R3H-assoc domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

R3H-associated N-terminal domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B4X0_LEIMU

TriTrypDb:

LmxM.33.1450

Length:

522

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B4X0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4X0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.711
CLV_C14_Caspase3-7	301	305	PF00656	0.603
CLV_C14_Caspase3-7	474	478	PF00656	0.728
CLV_C14_Caspase3-7	77	81	PF00656	0.642
CLV_NRD_NRD_1	101	103	PF00675	0.617
CLV_NRD_NRD_1	133	135	PF00675	0.368
CLV_NRD_NRD_1	319	321	PF00675	0.599
CLV_NRD_NRD_1	341	343	PF00675	0.543
CLV_NRD_NRD_1	498	500	PF00675	0.616
CLV_NRD_NRD_1	502	504	PF00675	0.602
CLV_PCSK_FUR_1	339	343	PF00082	0.543
CLV_PCSK_KEX2_1	101	103	PF00082	0.524
CLV_PCSK_KEX2_1	319	321	PF00082	0.616
CLV_PCSK_KEX2_1	338	340	PF00082	0.490
CLV_PCSK_KEX2_1	341	343	PF00082	0.535
CLV_PCSK_KEX2_1	50	52	PF00082	0.647
CLV_PCSK_KEX2_1	86	88	PF00082	0.514
CLV_PCSK_PC1ET2_1	338	340	PF00082	0.550
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.647
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.608
CLV_PCSK_SKI1_1	102	106	PF00082	0.548
CLV_PCSK_SKI1_1	151	155	PF00082	0.390
DEG_SCF_FBW7_1	489	495	PF00400	0.704
DOC_CKS1_1	10	15	PF01111	0.697
DOC_CKS1_1	353	358	PF01111	0.657
DOC_CKS1_1	489	494	PF01111	0.734
DOC_CYCLIN_yCln2_LP_2	395	401	PF00134	0.690
DOC_MAPK_gen_1	110	117	PF00069	0.499
DOC_PP2B_LxvP_1	395	398	PF13499	0.752
DOC_PP4_FxxP_1	455	458	PF00568	0.664
DOC_PP4_FxxP_1	490	493	PF00568	0.670
DOC_USP7_MATH_1	242	246	PF00917	0.455
DOC_USP7_MATH_1	346	350	PF00917	0.648
DOC_USP7_UBL2_3	264	268	PF12436	0.660
DOC_USP7_UBL2_3	500	504	PF12436	0.593
DOC_WW_Pin1_4	220	225	PF00397	0.440
DOC_WW_Pin1_4	266	271	PF00397	0.637
DOC_WW_Pin1_4	352	357	PF00397	0.656
DOC_WW_Pin1_4	358	363	PF00397	0.750
DOC_WW_Pin1_4	388	393	PF00397	0.764
DOC_WW_Pin1_4	481	486	PF00397	0.751
DOC_WW_Pin1_4	488	493	PF00397	0.738
DOC_WW_Pin1_4	511	516	PF00397	0.592
DOC_WW_Pin1_4	9	14	PF00397	0.677
LIG_14-3-3_CanoR_1	101	109	PF00244	0.634
LIG_14-3-3_CanoR_1	461	467	PF00244	0.753
LIG_14-3-3_CanoR_1	507	515	PF00244	0.736
LIG_APCC_ABBA_1	201	206	PF00400	0.438
LIG_APCC_ABBAyCdc20_2	200	206	PF00400	0.446
LIG_BIR_II_1	1	5	PF00653	0.657
LIG_BIR_III_2	512	516	PF00653	0.467
LIG_BRCT_BRCA1_1	271	275	PF00533	0.556
LIG_Clathr_ClatBox_1	195	199	PF01394	0.476
LIG_CtBP_PxDLS_1	270	274	PF00389	0.582
LIG_FHA_1	247	253	PF00498	0.460
