Putative cardiolipin synthetase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cardiolipin synthetase, putative

Species:

Leishmania mexicana

UniProt:

E9B4Z6_LEIMU

TriTrypDb:

LmxM.33.2110

Length:

752

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0020023	kinetoplast	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B4Z6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4Z6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0016740	transferase activity	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	742	746	PF00656	0.639
CLV_NRD_NRD_1	180	182	PF00675	0.494
CLV_NRD_NRD_1	22	24	PF00675	0.684
CLV_NRD_NRD_1	248	250	PF00675	0.409
CLV_NRD_NRD_1	314	316	PF00675	0.617
CLV_NRD_NRD_1	326	328	PF00675	0.637
CLV_NRD_NRD_1	349	351	PF00675	0.596
CLV_NRD_NRD_1	353	355	PF00675	0.633
CLV_NRD_NRD_1	498	500	PF00675	0.589
CLV_NRD_NRD_1	505	507	PF00675	0.563
CLV_NRD_NRD_1	526	528	PF00675	0.509
CLV_NRD_NRD_1	572	574	PF00675	0.435
CLV_NRD_NRD_1	577	579	PF00675	0.361
CLV_NRD_NRD_1	589	591	PF00675	0.255
CLV_NRD_NRD_1	601	603	PF00675	0.326
CLV_PCSK_KEX2_1	107	109	PF00082	0.608
CLV_PCSK_KEX2_1	180	182	PF00082	0.499
CLV_PCSK_KEX2_1	22	24	PF00082	0.684
CLV_PCSK_KEX2_1	240	242	PF00082	0.546
CLV_PCSK_KEX2_1	314	316	PF00082	0.660
CLV_PCSK_KEX2_1	326	328	PF00082	0.694
CLV_PCSK_KEX2_1	348	350	PF00082	0.595
CLV_PCSK_KEX2_1	353	355	PF00082	0.628
CLV_PCSK_KEX2_1	498	500	PF00082	0.619
CLV_PCSK_KEX2_1	505	507	PF00082	0.565
CLV_PCSK_KEX2_1	518	520	PF00082	0.431
CLV_PCSK_KEX2_1	526	528	PF00082	0.501
CLV_PCSK_KEX2_1	577	579	PF00082	0.391
CLV_PCSK_KEX2_1	601	603	PF00082	0.372
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.608
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.531
CLV_PCSK_PC1ET2_1	518	520	PF00082	0.618
CLV_PCSK_PC7_1	18	24	PF00082	0.674
CLV_PCSK_PC7_1	349	355	PF00082	0.510
CLV_PCSK_PC7_1	573	579	PF00082	0.438
CLV_PCSK_SKI1_1	156	160	PF00082	0.534
CLV_PCSK_SKI1_1	223	227	PF00082	0.471
CLV_PCSK_SKI1_1	249	253	PF00082	0.415
CLV_PCSK_SKI1_1	326	330	PF00082	0.750
CLV_PCSK_SKI1_1	37	41	PF00082	0.690
CLV_PCSK_SKI1_1	499	503	PF00082	0.574
CLV_PCSK_SKI1_1	506	510	PF00082	0.536
CLV_PCSK_SKI1_1	590	594	PF00082	0.376
DEG_COP1_1	532	539	PF00400	0.601
DEG_MDM2_SWIB_1	115	123	PF02201	0.425
DEG_MDM2_SWIB_1	148	155	PF02201	0.404
