Helicase C-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP dependent DEAD-box helicase, putative

Species:

Leishmania mexicana

UniProt:

E9B4X9_LEIMU

TriTrypDb:

LmxM.33.1550

Length:

775

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 11
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0000313	organellar ribosome	6	1
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005761	mitochondrial ribosome	7	1
GO:0005840	ribosome	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B4X9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4X9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004386	helicase activity	2	7
GO:0005488	binding	1	4
GO:0043021	ribonucleoprotein complex binding	3	1
GO:0043022	ribosome binding	4	1
GO:0044877	protein-containing complex binding	2	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	7
GO:0140657	ATP-dependent activity	1	7
GO:0000166	nucleotide binding	3	3
GO:0003676	nucleic acid binding	3	3
GO:0005524	ATP binding	5	3
GO:0017076	purine nucleotide binding	4	3
GO:0030554	adenyl nucleotide binding	5	3
GO:0032553	ribonucleotide binding	3	3
GO:0032555	purine ribonucleotide binding	4	3
GO:0032559	adenyl ribonucleotide binding	5	3
GO:0035639	purine ribonucleoside triphosphate binding	4	3
GO:0036094	small molecule binding	2	3
GO:0043167	ion binding	2	3
GO:0043168	anion binding	3	3
GO:0097159	organic cyclic compound binding	2	3
GO:0097367	carbohydrate derivative binding	2	3
GO:1901265	nucleoside phosphate binding	3	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	225	229	PF00656	0.685
CLV_NRD_NRD_1	13	15	PF00675	0.579
CLV_NRD_NRD_1	220	222	PF00675	0.652
CLV_NRD_NRD_1	326	328	PF00675	0.467
CLV_NRD_NRD_1	361	363	PF00675	0.439
CLV_NRD_NRD_1	365	367	PF00675	0.476
CLV_NRD_NRD_1	399	401	PF00675	0.331
CLV_NRD_NRD_1	539	541	PF00675	0.434
CLV_NRD_NRD_1	62	64	PF00675	0.552
CLV_NRD_NRD_1	686	688	PF00675	0.664
CLV_NRD_NRD_1	713	715	PF00675	0.481
CLV_NRD_NRD_1	756	758	PF00675	0.448
CLV_NRD_NRD_1	770	772	PF00675	0.705
CLV_NRD_NRD_1	773	775	PF00675	0.726
CLV_PCSK_FUR_1	60	64	PF00082	0.594
CLV_PCSK_FUR_1	771	775	PF00082	0.656
CLV_PCSK_KEX2_1	13	15	PF00082	0.579
CLV_PCSK_KEX2_1	326	328	PF00082	0.565
CLV_PCSK_KEX2_1	361	363	PF00082	0.416
CLV_PCSK_KEX2_1	365	367	PF00082	0.454
CLV_PCSK_KEX2_1	399	401	PF00082	0.331
CLV_PCSK_KEX2_1	538	540	PF00082	0.493
CLV_PCSK_KEX2_1	62	64	PF00082	0.578