LIG_FHA_1	353	359	PF00498	0.779
LIG_FHA_1	40	46	PF00498	0.499
LIG_FHA_1	461	467	PF00498	0.777
LIG_FHA_1	489	495	PF00498	0.704
LIG_FHA_1	53	59	PF00498	0.392
LIG_FHA_2	103	109	PF00498	0.557
LIG_FHA_2	299	305	PF00498	0.591
LIG_FHA_2	376	382	PF00498	0.712
LIG_FHA_2	92	98	PF00498	0.564
LIG_LIR_Apic_2	71	76	PF02991	0.568
LIG_LIR_Gen_1	175	184	PF02991	0.418
LIG_LIR_Gen_1	197	205	PF02991	0.440
LIG_LIR_Gen_1	256	263	PF02991	0.469
LIG_LIR_Gen_1	311	316	PF02991	0.549
LIG_LIR_Nem_3	175	179	PF02991	0.385
LIG_LIR_Nem_3	197	201	PF02991	0.440
LIG_LIR_Nem_3	225	231	PF02991	0.377
LIG_LIR_Nem_3	256	262	PF02991	0.426
LIG_LIR_Nem_3	279	284	PF02991	0.407
LIG_LIR_Nem_3	311	315	PF02991	0.546
LIG_LIR_Nem_3	37	43	PF02991	0.483
LIG_LIR_Nem_3	438	443	PF02991	0.719
LIG_LYPXL_yS_3	125	128	PF13949	0.334
LIG_MYND_1	485	489	PF01753	0.757
LIG_PCNA_yPIPBox_3	132	145	PF02747	0.354
LIG_PTB_Apo_2	139	146	PF02174	0.354
LIG_SH2_CRK	281	285	PF00017	0.382
LIG_SH2_NCK_1	73	77	PF00017	0.572
LIG_SH2_PTP2	312	315	PF00017	0.550
LIG_SH2_STAP1	34	38	PF00017	0.507
LIG_SH2_STAT5	293	296	PF00017	0.557
LIG_SH2_STAT5	312	315	PF00017	0.550
LIG_SH2_STAT5	456	459	PF00017	0.762
LIG_SH3_3	212	218	PF00018	0.363
LIG_SH3_3	310	316	PF00018	0.439
LIG_SH3_3	323	329	PF00018	0.489
LIG_SH3_3	386	392	PF00018	0.740
LIG_SH3_3	395	401	PF00018	0.753
LIG_SH3_3	486	492	PF00018	0.706
LIG_SH3_3	92	98	PF00018	0.635
LIG_SUMO_SIM_par_1	462	467	PF11976	0.767
LIG_TYR_ITIM	310	315	PF00017	0.549
LIG_UBA3_1	333	338	PF00899	0.524
MOD_CDK_SPxxK_3	220	227	PF00069	0.446
MOD_CK1_1	269	275	PF00069	0.571
MOD_CK1_1	351	357	PF00069	0.663
MOD_CK1_1	417	423	PF00069	0.659
MOD_CK1_1	6	12	PF00069	0.761
MOD_CK1_1	74	80	PF00069	0.508
MOD_CK1_1	91	97	PF00069	0.440
MOD_CK2_1	102	108	PF00069	0.575
MOD_CK2_1	375	381	PF00069	0.729
MOD_Cter_Amidation	48	51	PF01082	0.656
MOD_GlcNHglycan	13	16	PF01048	0.553
MOD_GlcNHglycan	304	308	PF01048	0.621
MOD_GlcNHglycan	350	353	PF01048	0.692
MOD_GlcNHglycan	403	406	PF01048	0.732
MOD_GlcNHglycan	431	434	PF01048	0.713
MOD_GlcNHglycan	479	482	PF01048	0.733
MOD_GlcNHglycan	509	512	PF01048	0.743
MOD_GSK3_1	104	111	PF00069	0.533
MOD_GSK3_1	168	175	PF00069	0.425
MOD_GSK3_1	19	26	PF00069	0.645
MOD_GSK3_1	242	249	PF00069	0.444
MOD_GSK3_1	294	301	PF00069	0.506
MOD_GSK3_1	311	318	PF00069	0.271
MOD_GSK3_1	348	355	PF00069	0.619
MOD_GSK3_1	375	382	PF00069	0.566
MOD_GSK3_1	401	408	PF00069	0.671
MOD_GSK3_1	435	442	PF00069	0.743
MOD_GSK3_1	477	484	PF00069	0.706
