PORR domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B4Z5_LEIMU

TriTrypDb:

LmxM.33.2100

Length:

836

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4Z5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4Z5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	349	353	PF00656	0.783
CLV_C14_Caspase3-7	406	410	PF00656	0.817
CLV_C14_Caspase3-7	423	427	PF00656	0.487
CLV_NRD_NRD_1	191	193	PF00675	0.603
CLV_NRD_NRD_1	2	4	PF00675	0.661
CLV_NRD_NRD_1	36	38	PF00675	0.592
CLV_NRD_NRD_1	496	498	PF00675	0.591
CLV_NRD_NRD_1	544	546	PF00675	0.612
CLV_NRD_NRD_1	547	549	PF00675	0.630
CLV_NRD_NRD_1	655	657	PF00675	0.642
CLV_NRD_NRD_1	671	673	PF00675	0.441
CLV_NRD_NRD_1	742	744	PF00675	0.575
CLV_NRD_NRD_1	8	10	PF00675	0.683
CLV_NRD_NRD_1	825	827	PF00675	0.623
CLV_PCSK_FUR_1	545	549	PF00082	0.565
CLV_PCSK_KEX2_1	17	19	PF00082	0.562
CLV_PCSK_KEX2_1	191	193	PF00082	0.563
CLV_PCSK_KEX2_1	496	498	PF00082	0.591
CLV_PCSK_KEX2_1	544	546	PF00082	0.605
CLV_PCSK_KEX2_1	547	549	PF00082	0.638
CLV_PCSK_KEX2_1	655	657	PF00082	0.661
CLV_PCSK_KEX2_1	671	673	PF00082	0.555
CLV_PCSK_KEX2_1	729	731	PF00082	0.628
CLV_PCSK_KEX2_1	827	829	PF00082	0.663
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.605
CLV_PCSK_PC1ET2_1	549	551	PF00082	0.664
CLV_PCSK_PC1ET2_1	729	731	PF00082	0.535
CLV_PCSK_PC1ET2_1	827	829	PF00082	0.663
CLV_PCSK_PC7_1	545	551	PF00082	0.573
CLV_PCSK_SKI1_1	10	14	PF00082	0.491
CLV_PCSK_SKI1_1	381	385	PF00082	0.742
CLV_PCSK_SKI1_1	632	636	PF00082	0.542
CLV_PCSK_SKI1_1	672	676	PF00082	0.613
CLV_PCSK_SKI1_1	716	720	PF00082	0.474
DEG_APCC_DBOX_1	670	678	PF00400	0.545
DEG_Nend_Nbox_1	1	3	PF02207	0.539
DEG_SCF_FBW7_1	209	215	PF00400	0.675
DEG_SPOP_SBC_1	88	92	PF00917	0.661
DOC_ANK_TNKS_1	659	666	PF00023	0.668
DOC_CDC14_PxL_1	708	716	PF14671	0.330
DOC_CDC14_PxL_1	99	107	PF14671	0.494
DOC_CKS1_1	209	214	PF01111	0.715
DOC_CKS1_1	48	53	PF01111	0.523
DOC_CYCLIN_RxL_1	235	245	PF00134	0.403
DOC_CYCLIN_RxL_1	669	680	PF00134	0.657
DOC_MAPK_gen_1	112	120	PF00069	0.509
DOC_MAPK_gen_1	191	198	PF00069	0.363
DOC_MAPK_gen_1	235	243	PF00069	0.668
DOC_MAPK_gen_1	259	269	PF00069	0.642
DOC_MAPK_gen_1	283	291	PF00069	0.727
DOC_MAPK_gen_1	582	591	PF00069	0.517
DOC_MAPK_gen_1	625	635	PF00069	0.700
DOC_MAPK_gen_1	655	661	PF00069	0.686
DOC_MAPK_gen_1	671	677	PF00069	0.459
DOC_MAPK_gen_1	729	735	PF00069	0.519
DOC_MAPK_gen_1	826	834	PF00069	0.588
DOC_MAPK_HePTP_8	780	792	PF00069	0.601
DOC_MAPK_MEF2A_6	783	792	PF00069	0.612
DOC_MAPK_MEF2A_6	826	834	PF00069	0.612
DOC_PP2B_LxvP_1	771	774	PF13499	0.586
DOC_PP2B_LxvP_1	790	793	PF13499	0.558
DOC_PP4_FxxP_1	151	154	PF00568	0.656
DOC_PP4_FxxP_1	486	489	PF00568	0.660