CLV_PCSK_KEX2_1	688	690	PF00082	0.658
CLV_PCSK_KEX2_1	713	715	PF00082	0.468
CLV_PCSK_KEX2_1	737	739	PF00082	0.541
CLV_PCSK_KEX2_1	752	754	PF00082	0.479
CLV_PCSK_KEX2_1	772	774	PF00082	0.723
CLV_PCSK_PC1ET2_1	688	690	PF00082	0.684
CLV_PCSK_PC1ET2_1	737	739	PF00082	0.541
CLV_PCSK_PC1ET2_1	752	754	PF00082	0.486
CLV_PCSK_PC1ET2_1	772	774	PF00082	0.723
CLV_PCSK_PC7_1	361	367	PF00082	0.482
CLV_PCSK_SKI1_1	110	114	PF00082	0.653
CLV_PCSK_SKI1_1	178	182	PF00082	0.572
CLV_PCSK_SKI1_1	365	369	PF00082	0.418
CLV_PCSK_SKI1_1	448	452	PF00082	0.402
CLV_PCSK_SKI1_1	46	50	PF00082	0.559
CLV_PCSK_SKI1_1	523	527	PF00082	0.514
CLV_PCSK_SKI1_1	565	569	PF00082	0.330
CLV_PCSK_SKI1_1	689	693	PF00082	0.548
CLV_PCSK_SKI1_1	738	742	PF00082	0.443
CLV_PCSK_SKI1_1	749	753	PF00082	0.392
CLV_PCSK_SKI1_1	85	89	PF00082	0.522
DEG_APCC_DBOX_1	537	545	PF00400	0.388
DEG_MDM2_SWIB_1	560	568	PF02201	0.373
DOC_CYCLIN_RxL_1	735	742	PF00134	0.540
DOC_CYCLIN_yCln2_LP_2	426	432	PF00134	0.477
DOC_MAPK_gen_1	326	334	PF00069	0.443
DOC_MAPK_gen_1	502	512	PF00069	0.366
DOC_MAPK_MEF2A_6	284	292	PF00069	0.342
DOC_MAPK_MEF2A_6	448	455	PF00069	0.381
DOC_MAPK_MEF2A_6	727	735	PF00069	0.445
DOC_MAPK_NFAT4_5	448	456	PF00069	0.377
DOC_MAPK_RevD_3	524	539	PF00069	0.404
DOC_PP1_RVXF_1	509	515	PF00149	0.355
DOC_PP1_RVXF_1	521	528	PF00149	0.350
DOC_PP2B_LxvP_1	526	529	PF13499	0.382
DOC_PP4_FxxP_1	692	695	PF00568	0.538
DOC_USP7_MATH_1	134	138	PF00917	0.715
DOC_USP7_MATH_1	144	148	PF00917	0.713
DOC_USP7_MATH_1	171	175	PF00917	0.599
DOC_USP7_MATH_1	223	227	PF00917	0.672
DOC_USP7_MATH_1	230	234	PF00917	0.587
DOC_USP7_MATH_1	580	584	PF00917	0.346
DOC_USP7_UBL2_3	561	565	PF12436	0.532
DOC_USP7_UBL2_3	619	623	PF12436	0.422
DOC_USP7_UBL2_3	694	698	PF12436	0.514
DOC_WW_Pin1_4	139	144	PF00397	0.688
DOC_WW_Pin1_4	210	215	PF00397	0.588
DOC_WW_Pin1_4	705	710	PF00397	0.406
DOC_WW_Pin1_4	90	95	PF00397	0.556
LIG_14-3-3_CanoR_1	118	124	PF00244	0.580
LIG_14-3-3_CanoR_1	372	381	PF00244	0.340
LIG_14-3-3_CanoR_1	486	492	PF00244	0.502
LIG_14-3-3_CanoR_1	5	12	PF00244	0.733
LIG_14-3-3_CanoR_1	505	509	PF00244	0.390
LIG_14-3-3_CanoR_1	672	678	PF00244	0.584
LIG_14-3-3_CanoR_1	757	764	PF00244	0.495
LIG_Actin_WH2_2	383	401	PF00022	0.374
LIG_AP2alpha_2	765	767	PF02296	0.636
LIG_APCC_ABBA_1	548	553	PF00400	0.375
LIG_BIR_II_1	1	5	PF00653	0.449
LIG_BIR_III_4	228	232	PF00653	0.651
LIG_BRCT_BRCA1_1	160	164	PF00533	0.615
LIG_BRCT_BRCA1_1	191	195	PF00533	0.484
