Regulator_of_chromosome_condensation_(RCC1)_repea t

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Regulator of chromosome condensation (RCC1) repeat, putative

Species:

Leishmania mexicana

UniProt:

E9B4Y7_LEIMU

TriTrypDb:

LmxM.33.2020

Length:

629

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005938	cell cortex	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B4Y7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4Y7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	34	38	PF00656	0.765
CLV_C14_Caspase3-7	341	345	PF00656	0.627
CLV_NRD_NRD_1	12	14	PF00675	0.604
CLV_NRD_NRD_1	297	299	PF00675	0.519
CLV_NRD_NRD_1	346	348	PF00675	0.538
CLV_NRD_NRD_1	584	586	PF00675	0.795
CLV_NRD_NRD_1	611	613	PF00675	0.718
CLV_PCSK_KEX2_1	12	14	PF00082	0.604
CLV_PCSK_KEX2_1	290	292	PF00082	0.620
CLV_PCSK_KEX2_1	297	299	PF00082	0.522
CLV_PCSK_KEX2_1	346	348	PF00082	0.555
CLV_PCSK_KEX2_1	584	586	PF00082	0.822
CLV_PCSK_KEX2_1	611	613	PF00082	0.792
CLV_PCSK_KEX2_1	71	73	PF00082	0.718
CLV_PCSK_PC1ET2_1	290	292	PF00082	0.592
CLV_PCSK_PC1ET2_1	584	586	PF00082	0.655
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.731
CLV_PCSK_SKI1_1	240	244	PF00082	0.671
CLV_PCSK_SKI1_1	298	302	PF00082	0.562
CLV_PCSK_SKI1_1	353	357	PF00082	0.492
CLV_PCSK_SKI1_1	394	398	PF00082	0.622
CLV_PCSK_SKI1_1	431	435	PF00082	0.533
CLV_PCSK_SKI1_1	450	454	PF00082	0.329
CLV_PCSK_SKI1_1	64	68	PF00082	0.747
DEG_Nend_Nbox_1	1	3	PF02207	0.621
DEG_SCF_FBW7_2	40	46	PF00400	0.690
DOC_ANK_TNKS_1	476	483	PF00023	0.644
DOC_CKS1_1	293	298	PF01111	0.542
DOC_CKS1_1	40	45	PF01111	0.691
DOC_CKS1_1	445	450	PF01111	0.472
DOC_MAPK_DCC_7	450	460	PF00069	0.611
DOC_MAPK_gen_1	152	160	PF00069	0.584
DOC_MAPK_MEF2A_6	71	78	PF00069	0.438
DOC_MAPK_NFAT4_5	71	79	PF00069	0.439
DOC_PP1_RVXF_1	259	266	PF00149	0.564
DOC_PP1_RVXF_1	448	454	PF00149	0.592
DOC_PP4_FxxP_1	126	129	PF00568	0.549
DOC_PP4_FxxP_1	475	478	PF00568	0.765
DOC_USP7_MATH_1	138	142	PF00917	0.542
DOC_USP7_MATH_1	253	257	PF00917	0.564
DOC_USP7_MATH_1	31	35	PF00917	0.642
DOC_USP7_MATH_1	372	376	PF00917	0.392
DOC_USP7_MATH_1	420	424	PF00917	0.482
DOC_USP7_MATH_1	487	491	PF00917	0.675
DOC_USP7_MATH_1	577	581	PF00917	0.875
DOC_USP7_UBL2_3	397	401	PF12436	0.536
DOC_USP7_UBL2_3	586	590	PF12436	0.854
DOC_USP7_UBL2_3	615	619	PF12436	0.684
DOC_USP7_UBL2_3	86	90	PF12436	0.717
DOC_WW_Pin1_4	104	109	PF00397	0.751
DOC_WW_Pin1_4	200	205	PF00397	0.590
DOC_WW_Pin1_4	292	297	PF00397	0.550
DOC_WW_Pin1_4	302	307	PF00397	0.501
DOC_WW_Pin1_4	39	44	PF00397	0.698
DOC_WW_Pin1_4	444	449	PF00397	0.601
DOC_WW_Pin1_4	453	458	PF00397	0.541
DOC_WW_Pin1_4	500	505	PF00397	0.804
LIG_14-3-3_CanoR_1	102	110	PF00244	0.571
LIG_14-3-3_CanoR_1	12	16	PF00244	0.709