DOC_PP4_MxPP_1	75	78	PF00568	0.306
DOC_USP7_MATH_1	212	216	PF00917	0.693
DOC_USP7_MATH_1	354	358	PF00917	0.638
DOC_USP7_MATH_1	363	367	PF00917	0.669
DOC_USP7_MATH_1	643	647	PF00917	0.674
DOC_USP7_MATH_1	66	70	PF00917	0.585
DOC_USP7_MATH_1	666	670	PF00917	0.669
DOC_USP7_MATH_1	759	763	PF00917	0.572
DOC_USP7_MATH_2	463	469	PF00917	0.743
DOC_USP7_UBL2_3	82	86	PF12436	0.502
DOC_WW_Pin1_4	106	111	PF00397	0.578
DOC_WW_Pin1_4	184	189	PF00397	0.571
DOC_WW_Pin1_4	208	213	PF00397	0.701
DOC_WW_Pin1_4	223	228	PF00397	0.699
DOC_WW_Pin1_4	327	332	PF00397	0.524
DOC_WW_Pin1_4	456	461	PF00397	0.730
DOC_WW_Pin1_4	47	52	PF00397	0.475
DOC_WW_Pin1_4	512	517	PF00397	0.560
DOC_WW_Pin1_4	527	532	PF00397	0.504
DOC_WW_Pin1_4	533	538	PF00397	0.595
LIG_14-3-3_CanoR_1	645	650	PF00244	0.728
LIG_14-3-3_CanoR_1	743	750	PF00244	0.674
LIG_14-3-3_CanoR_1	758	764	PF00244	0.445
LIG_14-3-3_CanoR_1	9	19	PF00244	0.699
LIG_Actin_WH2_2	267	285	PF00022	0.671
LIG_Actin_WH2_2	68	84	PF00022	0.506
LIG_APCC_ABBA_1	731	736	PF00400	0.585
LIG_APCC_ABBAyCdc20_2	730	736	PF00400	0.512
LIG_BIR_III_4	159	163	PF00653	0.574
LIG_BRCT_BRCA1_1	798	802	PF00533	0.537
LIG_Clathr_ClatBox_1	148	152	PF01394	0.648
LIG_Clathr_ClatBox_1	391	395	PF01394	0.589
LIG_Clathr_ClatBox_1	674	678	PF01394	0.564
LIG_CSK_EPIYA_1	164	168	PF00017	0.708
LIG_CtBP_PxDLS_1	240	244	PF00389	0.643
LIG_CtBP_PxDLS_1	33	38	PF00389	0.587
LIG_deltaCOP1_diTrp_1	245	250	PF00928	0.357
LIG_deltaCOP1_diTrp_1	558	563	PF00928	0.608
LIG_eIF4E_1	238	244	PF01652	0.616
LIG_FHA_1	24	30	PF00498	0.559
LIG_FHA_1	262	268	PF00498	0.581
LIG_FHA_1	269	275	PF00498	0.577
LIG_FHA_1	386	392	PF00498	0.690
LIG_FHA_1	62	68	PF00498	0.429
LIG_FHA_1	793	799	PF00498	0.516
LIG_FHA_1	89	95	PF00498	0.601
LIG_FHA_2	154	160	PF00498	0.680
LIG_FHA_2	373	379	PF00498	0.671
LIG_FHA_2	404	410	PF00498	0.818
LIG_FHA_2	48	54	PF00498	0.519
LIG_FHA_2	512	518	PF00498	0.603
LIG_FHA_2	759	765	PF00498	0.610
LIG_FHA_2	795	801	PF00498	0.491
LIG_FXI_DFP_1	148	152	PF00024	0.648
LIG_FXI_DFP_1	247	251	PF00024	0.326
LIG_KLC1_Yacidic_2	732	736	PF13176	0.589
LIG_LIR_Apic_2	150	154	PF02991	0.653
LIG_LIR_Apic_2	30	34	PF02991	0.604
LIG_LIR_Apic_2	484	489	PF02991	0.659
LIG_LIR_Gen_1	271	280	PF02991	0.540
LIG_LIR_Gen_1	687	698	PF02991	0.589
LIG_LIR_Nem_3	100	105	PF02991	0.433
LIG_LIR_Nem_3	122	127	PF02991	0.449
LIG_LIR_Nem_3	236	241	PF02991	0.650
LIG_LIR_Nem_3	271	276	PF02991	0.521
LIG_LIR_Nem_3	558	564	PF02991	0.525
LIG_LIR_Nem_3	56	61	PF02991	0.519
LIG_LIR_Nem_3	567	573	PF02991	0.511
LIG_LIR_Nem_3	583	588	PF02991	0.557
LIG_LIR_Nem_3	687	693	PF02991	0.589
LIG_LIR_Nem_3	799	805	PF02991	0.518
LIG_LYPXL_yS_3	102	105	PF13949	0.416
