Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B4X1_LEIMU

TriTrypDb:

LmxM.33.1460

Length:

705

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B4X1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4X1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	668	672	PF00656	0.543
CLV_NRD_NRD_1	107	109	PF00675	0.510
CLV_NRD_NRD_1	13	15	PF00675	0.677
CLV_NRD_NRD_1	137	139	PF00675	0.543
CLV_NRD_NRD_1	248	250	PF00675	0.578
CLV_NRD_NRD_1	479	481	PF00675	0.486
CLV_NRD_NRD_1	534	536	PF00675	0.365
CLV_NRD_NRD_1	552	554	PF00675	0.323
CLV_NRD_NRD_1	658	660	PF00675	0.571
CLV_NRD_NRD_1	685	687	PF00675	0.495
CLV_NRD_NRD_1	82	84	PF00675	0.446
CLV_PCSK_KEX2_1	107	109	PF00082	0.573
CLV_PCSK_KEX2_1	13	15	PF00082	0.745
CLV_PCSK_KEX2_1	137	139	PF00082	0.579
CLV_PCSK_KEX2_1	248	250	PF00082	0.539
CLV_PCSK_KEX2_1	311	313	PF00082	0.536
CLV_PCSK_KEX2_1	479	481	PF00082	0.501
CLV_PCSK_KEX2_1	497	499	PF00082	0.781
CLV_PCSK_KEX2_1	534	536	PF00082	0.351
CLV_PCSK_KEX2_1	563	565	PF00082	0.410
CLV_PCSK_KEX2_1	685	687	PF00082	0.495
CLV_PCSK_KEX2_1	82	84	PF00082	0.437
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.536
CLV_PCSK_PC1ET2_1	497	499	PF00082	0.781
CLV_PCSK_PC1ET2_1	563	565	PF00082	0.410
CLV_PCSK_SKI1_1	107	111	PF00082	0.532
CLV_PCSK_SKI1_1	137	141	PF00082	0.513
CLV_PCSK_SKI1_1	186	190	PF00082	0.442
CLV_PCSK_SKI1_1	311	315	PF00082	0.509
CLV_PCSK_SKI1_1	376	380	PF00082	0.477
CLV_PCSK_SKI1_1	429	433	PF00082	0.525
DEG_APCC_DBOX_1	185	193	PF00400	0.443
DEG_SCF_FBW7_2	593	600	PF00400	0.540
DEG_SPOP_SBC_1	43	47	PF00917	0.748
DOC_CKS1_1	594	599	PF01111	0.529
DOC_CYCLIN_RxL_1	104	112	PF00134	0.576
DOC_CYCLIN_yCln2_LP_2	674	680	PF00134	0.625
DOC_MAPK_gen_1	517	526	PF00069	0.546
DOC_MAPK_gen_1	563	569	PF00069	0.461
DOC_MAPK_MEF2A_6	180	189	PF00069	0.481
DOC_MAPK_MEF2A_6	563	571	PF00069	0.373
DOC_MAPK_MEF2A_6	620	628	PF00069	0.528
DOC_PP1_RVXF_1	310	317	PF00149	0.497
DOC_PP2B_LxvP_1	469	472	PF13499	0.414
DOC_PP2B_LxvP_1	674	677	PF13499	0.531
DOC_USP7_MATH_1	200	204	PF00917	0.509
DOC_USP7_MATH_1	230	234	PF00917	0.641
DOC_USP7_MATH_1	273	277	PF00917	0.694
DOC_USP7_MATH_1	322	326	PF00917	0.589
DOC_USP7_MATH_1	666	670	PF00917	0.611
DOC_WW_Pin1_4	116	121	PF00397	0.619
DOC_WW_Pin1_4	233	238	PF00397	0.689
DOC_WW_Pin1_4	408	413	PF00397	0.533
DOC_WW_Pin1_4	447	452	PF00397	0.525