DOC_CDC14_PxL_1	525	533	PF14671	0.650
DOC_CKS1_1	581	586	PF01111	0.357
DOC_CYCLIN_RxL_1	246	257	PF00134	0.493
DOC_CYCLIN_RxL_1	587	594	PF00134	0.391
DOC_CYCLIN_RxL_1	709	720	PF00134	0.456
DOC_CYCLIN_yClb5_NLxxxL_5	670	679	PF00134	0.438
DOC_CYCLIN_yCln2_LP_2	476	482	PF00134	0.715
DOC_MAPK_gen_1	246	254	PF00069	0.399
DOC_MAPK_gen_1	35	43	PF00069	0.470
DOC_MAPK_gen_1	372	380	PF00069	0.676
DOC_MAPK_gen_1	573	581	PF00069	0.430
DOC_MAPK_gen_1	601	608	PF00069	0.415
DOC_MAPK_gen_1	631	639	PF00069	0.492
DOC_MAPK_gen_1	710	718	PF00069	0.412
DOC_MAPK_MEF2A_6	601	608	PF00069	0.391
DOC_MAPK_MEF2A_6	710	718	PF00069	0.448
DOC_PP1_RVXF_1	159	165	PF00149	0.478
DOC_PP1_RVXF_1	233	240	PF00149	0.572
DOC_PP1_RVXF_1	730	736	PF00149	0.476
DOC_USP7_MATH_1	147	151	PF00917	0.479
DOC_USP7_MATH_1	359	363	PF00917	0.636
DOC_USP7_MATH_1	421	425	PF00917	0.651
DOC_USP7_MATH_1	481	485	PF00917	0.766
DOC_USP7_MATH_1	492	496	PF00917	0.619
DOC_USP7_MATH_1	82	86	PF00917	0.691
DOC_WW_Pin1_4	110	115	PF00397	0.569
DOC_WW_Pin1_4	239	244	PF00397	0.437
DOC_WW_Pin1_4	454	459	PF00397	0.605
DOC_WW_Pin1_4	475	480	PF00397	0.765
DOC_WW_Pin1_4	580	585	PF00397	0.357
LIG_14-3-3_CanoR_1	108	114	PF00244	0.630
LIG_14-3-3_CanoR_1	131	139	PF00244	0.448
LIG_14-3-3_CanoR_1	227	233	PF00244	0.556
LIG_14-3-3_CanoR_1	400	408	PF00244	0.575
LIG_14-3-3_CanoR_1	493	501	PF00244	0.621
LIG_14-3-3_CanoR_1	519	528	PF00244	0.599
LIG_14-3-3_CanoR_1	578	584	PF00244	0.357
LIG_14-3-3_CanoR_1	717	722	PF00244	0.426
LIG_14-3-3_CanoR_1	732	736	PF00244	0.474
LIG_AP2alpha_2	617	619	PF02296	0.357
LIG_APCC_ABBA_1	138	143	PF00400	0.450
LIG_BIR_II_1	1	5	PF00653	0.641
LIG_BIR_III_4	745	749	PF00653	0.674
LIG_BRCT_BRCA1_1	111	115	PF00533	0.548
LIG_BRCT_BRCA1_1	427	431	PF00533	0.495
LIG_BRCT_BRCA1_1	60	64	PF00533	0.605
LIG_BRCT_BRCA1_1	719	723	PF00533	0.407
LIG_deltaCOP1_diTrp_1	617	622	PF00928	0.357
LIG_eIF4E_1	627	633	PF01652	0.357
LIG_eIF4E_1	724	730	PF01652	0.509
LIG_FHA_1	190	196	PF00498	0.396
LIG_FHA_1	207	213	PF00498	0.472
LIG_FHA_1	229	235	PF00498	0.563
LIG_FHA_1	323	329	PF00498	0.691
LIG_FHA_1	434	440	PF00498	0.697
LIG_FHA_1	463	469	PF00498	0.523
LIG_FHA_1	520	526	PF00498	0.545
LIG_FHA_1	531	537	PF00498	0.431
LIG_FHA_1	548	554	PF00498	0.283
LIG_FHA_1	587	593	PF00498	0.438