LIG_14-3-3_CanoR_1	240	245	PF00244	0.652
LIG_14-3-3_CanoR_1	291	296	PF00244	0.591
LIG_14-3-3_CanoR_1	297	303	PF00244	0.518
LIG_14-3-3_CanoR_1	32	40	PF00244	0.437
LIG_14-3-3_CanoR_1	519	527	PF00244	0.774
LIG_14-3-3_CanoR_1	64	74	PF00244	0.705
LIG_Actin_WH2_2	71	88	PF00022	0.505
LIG_BRCT_BRCA1_1	458	462	PF00533	0.401
LIG_Clathr_ClatBox_1	317	321	PF01394	0.530
LIG_FHA_1	114	120	PF00498	0.629
LIG_FHA_1	223	229	PF00498	0.644
LIG_FHA_1	277	283	PF00498	0.532
LIG_FHA_1	432	438	PF00498	0.549
LIG_FHA_1	60	66	PF00498	0.691
LIG_FHA_2	1	7	PF00498	0.773
LIG_FHA_2	186	192	PF00498	0.572
LIG_FHA_2	39	45	PF00498	0.739
LIG_FHA_2	551	557	PF00498	0.770
LIG_Integrin_isoDGR_2	429	431	PF01839	0.583
LIG_Integrin_isoDGR_2	601	603	PF01839	0.578
LIG_Integrin_isoDGR_2	609	611	PF01839	0.551
LIG_LIR_Gen_1	113	120	PF02991	0.437
LIG_LIR_Gen_1	181	191	PF02991	0.505
LIG_LIR_Gen_1	19	29	PF02991	0.582
LIG_LIR_Gen_1	6	15	PF02991	0.717
LIG_LIR_Nem_3	181	187	PF02991	0.498
LIG_LIR_Nem_3	272	277	PF02991	0.490
LIG_LIR_Nem_3	459	465	PF02991	0.594
LIG_LIR_Nem_3	469	475	PF02991	0.633
LIG_LIR_Nem_3	6	11	PF02991	0.708
LIG_LRP6_Inhibitor_1	249	255	PF00058	0.661
LIG_PCNA_PIPBox_1	352	361	PF02747	0.588
LIG_SH2_CRK	135	139	PF00017	0.565
LIG_SH2_NCK_1	135	139	PF00017	0.565
LIG_SH2_STAP1	468	472	PF00017	0.601
LIG_SH2_STAT3	359	362	PF00017	0.569
LIG_SH2_STAT5	131	134	PF00017	0.692
LIG_SH2_STAT5	350	353	PF00017	0.511
LIG_SH2_STAT5	359	362	PF00017	0.471
LIG_SH2_STAT5	426	429	PF00017	0.546
LIG_SH2_STAT5	468	471	PF00017	0.642
LIG_SH3_3	163	169	PF00018	0.564
LIG_SH3_3	198	204	PF00018	0.473
LIG_SH3_3	290	296	PF00018	0.643
LIG_SH3_3	37	43	PF00018	0.695
LIG_SH3_3	449	455	PF00018	0.485
LIG_SH3_4	348	355	PF00018	0.603
LIG_SUMO_SIM_anti_2	225	230	PF11976	0.595
LIG_SUMO_SIM_anti_2	23	30	PF11976	0.708
LIG_SUMO_SIM_anti_2	456	462	PF11976	0.684
LIG_SUMO_SIM_par_1	316	321	PF11976	0.536
LIG_TRAF2_1	570	573	PF00917	0.575
LIG_TRAF2_1	580	583	PF00917	0.559
LIG_UBA3_1	506	514	PF00899	0.554
LIG_Vh1_VBS_1	109	127	PF01044	0.651
LIG_WRC_WIRS_1	157	162	PF05994	0.551
LIG_WRC_WIRS_1	326	331	PF05994	0.515
MOD_CDK_SPK_2	292	297	PF00069	0.550
MOD_CDK_SPxK_1	292	298	PF00069	0.548
MOD_CDK_SPxK_1	39	45	PF00069	0.694
MOD_CDK_SPxK_1	444	450	PF00069	0.419
MOD_CDK_SPxxK_3	302	309	PF00069	0.539
MOD_CK1_1	104	110	PF00069	0.662
MOD_CK1_1	113	119	PF00069	0.651
MOD_CK1_1	143	149	PF00069	0.535
MOD_CK1_1	202	208	PF00069	0.686
MOD_CK1_1	248	254	PF00069	0.600
MOD_CK1_1	384	390	PF00069	0.472
MOD_CK1_1	500	506	PF00069	0.773
MOD_CK1_1	530	536	PF00069	0.735
MOD_CK2_1	38	44	PF00069	0.662
MOD_CK2_1	550	556	PF00069	0.772
MOD_CK2_1	577	583	PF00069	0.830
MOD_Cter_Amidation	609	612	PF01082	0.792
MOD_GlcNHglycan	15	18	PF01048	0.681
MOD_GlcNHglycan	161	164	PF01048	0.735
