Ubiquitin-like protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin-like protein

Species:

Leishmania mexicana

UniProt:

E9B4Z8_LEIMU

TriTrypDb:

LmxM.33.2125

Length:

Annotations

Annotations by Jardim et al.

Protein modification, Ubiquitin-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

E9B4Z8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4Z8

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0019222	regulation of metabolic process	3	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030162	regulation of proteolysis	6	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0045116	protein neddylation	7	1
GO:0050789	regulation of biological process	2	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0031386	protein tag	1	1
GO:0031625	ubiquitin protein ligase binding	5	1
GO:0044389	ubiquitin-like protein ligase binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	50	52	PF00675	0.318
DEG_SPOP_SBC_1	7	11	PF00917	0.401
LIG_14-3-3_CanoR_1	14	20	PF00244	0.487
LIG_Actin_WH2_2	61	79	PF00022	0.518
LIG_FHA_1	34	40	PF00498	0.518
LIG_FHA_2	23	29	PF00498	0.444
LIG_FHA_2	56	62	PF00498	0.518
LIG_LIR_Nem_3	2	8	PF02991	0.436
LIG_NRP_CendR_1	77	80	PF00754	0.571
LIG_SH3_3	16	22	PF00018	0.518
LIG_SUMO_SIM_anti_2	16	21	PF11976	0.518
LIG_TRAF2_1	58	61	PF00917	0.518
MOD_CK1_1	6	12	PF00069	0.401
MOD_CK2_1	55	61	PF00069	0.518
MOD_Cter_Amidation	49	52	PF01082	0.296
MOD_GlcNHglycan	48	51	PF01048	0.311
MOD_GSK3_1	3	10	PF00069	0.443
MOD_N-GLC_1	55	60	PF02516	0.318
MOD_NEK2_1	1	6	PF00069	0.489
MOD_NEK2_1	46	51	PF00069	0.498
MOD_PKA_2	13	19	PF00069	0.518
MOD_Plk_1	22	28	PF00069	0.434
MOD_Plk_1	55	61	PF00069	0.518
MOD_Plk_2-3	55	61	PF00069	0.518
MOD_SUMO_for_1	31	34	PF00179	0.490
MOD_SUMO_rev_2	23	31	PF00179	0.518
TRG_Pf-PMV_PEXEL_1	51	55	PF00026	0.318

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAA2	Leptomonas seymouri	97%	100%
A0A0S4JFN2	Bodo saltans	41%	100%
A0A3Q8IFJ6	Leishmania donovani	100%	100%
A0A3S5IS95	Trypanosoma rangeli	48%	72%
A0A422N1A4	Trypanosoma rangeli	38%	72%
A4HAS4	Leishmania braziliensis	99%	100%
A4IAM5	Leishmania infantum	100%	100%
C9ZMP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9ATD2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
O14399	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
P16709	Autographa californica nuclear polyhedrosis virus	41%	100%
P19848	Coprinellus congregatus	40%	100%
P61282	Bos taurus	37%	99%
P62975	Oryctolagus cuniculus	40%	100%
P68197	Ceratitis capitata	40%	100%
P69310	Avena sativa	40%	100%
P69313	Helianthus annuus	40%	100%
P69317	Lupinus polyphyllus	40%	100%
P69326	Triticum aestivum	39%	100%
P84589	Lumbricus terrestris	41%	100%
Q05120	Orgyia pseudotsugata multicapsid polyhedrosis virus	40%	86%
Q15843	Homo sapiens	37%	99%
Q4PLJ0	Oryctolagus cuniculus	37%	99%
Q4Q2Y8	Leishmania major	99%	100%
Q54XV3	Dictyostelium discoideum	35%	100%
Q865C5	Camelus dromedarius	40%	100%
Q8SWD4	Encephalitozoon cuniculi (strain GB-M1)	38%	100%
Q93725	Caenorhabditis elegans	35%	100%
Q9VJ33	Drosophila melanogaster	36%	95%
V5BFY9	Trypanosoma cruzi	47%	100%