DOC_WW_Pin1_4	593	598	PF00397	0.496
LIG_14-3-3_CanoR_1	13	21	PF00244	0.680
LIG_14-3-3_CanoR_1	193	200	PF00244	0.508
LIG_14-3-3_CanoR_1	248	252	PF00244	0.468
LIG_14-3-3_CanoR_1	376	381	PF00244	0.454
LIG_14-3-3_CanoR_1	479	486	PF00244	0.564
LIG_14-3-3_CanoR_1	572	578	PF00244	0.409
LIG_14-3-3_CanoR_1	68	78	PF00244	0.433
LIG_APCC_ABBA_1	624	629	PF00400	0.527
LIG_deltaCOP1_diTrp_1	287	293	PF00928	0.387
LIG_eIF4E_1	86	92	PF01652	0.521
LIG_FHA_1	16	22	PF00498	0.695
LIG_FHA_1	193	199	PF00498	0.582
LIG_FHA_1	234	240	PF00498	0.656
LIG_FHA_1	286	292	PF00498	0.463
LIG_FHA_1	426	432	PF00498	0.542
LIG_FHA_1	519	525	PF00498	0.315
LIG_FHA_1	52	58	PF00498	0.592
LIG_FHA_1	699	705	PF00498	0.559
LIG_FHA_2	179	185	PF00498	0.527
LIG_FHA_2	491	497	PF00498	0.701
LIG_FHA_2	557	563	PF00498	0.529
LIG_GBD_Chelix_1	57	65	PF00786	0.502
LIG_LIR_Apic_2	452	458	PF02991	0.546
LIG_LIR_Gen_1	141	151	PF02991	0.484
LIG_LIR_Gen_1	168	178	PF02991	0.390
LIG_LIR_Gen_1	203	212	PF02991	0.376
LIG_LIR_Gen_1	287	297	PF02991	0.407
LIG_LIR_Gen_1	456	467	PF02991	0.440
LIG_LIR_Gen_1	546	556	PF02991	0.435
LIG_LIR_Gen_1	639	646	PF02991	0.482
LIG_LIR_Nem_3	141	146	PF02991	0.539
LIG_LIR_Nem_3	168	173	PF02991	0.385
LIG_LIR_Nem_3	201	207	PF02991	0.367
LIG_LIR_Nem_3	287	292	PF02991	0.360
LIG_LIR_Nem_3	37	43	PF02991	0.766
LIG_LIR_Nem_3	456	462	PF02991	0.413
LIG_LIR_Nem_3	546	552	PF02991	0.423
LIG_LIR_Nem_3	639	645	PF02991	0.461
LIG_LIR_Nem_3	648	654	PF02991	0.542
LIG_LIR_Nem_3	72	78	PF02991	0.527
LIG_LYPXL_SIV_4	346	354	PF13949	0.371
LIG_NRBOX	105	111	PF00104	0.490
LIG_NRBOX	608	614	PF00104	0.467
LIG_PCNA_yPIPBox_3	103	113	PF02747	0.360
LIG_Pex14_1	289	293	PF04695	0.382
LIG_Pex14_2	209	213	PF04695	0.466
LIG_RPA_C_Fungi	681	693	PF08784	0.522
LIG_SH2_CRK	170	174	PF00017	0.404
LIG_SH2_CRK	347	351	PF00017	0.213
LIG_SH2_CRK	610	614	PF00017	0.362
LIG_SH2_CRK	651	655	PF00017	0.685
LIG_SH2_CRK	75	79	PF00017	0.469
LIG_SH2_GRB2like	369	372	PF00017	0.483
LIG_SH2_STAP1	170	174	PF00017	0.447
LIG_SH2_STAP1	205	209	PF00017	0.430
LIG_SH2_STAT3	86	89	PF00017	0.348
LIG_SH2_STAT5	162	165	PF00017	0.514
LIG_SH2_STAT5	369	372	PF00017	0.518
LIG_SH2_STAT5	455	458	PF00017	0.521
LIG_SH2_STAT5	574	577	PF00017	0.500
LIG_SUMO_SIM_anti_2	565	571	PF11976	0.375
LIG_TRAF2_1	412	415	PF00917	0.259
LIG_TYR_ITIM	345	350	PF00017	0.220
