PCI domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF3808), putative

Species:

Leishmania mexicana

UniProt:

E9B4X5_LEIMU

TriTrypDb:

LmxM.33.1500

Length:

803

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	2

Expansion

Sequence features

E9B4X5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4X5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	241	245	PF00656	0.530
CLV_C14_Caspase3-7	479	483	PF00656	0.502
CLV_NRD_NRD_1	365	367	PF00675	0.177
CLV_NRD_NRD_1	529	531	PF00675	0.360
CLV_NRD_NRD_1	607	609	PF00675	0.511
CLV_NRD_NRD_1	680	682	PF00675	0.434
CLV_PCSK_FUR_1	641	645	PF00082	0.356
CLV_PCSK_FUR_1	678	682	PF00082	0.451
CLV_PCSK_KEX2_1	365	367	PF00082	0.177
CLV_PCSK_KEX2_1	439	441	PF00082	0.344
CLV_PCSK_KEX2_1	548	550	PF00082	0.333
CLV_PCSK_KEX2_1	643	645	PF00082	0.371
CLV_PCSK_KEX2_1	680	682	PF00082	0.566
CLV_PCSK_PC1ET2_1	439	441	PF00082	0.344
CLV_PCSK_PC1ET2_1	548	550	PF00082	0.360
CLV_PCSK_PC1ET2_1	643	645	PF00082	0.371
CLV_PCSK_PC7_1	639	645	PF00082	0.347
CLV_PCSK_SKI1_1	291	295	PF00082	0.370
CLV_PCSK_SKI1_1	302	306	PF00082	0.314
CLV_PCSK_SKI1_1	366	370	PF00082	0.241
CLV_PCSK_SKI1_1	531	535	PF00082	0.343
CLV_PCSK_SKI1_1	56	60	PF00082	0.456
CLV_PCSK_SKI1_1	697	701	PF00082	0.468
CLV_PCSK_SKI1_1	797	801	PF00082	0.627
DEG_APCC_DBOX_1	301	309	PF00400	0.562
DEG_SPOP_SBC_1	655	659	PF00917	0.502
DOC_CKS1_1	234	239	PF01111	0.377
DOC_CKS1_1	721	726	PF01111	0.563
DOC_CYCLIN_yCln2_LP_2	570	576	PF00134	0.606
DOC_MAPK_gen_1	373	381	PF00069	0.597
DOC_MAPK_gen_1	389	398	PF00069	0.501
DOC_MAPK_gen_1	439	447	PF00069	0.535
DOC_MAPK_gen_1	548	555	PF00069	0.629
DOC_MAPK_gen_1	608	615	PF00069	0.527
DOC_MAPK_gen_1	707	716	PF00069	0.578
DOC_MAPK_MEF2A_6	375	383	PF00069	0.524
DOC_USP7_MATH_1	205	209	PF00917	0.586
DOC_USP7_MATH_1	333	337	PF00917	0.499
DOC_USP7_MATH_1	347	351	PF00917	0.475
DOC_USP7_MATH_1	406	410	PF00917	0.530
DOC_USP7_MATH_1	501	505	PF00917	0.377
DOC_USP7_MATH_1	647	651	PF00917	0.727
DOC_USP7_MATH_1	756	760	PF00917	0.494
DOC_USP7_UBL2_3	223	227	PF12436	0.487
DOC_USP7_UBL2_3	778	782	PF12436	0.540
DOC_WW_Pin1_4	1	6	PF00397	0.577
DOC_WW_Pin1_4	233	238	PF00397	0.568
DOC_WW_Pin1_4	246	251	PF00397	0.559
DOC_WW_Pin1_4	329	334	PF00397	0.508
DOC_WW_Pin1_4	56	61	PF00397	0.594
DOC_WW_Pin1_4	626	631	PF00397	0.544
DOC_WW_Pin1_4	651	656	PF00397	0.681