LIG_BRCT_BRCA1_1	341	345	PF00533	0.470
LIG_BRCT_BRCA1_1	571	575	PF00533	0.371
LIG_BRCT_BRCA1_1	582	586	PF00533	0.321
LIG_BRCT_BRCA1_1	632	636	PF00533	0.531
LIG_deltaCOP1_diTrp_1	339	345	PF00928	0.378
LIG_FHA_1	119	125	PF00498	0.494
LIG_FHA_1	283	289	PF00498	0.354
LIG_FHA_1	31	37	PF00498	0.645
LIG_FHA_1	375	381	PF00498	0.409
LIG_FHA_1	40	46	PF00498	0.683
LIG_FHA_1	477	483	PF00498	0.480
LIG_FHA_1	505	511	PF00498	0.417
LIG_FHA_1	52	58	PF00498	0.517
LIG_FHA_1	746	752	PF00498	0.455
LIG_FHA_2	120	126	PF00498	0.491
LIG_FHA_2	179	185	PF00498	0.522
LIG_FHA_2	186	192	PF00498	0.538
LIG_FHA_2	346	352	PF00498	0.486
LIG_FHA_2	374	380	PF00498	0.303
LIG_FHA_2	757	763	PF00498	0.516
LIG_LIR_Apic_2	690	695	PF02991	0.545
LIG_LIR_Gen_1	232	242	PF02991	0.488
LIG_LIR_Gen_1	24	32	PF02991	0.618
LIG_LIR_Gen_1	339	349	PF02991	0.360
LIG_LIR_Gen_1	354	364	PF02991	0.461
LIG_LIR_Gen_1	391	398	PF02991	0.395
LIG_LIR_Gen_1	503	513	PF02991	0.366
LIG_LIR_Gen_1	583	591	PF02991	0.320
LIG_LIR_Gen_1	592	600	PF02991	0.369
LIG_LIR_Nem_3	232	237	PF02991	0.498
LIG_LIR_Nem_3	24	29	PF02991	0.583
LIG_LIR_Nem_3	248	254	PF02991	0.444
LIG_LIR_Nem_3	273	279	PF02991	0.394
LIG_LIR_Nem_3	339	344	PF02991	0.360
LIG_LIR_Nem_3	351	356	PF02991	0.394
LIG_LIR_Nem_3	391	395	PF02991	0.390
LIG_LIR_Nem_3	503	509	PF02991	0.348
LIG_LIR_Nem_3	583	589	PF02991	0.316
LIG_LIR_Nem_3	592	597	PF02991	0.378
LIG_LIR_Nem_3	89	95	PF02991	0.620
LIG_NRBOX	508	514	PF00104	0.329
LIG_PCNA_PIPBox_1	668	677	PF02747	0.517
LIG_Pex14_2	560	564	PF04695	0.404
LIG_PTAP_UEV_1	14	19	PF05743	0.437
LIG_REV1ctd_RIR_1	689	694	PF16727	0.566
LIG_RPA_C_Fungi	189	201	PF08784	0.600
LIG_SH2_CRK	251	255	PF00017	0.486
LIG_SH2_NCK_1	92	96	PF00017	0.665
LIG_SH2_STAP1	341	345	PF00017	0.470
LIG_SH2_STAP1	353	357	PF00017	0.329
LIG_SH2_STAP1	675	679	PF00017	0.643
LIG_SH2_STAT3	675	678	PF00017	0.511
LIG_SH2_STAT5	397	400	PF00017	0.357
LIG_SH2_STAT5	402	405	PF00017	0.313
LIG_SH2_STAT5	508	511	PF00017	0.337
LIG_SH2_STAT5	614	617	PF00017	0.360
LIG_SH2_STAT5	675	678	PF00017	0.530
LIG_SH2_STAT5	705	708	PF00017	0.489
LIG_SH3_3	12	18	PF00018	0.447
LIG_SH3_3	247	253	PF00018	0.285
LIG_SH3_3	331	337	PF00018	0.385
LIG_SH3_3	408	414	PF00018	0.421
LIG_SH3_3	482	488	PF00018	0.453
LIG_SH3_3	574	580	PF00018	0.438
LIG_SH3_4	474	481	PF00018	0.610
LIG_SH3_4	694	701	PF00018	0.520
LIG_SH3_5	337	341	PF00018	0.518
LIG_SUMO_SIM_anti_2	285	291	PF11976	0.281
