Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B4Y9_LEIMU

TriTrypDb:

LmxM.33.2040

Length:

416

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4Y9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4Y9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	192	196	PF00656	0.672
CLV_C14_Caspase3-7	308	312	PF00656	0.588
CLV_NRD_NRD_1	355	357	PF00675	0.558
CLV_NRD_NRD_1	371	373	PF00675	0.384
CLV_NRD_NRD_1	406	408	PF00675	0.645
CLV_NRD_NRD_1	81	83	PF00675	0.491
CLV_PCSK_FUR_1	79	83	PF00082	0.529
CLV_PCSK_KEX2_1	355	357	PF00082	0.549
CLV_PCSK_KEX2_1	370	372	PF00082	0.396
CLV_PCSK_KEX2_1	396	398	PF00082	0.670
CLV_PCSK_KEX2_1	81	83	PF00082	0.491
CLV_PCSK_PC1ET2_1	396	398	PF00082	0.642
CLV_PCSK_SKI1_1	118	122	PF00082	0.525
CLV_PCSK_SKI1_1	396	400	PF00082	0.597
CLV_PCSK_SKI1_1	407	411	PF00082	0.699
CLV_PCSK_SKI1_1	7	11	PF00082	0.467
DEG_APCC_DBOX_1	388	396	PF00400	0.382
DOC_ANK_TNKS_1	50	57	PF00023	0.730
DOC_CKS1_1	183	188	PF01111	0.730
DOC_CKS1_1	8	13	PF01111	0.654
DOC_CYCLIN_RxL_1	405	416	PF00134	0.462
DOC_CYCLIN_yCln2_LP_2	388	394	PF00134	0.335
DOC_MAPK_gen_1	370	382	PF00069	0.539
DOC_MAPK_MEF2A_6	375	384	PF00069	0.236
DOC_PP2B_LxvP_1	388	391	PF13499	0.335
DOC_PP4_FxxP_1	116	119	PF00568	0.766
DOC_PP4_FxxP_1	261	264	PF00568	0.713
DOC_PP4_FxxP_1	8	11	PF00568	0.651
DOC_USP7_MATH_1	109	113	PF00917	0.723
DOC_USP7_MATH_1	141	145	PF00917	0.695
DOC_USP7_MATH_1	157	161	PF00917	0.664
DOC_USP7_MATH_1	196	200	PF00917	0.759
DOC_USP7_MATH_1	228	232	PF00917	0.711
DOC_USP7_MATH_1	30	34	PF00917	0.677
DOC_WW_Pin1_4	149	154	PF00397	0.705
DOC_WW_Pin1_4	182	187	PF00397	0.755
DOC_WW_Pin1_4	198	203	PF00397	0.635
DOC_WW_Pin1_4	272	277	PF00397	0.766
DOC_WW_Pin1_4	49	54	PF00397	0.674
DOC_WW_Pin1_4	7	12	PF00397	0.677
DOC_WW_Pin1_4	74	79	PF00397	0.741
DOC_WW_Pin1_4	94	99	PF00397	0.780
LIG_14-3-3_CanoR_1	108	117	PF00244	0.756
LIG_14-3-3_CanoR_1	143	151	PF00244	0.741
LIG_14-3-3_CanoR_1	197	202	PF00244	0.770
LIG_14-3-3_CanoR_1	236	241	PF00244	0.730
LIG_14-3-3_CanoR_1	279	284	PF00244	0.678
LIG_14-3-3_CanoR_1	356	362	PF00244	0.780
LIG_14-3-3_CanoR_1	397	406	PF00244	0.463
LIG_14-3-3_CanoR_1	84	92	PF00244	0.708
LIG_Actin_WH2_2	118	136	PF00022	0.727
LIG_Actin_WH2_2	381	398	PF00022	0.372