LIG_FHA_1	627	633	PF00498	0.357
LIG_FHA_1	650	656	PF00498	0.391
LIG_FHA_1	690	696	PF00498	0.438
LIG_FHA_2	100	106	PF00498	0.586
LIG_FHA_2	111	117	PF00498	0.598
LIG_FHA_2	390	396	PF00498	0.618
LIG_FHA_2	43	49	PF00498	0.534
LIG_FHA_2	468	474	PF00498	0.588
LIG_LIR_Apic_2	582	588	PF02991	0.357
LIG_LIR_Gen_1	116	127	PF02991	0.464
LIG_LIR_Gen_1	14	24	PF02991	0.700
LIG_LIR_Gen_1	149	158	PF02991	0.493
LIG_LIR_Gen_1	45	54	PF02991	0.565
LIG_LIR_Gen_1	61	72	PF02991	0.493
LIG_LIR_Gen_1	656	665	PF02991	0.357
LIG_LIR_Gen_1	713	723	PF02991	0.420
LIG_LIR_Nem_3	116	122	PF02991	0.462
LIG_LIR_Nem_3	14	19	PF02991	0.691
LIG_LIR_Nem_3	149	155	PF02991	0.473
LIG_LIR_Nem_3	339	344	PF02991	0.669
LIG_LIR_Nem_3	45	50	PF02991	0.617
LIG_LIR_Nem_3	61	67	PF02991	0.571
LIG_LIR_Nem_3	656	662	PF02991	0.336
LIG_LIR_Nem_3	713	718	PF02991	0.466
LIG_LIR_Nem_3	720	726	PF02991	0.469
LIG_LIR_Nem_3	734	738	PF02991	0.479
LIG_PCNA_yPIPBox_3	170	183	PF02747	0.496
LIG_Pex14_2	115	119	PF04695	0.424
LIG_Pex14_2	148	152	PF04695	0.407
LIG_PTB_Apo_2	553	560	PF02174	0.521
LIG_PTB_Apo_2	722	729	PF02174	0.501
LIG_PTB_Phospho_1	553	559	PF10480	0.514
LIG_REV1ctd_RIR_1	223	231	PF16727	0.557
LIG_RPA_C_Fungi	500	512	PF08784	0.638
LIG_RPA_C_Fungi	596	608	PF08784	0.438
LIG_SH2_CRK	724	728	PF00017	0.449
LIG_SH2_GRB2like	109	112	PF00017	0.567
LIG_SH2_STAP1	47	51	PF00017	0.617
LIG_SH2_STAP1	521	525	PF00017	0.586
LIG_SH2_STAP1	562	566	PF00017	0.487
LIG_SH2_STAT3	562	565	PF00017	0.478
LIG_SH2_STAT3	640	643	PF00017	0.415
LIG_SH2_STAT5	167	170	PF00017	0.417
LIG_SH2_STAT5	232	235	PF00017	0.474
LIG_SH2_STAT5	270	273	PF00017	0.428
LIG_SH2_STAT5	521	524	PF00017	0.594
LIG_SH2_STAT5	542	545	PF00017	0.569
LIG_SH2_STAT5	586	589	PF00017	0.391
LIG_SH2_STAT5	627	630	PF00017	0.357
LIG_SH2_STAT5	95	98	PF00017	0.598
LIG_SH3_1	218	224	PF00018	0.516
LIG_SH3_3	134	140	PF00018	0.447
LIG_SH3_3	218	224	PF00018	0.516
LIG_SH3_3	285	291	PF00018	0.427
LIG_SH3_3	72	78	PF00018	0.699
LIG_SH3_3	741	747	PF00018	0.653
LIG_Sin3_3	593	600	PF02671	0.438
LIG_SUMO_SIM_anti_2	124	130	PF11976	0.516
LIG_SUMO_SIM_par_1	250	255	PF11976	0.392
LIG_SUMO_SIM_par_1	650	657	PF11976	0.391
LIG_TRAF2_1	102	105	PF00917	0.479
LIG_TRAF2_1	343	346	PF00917	0.736
LIG_TYR_ITIM	722	727	PF00017	0.494
LIG_WRC_WIRS_1	735	740	PF05994	0.502