LIG_TYR_ITIM	608	613	PF00017	0.503
LIG_TYR_ITSM	647	654	PF00017	0.594
LIG_UBA3_1	305	311	PF00899	0.545
LIG_UBA3_1	420	429	PF00899	0.395
LIG_UBA3_1	548	555	PF00899	0.449
MOD_CK1_1	16	22	PF00069	0.679
MOD_CK1_1	233	239	PF00069	0.642
MOD_CK1_1	268	274	PF00069	0.650
MOD_CK1_1	33	39	PF00069	0.732
MOD_CK1_1	406	412	PF00069	0.567
MOD_CK1_1	42	48	PF00069	0.666
MOD_CK1_1	427	433	PF00069	0.544
MOD_CK1_1	470	476	PF00069	0.405
MOD_CK1_1	492	498	PF00069	0.776
MOD_CK1_1	94	100	PF00069	0.468
MOD_CK2_1	109	115	PF00069	0.597
MOD_CK2_1	178	184	PF00069	0.513
MOD_CK2_1	200	206	PF00069	0.481
MOD_CK2_1	490	496	PF00069	0.699
MOD_CK2_1	556	562	PF00069	0.534
MOD_CK2_1	57	63	PF00069	0.469
MOD_GlcNHglycan	163	166	PF01048	0.403
MOD_GlcNHglycan	175	178	PF01048	0.407
MOD_GlcNHglycan	270	273	PF01048	0.720
MOD_GlcNHglycan	275	278	PF01048	0.740
MOD_GlcNHglycan	324	327	PF01048	0.621
MOD_GlcNHglycan	390	393	PF01048	0.391
MOD_GlcNHglycan	472	475	PF01048	0.438
MOD_GlcNHglycan	513	516	PF01048	0.751
MOD_GlcNHglycan	583	586	PF01048	0.400
MOD_GSK3_1	13	20	PF00069	0.692
MOD_GSK3_1	169	176	PF00069	0.397
MOD_GSK3_1	218	225	PF00069	0.676
MOD_GSK3_1	267	274	PF00069	0.524
MOD_GSK3_1	29	36	PF00069	0.770
MOD_GSK3_1	292	299	PF00069	0.471
MOD_GSK3_1	322	329	PF00069	0.638
MOD_GSK3_1	376	383	PF00069	0.487
MOD_GSK3_1	39	46	PF00069	0.724
MOD_GSK3_1	402	409	PF00069	0.501
MOD_GSK3_1	47	54	PF00069	0.519
MOD_GSK3_1	486	493	PF00069	0.663
MOD_GSK3_1	646	653	PF00069	0.541
MOD_GSK3_1	90	97	PF00069	0.518
MOD_N-GLC_1	386	391	PF02516	0.462
MOD_NEK2_1	109	114	PF00069	0.525
MOD_NEK2_1	139	144	PF00069	0.532
MOD_NEK2_1	169	174	PF00069	0.386
MOD_NEK2_1	247	252	PF00069	0.525
MOD_NEK2_1	267	272	PF00069	0.553
MOD_NEK2_1	292	297	PF00069	0.459
MOD_NEK2_1	31	36	PF00069	0.688
MOD_NEK2_1	380	385	PF00069	0.518
MOD_NEK2_1	404	409	PF00069	0.401
MOD_NEK2_1	424	429	PF00069	0.381
MOD_NEK2_1	556	561	PF00069	0.496
MOD_NEK2_1	57	62	PF00069	0.573
MOD_NEK2_1	573	578	PF00069	0.337
MOD_NEK2_1	645	650	PF00069	0.570
MOD_NEK2_1	697	702	PF00069	0.583
MOD_NEK2_1	90	95	PF00069	0.511
MOD_NEK2_2	200	205	PF00069	0.485
MOD_PIKK_1	118	124	PF00454	0.699
MOD_PIKK_1	296	302	PF00454	0.534
MOD_PIKK_1	31	37	PF00454	0.484
MOD_PIKK_1	646	652	PF00454	0.633
MOD_PK_1	335	341	PF00069	0.401
MOD_PK_1	554	560	PF00069	0.397
MOD_PKA_1	13	19	PF00069	0.736
MOD_PKA_1	479	485	PF00069	0.554