MOD_GSK3_1	488	495	PF00069	0.676
MOD_GSK3_1	507	514	PF00069	0.406
MOD_GSK3_1	54	61	PF00069	0.442
MOD_LATS_1	444	450	PF00433	0.672
MOD_N-GLC_1	401	406	PF02516	0.515
MOD_NEK2_1	168	173	PF00069	0.196
MOD_NEK2_1	303	308	PF00069	0.661
MOD_NEK2_1	364	369	PF00069	0.509
MOD_NEK2_1	460	465	PF00069	0.715
MOD_NEK2_1	494	499	PF00069	0.669
MOD_PIKK_1	246	252	PF00454	0.481
MOD_PIKK_1	364	370	PF00454	0.544
MOD_PIKK_1	494	500	PF00454	0.644
MOD_PIKK_1	6	12	PF00454	0.755
MOD_PKA_2	23	29	PF00069	0.626
MOD_PKA_2	406	412	PF00069	0.525
MOD_PKA_2	460	466	PF00069	0.754
MOD_Plk_1	168	174	PF00069	0.476
MOD_Plk_2-3	298	304	PF00069	0.566
MOD_Plk_4	269	275	PF00069	0.572
MOD_Plk_4	308	314	PF00069	0.501
MOD_Plk_4	435	441	PF00069	0.739
MOD_Plk_4	91	97	PF00069	0.562
MOD_ProDKin_1	220	226	PF00069	0.440
MOD_ProDKin_1	266	272	PF00069	0.627
MOD_ProDKin_1	352	358	PF00069	0.658
MOD_ProDKin_1	388	394	PF00069	0.765
MOD_ProDKin_1	481	487	PF00069	0.751
MOD_ProDKin_1	488	494	PF00069	0.731
MOD_ProDKin_1	511	517	PF00069	0.595
MOD_ProDKin_1	9	15	PF00069	0.671
TRG_DiLeu_BaLyEn_6	136	141	PF01217	0.407
TRG_DiLeu_BaLyEn_6	280	285	PF01217	0.505
TRG_ENDOCYTIC_2	125	128	PF00928	0.334
TRG_ENDOCYTIC_2	281	284	PF00928	0.388
TRG_ENDOCYTIC_2	292	295	PF00928	0.389
TRG_ENDOCYTIC_2	312	315	PF00928	0.550
TRG_ENDOCYTIC_2	456	459	PF00928	0.650
TRG_ER_diArg_1	101	103	PF00400	0.619
TRG_ER_diArg_1	119	122	PF00400	0.432
TRG_ER_diArg_1	136	139	PF00400	0.212
TRG_ER_diArg_1	200	203	PF00400	0.476
TRG_ER_diArg_1	339	342	PF00400	0.592
TRG_NES_CRM1_1	178	193	PF08389	0.400
TRG_NES_CRM1_1	194	206	PF08389	0.290
TRG_NES_CRM1_1	246	261	PF08389	0.429
TRG_NLS_Bipartite_1	101	116	PF00514	0.587
TRG_NLS_Bipartite_1	123	138	PF00514	0.377
TRG_NLS_MonoExtC_3	337	342	PF00514	0.537
TRG_NLS_MonoExtC_3	498	503	PF00514	0.610
TRG_NLS_MonoExtN_4	110	116	PF00514	0.454
TRG_NLS_MonoExtN_4	131	138	PF00514	0.406
TRG_NLS_MonoExtN_4	499	504	PF00514	0.589
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.560
TRG_Pf-PMV_PEXEL_1	139	143	PF00026	0.358
TRG_Pf-PMV_PEXEL_1	161	166	PF00026	0.407

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P399	Leptomonas seymouri	69%	80%
A0A0S4ILK0	Bodo saltans	40%	100%
A0A1X0P9H7	Trypanosomatidae	51%	100%
A0A3S7X7Q4	Leishmania donovani	93%	100%
A0A422N0N2	Trypanosoma rangeli	50%	100%
A4H7S9	Leishmania braziliensis	81%	100%
A4I9V7	Leishmania infantum	92%	100%
C9ZMS4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
Q4Q357	Leishmania major	91%	100%