LIG_WRPW_2	222	225	PF00400	0.505
MOD_CDK_SPxxK_3	239	246	PF00069	0.451
MOD_CK1_1	203	209	PF00069	0.411
MOD_CK1_1	228	234	PF00069	0.555
MOD_CK1_1	386	392	PF00069	0.668
MOD_CK1_1	42	48	PF00069	0.466
MOD_CK1_1	449	455	PF00069	0.813
MOD_CK1_1	461	467	PF00069	0.759
MOD_CK1_1	510	516	PF00069	0.621
MOD_CK1_1	612	618	PF00069	0.348
MOD_CK1_1	657	663	PF00069	0.358
MOD_CK1_1	68	74	PF00069	0.673
MOD_CK1_1	689	695	PF00069	0.492
MOD_CK1_1	7	13	PF00069	0.561
MOD_CK1_1	76	82	PF00069	0.685
MOD_CK2_1	11	17	PF00069	0.611
MOD_CK2_1	42	48	PF00069	0.388
MOD_CK2_1	467	473	PF00069	0.668
MOD_CK2_1	99	105	PF00069	0.654
MOD_CMANNOS	313	316	PF00535	0.622
MOD_CMANNOS	619	622	PF00535	0.357
MOD_Cter_Amidation	351	354	PF01082	0.701
MOD_GlcNHglycan	143	146	PF01048	0.446
MOD_GlcNHglycan	202	205	PF01048	0.540
MOD_GlcNHglycan	28	31	PF01048	0.719
MOD_GlcNHglycan	350	353	PF01048	0.714
MOD_GlcNHglycan	359	362	PF01048	0.700
MOD_GlcNHglycan	385	388	PF01048	0.661
MOD_GlcNHglycan	427	430	PF01048	0.745
MOD_GlcNHglycan	454	457	PF01048	0.818
MOD_GlcNHglycan	484	487	PF01048	0.717
MOD_GlcNHglycan	490	493	PF01048	0.639
MOD_GlcNHglycan	494	497	PF01048	0.569
MOD_GlcNHglycan	593	596	PF01048	0.494
MOD_GlcNHglycan	67	70	PF01048	0.653
MOD_GlcNHglycan	81	85	PF01048	0.767
MOD_GSK3_1	318	325	PF00069	0.714
MOD_GSK3_1	421	428	PF00069	0.702
MOD_GSK3_1	446	453	PF00069	0.819
MOD_GSK3_1	454	461	PF00069	0.790
MOD_GSK3_1	463	470	PF00069	0.676
MOD_GSK3_1	488	495	PF00069	0.702
MOD_GSK3_1	547	554	PF00069	0.435
MOD_GSK3_1	609	616	PF00069	0.357
MOD_GSK3_1	622	629	PF00069	0.357
MOD_GSK3_1	654	661	PF00069	0.357
MOD_GSK3_1	7	14	PF00069	0.551
MOD_GSK3_1	73	80	PF00069	0.708
MOD_LATS_1	517	523	PF00433	0.610
MOD_N-GLC_1	110	115	PF02516	0.527
MOD_N-GLC_1	200	205	PF02516	0.478
MOD_N-GLC_1	612	617	PF02516	0.383
MOD_NEK2_1	141	146	PF00069	0.493
MOD_NEK2_1	225	230	PF00069	0.566
MOD_NEK2_1	26	31	PF00069	0.630
MOD_NEK2_1	281	286	PF00069	0.399
MOD_NEK2_1	381	386	PF00069	0.756
MOD_NEK2_1	463	468	PF00069	0.816
MOD_NEK2_1	609	614	PF00069	0.369
MOD_NEK2_1	65	70	PF00069	0.632
MOD_NEK2_2	175	180	PF00069	0.435
MOD_NEK2_2	359	364	PF00069	0.688
MOD_PIKK_1	254	260	PF00454	0.538
MOD_PIKK_1	318	324	PF00454	0.657
MOD_PIKK_1	399	405	PF00454	0.800
MOD_PIKK_1	547	553	PF00454	0.413
MOD_PIKK_1	59	65	PF00454	0.627
