Putative amastin-like surface protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amastin-like surface protein, putative

Species:

Leishmania mexicana

UniProt:

E9B4Y3_LEIMU

TriTrypDb:

LmxM.33.1980

Length:

206

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 12, no: 200
NetGPI	no	yes: 0, no: 212

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	189
GO:0110165	cellular anatomical entity	1	189

Expansion

Sequence features

E9B4Y3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4Y3

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016540	protein autoprocessing	6	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	62	64	PF00675	0.510
CLV_NRD_NRD_1	86	88	PF00675	0.481
CLV_PCSK_KEX2_1	86	88	PF00082	0.491
DEG_MDM2_SWIB_1	170	178	PF02201	0.316
DOC_CKS1_1	39	44	PF01111	0.357
DOC_CYCLIN_yCln2_LP_2	13	19	PF00134	0.602
DOC_MAPK_MEF2A_6	122	130	PF00069	0.563
DOC_MAPK_RevD_3	134	149	PF00069	0.202
DOC_PP2B_LxvP_1	13	16	PF13499	0.616
DOC_PP2B_LxvP_1	184	187	PF13499	0.578
DOC_PP4_FxxP_1	4	7	PF00568	0.571
DOC_WW_Pin1_4	38	43	PF00397	0.367
LIG_14-3-3_CanoR_1	63	72	PF00244	0.304
LIG_APCC_ABBA_1	1	6	PF00400	0.551
LIG_BIR_II_1	1	5	PF00653	0.709
LIG_EH1_1	18	26	PF00400	0.532
LIG_eIF4E_1	19	25	PF01652	0.513
LIG_FHA_1	16	22	PF00498	0.588
LIG_FHA_1	179	185	PF00498	0.281
LIG_FHA_1	53	59	PF00498	0.307
LIG_FHA_2	187	193	PF00498	0.664
LIG_FHA_2	39	45	PF00498	0.390
LIG_LIR_Gen_1	111	120	PF02991	0.347
LIG_LIR_Gen_1	18	27	PF02991	0.491
LIG_LIR_Gen_1	69	79	PF02991	0.348
LIG_LIR_Nem_3	111	115	PF02991	0.371
LIG_LIR_Nem_3	18	22	PF02991	0.510
LIG_LIR_Nem_3	69	75	PF02991	0.299
LIG_Pex14_2	108	112	PF04695	0.393
LIG_Pex14_2	170	174	PF04695	0.419
LIG_Pex14_2	31	35	PF04695	0.255
LIG_SH2_CRK	118	122	PF00017	0.405
LIG_SH2_CRK	19	23	PF00017	0.512
LIG_SH2_PTP2	26	29	PF00017	0.514
LIG_SH2_STAP1	19	23	PF00017	0.469
LIG_SH2_STAP1	72	76	PF00017	0.311
LIG_SH2_STAT5	26	29	PF00017	0.448
LIG_SH2_STAT5	74	77	PF00017	0.427
LIG_SH3_3	36	42	PF00018	0.368
LIG_SH3_3	45	51	PF00018	0.321
LIG_SUMO_SIM_anti_2	181	187	PF11976	0.391
LIG_SUMO_SIM_anti_2	20	26	PF11976	0.283
LIG_TRAF2_1	203	206	PF00917	0.669
LIG_TYR_ITIM	24	29	PF00017	0.472
LIG_WRC_WIRS_1	109	114	PF05994	0.293
MOD_CK1_1	66	72	PF00069	0.372
MOD_CK2_1	186	192	PF00069	0.692
MOD_CK2_1	38	44	PF00069	0.337
MOD_Cter_Amidation	61	64	PF01082	0.396
MOD_GlcNHglycan	154	157	PF01048	0.491
MOD_GSK3_1	186	193	PF00069	0.720
MOD_GSK3_1	52	59	PF00069	0.285
MOD_GSK3_1	66	73	PF00069	0.326
MOD_NEK2_1	108	113	PF00069	0.313
MOD_NEK2_1	143	148	PF00069	0.447
MOD_NEK2_1	17	22	PF00069	0.696
MOD_NEK2_1	70	75	PF00069	0.318
MOD_PKA_1	63	69	PF00069	0.209
MOD_Plk_4	116	122	PF00069	0.379
MOD_Plk_4	17	23	PF00069	0.478
MOD_Plk_4	178	184	PF00069	0.303
MOD_Plk_4	70	76	PF00069	0.316
MOD_ProDKin_1	38	44	PF00069	0.367
MOD_SUMO_rev_2	192	199	PF00179	0.588
TRG_ENDOCYTIC_2	118	121	PF00928	0.460
TRG_ENDOCYTIC_2	19	22	PF00928	0.542
TRG_ENDOCYTIC_2	26	29	PF00928	0.437
TRG_ENDOCYTIC_2	72	75	PF00928	0.287
TRG_ER_diArg_1	86	89	PF00400	0.389

