Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B4Y6_LEIMU

TriTrypDb:

LmxM.33.2010

Length:

165

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005635	nuclear envelope	4	1
GO:0005783	endoplasmic reticulum	5	1
GO:0016020	membrane	2	4
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9B4Y6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4Y6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	90	92	PF00675	0.448
CLV_PCSK_KEX2_1	90	92	PF00082	0.449
CLV_PCSK_SKI1_1	153	157	PF00082	0.650
CLV_PCSK_SKI1_1	37	41	PF00082	0.587
CLV_PCSK_SKI1_1	84	88	PF00082	0.495
DEG_Nend_Nbox_1	1	3	PF02207	0.689
DOC_PP1_RVXF_1	126	133	PF00149	0.546
DOC_USP7_MATH_1	45	49	PF00917	0.768
DOC_WW_Pin1_4	158	163	PF00397	0.506
LIG_14-3-3_CanoR_1	91	100	PF00244	0.695
LIG_BRCT_BRCA1_1	135	139	PF00533	0.513
LIG_CSL_BTD_1	159	162	PF09270	0.507
LIG_deltaCOP1_diTrp_1	121	126	PF00928	0.625
LIG_deltaCOP1_diTrp_1	157	163	PF00928	0.394
LIG_FHA_2	108	114	PF00498	0.761
LIG_FHA_2	54	60	PF00498	0.710
LIG_LIR_Gen_1	121	132	PF02991	0.618
LIG_LIR_Nem_3	121	127	PF02991	0.621
LIG_LIR_Nem_3	157	163	PF02991	0.492
LIG_SH2_STAT5	146	149	PF00017	0.460
LIG_SH2_STAT5	154	157	PF00017	0.408
LIG_SH2_STAT5	99	102	PF00017	0.725
LIG_SH3_1	156	162	PF00018	0.507
LIG_SH3_2	159	164	PF14604	0.458
LIG_SH3_3	156	162	PF00018	0.477
LIG_SH3_3	26	32	PF00018	0.649
LIG_TRAF2_1	120	123	PF00917	0.503
LIG_TRAF2_1	61	64	PF00917	0.719
MOD_CDC14_SPxK_1	161	164	PF00782	0.455
MOD_CDK_SPxK_1	158	164	PF00069	0.454
MOD_CK2_1	107	113	PF00069	0.703
MOD_CK2_1	53	59	PF00069	0.601
MOD_Cter_Amidation	88	91	PF01082	0.473
MOD_GlcNHglycan	13	16	PF01048	0.522
MOD_GlcNHglycan	47	50	PF01048	0.548
MOD_GlcNHglycan	75	78	PF01048	0.446
MOD_GSK3_1	134	141	PF00069	0.416
MOD_GSK3_1	45	52	PF00069	0.754
MOD_LATS_1	60	66	PF00433	0.685
MOD_NEK2_1	13	18	PF00069	0.704
MOD_NEK2_1	133	138	PF00069	0.397
MOD_NEK2_1	139	144	PF00069	0.366
MOD_PIKK_1	75	81	PF00454	0.730
MOD_PKA_2	5	11	PF00069	0.632
MOD_Plk_1	54	60	PF00069	0.803
MOD_Plk_4	13	19	PF00069	0.675
MOD_Plk_4	139	145	PF00069	0.411
MOD_ProDKin_1	158	164	PF00069	0.509
MOD_SUMO_for_1	155	158	PF00179	0.507
MOD_SUMO_for_1	61	64	PF00179	0.694

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P996	Leptomonas seymouri	57%	100%
A0A3Q8INA7	Leishmania donovani	77%	100%
A4HAR4	Leishmania braziliensis	66%	98%
A4I9X8	Leishmania infantum	77%	100%
Q4Q300	Leishmania major	76%	100%