LIG_SUMO_SIM_anti_2	418	424	PF11976	0.307
LIG_TRAF2_1	78	81	PF00917	0.603
LIG_TRFH_1	100	104	PF08558	0.517
LIG_TRFH_1	663	667	PF08558	0.514
LIG_TYR_ITIM	90	95	PF00017	0.634
LIG_WRC_WIRS_1	494	499	PF05994	0.357
LIG_WRC_WIRS_1	586	591	PF05994	0.284
MOD_CDK_SPxK_1	705	711	PF00069	0.367
MOD_CDK_SPxxK_3	90	97	PF00069	0.577
MOD_CK1_1	137	143	PF00069	0.726
MOD_CK1_1	147	153	PF00069	0.700
MOD_CK1_1	174	180	PF00069	0.674
MOD_CK1_1	203	209	PF00069	0.569
MOD_CK1_1	213	219	PF00069	0.563
MOD_CK1_1	24	30	PF00069	0.602
MOD_CK1_1	282	288	PF00069	0.361
MOD_CK1_1	39	45	PF00069	0.523
MOD_CK2_1	119	125	PF00069	0.511
MOD_CK2_1	132	138	PF00069	0.595
MOD_CK2_1	185	191	PF00069	0.493
MOD_CK2_1	242	248	PF00069	0.422
MOD_CK2_1	345	351	PF00069	0.474
MOD_CK2_1	352	358	PF00069	0.473
MOD_CK2_1	621	627	PF00069	0.373
MOD_CK2_1	756	762	PF00069	0.513
MOD_CK2_1	90	96	PF00069	0.563
MOD_Cter_Amidation	769	772	PF01082	0.485
MOD_GlcNHglycan	134	137	PF01048	0.755
MOD_GlcNHglycan	191	194	PF01048	0.549
MOD_GlcNHglycan	23	26	PF01048	0.587
MOD_GlcNHglycan	234	237	PF01048	0.439
MOD_GlcNHglycan	244	247	PF01048	0.520
MOD_GlcNHglycan	281	284	PF01048	0.359
MOD_GlcNHglycan	415	418	PF01048	0.467
MOD_GlcNHglycan	456	459	PF01048	0.345
MOD_GlcNHglycan	535	538	PF01048	0.306
MOD_GlcNHglycan	7	10	PF01048	0.693
MOD_GSK3_1	132	139	PF00069	0.645
MOD_GSK3_1	174	181	PF00069	0.575
MOD_GSK3_1	185	192	PF00069	0.542
MOD_GSK3_1	208	215	PF00069	0.574
MOD_GSK3_1	279	286	PF00069	0.401
MOD_GSK3_1	32	39	PF00069	0.616
MOD_GSK3_1	476	483	PF00069	0.489
MOD_GSK3_1	585	592	PF00069	0.402
MOD_LATS_1	717	723	PF00433	0.532
MOD_N-GLC_1	150	155	PF02516	0.497
MOD_N-GLC_1	158	163	PF02516	0.507
MOD_N-GLC_1	39	44	PF02516	0.619
MOD_NEK2_1	164	169	PF00069	0.579
MOD_NEK2_1	242	247	PF00069	0.343
MOD_NEK2_1	317	322	PF00069	0.357
MOD_NEK2_1	345	350	PF00069	0.434
MOD_NEK2_1	373	378	PF00069	0.337
MOD_NEK2_1	435	440	PF00069	0.359
MOD_NEK2_2	493	498	PF00069	0.341
MOD_NEK2_2	747	752	PF00069	0.620
MOD_PIKK_1	719	725	PF00454	0.528
MOD_PIKK_1	76	82	PF00454	0.673
MOD_PK_1	727	733	PF00069	0.452
MOD_PKA_1	13	19	PF00069	0.579
MOD_PKA_1	365	371	PF00069	0.489
MOD_PKA_2	13	19	PF00069	0.682
MOD_PKA_2	365	371	PF00069	0.512
MOD_PKA_2	4	10	PF00069	0.778
MOD_PKA_2	504	510	PF00069	0.431
MOD_PKA_2	516	522	PF00069	0.366
MOD_PKA_2	569	575	PF00069	0.254
MOD_PKA_2	654	660	PF00069	0.448
MOD_PKA_2	756	762	PF00069	0.494
MOD_PKB_1	3	11	PF00069	0.563