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C4	Leptomonas seymouri	32%	100%
A0A0N0P547	Leptomonas seymouri	41%	100%
A0A0N0P6P9	Leptomonas seymouri	29%	90%
A0A0N1HWY5	Leptomonas seymouri	28%	100%
A0A0N1PDH0	Leptomonas seymouri	36%	100%
A0A1X0NQ58	Trypanosomatidae	38%	100%
A0A1X0NUH1	Trypanosomatidae	26%	91%
A0A1X0NVT7	Trypanosomatidae	33%	100%
A0A1X0NX02	Trypanosomatidae	31%	100%
A0A1X0P2R3	Trypanosomatidae	27%	98%
A0A1X0P988	Trypanosomatidae	41%	100%
A0A381MTA7	Leishmania infantum	59%	100%
A0A381MTB8	Leishmania infantum	44%	100%
A0A381MTC7	Leishmania infantum	49%	100%
A0A381MTN2	Leishmania infantum	41%	100%
A0A381MVY0	Leishmania infantum	53%	100%
A0A3Q8ID16	Leishmania donovani	28%	100%
A0A3Q8IE85	Leishmania donovani	49%	100%
A0A3Q8IEC2	Leishmania donovani	50%	100%
A0A3Q8IEI1	Leishmania donovani	45%	100%
A0A3Q8IF65	Leishmania donovani	42%	100%
A0A3Q8IFB9	Leishmania donovani	33%	100%
A0A3Q8IFH7	Leishmania donovani	49%	100%
A0A3Q8IH65	Leishmania donovani	46%	100%
A0A3Q8IHN2	Leishmania donovani	46%	100%
A0A3Q8IHW7	Leishmania donovani	50%	100%
A0A3Q8IHZ6	Leishmania donovani	49%	98%
A0A3Q8IIH1	Leishmania donovani	45%	100%
A0A3Q8IL03	Leishmania donovani	41%	100%
A0A3Q8IMR4	Leishmania donovani	27%	100%
A0A3Q8IUK8	Leishmania donovani	58%	100%
A0A3Q8IUR5	Leishmania donovani	41%	100%
A0A3S5H662	Leishmania donovani	45%	100%
A0A3S5H663	Leishmania donovani	45%	100%
A0A3S5H665	Leishmania donovani	45%	100%
A0A3S5H666	Leishmania donovani	43%	100%
A0A3S5H667	Leishmania donovani	45%	100%
A0A3S5H7D2	Leishmania donovani	31%	100%
A0A3S5H7L2	Leishmania donovani	44%	100%
A0A3S5H7V9	Leishmania donovani	44%	100%
A0A3S5H7W2	Leishmania donovani	27%	100%
A0A3S5H7W6	Leishmania donovani	49%	100%
A0A3S7WQA0	Leishmania donovani	45%	100%
A0A3S7WQA8	Leishmania donovani	45%	100%
A0A3S7WQC1	Leishmania donovani	46%	100%
A0A3S7X2E6	Leishmania donovani	41%	100%
A0A3S7X357	Leishmania donovani	25%	93%
A0A3S7X453	Leishmania donovani	41%	100%
A0A3S7X472	Leishmania donovani	41%	100%
A0A3S7X7E5	Leishmania donovani	50%	82%
A0A3S7X7M4	Leishmania donovani	49%	98%
A0A3S7X7U1	Leishmania donovani	47%	98%
A0A3S7X7U4	Leishmania donovani	49%	80%
A0A3S7X7W2	Leishmania donovani	45%	98%
A0A3S7X7Y0	Leishmania donovani	45%	100%
A4H595	Leishmania braziliensis	45%	100%
A4H596	Leishmania braziliensis	46%	100%
A4H597	Leishmania braziliensis	45%	100%
A4H5D1	Leishmania braziliensis	48%	99%
A4H5D2	Leishmania braziliensis	38%	100%
A4H5G0	Leishmania braziliensis	49%	100%
A4H5G4	Leishmania braziliensis	36%	100%
A4H5G6	Leishmania braziliensis	45%	100%
A4H5G7	Leishmania braziliensis	43%	100%
A4H5G9	Leishmania braziliensis	47%	99%
A4H5H0	Leishmania braziliensis	47%	100%
A4H5H1	Leishmania braziliensis	49%	100%
A4H5H2	Leishmania braziliensis	48%	99%
A4H5H3	Leishmania braziliensis	37%	100%
A4H6C8	Leishmania braziliensis	45%	100%
A4H7D7	Leishmania braziliensis	47%	100%
A4H9E8	Leishmania braziliensis	54%	100%
A4H9E9	Leishmania braziliensis	49%	100%
A4HAJ4	Leishmania braziliensis	51%	100%
A4HAJ5	Leishmania braziliensis	45%	100%
A4HAJ6	Leishmania braziliensis	44%	100%
A4HAL2	Leishmania braziliensis	29%	100%
A4HAM2	Leishmania braziliensis	44%	100%
A4HAM4	Leishmania braziliensis	43%	100%
A4HAR1	Leishmania braziliensis	45%	100%
A4HAZ8	Leishmania braziliensis	44%	100%
A4HB00	Leishmania braziliensis	44%	100%
A4HB02	Leishmania braziliensis	44%	100%
A4HB47	Leishmania braziliensis	30%	100%
A4HBJ0	Leishmania braziliensis	48%	99%
A4HBJ1	Leishmania braziliensis	44%	100%
A4HBJ2	Leishmania braziliensis	44%	100%
A4HDI2	Leishmania braziliensis	31%	100%
A4HDI3	Leishmania braziliensis	32%	100%
A4HDI4	Leishmania braziliensis	29%	100%
A4HDL3	Leishmania braziliensis	32%	100%
A4HDL4	Leishmania braziliensis	29%	100%
A4HDL5	Leishmania braziliensis	31%	67%
A4HTM3	Leishmania infantum	45%	100%
A4HTM4	Leishmania infantum	46%	100%
A4HTM5	Leishmania infantum	45%	100%
A4I0W3	Leishmania infantum	27%	95%
A4I0W4	Leishmania infantum	31%	100%
A4I0W5	Leishmania infantum	28%	100%
A4I0W6	Leishmania infantum	27%	70%
A4I4J2	Leishmania infantum	43%	100%
A4I4J3	Leishmania infantum	44%	80%
A4I5B9	Leishmania infantum	25%	93%
A4I6E5	Leishmania infantum	40%	100%
A4I9Q4	Leishmania infantum	47%	100%
A4I9R4	Leishmania infantum	27%	100%
A4I9R5	Leishmania infantum	33%	100%
A4I9R7	Leishmania infantum	48%	100%
A4I9W8	Leishmania infantum	49%	80%
A4I9X0	Leishmania infantum	45%	98%
A4IA59	Leishmania infantum	41%	79%
A4IAL7	Leishmania infantum	50%	100%
A4IAM1	Leishmania infantum	44%	100%
A4IAM2	Leishmania infantum	46%	100%
C6K3X9	Leptomonas seymouri	26%	100%