LIG_BIR_III_2	195	199	PF00653	0.729
LIG_BIR_III_4	245	249	PF00653	0.603
LIG_BRCT_BRCA1_1	144	148	PF00533	0.631
LIG_BRCT_BRCA1_1	187	191	PF00533	0.751
LIG_BRCT_BRCA1_1	200	204	PF00533	0.677
LIG_BRCT_BRCA1_1	270	274	PF00533	0.585
LIG_BRCT_BRCA1_1	4	8	PF00533	0.647
LIG_FHA_1	175	181	PF00498	0.673
LIG_FHA_1	27	33	PF00498	0.744
LIG_FHA_1	39	45	PF00498	0.642
LIG_FHA_1	86	92	PF00498	0.637
LIG_FHA_2	156	162	PF00498	0.786
LIG_FHA_2	167	173	PF00498	0.682
LIG_FHA_2	190	196	PF00498	0.722
LIG_FHA_2	50	56	PF00498	0.776
LIG_LIR_Apic_2	114	119	PF02991	0.714
LIG_LIR_Apic_2	258	264	PF02991	0.716
LIG_LIR_Apic_2	5	11	PF02991	0.629
LIG_LIR_Gen_1	201	208	PF02991	0.710
LIG_LIR_Gen_1	290	300	PF02991	0.596
LIG_LIR_Gen_1	378	388	PF02991	0.328
LIG_LIR_Nem_3	145	151	PF02991	0.604
LIG_LIR_Nem_3	201	207	PF02991	0.712
LIG_LIR_Nem_3	271	277	PF02991	0.594
LIG_LIR_Nem_3	290	295	PF02991	0.595
LIG_LIR_Nem_3	378	384	PF02991	0.328
LIG_LIR_Nem_3	385	390	PF02991	0.378
LIG_NRBOX	405	411	PF00104	0.431
LIG_SH2_STAT5	206	209	PF00017	0.785
LIG_SUMO_SIM_anti_2	24	29	PF11976	0.689
LIG_SUMO_SIM_par_1	408	413	PF11976	0.457
LIG_TRAF2_1	214	217	PF00917	0.620
LIG_WW_3	10	14	PF00397	0.717
MOD_CDK_SPK_2	74	79	PF00069	0.774
MOD_CDK_SPK_2	98	103	PF00069	0.680
MOD_CDK_SPxK_1	7	13	PF00069	0.663
MOD_CDK_SPxxK_3	272	279	PF00069	0.768
MOD_CDK_SPxxK_3	74	81	PF00069	0.686
MOD_CK1_1	111	117	PF00069	0.715
MOD_CK1_1	124	130	PF00069	0.769
MOD_CK1_1	170	176	PF00069	0.782
MOD_CK1_1	200	206	PF00069	0.704
MOD_CK1_1	219	225	PF00069	0.614
MOD_CK1_1	282	288	PF00069	0.702
MOD_CK1_1	290	296	PF00069	0.676
MOD_CK1_1	62	68	PF00069	0.704
MOD_CK2_1	155	161	PF00069	0.833
MOD_CK2_1	166	172	PF00069	0.694
MOD_CK2_1	290	296	PF00069	0.593
MOD_CK2_1	356	362	PF00069	0.638
MOD_CK2_1	399	405	PF00069	0.382
MOD_GlcNHglycan	145	148	PF01048	0.505
MOD_GlcNHglycan	155	158	PF01048	0.526
MOD_GlcNHglycan	169	172	PF01048	0.590
MOD_GlcNHglycan	19	22	PF01048	0.565
MOD_GlcNHglycan	401	404	PF01048	0.614
MOD_GlcNHglycan	72	75	PF01048	0.492
MOD_GSK3_1	104	111	PF00069	0.650
MOD_GSK3_1	121	128	PF00069	0.802
MOD_GSK3_1	149	156	PF00069	0.747
MOD_GSK3_1	166	173	PF00069	0.766
MOD_GSK3_1	185	192	PF00069	0.633
MOD_GSK3_1	196	203	PF00069	0.776
MOD_GSK3_1	212	219	PF00069	0.675
MOD_GSK3_1	26	33	PF00069	0.737