MOD_PIKK_1	689	695	PF00454	0.438
MOD_PIKK_1	73	79	PF00454	0.477
MOD_PK_1	560	566	PF00069	0.418
MOD_PKA_1	348	354	PF00069	0.548
MOD_PKA_2	130	136	PF00069	0.472
MOD_PKA_2	206	212	PF00069	0.508
MOD_PKA_2	281	287	PF00069	0.412
MOD_PKA_2	300	306	PF00069	0.471
MOD_PKA_2	348	354	PF00069	0.527
MOD_PKA_2	389	395	PF00069	0.650
MOD_PKA_2	399	405	PF00069	0.631
MOD_PKA_2	482	488	PF00069	0.605
MOD_PKA_2	492	498	PF00069	0.717
MOD_PKA_2	510	516	PF00069	0.557
MOD_PKA_2	731	737	PF00069	0.567
MOD_PKB_1	558	566	PF00069	0.511
MOD_Plk_1	11	17	PF00069	0.437
MOD_Plk_1	560	566	PF00069	0.439
MOD_Plk_4	147	153	PF00069	0.517
MOD_Plk_4	163	169	PF00069	0.384
MOD_Plk_4	228	234	PF00069	0.555
MOD_Plk_4	376	382	PF00069	0.640
MOD_Plk_4	389	395	PF00069	0.662
MOD_Plk_4	39	45	PF00069	0.463
MOD_Plk_4	649	655	PF00069	0.357
MOD_Plk_4	717	723	PF00069	0.395
MOD_ProDKin_1	110	116	PF00069	0.567
MOD_ProDKin_1	239	245	PF00069	0.430
MOD_ProDKin_1	454	460	PF00069	0.604
MOD_ProDKin_1	475	481	PF00069	0.766
MOD_ProDKin_1	580	586	PF00069	0.357
MOD_SUMO_rev_2	298	306	PF00179	0.499
TRG_DiLeu_BaLyEn_6	604	609	PF01217	0.438
TRG_DiLeu_BaLyEn_6	628	633	PF01217	0.422
TRG_ENDOCYTIC_2	222	225	PF00928	0.527
TRG_ENDOCYTIC_2	341	344	PF00928	0.692
TRG_ENDOCYTIC_2	47	50	PF00928	0.695
TRG_ENDOCYTIC_2	521	524	PF00928	0.594
TRG_ENDOCYTIC_2	724	727	PF00928	0.415
TRG_ER_diArg_1	179	181	PF00400	0.569
TRG_ER_diArg_1	205	208	PF00400	0.455
TRG_ER_diArg_1	22	24	PF00400	0.684
TRG_ER_diArg_1	313	315	PF00400	0.670
TRG_ER_diArg_1	326	328	PF00400	0.694
TRG_ER_diArg_1	332	335	PF00400	0.698
TRG_ER_diArg_1	348	350	PF00400	0.521
TRG_ER_diArg_1	353	355	PF00400	0.634
TRG_ER_diArg_1	366	369	PF00400	0.610
TRG_ER_diArg_1	497	499	PF00400	0.577
TRG_ER_diArg_1	525	527	PF00400	0.511
TRG_ER_diArg_1	543	546	PF00400	0.303
TRG_ER_diArg_1	577	579	PF00400	0.391
TRG_NES_CRM1_1	693	708	PF08389	0.470
TRG_Pf-PMV_PEXEL_1	180	184	PF00026	0.516
TRG_Pf-PMV_PEXEL_1	353	357	PF00026	0.684

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IC19	Leptomonas seymouri	67%	89%
A0A3Q8III3	Leishmania donovani	92%	100%
A0A3R7MZ93	Trypanosoma rangeli	45%	100%
A4IAM8	Leishmania infantum	92%	100%
C9ZMP8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AI68	Leishmania braziliensis	81%	100%
Q4Q2Z0	Leishmania major	92%	100%