Secreted protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Secreted protein

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B4X4_LEIMU

TriTrypDb:

LmxM.33.1490

Length:

352

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9B4X4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4X4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	59	63	PF00656	0.425
CLV_NRD_NRD_1	193	195	PF00675	0.611
CLV_NRD_NRD_1	33	35	PF00675	0.433
CLV_NRD_NRD_1	56	58	PF00675	0.624
CLV_NRD_NRD_1	63	65	PF00675	0.547
CLV_PCSK_KEX2_1	33	35	PF00082	0.433
CLV_PCSK_SKI1_1	195	199	PF00082	0.602
CLV_PCSK_SKI1_1	24	28	PF00082	0.445
CLV_PCSK_SKI1_1	259	263	PF00082	0.519
CLV_PCSK_SKI1_1	34	38	PF00082	0.257
DOC_MAPK_gen_1	30	38	PF00069	0.625
DOC_MAPK_gen_1	64	72	PF00069	0.302
DOC_MAPK_gen_1	86	95	PF00069	0.400
DOC_MAPK_MEF2A_6	64	72	PF00069	0.280
DOC_USP7_MATH_1	150	154	PF00917	0.334
DOC_USP7_MATH_1	50	54	PF00917	0.355
DOC_USP7_MATH_1	84	88	PF00917	0.331
DOC_USP7_UBL2_3	141	145	PF12436	0.348
DOC_USP7_UBL2_3	322	326	PF12436	0.306
DOC_WW_Pin1_4	161	166	PF00397	0.454
DOC_WW_Pin1_4	74	79	PF00397	0.394
DOC_WW_Pin1_4	87	92	PF00397	0.442
LIG_14-3-3_CanoR_1	33	37	PF00244	0.545
LIG_14-3-3_CanoR_1	57	61	PF00244	0.441
LIG_Actin_WH2_2	20	35	PF00022	0.690
LIG_Clathr_ClatBox_1	211	215	PF01394	0.350
LIG_eIF4E_1	206	212	PF01652	0.357
LIG_eIF4E_1	297	303	PF01652	0.265
LIG_FHA_1	131	137	PF00498	0.365
LIG_FHA_1	312	318	PF00498	0.343
LIG_FHA_1	33	39	PF00498	0.457
LIG_FHA_1	330	336	PF00498	0.397
LIG_FHA_2	17	23	PF00498	0.728
LIG_FHA_2	196	202	PF00498	0.432
LIG_FHA_2	266	272	PF00498	0.395
LIG_FHA_2	296	302	PF00498	0.365
LIG_FHA_2	338	344	PF00498	0.408
LIG_FHA_2	57	63	PF00498	0.436
LIG_GBD_Chelix_1	41	49	PF00786	0.330
LIG_LIR_Gen_1	273	279	PF02991	0.310
LIG_LIR_Gen_1	90	99	PF02991	0.377
LIG_LIR_Nem_3	153	158	PF02991	0.485
LIG_LIR_Nem_3	223	229	PF02991	0.310
LIG_LIR_Nem_3	273	278	PF02991	0.372
LIG_LIR_Nem_3	90	95	PF02991	0.375
LIG_PDZ_Class_2	347	352	PF00595	0.280
LIG_SH2_STAT5	189	192	PF00017	0.344
LIG_SH2_STAT5	196	199	PF00017	0.320
LIG_SH2_STAT5	226	229	PF00017	0.306
LIG_SH2_STAT5	297	300	PF00017	0.339
LIG_SH3_1	6	12	PF00018	0.737
LIG_SH3_2	2	7	PF14604	0.678
LIG_SH3_3	146	152	PF00018	0.356
LIG_SH3_3	5	11	PF00018	0.720
LIG_SUMO_SIM_par_1	292	298	PF11976	0.262