LIG_MAD2	660	668	PF02301	0.594
LIG_Pex14_1	246	250	PF04695	0.471
LIG_REV1ctd_RIR_1	540	549	PF16727	0.612
LIG_SH2_CRK	20	24	PF00017	0.482
LIG_SH2_CRK	238	242	PF00017	0.667
LIG_SH2_CRK	585	589	PF00017	0.566
LIG_SH2_GRB2like	629	632	PF00017	0.579
LIG_SH2_NCK_1	690	694	PF00017	0.575
LIG_SH2_PTP2	273	276	PF00017	0.590
LIG_SH2_SRC	273	276	PF00017	0.629
LIG_SH2_SRC	607	610	PF00017	0.632
LIG_SH2_SRC	690	693	PF00017	0.579
LIG_SH2_STAP1	629	633	PF00017	0.695
LIG_SH2_STAP1	690	694	PF00017	0.575
LIG_SH2_STAT5	108	111	PF00017	0.588
LIG_SH2_STAT5	273	276	PF00017	0.542
LIG_SH2_STAT5	31	34	PF00017	0.555
LIG_SH2_STAT5	48	51	PF00017	0.436
LIG_SH2_STAT5	494	497	PF00017	0.641
LIG_SH2_STAT5	607	610	PF00017	0.593
LIG_SH2_STAT5	704	707	PF00017	0.534
LIG_SH2_STAT5	734	737	PF00017	0.612
LIG_SH2_STAT5	815	818	PF00017	0.460
LIG_SH3_1	204	210	PF00018	0.561
LIG_SH3_3	204	210	PF00018	0.538
LIG_SH3_3	306	312	PF00018	0.774
LIG_SH3_3	454	460	PF00018	0.724
LIG_SH3_3	54	60	PF00018	0.511
LIG_SH3_3	616	622	PF00018	0.590
LIG_SH3_3	630	636	PF00018	0.507
LIG_SH3_3	676	682	PF00018	0.519
LIG_SH3_3	695	701	PF00018	0.464
LIG_SUMO_SIM_anti_2	195	200	PF11976	0.588
LIG_SUMO_SIM_par_1	673	678	PF11976	0.561
LIG_TRAF2_1	335	338	PF00917	0.770
LIG_TRAF2_1	489	492	PF00917	0.676
LIG_TRAF2_1	762	765	PF00917	0.623
LIG_TRFH_1	20	24	PF08558	0.408
LIG_TYR_ITIM	688	693	PF00017	0.580
LIG_TYR_ITSM	269	276	PF00017	0.526
LIG_UBA3_1	279	284	PF00899	0.640
LIG_UBA3_1	80	86	PF00899	0.610
LIG_ULM_U2AF65_1	547	552	PF00076	0.589
LIG_WRC_WIRS_1	667	672	PF05994	0.600
LIG_WW_3	473	477	PF00397	0.598
MOD_CDC14_SPxK_1	330	333	PF00782	0.594
MOD_CDK_SPK_2	208	213	PF00069	0.442
MOD_CDK_SPxK_1	106	112	PF00069	0.610
MOD_CDK_SPxK_1	327	333	PF00069	0.597
MOD_CDK_SPxxK_3	184	191	PF00069	0.450
MOD_CK1_1	298	304	PF00069	0.687
MOD_CK1_1	315	321	PF00069	0.704
MOD_CK1_1	347	353	PF00069	0.665
MOD_CK1_1	530	536	PF00069	0.620
MOD_CK1_1	90	96	PF00069	0.631
MOD_CK2_1	47	53	PF00069	0.496
MOD_CK2_1	758	764	PF00069	0.651
MOD_DYRK1A_RPxSP_1	184	188	PF00069	0.463
MOD_DYRK1A_RPxSP_1	208	212	PF00069	0.724
MOD_GlcNHglycan	121	124	PF01048	0.397
MOD_GlcNHglycan	297	300	PF01048	0.749
MOD_GlcNHglycan	317	320	PF01048	0.469
MOD_GlcNHglycan	349	352	PF01048	0.706
MOD_GlcNHglycan	356	359	PF01048	0.767
MOD_GlcNHglycan	426	429	PF01048	0.615
MOD_GlcNHglycan	600	604	PF01048	0.598
MOD_GlcNHglycan	644	648	PF01048	0.667
MOD_GSK3_1	138	145	PF00069	0.635
MOD_GSK3_1	208	215	PF00069	0.738
MOD_GSK3_1	23	30	PF00069	0.554
MOD_GSK3_1	403	410	PF00069	0.746
MOD_GSK3_1	519	526	PF00069	0.655
MOD_GSK3_1	754	761	PF00069	0.667
MOD_GSK3_1	788	795	PF00069	0.505
MOD_NEK2_1	510	515	PF00069	0.699
MOD_NEK2_1	725	730	PF00069	0.493
