	0.735
MOD_NEK2_1	16	21	PF00069	0.553
MOD_NEK2_1	298	303	PF00069	0.614
MOD_NEK2_1	322	327	PF00069	0.529
MOD_NEK2_1	65	70	PF00069	0.578
MOD_NEK2_1	85	90	PF00069	0.593
MOD_PIKK_1	234	240	PF00454	0.639
MOD_PIKK_1	385	391	PF00454	0.602
MOD_PIKK_1	72	78	PF00454	0.595
MOD_PIKK_1	90	96	PF00454	0.615
MOD_PKA_2	124	130	PF00069	0.653
MOD_PKA_2	182	188	PF00069	0.523
MOD_PKA_2	232	238	PF00069	0.683
MOD_PKA_2	285	291	PF00069	0.550
MOD_PKA_2	340	346	PF00069	0.622
MOD_PKA_2	352	358	PF00069	0.509
MOD_PKA_2	368	374	PF00069	0.502
MOD_PKA_2	409	415	PF00069	0.533
MOD_PKA_2	85	91	PF00069	0.606
MOD_Plk_1	256	262	PF00069	0.678
MOD_Plk_2-3	124	130	PF00069	0.654
MOD_Plk_2-3	163	169	PF00069	0.551
MOD_Plk_4	110	116	PF00069	0.570
MOD_Plk_4	266	272	PF00069	0.578
MOD_Plk_4	368	374	PF00069	0.553
MOD_Plk_4	479	485	PF00069	0.671
MOD_ProDKin_1	103	109	PF00069	0.652
MOD_ProDKin_1	115	121	PF00069	0.665
MOD_ProDKin_1	2	8	PF00069	0.506
MOD_ProDKin_1	405	411	PF00069	0.566
MOD_ProDKin_1	451	457	PF00069	0.400
MOD_ProDKin_1	468	474	PF00069	0.663
MOD_SUMO_rev_2	355	361	PF00179	0.704
MOD_SUMO_rev_2	412	422	PF00179	0.557
TRG_DiLeu_BaEn_1	54	59	PF01217	0.556
TRG_ER_diArg_1	119	121	PF00400	0.455
TRG_ER_diArg_1	425	427	PF00400	0.397
TRG_ER_diArg_1	61	64	PF00400	0.479
TRG_ER_diArg_1	79	81	PF00400	0.584
TRG_ER_diArg_1	85	87	PF00400	0.608
TRG_NES_CRM1_1	11	25	PF08389	0.614
TRG_Pf-PMV_PEXEL_1	420	424	PF00026	0.571
TRG_Pf-PMV_PEXEL_1	435	439	PF00026	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PED0	Leptomonas seymouri	57%	100%
A0A0S4J9S2	Bodo saltans	26%	98%
A0A1X0P9K0	Trypanosomatidae	30%	100%
A0A3Q8INC5	Leishmania donovani	88%	100%
A0A422NY19	Trypanosoma rangeli	31%	100%
A4HAS8	Leishmania braziliensis	75%	100%
A4I9Y8	Leishmania infantum	89%	100%
C9ZMP0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
Q4Q2Y4	Leishmania major	88%	100%
V5BPZ9	Trypanosoma cruzi	31%	97%