Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B4X6_LEIMU

TriTrypDb:

LmxM.33.1510

Length:

508

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4X6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4X6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	201	205	PF00656	0.682
CLV_C14_Caspase3-7	370	374	PF00656	0.532
CLV_C14_Caspase3-7	97	101	PF00656	0.693
CLV_NRD_NRD_1	360	362	PF00675	0.705
CLV_NRD_NRD_1	37	39	PF00675	0.616
CLV_PCSK_KEX2_1	360	362	PF00082	0.705
CLV_PCSK_KEX2_1	37	39	PF00082	0.616
CLV_PCSK_SKI1_1	218	222	PF00082	0.671
CLV_PCSK_SKI1_1	461	465	PF00082	0.496
CLV_PCSK_SKI1_1	71	75	PF00082	0.536
DEG_APCC_DBOX_1	359	367	PF00400	0.645
DEG_APCC_KENBOX_2	260	264	PF00400	0.592
DEG_SCF_FBW7_2	6	11	PF00400	0.553
DEG_SPOP_SBC_1	182	186	PF00917	0.649
DEG_SPOP_SBC_1	205	209	PF00917	0.574
DEG_SPOP_SBC_1	422	426	PF00917	0.602
DOC_CYCLIN_RxL_1	475	486	PF00134	0.499
DOC_CYCLIN_yClb5_NLxxxL_5	144	153	PF00134	0.577
DOC_USP7_MATH_1	143	147	PF00917	0.623
DOC_USP7_MATH_1	205	209	PF00917	0.501
DOC_USP7_MATH_1	355	359	PF00917	0.613
DOC_USP7_MATH_1	376	380	PF00917	0.654
DOC_USP7_MATH_1	422	426	PF00917	0.680
DOC_USP7_MATH_1	454	458	PF00917	0.592
DOC_USP7_UBL2_3	70	74	PF12436	0.551
DOC_WW_Pin1_4	132	137	PF00397	0.638
DOC_WW_Pin1_4	273	278	PF00397	0.551
DOC_WW_Pin1_4	387	392	PF00397	0.711
DOC_WW_Pin1_4	4	9	PF00397	0.762
LIG_14-3-3_CanoR_1	138	143	PF00244	0.704
LIG_14-3-3_CanoR_1	360	364	PF00244	0.647
LIG_APCC_ABBA_1	15	20	PF00400	0.617
LIG_BIR_II_1	1	5	PF00653	0.590
LIG_FHA_1	139	145	PF00498	0.662
LIG_FHA_1	182	188	PF00498	0.619
LIG_FHA_1	34	40	PF00498	0.679
LIG_FHA_2	226	232	PF00498	0.528
LIG_FHA_2	249	255	PF00498	0.625
LIG_FHA_2	302	308	PF00498	0.601
LIG_FHA_2	360	366	PF00498	0.618
LIG_FHA_2	424	430	PF00498	0.751
LIG_FHA_2	440	446	PF00498	0.503
LIG_FHA_2	492	498	PF00498	0.505
LIG_LIR_Gen_1	103	110	PF02991	0.503
LIG_LIR_Gen_1	238	248	PF02991	0.607
LIG_LIR_Nem_3	103	108	PF02991	0.527
LIG_LIR_Nem_3	462	467	PF02991	0.500
LIG_LIR_Nem_3	53	59	PF02991	0.590
LIG_LRP6_Inhibitor_1	341	347	PF00058	0.488
LIG_PCNA_PIPBox_1	484	493	PF02747	0.508
LIG_PCNA_yPIPBox_3	478	491	PF02747	0.459
LIG_PTB_Apo_2	381	388	PF02174	0.604
LIG_SH2_CRK	105	109	PF00017	0.614
LIG_SH2_GRB2like	105	108	PF00017	0.685
LIG_SH2_NCK_1	105	109	PF00017	0.577
LIG_SH2_STAT3	382	385	PF00017	0.551
LIG_SH2_STAT5	245	248	PF00017	0.621
LIG_SH2_STAT5	490	493	PF00017	0.564
LIG_SH2_STAT5	56	59	PF00017	0.589
LIG_SH3_3	130	136	PF00018	0.635
LIG_SH3_3	274	280	PF00018	0.556
LIG_SH3_3	361	367	PF00018	0.634
LIG_SUMO_SIM_par_1	207	215	PF11976	0.548
LIG_TRAF2_1	383	386	PF00917	0.630
LIG_TYR_ITSM	101	108	PF00017	0.502
LIG_WRC_WIRS_1	328	333	PF05994	0.663
MOD_CDC14_SPxK_1	135	138	PF00782	0.714
MOD_CDK_SPxK_1	132	138	PF00069	0.713
MOD_CDK_SPxK_1	273	279	PF00069	0.552
MOD_CK1_1	106	112	PF00069	0.611
MOD_CK1_1	183	189	PF00069	0.678
MOD_CK1_1	234	240	PF00069	0.541
MOD_CK1_1	273	279	PF00069	0.559
MOD_CK1_1	298	304	PF00069	0.607
