P25-alpha domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

p25-alpha, putative

Species:

Leishmania mexicana

UniProt:

E9B4X7_LEIMU

TriTrypDb:

LmxM.33.1520

Length:

132

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 14

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

E9B4X7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4X7

Function

Biological processes
Term	Name	Level	Count
GO:0031334	positive regulation of protein-containing complex assembly	6	2
GO:0032271	regulation of protein polymerization	6	2
GO:0032273	positive regulation of protein polymerization	7	2
GO:0043254	regulation of protein-containing complex assembly	5	2
GO:0044087	regulation of cellular component biogenesis	4	2
GO:0044089	positive regulation of cellular component biogenesis	5	2
GO:0048518	positive regulation of biological process	3	2
GO:0048522	positive regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051128	regulation of cellular component organization	4	2
GO:0051130	positive regulation of cellular component organization	5	2
GO:0065007	biological regulation	1	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	120	124	PF00656	0.469
CLV_C14_Caspase3-7	21	25	PF00656	0.472
CLV_NRD_NRD_1	117	119	PF00675	0.272
CLV_NRD_NRD_1	37	39	PF00675	0.271
CLV_PCSK_KEX2_1	117	119	PF00082	0.272
CLV_PCSK_SKI1_1	18	22	PF00082	0.272
CLV_PCSK_SKI1_1	8	12	PF00082	0.272
DEG_Nend_UBRbox_2	1	3	PF02207	0.451
DOC_MAPK_gen_1	33	42	PF00069	0.497
DOC_PP1_RVXF_1	36	43	PF00149	0.515
DOC_USP7_MATH_1	73	77	PF00917	0.521
DOC_USP7_UBL2_3	14	18	PF12436	0.482
DOC_USP7_UBL2_3	31	35	PF12436	0.424
DOC_WW_Pin1_4	57	62	PF00397	0.528
LIG_14-3-3_CanoR_1	125	132	PF00244	0.750
LIG_14-3-3_CanoR_1	38	43	PF00244	0.483
LIG_FHA_2	100	106	PF00498	0.494
LIG_FHA_2	19	25	PF00498	0.472
LIG_FHA_2	58	64	PF00498	0.596
LIG_FHA_2	76	82	PF00498	0.398
LIG_LIR_Gen_1	26	37	PF02991	0.472
LIG_LIR_Gen_1	4	10	PF02991	0.605
LIG_LIR_Gen_1	41	50	PF02991	0.472
LIG_LIR_Nem_3	26	32	PF02991	0.479
LIG_LIR_Nem_3	41	45	PF02991	0.523
LIG_SH2_STAT5	92	95	PF00017	0.472
MOD_CK1_1	19	25	PF00069	0.497
MOD_CK1_1	4	10	PF00069	0.502
MOD_CK1_1	75	81	PF00069	0.535
MOD_CK1_1	90	96	PF00069	0.472
MOD_CK2_1	38	44	PF00069	0.512
MOD_GlcNHglycan	75	78	PF01048	0.357
MOD_GSK3_1	16	23	PF00069	0.484
MOD_GSK3_1	75	82	PF00069	0.587
MOD_NEK2_1	1	6	PF00069	0.493
MOD_NEK2_1	27	32	PF00069	0.593
MOD_PKA_1	38	44	PF00069	0.482
MOD_PKA_2	124	130	PF00069	0.482
MOD_Plk_1	1	7	PF00069	0.498
MOD_Plk_1	87	93	PF00069	0.511
MOD_ProDKin_1	57	63	PF00069	0.528
MOD_SUMO_rev_2	7	16	PF00179	0.472
MOD_SUMO_rev_2	81	91	PF00179	0.472
TRG_Pf-PMV_PEXEL_1	8	12	PF00026	0.272

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMI7	Leptomonas seymouri	80%	85%
A0A0N1PDJ8	Leptomonas seymouri	77%	85%
A0A0S4IQF6	Bodo saltans	68%	67%
A0A1X0PAD0	Trypanosomatidae	70%	87%
A0A3R7N9A0	Trypanosoma rangeli	67%	87%
A0A3S7X7W0	Leishmania donovani	100%	93%
A4H7S1	Leishmania braziliensis	90%	70%
A4H7S2	Leishmania braziliensis	91%	100%
A4I9W4	Leishmania infantum	99%	86%
A4I9W5	Leishmania infantum	99%	93%
A4IIY2	Xenopus tropicalis	40%	75%
C9ZMR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	88%
Q0P5Y3	Mus musculus	41%	78%
Q2VPM9	Xenopus laevis	42%	75%
Q3T077	Bos taurus	37%	77%
Q3ZCC8	Bos taurus	39%	75%
Q4Q349	Leishmania major	98%	100%
Q4Q350	Leishmania major	100%	100%
Q5PPN5	Rattus norvegicus	39%	75%
Q9BW30	Homo sapiens	39%	75%
Q9CRB6	Mus musculus	39%	75%