MOD_GSK3_1	268	275	PF00069	0.645
MOD_GSK3_1	278	285	PF00069	0.715
MOD_GSK3_1	287	294	PF00069	0.671
MOD_GSK3_1	371	378	PF00069	0.582
MOD_GSK3_1	61	68	PF00069	0.679
MOD_GSK3_1	70	77	PF00069	0.712
MOD_GSK3_1	94	101	PF00069	0.723
MOD_N-GLC_1	141	146	PF02516	0.610
MOD_N-GLC_1	15	20	PF02516	0.462
MOD_N-GLC_1	253	258	PF02516	0.518
MOD_N-GLC_1	357	362	PF02516	0.447
MOD_N-GLC_1	49	54	PF02516	0.481
MOD_N-GLC_1	62	67	PF02516	0.559
MOD_N-GLC_1	85	90	PF02516	0.393
MOD_NEK2_1	1	6	PF00069	0.686
MOD_NEK2_1	121	126	PF00069	0.745
MOD_NEK2_1	155	160	PF00069	0.736
MOD_NEK2_1	235	240	PF00069	0.728
MOD_NEK2_1	382	387	PF00069	0.347
MOD_NEK2_1	399	404	PF00069	0.358
MOD_NEK2_1	87	92	PF00069	0.658
MOD_PIKK_1	212	218	PF00454	0.621
MOD_PIKK_1	283	289	PF00454	0.725
MOD_PIKK_1	410	416	PF00454	0.468
MOD_PK_1	236	242	PF00069	0.757
MOD_PK_1	279	285	PF00069	0.658
MOD_PK_1	375	381	PF00069	0.294
MOD_PKA_1	371	377	PF00069	0.624
MOD_PKA_2	112	118	PF00069	0.669
MOD_PKA_2	142	148	PF00069	0.783
MOD_PKA_2	196	202	PF00069	0.786
MOD_PKA_2	235	241	PF00069	0.782
MOD_PKA_2	278	284	PF00069	0.771
MOD_PKA_2	287	293	PF00069	0.630
MOD_PKA_2	371	377	PF00069	0.624
MOD_Plk_1	15	21	PF00069	0.719
MOD_Plk_1	164	170	PF00069	0.721
MOD_Plk_1	23	29	PF00069	0.602
MOD_Plk_1	357	363	PF00069	0.648
MOD_Plk_1	62	68	PF00069	0.760
MOD_Plk_4	112	118	PF00069	0.596
MOD_Plk_4	170	176	PF00069	0.735
MOD_Plk_4	23	29	PF00069	0.738
MOD_Plk_4	375	381	PF00069	0.389
MOD_Plk_4	44	50	PF00069	0.721
MOD_Plk_4	87	93	PF00069	0.660
MOD_ProDKin_1	149	155	PF00069	0.707
MOD_ProDKin_1	182	188	PF00069	0.758
MOD_ProDKin_1	198	204	PF00069	0.637
MOD_ProDKin_1	272	278	PF00069	0.767
MOD_ProDKin_1	49	55	PF00069	0.676
MOD_ProDKin_1	7	13	PF00069	0.679
MOD_ProDKin_1	74	80	PF00069	0.740
MOD_ProDKin_1	94	100	PF00069	0.781
MOD_SUMO_rev_2	256	262	PF00179	0.698
TRG_DiLeu_BaEn_1	405	410	PF01217	0.336
TRG_DiLeu_BaLyEn_6	372	377	PF01217	0.577
TRG_ER_diArg_1	370	372	PF00400	0.634
TRG_ER_diArg_1	78	81	PF00400	0.725
TRG_NES_CRM1_1	24	37	PF08389	0.680

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8U0	Leptomonas seymouri	30%	95%
A0A3Q8IHI2	Leishmania donovani	84%	100%
A4HBI6	Leishmania braziliensis	56%	100%
A4I9Y1	Leishmania infantum	84%	100%
Q4Q2Z7	Leishmania major	80%	100%