MOD_Plk_1	171	177	PF00069	0.620
MOD_Plk_1	339	345	PF00069	0.358
MOD_Plk_1	88	94	PF00069	0.531
MOD_Plk_2-3	158	164	PF00069	0.562
MOD_Plk_2-3	352	358	PF00069	0.372
MOD_Plk_2-3	621	627	PF00069	0.473
MOD_Plk_2-3	630	636	PF00069	0.486
MOD_Plk_4	119	125	PF00069	0.646
MOD_Plk_4	164	170	PF00069	0.586
MOD_Plk_4	185	191	PF00069	0.505
MOD_Plk_4	283	289	PF00069	0.293
MOD_Plk_4	339	345	PF00069	0.437
MOD_Plk_4	352	358	PF00069	0.439
MOD_Plk_4	477	483	PF00069	0.495
MOD_Plk_4	727	733	PF00069	0.532
MOD_ProDKin_1	139	145	PF00069	0.689
MOD_ProDKin_1	210	216	PF00069	0.591
MOD_ProDKin_1	705	711	PF00069	0.406
MOD_ProDKin_1	90	96	PF00069	0.555
MOD_SUMO_rev_2	457	464	PF00179	0.498
MOD_SUMO_rev_2	552	560	PF00179	0.384
MOD_SUMO_rev_2	617	625	PF00179	0.416
TRG_DiLeu_BaEn_1	53	58	PF01217	0.569
TRG_DiLeu_BaLyEn_6	238	243	PF01217	0.469
TRG_DiLeu_BaLyEn_6	258	263	PF01217	0.324
TRG_DiLeu_BaLyEn_6	408	413	PF01217	0.358
TRG_DiLeu_BaLyEn_6	508	513	PF01217	0.321
TRG_ENDOCYTIC_2	251	254	PF00928	0.496
TRG_ENDOCYTIC_2	341	344	PF00928	0.471
TRG_ENDOCYTIC_2	357	360	PF00928	0.380
TRG_ENDOCYTIC_2	69	72	PF00928	0.600
TRG_ENDOCYTIC_2	92	95	PF00928	0.618
TRG_ER_diArg_1	12	14	PF00400	0.587
TRG_ER_diArg_1	3	6	PF00400	0.627
TRG_ER_diArg_1	360	362	PF00400	0.433
TRG_ER_diArg_1	364	366	PF00400	0.432
TRG_ER_diArg_1	398	400	PF00400	0.340
TRG_ER_diArg_1	538	540	PF00400	0.509
TRG_ER_diArg_1	60	63	PF00400	0.641
TRG_ER_diArg_1	686	689	PF00400	0.554
TRG_ER_diArg_1	713	715	PF00400	0.466
TRG_ER_diArg_1	771	774	PF00400	0.585
TRG_NLS_Bipartite_1	757	775	PF00514	0.677
TRG_NLS_MonoCore_2	770	775	PF00514	0.616
TRG_NLS_MonoExtN_4	769	775	PF00514	0.644
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.679
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.546
TRG_Pf-PMV_PEXEL_1	542	547	PF00026	0.423
TRG_Pf-PMV_PEXEL_1	719	723	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	738	742	PF00026	0.378
TRG_Pf-PMV_PEXEL_1	85	89	PF00026	0.626

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IC11	Leptomonas seymouri	71%	100%
A0A0S4IWL5	Bodo saltans	38%	87%
A0A1X0P9H1	Trypanosomatidae	55%	100%
A0A3R7MZ37	Trypanosoma rangeli	56%	100%
A0A3S7X7R6	Leishmania donovani	91%	100%
A4HAM5	Leishmania braziliensis	82%	100%
A4HAQ8	Leishmania braziliensis	72%	98%
C9ZMR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9AHT4	Leishmania infantum	91%	100%
Q4Q347	Leishmania major	92%	100%
V5BT32	Trypanosoma cruzi	57%	100%