LIG_SUMO_SIM_par_1	34	39	PF11976	0.500
LIG_SUMO_SIM_par_1	68	74	PF11976	0.291
LIG_TRAF2_1	243	246	PF00917	0.392
LIG_UBA3_1	136	145	PF00899	0.355
MOD_CDK_SPxxK_3	87	94	PF00069	0.387
MOD_CK1_1	122	128	PF00069	0.392
MOD_CK1_1	265	271	PF00069	0.373
MOD_CK1_1	74	80	PF00069	0.408
MOD_CK1_1	87	93	PF00069	0.371
MOD_CK2_1	16	22	PF00069	0.705
MOD_CK2_1	265	271	PF00069	0.401
MOD_CK2_1	295	301	PF00069	0.364
MOD_CK2_1	337	343	PF00069	0.371
MOD_GlcNHglycan	152	155	PF01048	0.539
MOD_GlcNHglycan	175	179	PF01048	0.575
MOD_GlcNHglycan	186	189	PF01048	0.611
MOD_GlcNHglycan	220	223	PF01048	0.554
MOD_GlcNHglycan	254	257	PF01048	0.579
MOD_GlcNHglycan	73	76	PF01048	0.497
MOD_GSK3_1	102	109	PF00069	0.323
MOD_GSK3_1	117	124	PF00069	0.426
MOD_GSK3_1	126	133	PF00069	0.378
MOD_GSK3_1	150	157	PF00069	0.343
MOD_GSK3_1	262	269	PF00069	0.344
MOD_GSK3_1	32	39	PF00069	0.511
MOD_GSK3_1	52	59	PF00069	0.668
MOD_N-GLC_1	218	223	PF02516	0.564
MOD_N-GLC_1	237	242	PF02516	0.514
MOD_N-GLC_1	330	335	PF02516	0.565
MOD_N-GLC_1	87	92	PF02516	0.640
MOD_NEK2_1	119	124	PF00069	0.378
MOD_NEK2_1	130	135	PF00069	0.391
MOD_NEK2_1	252	257	PF00069	0.309
MOD_NEK2_1	262	267	PF00069	0.299
MOD_NEK2_1	317	322	PF00069	0.372
MOD_NEK2_1	32	37	PF00069	0.609
MOD_PIKK_1	139	145	PF00454	0.385
MOD_PKA_2	266	272	PF00069	0.337
MOD_PKA_2	32	38	PF00069	0.513
MOD_PKA_2	56	62	PF00069	0.497
MOD_Plk_1	330	336	PF00069	0.369
MOD_Plk_4	132	138	PF00069	0.297
MOD_Plk_4	144	150	PF00069	0.363
MOD_ProDKin_1	161	167	PF00069	0.454
MOD_ProDKin_1	74	80	PF00069	0.393
MOD_ProDKin_1	87	93	PF00069	0.437
MOD_SUMO_rev_2	177	187	PF00179	0.464
TRG_DiLeu_BaEn_1	175	180	PF01217	0.277
TRG_DiLeu_BaLyEn_6	288	293	PF01217	0.366
TRG_DiLeu_BaLyEn_6	331	336	PF01217	0.400
TRG_DiLeu_BaLyEn_6	91	96	PF01217	0.390
TRG_ENDOCYTIC_2	155	158	PF00928	0.361
TRG_ENDOCYTIC_2	226	229	PF00928	0.331
TRG_ER_diArg_1	32	34	PF00400	0.635
TRG_NLS_MonoCore_2	63	68	PF00514	0.325

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAP6	Leptomonas seymouri	65%	100%
A0A0S4IM03	Bodo saltans	29%	96%
A0A1X0PAG1	Trypanosomatidae	38%	98%
A0A3S7X7R9	Leishmania donovani	90%	100%
A0A422N0E3	Trypanosoma rangeli	38%	99%
A4H7S5	Leishmania braziliensis	79%	100%
A4I9W1	Leishmania infantum	90%	100%
C9ZMS1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
Q4Q353	Leishmania major	90%	100%