DOC_WW_Pin1_4	659	664	PF00397	0.742
DOC_WW_Pin1_4	667	672	PF00397	0.744
DOC_WW_Pin1_4	720	725	PF00397	0.529
DOC_WW_Pin1_4	750	755	PF00397	0.458
LIG_14-3-3_CanoR_1	110	116	PF00244	0.544
LIG_14-3-3_CanoR_1	129	137	PF00244	0.384
LIG_14-3-3_CanoR_1	14	18	PF00244	0.499
LIG_14-3-3_CanoR_1	170	175	PF00244	0.544
LIG_14-3-3_CanoR_1	204	210	PF00244	0.586
LIG_14-3-3_CanoR_1	277	281	PF00244	0.492
LIG_14-3-3_CanoR_1	389	395	PF00244	0.594
LIG_14-3-3_CanoR_1	530	536	PF00244	0.562
LIG_14-3-3_CanoR_1	680	685	PF00244	0.670
LIG_14-3-3_CanoR_1	729	734	PF00244	0.434
LIG_14-3-3_CanoR_1	92	97	PF00244	0.558
LIG_Actin_WH2_2	290	308	PF00022	0.562
LIG_BIR_II_1	1	5	PF00653	0.774
LIG_BRCT_BRCA1_1	145	149	PF00533	0.550
LIG_BRCT_BRCA1_1	503	507	PF00533	0.377
LIG_BRCT_BRCA1_2	145	151	PF00533	0.586
LIG_Clathr_ClatBox_1	30	34	PF01394	0.383
LIG_DLG_GKlike_1	729	737	PF00625	0.543
LIG_FHA_1	270	276	PF00498	0.539
LIG_FHA_1	389	395	PF00498	0.543
LIG_FHA_1	93	99	PF00498	0.377
LIG_FHA_2	256	262	PF00498	0.499
LIG_FHA_2	504	510	PF00498	0.510
LIG_FHA_2	655	661	PF00498	0.629
LIG_HCF-1_HBM_1	217	220	PF13415	0.530
LIG_LIR_Gen_1	146	153	PF02991	0.538
LIG_LIR_Gen_1	211	220	PF02991	0.532
LIG_LIR_Gen_1	504	515	PF02991	0.563
LIG_LIR_Nem_3	146	152	PF02991	0.567
LIG_LIR_Nem_3	207	212	PF02991	0.487
LIG_LIR_Nem_3	355	360	PF02991	0.533
LIG_LIR_Nem_3	422	426	PF02991	0.482
LIG_LIR_Nem_3	427	432	PF02991	0.482
LIG_LIR_Nem_3	504	510	PF02991	0.563
LIG_LIR_Nem_3	686	691	PF02991	0.411
LIG_LIR_Nem_3	743	749	PF02991	0.429
LIG_PCNA_yPIPBox_3	182	196	PF02747	0.576
LIG_PCNA_yPIPBox_3	622	635	PF02747	0.518
LIG_Pex14_1	731	735	PF04695	0.461
LIG_Pex14_2	149	153	PF04695	0.586
LIG_REV1ctd_RIR_1	75	85	PF16727	0.513
LIG_RPA_C_Fungi	44	56	PF08784	0.547
LIG_SH2_CRK	209	213	PF00017	0.386
LIG_SH2_CRK	343	347	PF00017	0.447
LIG_SH2_CRK	432	436	PF00017	0.402
LIG_SH2_CRK	688	692	PF00017	0.439
LIG_SH2_NCK_1	735	739	PF00017	0.425
LIG_SH2_NCK_1	742	746	PF00017	0.382
LIG_SH2_SRC	357	360	PF00017	0.447
LIG_SH2_SRC	432	435	PF00017	0.402
LIG_SH2_SRC	459	462	PF00017	0.366
LIG_SH2_STAP1	426	430	PF00017	0.378
LIG_SH2_STAP1	592	596	PF00017	0.468
LIG_SH2_STAP1	72	76	PF00017	0.402
LIG_SH2_STAP1	735	739	PF00017	0.447
LIG_SH2_STAP1	742	746	PF00017	0.420
LIG_SH2_STAT5	357	360	PF00017	0.447
LIG_SH2_STAT5	619	622	PF00017	0.501
LIG_SH2_STAT5	634	637	PF00017	0.443
LIG_SH2_STAT5	746	749	PF00017	0.459