E8NHC3	Leishmania infantum	44%	100%
E8NHD3	Leishmania infantum	44%	100%
E8NHD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%
E8NHE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	100%
E8NHF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E8NHF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E8NHF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E8NHG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E8NHH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E8NHH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%
E8NHI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	99%
E8NHI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	99%
E8NHK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E8NHK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	98%
E8NHL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
E8NHL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	99%
E8NHM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
E8NHM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E8NHM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E8NHM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E8NHM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
E8NHM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
E8NHP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
E8NHQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E8NHQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E8NHR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%
E8NHR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	100%
E8NHS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E8NHS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	66%
E9AG81	Leishmania infantum	44%	100%
E9AG82	Leishmania infantum	43%	100%
E9AG83	Leishmania infantum	39%	100%
E9AG85	Leishmania infantum	43%	100%
E9AHI9	Leishmania infantum	41%	100%
E9AHT2	Leishmania infantum	50%	98%
E9AME9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9AMF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9AMF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9AMF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9AMF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9AMF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9AMF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9AMF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9AMF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AMF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9ASP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
E9AWW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	96%
E9AWW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AWW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AWX0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	95%
E9B0L6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B1J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	99%
E9B1J4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9B1J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9B4L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9B4R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	99%
E9B4R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E9B4R9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B4S0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
Q4Q1U9	Leishmania major	49%	100%
Q4Q305	Leishmania major	51%	100%
Q4Q309	Leishmania major	46%	100%
Q4Q313	Leishmania major	51%	100%
Q4Q317	Leishmania major	43%	100%
Q4Q325	Leishmania major	49%	100%
Q4Q327	Leishmania major	50%	100%
Q4Q329	Leishmania major	52%	100%
Q4Q333	Leishmania major	51%	100%
Q4Q335	Leishmania major	51%	100%
Q4Q337	Leishmania major	46%	100%
Q4Q339	Leishmania major	51%	100%
Q4Q341	Leishmania major	55%	100%
Q4Q397	Leishmania major	49%	79%
Q4Q3A7	Leishmania major	29%	100%
Q4Q3A8	Leishmania major	33%	100%
Q4Q3A9	Leishmania major	45%	100%
Q4Q3F7	Leishmania major	51%	100%
Q4Q6L8	Leishmania major	40%	99%
Q4Q7L6	Leishmania major	25%	100%
Q4Q7L7	Leishmania major	29%	100%
Q4Q7L8	Leishmania major	29%	100%
Q4QAK4	Leishmania major	27%	95%
Q4QAK5	Leishmania major	28%	100%
Q4QAK6	Leishmania major	32%	100%
Q4QAK7	Leishmania major	27%	95%
Q4QI84	Leishmania major	47%	100%
Q4QI85	Leishmania major	46%	100%
Q4QI86	Leishmania major	48%	100%
Q4QI87	Leishmania major	46%	100%
Q4QI88	Leishmania major	44%	100%
Q4QI92	Leishmania major	43%	100%
Q4QI93	Leishmania major	42%	100%
Q4QI95	Leishmania major	43%	100%
Q4QI97	Leishmania major	44%	100%
Q4QIA0	Leishmania major	43%	100%
Q4QIA1	Leishmania major	43%	100%