MOD_NEK2_1	754	759	PF00069	0.495
MOD_NEK2_1	788	793	PF00069	0.555
MOD_PIKK_1	10	16	PF00454	0.623
MOD_PIKK_1	138	144	PF00454	0.567
MOD_PIKK_1	186	192	PF00454	0.652
MOD_PIKK_1	213	219	PF00454	0.711
MOD_PIKK_1	268	274	PF00454	0.578
MOD_PIKK_1	465	471	PF00454	0.706
MOD_PK_1	192	198	PF00069	0.635
MOD_PK_1	476	482	PF00069	0.487
MOD_PKA_1	743	749	PF00069	0.612
MOD_PKA_2	261	267	PF00069	0.459
MOD_PKA_2	448	454	PF00069	0.548
MOD_PKA_2	8	14	PF00069	0.448
MOD_Plk_1	820	826	PF00069	0.550
MOD_Plk_2-3	407	413	PF00069	0.768
MOD_Plk_4	27	33	PF00069	0.534
MOD_Plk_4	523	529	PF00069	0.598
MOD_Plk_4	645	651	PF00069	0.623
MOD_ProDKin_1	106	112	PF00069	0.594
MOD_ProDKin_1	184	190	PF00069	0.568
MOD_ProDKin_1	208	214	PF00069	0.706
MOD_ProDKin_1	223	229	PF00069	0.695
MOD_ProDKin_1	327	333	PF00069	0.523
MOD_ProDKin_1	456	462	PF00069	0.733
MOD_ProDKin_1	47	53	PF00069	0.471
MOD_ProDKin_1	512	518	PF00069	0.560
MOD_ProDKin_1	527	533	PF00069	0.499
MOD_SUMO_rev_2	226	233	PF00179	0.738
TRG_DiLeu_BaEn_1	292	297	PF01217	0.708
TRG_DiLeu_BaEn_1	692	697	PF01217	0.548
TRG_DiLeu_BaEn_2	653	659	PF01217	0.690
TRG_DiLeu_BaEn_4	389	395	PF01217	0.727
TRG_DiLeu_BaLyEn_6	710	715	PF01217	0.325
TRG_ENDOCYTIC_2	102	105	PF00928	0.407
TRG_ENDOCYTIC_2	20	23	PF00928	0.584
TRG_ENDOCYTIC_2	238	241	PF00928	0.676
TRG_ENDOCYTIC_2	273	276	PF00928	0.517
TRG_ENDOCYTIC_2	570	573	PF00928	0.516
TRG_ENDOCYTIC_2	585	588	PF00928	0.457
TRG_ENDOCYTIC_2	690	693	PF00928	0.579
TRG_ENDOCYTIC_2	704	707	PF00928	0.380
TRG_ENDOCYTIC_2	815	818	PF00928	0.499
TRG_ER_diArg_1	181	184	PF00400	0.758
TRG_ER_diArg_1	191	193	PF00400	0.624
TRG_ER_diArg_1	495	497	PF00400	0.591
TRG_ER_diArg_1	543	545	PF00400	0.621
TRG_ER_diArg_1	547	550	PF00400	0.591
TRG_ER_diArg_1	670	672	PF00400	0.619
TRG_ER_diArg_1	826	829	PF00400	0.637
TRG_ER_diArg_1	832	835	PF00400	0.571
TRG_NES_CRM1_1	765	778	PF08389	0.575
TRG_NLS_Bipartite_1	729	747	PF00514	0.545
TRG_NLS_MonoExtC_3	547	552	PF00514	0.589
TRG_NLS_MonoExtN_4	545	552	PF00514	0.580
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.638
TRG_Pf-PMV_PEXEL_1	37	41	PF00026	0.605
TRG_Pf-PMV_PEXEL_1	496	501	PF00026	0.655
TRG_Pf-PMV_PEXEL_1	505	509	PF00026	0.571
TRG_Pf-PMV_PEXEL_1	660	664	PF00026	0.677
TRG_Pf-PMV_PEXEL_1	810	814	PF00026	0.605

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P998	Leptomonas seymouri	43%	80%
A0A0S4JAQ4	Bodo saltans	29%	79%
A0A1X0PAE2	Trypanosomatidae	32%	76%
A0A3Q8IED0	Leishmania donovani	90%	100%
A0A3R7KV38	Trypanosoma rangeli	33%	82%
A4HAS2	Leishmania braziliensis	74%	100%
A4I9Y6	Leishmania infantum	90%	83%
C9ZMQ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	82%
Q4Q2Z1	Leishmania major	89%	100%