MOD_GlcNHglycan	195	198	PF01048	0.501
MOD_GlcNHglycan	247	250	PF01048	0.673
MOD_GlcNHglycan	311	314	PF01048	0.505
MOD_GlcNHglycan	33	36	PF01048	0.551
MOD_GlcNHglycan	363	366	PF01048	0.456
MOD_GlcNHglycan	386	389	PF01048	0.447
MOD_GlcNHglycan	488	492	PF01048	0.762
MOD_GlcNHglycan	507	510	PF01048	0.698
MOD_GlcNHglycan	531	535	PF01048	0.727
MOD_GlcNHglycan	575	578	PF01048	0.639
MOD_GSK3_1	140	147	PF00069	0.544
MOD_GSK3_1	236	243	PF00069	0.594
MOD_GSK3_1	298	305	PF00069	0.571
MOD_GSK3_1	367	374	PF00069	0.382
MOD_GSK3_1	514	521	PF00069	0.728
MOD_GSK3_1	573	580	PF00069	0.811
MOD_N-GLC_1	144	149	PF02516	0.678
MOD_N-GLC_1	384	389	PF02516	0.428
MOD_N-GLC_1	437	442	PF02516	0.676
MOD_N-GLC_1	512	517	PF02516	0.715
MOD_N-GLC_1	527	532	PF02516	0.808
MOD_N-GLC_1	535	540	PF02516	0.819
MOD_N-GLC_1	541	546	PF02516	0.821
MOD_N-GLC_1	573	578	PF02516	0.794
MOD_NEK2_1	140	145	PF00069	0.543
MOD_NEK2_1	199	204	PF00069	0.677
MOD_NEK2_1	371	376	PF00069	0.439
MOD_NEK2_1	392	397	PF00069	0.496
MOD_NEK2_1	437	442	PF00069	0.662
MOD_NEK2_2	144	149	PF00069	0.624
MOD_NEK2_2	420	425	PF00069	0.463
MOD_PIKK_1	518	524	PF00454	0.800
MOD_PKA_1	353	359	PF00069	0.457
MOD_PKA_1	585	591	PF00069	0.687
MOD_PKA_1	618	624	PF00069	0.666
MOD_PKA_2	101	107	PF00069	0.645
MOD_PKA_2	11	17	PF00069	0.662
MOD_PKA_2	151	157	PF00069	0.570
MOD_PKA_2	31	37	PF00069	0.628
MOD_PKA_2	518	524	PF00069	0.769
MOD_Plk_1	144	150	PF00069	0.672
MOD_Plk_1	437	443	PF00069	0.660
MOD_Plk_1	522	528	PF00069	0.778
MOD_Plk_1	577	583	PF00069	0.863
MOD_Plk_2-3	466	472	PF00069	0.611
MOD_Plk_4	21	27	PF00069	0.656
MOD_Plk_4	222	228	PF00069	0.624
MOD_Plk_4	278	284	PF00069	0.479
MOD_Plk_4	420	426	PF00069	0.464
MOD_Plk_4	522	528	PF00069	0.783
MOD_Plk_4	558	564	PF00069	0.798
MOD_ProDKin_1	104	110	PF00069	0.753
MOD_ProDKin_1	200	206	PF00069	0.594
MOD_ProDKin_1	292	298	PF00069	0.548
MOD_ProDKin_1	302	308	PF00069	0.498
MOD_ProDKin_1	39	45	PF00069	0.694
MOD_ProDKin_1	444	450	PF00069	0.603
MOD_ProDKin_1	453	459	PF00069	0.551
MOD_ProDKin_1	500	506	PF00069	0.806
MOD_SUMO_rev_2	77	85	PF00179	0.495
TRG_ENDOCYTIC_2	274	277	PF00928	0.466
TRG_ER_diArg_1	11	13	PF00400	0.677
TRG_ER_diArg_1	296	298	PF00400	0.539
TRG_NLS_MonoExtC_3	611	617	PF00514	0.665
TRG_NLS_MonoExtN_4	611	616	PF00514	0.760
TRG_NLS_MonoExtN_4	618	623	PF00514	0.708
TRG_Pf-PMV_PEXEL_1	394	398	PF00026	0.648

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFG4	Leptomonas seymouri	63%	100%
A0A1X0PAD3	Trypanosomatidae	57%	100%
A0A3Q8IH78	Leishmania donovani	89%	100%
A0A422NXS0	Trypanosoma rangeli	52%	100%
A4HAR5	Leishmania braziliensis	77%	100%
A4I9X9	Leishmania infantum	89%	100%
C9ZMQ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
Q4Q2Z9	Leishmania major	87%	100%
V5BIX4	Trypanosoma cruzi	57%	100%