Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B4Z1_LEIMU

TriTrypDb:

LmxM.33.2060

Length:

310

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B4Z1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4Z1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.800
CLV_C14_Caspase3-7	141	145	PF00656	0.666
CLV_C14_Caspase3-7	162	166	PF00656	0.466
CLV_C14_Caspase3-7	269	273	PF00656	0.650
CLV_C14_Caspase3-7	7	11	PF00656	0.501
CLV_NRD_NRD_1	174	176	PF00675	0.567
CLV_NRD_NRD_1	197	199	PF00675	0.757
CLV_NRD_NRD_1	21	23	PF00675	0.668
CLV_NRD_NRD_1	210	212	PF00675	0.583
CLV_PCSK_KEX2_1	197	199	PF00082	0.710
CLV_PCSK_KEX2_1	21	23	PF00082	0.668
CLV_PCSK_KEX2_1	210	212	PF00082	0.674
CLV_PCSK_PC7_1	17	23	PF00082	0.668
DEG_SPOP_SBC_1	92	96	PF00917	0.686
DOC_CKS1_1	133	138	PF01111	0.671
DOC_CKS1_1	52	57	PF01111	0.639
DOC_MAPK_gen_1	19	28	PF00069	0.622
DOC_PP1_RVXF_1	231	237	PF00149	0.522
DOC_PP2B_LxvP_1	104	107	PF13499	0.715
DOC_PP4_FxxP_1	284	287	PF00568	0.542
DOC_PP4_FxxP_1	52	55	PF00568	0.628
DOC_USP7_MATH_1	13	17	PF00917	0.790
DOC_USP7_MATH_1	266	270	PF00917	0.507
DOC_USP7_MATH_1	55	59	PF00917	0.614
DOC_WW_Pin1_4	132	137	PF00397	0.617
DOC_WW_Pin1_4	217	222	PF00397	0.591
DOC_WW_Pin1_4	237	242	PF00397	0.409
DOC_WW_Pin1_4	248	253	PF00397	0.632
DOC_WW_Pin1_4	51	56	PF00397	0.592
LIG_14-3-3_CanoR_1	21	28	PF00244	0.500
LIG_14-3-3_CanoR_1	69	75	PF00244	0.610
LIG_ActinCP_TwfCPI_2	284	292	PF01115	0.540
LIG_APCC_ABBAyCdc20_2	226	232	PF00400	0.513
LIG_BIR_II_1	1	5	PF00653	0.760
LIG_BRCT_BRCA1_1	257	261	PF00533	0.477
LIG_BRCT_BRCA1_1	29	33	PF00533	0.597
LIG_FHA_1	124	130	PF00498	0.673
LIG_FHA_1	21	27	PF00498	0.654
LIG_FHA_1	241	247	PF00498	0.502
LIG_FHA_1	266	272	PF00498	0.653
LIG_FHA_1	29	35	PF00498	0.655
LIG_FHA_1	40	46	PF00498	0.475
LIG_FHA_1	65	71	PF00498	0.652
LIG_FHA_2	106	112	PF00498	0.713
LIG_FHA_2	160	166	PF00498	0.495
LIG_FHA_2	2	8	PF00498	0.505
LIG_FHA_2	30	36	PF00498	0.698
LIG_FHA_2	42	48	PF00498	0.541
LIG_FHA_2	52	58	PF00498	0.565
LIG_FHA_2	79	85	PF00498	0.672
LIG_LIR_Apic_2	199	203	PF02991	0.730
LIG_LIR_Apic_2	283	287	PF02991	0.447
LIG_LIR_Apic_2	50	55	PF02991	0.634
LIG_LIR_Gen_1	124	134	PF02991	0.619
LIG_LIR_Gen_1	30	40	PF02991	0.560
LIG_LIR_Nem_3	124	130	PF02991	0.641
LIG_LIR_Nem_3	217	222	PF02991	0.565
LIG_LIR_Nem_3	30	36	PF02991	0.561
LIG_MYND_3	79	83	PF01753	0.670
LIG_PDZ_Class_2	305	310	PF00595	0.601
LIG_Pex14_2	52	56	PF04695	0.636
LIG_PTAP_UEV_1	135	140	PF05743	0.636
LIG_SH2_CRK	127	131	PF00017	0.628
LIG_SH2_GRB2like	110	113	PF00017	0.730
LIG_SH2_NCK_1	110	114	PF00017	0.729
LIG_SH2_NCK_1	127	131	PF00017	0.628
LIG_SH2_NCK_1	200	204	PF00017	0.668
LIG_SH2_SRC	110	113	PF00017	0.730
LIG_SH2_SRC	270	273	PF00017	0.650
LIG_SH2_STAP1	127	131	PF00017	0.628