LIG_SH3_3	244	250	PF00018	0.456
LIG_SH3_3	570	576	PF00018	0.552
LIG_SH3_3	584	590	PF00018	0.437
LIG_SH3_3	649	655	PF00018	0.551
LIG_SH3_3	665	671	PF00018	0.783
LIG_SH3_5	630	634	PF00018	0.589
LIG_SUMO_SIM_anti_2	25	32	PF11976	0.646
LIG_SUMO_SIM_par_1	610	617	PF11976	0.494
LIG_TRAF2_1	23	26	PF00917	0.677
LIG_TRAF2_1	239	242	PF00917	0.402
LIG_UBA3_1	690	697	PF00899	0.457
LIG_UBA3_1	760	766	PF00899	0.546
MOD_CDK_SPK_2	1	6	PF00069	0.518
MOD_CDK_SPxxK_3	659	666	PF00069	0.621
MOD_CDK_SPxxK_3	720	727	PF00069	0.559
MOD_CK1_1	140	146	PF00069	0.444
MOD_CK1_1	208	214	PF00069	0.488
MOD_CK1_1	229	235	PF00069	0.390
MOD_CK1_1	4	10	PF00069	0.756
MOD_CK1_1	449	455	PF00069	0.331
MOD_CK1_1	508	514	PF00069	0.402
MOD_CK1_1	637	643	PF00069	0.487
MOD_CK1_1	650	656	PF00069	0.676
MOD_CK1_1	659	665	PF00069	0.703
MOD_CK2_1	162	168	PF00069	0.447
MOD_CK2_1	45	51	PF00069	0.528
MOD_CK2_1	508	514	PF00069	0.398
MOD_CK2_1	639	645	PF00069	0.591
MOD_CK2_1	65	71	PF00069	0.367
MOD_CK2_1	654	660	PF00069	0.617
MOD_CK2_1	680	686	PF00069	0.610
MOD_CK2_1	7	13	PF00069	0.717
MOD_GlcNHglycan	130	133	PF01048	0.447
MOD_GlcNHglycan	164	167	PF01048	0.405
MOD_GlcNHglycan	192	195	PF01048	0.434
MOD_GlcNHglycan	265	269	PF01048	0.404
MOD_GlcNHglycan	335	338	PF01048	0.414
MOD_GlcNHglycan	349	352	PF01048	0.399
MOD_GlcNHglycan	561	564	PF01048	0.347
MOD_GSK3_1	128	135	PF00069	0.340
MOD_GSK3_1	136	143	PF00069	0.351
MOD_GSK3_1	204	211	PF00069	0.445
MOD_GSK3_1	226	233	PF00069	0.442
MOD_GSK3_1	242	249	PF00069	0.490
MOD_GSK3_1	260	267	PF00069	0.360
MOD_GSK3_1	329	336	PF00069	0.402
MOD_GSK3_1	390	397	PF00069	0.393
MOD_GSK3_1	501	508	PF00069	0.349
MOD_GSK3_1	647	654	PF00069	0.656
MOD_GSK3_1	655	662	PF00069	0.619
MOD_N-GLC_1	205	210	PF02516	0.370
MOD_N-GLC_1	56	61	PF02516	0.463
MOD_N-GLC_1	655	660	PF02516	0.775
MOD_N-GLC_2	402	404	PF02516	0.480
MOD_NEK2_1	127	132	PF00069	0.357
MOD_NEK2_1	188	193	PF00069	0.386
MOD_NEK2_1	264	269	PF00069	0.428
MOD_NEK2_1	292	297	PF00069	0.445
MOD_NEK2_1	353	358	PF00069	0.391
MOD_NEK2_1	374	379	PF00069	0.306
MOD_NEK2_1	396	401	PF00069	0.407
MOD_NEK2_1	448	453	PF00069	0.403
MOD_NEK2_1	45	50	PF00069	0.567
MOD_NEK2_2	634	639	PF00069	0.492
MOD_PIKK_1	132	138	PF00454	0.414
MOD_PIKK_1	175	181	PF00454	0.470
MOD_PIKK_1	230	236	PF00454	0.402
MOD_PIKK_1	43	49	PF00454	0.372
MOD_PKA_1	439	445	PF00069	0.447