MOD_CK1_1	327	333	PF00069	0.616
MOD_CK1_1	427	433	PF00069	0.782
MOD_CK1_1	80	86	PF00069	0.633
MOD_CK1_1	9	15	PF00069	0.672
MOD_CK2_1	204	210	PF00069	0.608
MOD_CK2_1	248	254	PF00069	0.650
MOD_CK2_1	301	307	PF00069	0.622
MOD_GlcNHglycan	11	15	PF01048	0.628
MOD_GlcNHglycan	145	148	PF01048	0.611
MOD_GlcNHglycan	170	173	PF01048	0.627
MOD_GlcNHglycan	272	275	PF01048	0.557
MOD_GlcNHglycan	300	303	PF01048	0.604
MOD_GlcNHglycan	319	322	PF01048	0.783
MOD_GlcNHglycan	341	344	PF01048	0.670
MOD_GlcNHglycan	350	354	PF01048	0.583
MOD_GlcNHglycan	501	505	PF01048	0.459
MOD_GSK3_1	134	141	PF00069	0.714
MOD_GSK3_1	188	195	PF00069	0.704
MOD_GSK3_1	206	213	PF00069	0.650
MOD_GSK3_1	221	228	PF00069	0.573
MOD_GSK3_1	231	238	PF00069	0.513
MOD_GSK3_1	248	255	PF00069	0.634
MOD_GSK3_1	291	298	PF00069	0.559
MOD_GSK3_1	308	315	PF00069	0.766
MOD_GSK3_1	323	330	PF00069	0.515
MOD_GSK3_1	351	358	PF00069	0.565
MOD_GSK3_1	423	430	PF00069	0.642
MOD_GSK3_1	6	13	PF00069	0.706
MOD_LATS_1	421	427	PF00433	0.703
MOD_N-GLC_1	106	111	PF02516	0.686
MOD_N-GLC_1	434	439	PF02516	0.618
MOD_NEK2_1	10	15	PF00069	0.742
MOD_NEK2_1	232	237	PF00069	0.511
MOD_NEK2_1	25	30	PF00069	0.542
MOD_NEK2_1	293	298	PF00069	0.585
MOD_NEK2_1	317	322	PF00069	0.733
MOD_NEK2_1	324	329	PF00069	0.585
MOD_NEK2_1	331	336	PF00069	0.575
MOD_NEK2_1	339	344	PF00069	0.550
MOD_NEK2_1	359	364	PF00069	0.490
MOD_NEK2_1	491	496	PF00069	0.503
MOD_NEK2_2	240	245	PF00069	0.652
MOD_NEK2_2	355	360	PF00069	0.615
MOD_PIKK_1	100	106	PF00454	0.677
MOD_PIKK_1	291	297	PF00454	0.529
MOD_PK_1	221	227	PF00069	0.521
MOD_PK_1	77	83	PF00069	0.656
MOD_PKA_2	359	365	PF00069	0.648
MOD_PKB_1	178	186	PF00069	0.601
MOD_Plk_1	10	16	PF00069	0.540
MOD_Plk_1	106	112	PF00069	0.687
MOD_Plk_1	113	119	PF00069	0.613
MOD_Plk_1	124	130	PF00069	0.510
MOD_Plk_1	189	195	PF00069	0.529
MOD_Plk_1	252	258	PF00069	0.648
MOD_Plk_1	434	440	PF00069	0.617
MOD_Plk_1	472	478	PF00069	0.462
MOD_Plk_1	500	506	PF00069	0.461
MOD_Plk_1	77	83	PF00069	0.628
MOD_Plk_2-3	125	131	PF00069	0.620
MOD_Plk_4	183	189	PF00069	0.695
MOD_Plk_4	192	198	PF00069	0.597
MOD_Plk_4	240	246	PF00069	0.607
MOD_Plk_4	285	291	PF00069	0.538
MOD_Plk_4	434	440	PF00069	0.602
MOD_Plk_4	77	83	PF00069	0.668
MOD_ProDKin_1	132	138	PF00069	0.637
MOD_ProDKin_1	273	279	PF00069	0.552
MOD_ProDKin_1	387	393	PF00069	0.709
MOD_ProDKin_1	4	10	PF00069	0.763
MOD_SUMO_rev_2	67	73	PF00179	0.514
TRG_DiLeu_BaEn_1	462	467	PF01217	0.500
TRG_DiLeu_BaEn_4	415	421	PF01217	0.614
TRG_ENDOCYTIC_2	105	108	PF00928	0.613
TRG_ER_diArg_1	216	219	PF00400	0.628
TRG_ER_diArg_1	359	361	PF00400	0.649
TRG_ER_diArg_1	37	39	PF00400	0.616
TRG_Pf-PMV_PEXEL_1	265	270	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	361	365	PF00026	0.647
TRG_Pf-PMV_PEXEL_1	478	483	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8X2	Leptomonas seymouri	55%	92%
A0A3S7X7T0	Leishmania donovani	91%	100%
A4H7S3	Leishmania braziliensis	76%	100%
A4I9W3	Leishmania infantum	92%	100%
Q4Q351	Leishmania major	91%	100%