LIG_SH2_STAP1	230	234	PF00017	0.425
LIG_SH2_STAP1	267	271	PF00017	0.640
LIG_SH2_STAT5	267	270	PF00017	0.617
LIG_SH2_STAT5	27	30	PF00017	0.689
LIG_SH3_1	200	206	PF00018	0.715
LIG_SH3_3	133	139	PF00018	0.641
LIG_SH3_3	200	206	PF00018	0.622
LIG_SH3_3	72	78	PF00018	0.678
LIG_SUMO_SIM_par_1	189	194	PF11976	0.652
LIG_SUMO_SIM_par_1	41	47	PF11976	0.615
LIG_TRAF2_1	119	122	PF00917	0.636
LIG_TRAF2_1	44	47	PF00917	0.607
LIG_TYR_ITIM	129	134	PF00017	0.641
LIG_TYR_ITSM	123	130	PF00017	0.749
MOD_CDC14_SPxK_1	220	223	PF00782	0.561
MOD_CDK_SPxK_1	217	223	PF00069	0.562
MOD_CK1_1	20	26	PF00069	0.644
MOD_CK1_1	217	223	PF00069	0.579
MOD_CK1_1	240	246	PF00069	0.589
MOD_CK1_1	248	254	PF00069	0.632
MOD_CK1_1	41	47	PF00069	0.636
MOD_CK2_1	116	122	PF00069	0.543
MOD_CK2_1	193	199	PF00069	0.562
MOD_CK2_1	29	35	PF00069	0.706
MOD_CK2_1	297	303	PF00069	0.511
MOD_CK2_1	41	47	PF00069	0.664
MOD_CK2_1	51	57	PF00069	0.607
MOD_GlcNHglycan	118	121	PF01048	0.531
MOD_GlcNHglycan	136	139	PF01048	0.422
MOD_GlcNHglycan	247	250	PF01048	0.668
MOD_GlcNHglycan	57	60	PF01048	0.581
MOD_GSK3_1	13	20	PF00069	0.729
MOD_GSK3_1	154	161	PF00069	0.603
MOD_GSK3_1	189	196	PF00069	0.469
MOD_GSK3_1	232	239	PF00069	0.590
MOD_GSK3_1	247	254	PF00069	0.539
MOD_GSK3_1	266	273	PF00069	0.662
MOD_GSK3_1	51	58	PF00069	0.558
MOD_GSK3_1	91	98	PF00069	0.728
MOD_N-GLC_1	158	163	PF02516	0.654
MOD_N-GLC_1	274	279	PF02516	0.435
MOD_NEK2_1	1	6	PF00069	0.738
MOD_NEK2_1	191	196	PF00069	0.707
MOD_NEK2_1	236	241	PF00069	0.602
MOD_NEK2_1	28	33	PF00069	0.703
MOD_NEK2_1	280	285	PF00069	0.512
MOD_PIKK_1	1	7	PF00454	0.645
MOD_PIKK_1	191	197	PF00454	0.732
MOD_PIKK_1	214	220	PF00454	0.608
MOD_PIKK_1	8	14	PF00454	0.701
MOD_PKA_2	20	26	PF00069	0.513
MOD_PKA_2	64	70	PF00069	0.583
MOD_Plk_1	123	129	PF00069	0.615
MOD_Plk_1	92	98	PF00069	0.710
MOD_Plk_4	232	238	PF00069	0.731
MOD_Plk_4	242	248	PF00069	0.553
MOD_Plk_4	266	272	PF00069	0.675
MOD_Plk_4	280	286	PF00069	0.686
MOD_Plk_4	29	35	PF00069	0.706
MOD_ProDKin_1	132	138	PF00069	0.621
MOD_ProDKin_1	217	223	PF00069	0.588
MOD_ProDKin_1	237	243	PF00069	0.410
MOD_ProDKin_1	248	254	PF00069	0.631
MOD_ProDKin_1	51	57	PF00069	0.595
MOD_SUMO_rev_2	225	235	PF00179	0.621
TRG_DiLeu_BaEn_1	204	209	PF01217	0.582
TRG_ENDOCYTIC_2	127	130	PF00928	0.641
TRG_ENDOCYTIC_2	131	134	PF00928	0.576
TRG_ER_diArg_1	209	211	PF00400	0.657
TRG_NES_CRM1_1	169	184	PF08389	0.355
TRG_Pf-PMV_PEXEL_1	175	179	PF00026	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I215	Leptomonas seymouri	49%	100%
A0A3S7X7Y3	Leishmania donovani	84%	98%
A4HAR8	Leishmania braziliensis	74%	100%
A4I9Y3	Leishmania infantum	83%	98%
C9ZMQ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
Q4Q2Z5	Leishmania major	84%	100%
V5BT40	Trypanosoma cruzi	30%	96%