MOD_PKA_1	680	686	PF00069	0.363
MOD_PKA_2	128	134	PF00069	0.365
MOD_PKA_2	13	19	PF00069	0.496
MOD_PKA_2	276	282	PF00069	0.356
MOD_PKA_2	374	380	PF00069	0.386
MOD_PKA_2	388	394	PF00069	0.306
MOD_PKA_2	439	445	PF00069	0.447
MOD_PKA_2	680	686	PF00069	0.577
MOD_PKB_1	678	686	PF00069	0.389
MOD_PKB_1	90	98	PF00069	0.188
MOD_Plk_1	140	146	PF00069	0.432
MOD_Plk_1	205	211	PF00069	0.370
MOD_Plk_1	260	266	PF00069	0.424
MOD_Plk_1	394	400	PF00069	0.434
MOD_Plk_4	140	146	PF00069	0.447
MOD_Plk_4	208	214	PF00069	0.439
MOD_Plk_4	292	298	PF00069	0.402
MOD_Plk_4	326	332	PF00069	0.340
MOD_Plk_4	353	359	PF00069	0.391
MOD_Plk_4	374	380	PF00069	0.322
MOD_Plk_4	695	701	PF00069	0.410
MOD_Plk_4	756	762	PF00069	0.537
MOD_ProDKin_1	1	7	PF00069	0.576
MOD_ProDKin_1	233	239	PF00069	0.455
MOD_ProDKin_1	246	252	PF00069	0.443
MOD_ProDKin_1	329	335	PF00069	0.372
MOD_ProDKin_1	56	62	PF00069	0.593
MOD_ProDKin_1	626	632	PF00069	0.539
MOD_ProDKin_1	651	657	PF00069	0.683
MOD_ProDKin_1	659	665	PF00069	0.741
MOD_ProDKin_1	667	673	PF00069	0.742
MOD_ProDKin_1	720	726	PF00069	0.526
MOD_ProDKin_1	750	756	PF00069	0.458
MOD_SUMO_for_1	31	34	PF00179	0.557
MOD_SUMO_for_1	790	793	PF00179	0.275
MOD_SUMO_rev_2	34	42	PF00179	0.496
MOD_SUMO_rev_2	498	504	PF00179	0.476
TRG_DiLeu_BaEn_1	26	31	PF01217	0.402
TRG_DiLeu_BaEn_1	316	321	PF01217	0.480
TRG_DiLeu_BaEn_1	686	691	PF01217	0.516
TRG_DiLeu_LyEn_5	686	691	PF01217	0.452
TRG_ENDOCYTIC_2	209	212	PF00928	0.346
TRG_ENDOCYTIC_2	213	216	PF00928	0.349
TRG_ENDOCYTIC_2	343	346	PF00928	0.411
TRG_ENDOCYTIC_2	357	360	PF00928	0.397
TRG_ENDOCYTIC_2	432	435	PF00928	0.408
TRG_ENDOCYTIC_2	688	691	PF00928	0.443
TRG_ENDOCYTIC_2	696	699	PF00928	0.414
TRG_ER_diArg_1	364	366	PF00400	0.188
TRG_ER_diArg_1	638	641	PF00400	0.314
TRG_ER_diArg_1	89	92	PF00400	0.447
TRG_NES_CRM1_1	372	384	PF08389	0.402
TRG_NLS_MonoExtC_3	566	572	PF00514	0.597
TRG_Pf-PMV_PEXEL_1	56	61	PF00026	0.512
TRG_Pf-PMV_PEXEL_1	568	572	PF00026	0.596

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I210	Leptomonas seymouri	61%	100%
A0A1X0PAU9	Trypanosomatidae	30%	100%
A0A3Q8IUJ9	Leishmania donovani	90%	100%
A0A3R7K1I3	Trypanosoma rangeli	28%	100%
A4H7S4	Leishmania braziliensis	75%	100%
A4I9W2	Leishmania infantum	90%	100%
C9ZMS0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
Q4Q352	Leishmania major	90%	100%
V5B3F2	Trypanosoma cruzi	26%	100%