MOD_PKA_1	497	503	PF00069	0.603
MOD_PKA_1	554	560	PF00069	0.507
MOD_PKA_2	13	19	PF00069	0.698
MOD_PKA_2	192	198	PF00069	0.551
MOD_PKA_2	218	224	PF00069	0.614
MOD_PKA_2	247	253	PF00069	0.462
MOD_PKA_2	479	485	PF00069	0.536
MOD_PKA_2	497	503	PF00069	0.706
MOD_PKA_2	518	524	PF00069	0.341
MOD_Plk_1	200	206	PF00069	0.486
MOD_Plk_1	219	225	PF00069	0.621
MOD_Plk_1	335	341	PF00069	0.655
MOD_Plk_1	386	392	PF00069	0.337
MOD_Plk_4	169	175	PF00069	0.460
MOD_Plk_4	200	206	PF00069	0.389
MOD_Plk_4	4	10	PF00069	0.721
MOD_Plk_4	481	487	PF00069	0.522
MOD_Plk_4	528	534	PF00069	0.374
MOD_Plk_4	544	550	PF00069	0.404
MOD_Plk_4	70	76	PF00069	0.422
MOD_ProDKin_1	116	122	PF00069	0.621
MOD_ProDKin_1	233	239	PF00069	0.678
MOD_ProDKin_1	408	414	PF00069	0.525
MOD_ProDKin_1	447	453	PF00069	0.520
MOD_ProDKin_1	593	599	PF00069	0.503
TRG_DiLeu_BaEn_1	101	106	PF01217	0.286
TRG_DiLeu_BaEn_1	562	567	PF01217	0.459
TRG_DiLeu_BaEn_2	522	528	PF01217	0.536
TRG_DiLeu_BaLyEn_6	105	110	PF01217	0.497
TRG_DiLeu_BaLyEn_6	183	188	PF01217	0.512
TRG_DiLeu_BaLyEn_6	309	314	PF01217	0.448
TRG_ENDOCYTIC_2	170	173	PF00928	0.361
TRG_ENDOCYTIC_2	205	208	PF00928	0.370
TRG_ENDOCYTIC_2	347	350	PF00928	0.212
TRG_ENDOCYTIC_2	574	577	PF00928	0.522
TRG_ENDOCYTIC_2	610	613	PF00928	0.377
TRG_ENDOCYTIC_2	651	654	PF00928	0.686
TRG_ENDOCYTIC_2	75	78	PF00928	0.550
TRG_ER_diArg_1	106	108	PF00400	0.504
TRG_ER_diArg_1	136	138	PF00400	0.545
TRG_ER_diArg_1	247	249	PF00400	0.546
TRG_ER_diArg_1	478	480	PF00400	0.529
TRG_ER_diArg_1	533	535	PF00400	0.369
TRG_ER_diArg_1	684	686	PF00400	0.499
TRG_ER_diArg_1	690	693	PF00400	0.516
TRG_ER_diArg_1	82	84	PF00400	0.444
TRG_NES_CRM1_1	546	562	PF08389	0.440
TRG_Pf-PMV_PEXEL_1	137	141	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	311	315	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	564	568	PF00026	0.494
TRG_Pf-PMV_PEXEL_1	659	664	PF00026	0.572

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA97	Leptomonas seymouri	54%	100%
A0A0S4IIE1	Bodo saltans	33%	100%
A0A1X0P9G0	Trypanosomatidae	38%	100%
A0A3R7MA99	Trypanosoma rangeli	40%	100%
A0A3S7X7S0	Leishmania donovani	90%	100%
A4H7S8	Leishmania braziliensis	77%	100%
A4I9V8	Leishmania infantum	91%	100%
C9ZMS3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
Q4Q356	Leishmania major	88%	100%
V5BT29	Trypanosoma cruzi	39%	100%