C2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B4W9_LEIMU

TriTrypDb:

LmxM.33.1440

Length:

877

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4W9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4W9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.678
CLV_C14_Caspase3-7	505	509	PF00656	0.686
CLV_NRD_NRD_1	130	132	PF00675	0.680
CLV_NRD_NRD_1	177	179	PF00675	0.708
CLV_NRD_NRD_1	183	185	PF00675	0.668
CLV_NRD_NRD_1	295	297	PF00675	0.592
CLV_NRD_NRD_1	611	613	PF00675	0.658
CLV_NRD_NRD_1	64	66	PF00675	0.541
CLV_PCSK_FUR_1	181	185	PF00082	0.546
CLV_PCSK_FUR_1	293	297	PF00082	0.585
CLV_PCSK_KEX2_1	112	114	PF00082	0.674
CLV_PCSK_KEX2_1	130	132	PF00082	0.680
CLV_PCSK_KEX2_1	177	179	PF00082	0.710
CLV_PCSK_KEX2_1	183	185	PF00082	0.666
CLV_PCSK_KEX2_1	295	297	PF00082	0.592
CLV_PCSK_KEX2_1	610	612	PF00082	0.671
CLV_PCSK_KEX2_1	64	66	PF00082	0.541
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.679
CLV_PCSK_PC7_1	126	132	PF00082	0.640
CLV_PCSK_PC7_1	173	179	PF00082	0.679
CLV_PCSK_SKI1_1	281	285	PF00082	0.566
CLV_PCSK_SKI1_1	43	47	PF00082	0.469
CLV_PCSK_SKI1_1	525	529	PF00082	0.566
CLV_PCSK_SKI1_1	553	557	PF00082	0.611
CLV_PCSK_SKI1_1	834	838	PF00082	0.529
CLV_Separin_Metazoa	622	626	PF03568	0.620
DEG_APCC_DBOX_1	42	50	PF00400	0.510
DEG_APCC_DBOX_1	609	617	PF00400	0.637
DEG_APCC_DBOX_1	826	834	PF00400	0.508
DEG_APCC_KENBOX_2	555	559	PF00400	0.616
DEG_SPOP_SBC_1	527	531	PF00917	0.548
DEG_SPOP_SBC_1	692	696	PF00917	0.704
DEG_SPOP_SBC_1	701	705	PF00917	0.604
DOC_AGCK_PIF_1	357	362	PF00069	0.420
DOC_CYCLIN_RxL_1	217	228	PF00134	0.528
DOC_MAPK_gen_1	239	248	PF00069	0.494
DOC_MAPK_gen_1	373	380	PF00069	0.433
DOC_MAPK_gen_1	610	617	PF00069	0.543
DOC_MAPK_MEF2A_6	350	357	PF00069	0.415
DOC_MAPK_MEF2A_6	373	380	PF00069	0.435
DOC_MAPK_MEF2A_6	454	462	PF00069	0.432
DOC_MAPK_MEF2A_6	610	617	PF00069	0.543
DOC_PP1_RVXF_1	468	475	PF00149	0.434
DOC_PP2B_LxvP_1	507	510	PF13499	0.647
DOC_PP2B_LxvP_1	532	535	PF13499	0.565
DOC_PP2B_LxvP_1	742	745	PF13499	0.602
DOC_PP4_FxxP_1	397	400	PF00568	0.516
DOC_PP4_FxxP_1	474	477	PF00568	0.453
DOC_USP7_MATH_1	163	167	PF00917	0.757
DOC_USP7_MATH_1	322	326	PF00917	0.530
DOC_USP7_MATH_1	363	367	PF00917	0.523
DOC_USP7_MATH_1	479	483	PF00917	0.471
DOC_USP7_MATH_1	527	531	PF00917	0.674
DOC_USP7_MATH_1	547	551	PF00917	0.698
DOC_USP7_MATH_1	569	573	PF00917	0.564
DOC_USP7_MATH_1	646	650	PF00917	0.562
DOC_USP7_MATH_1	693	697	PF00917	0.741
DOC_USP7_MATH_1	702	706	PF00917	0.603
DOC_USP7_MATH_1	728	732	PF00917	0.618
DOC_USP7_MATH_2	147	153	PF00917	0.634
DOC_WW_Pin1_4	13	18	PF00397	0.524
DOC_WW_Pin1_4	143	148	PF00397	0.570
DOC_WW_Pin1_4	159	164	PF00397	0.762
DOC_WW_Pin1_4	166	171	PF00397	0.814
DOC_WW_Pin1_4	231	236	PF00397	0.509
DOC_WW_Pin1_4	564	569	PF00397	0.610
DOC_WW_Pin1_4	847	852	PF00397	0.608
LIG_14-3-3_CanoR_1	130	136	PF00244	0.683
LIG_14-3-3_CanoR_1	220	225	PF00244	0.656
LIG_14-3-3_CanoR_1	34	40	PF00244	0.536
LIG_14-3-3_CanoR_1	379	387	PF00244	0.485
LIG_14-3-3_CanoR_1	498	507	PF00244	0.745
LIG_14-3-3_CanoR_1	525	535	PF00244	0.649
LIG_14-3-3_CanoR_1	65	75	PF00244	0.578
LIG_14-3-3_CanoR_1	697	702	PF00244	0.632
LIG_14-3-3_CanoR_1	834	840	PF00244	0.551
LIG_14-3-3_CanoR_1	871	877	PF00244	0.449
LIG_14-3-3_CanoR_1	99	105	PF00244	0.509
LIG_APCC_ABBAyCdc20_2	470	476	PF00400	0.437
LIG_BIR_II_1	1	5	PF00653	0.378
LIG_BIR_III_2	508	512	PF00653	0.578
LIG_BIR_III_2	538	542	PF00653	0.604
LIG_BIR_III_2	551	555	PF00653	0.525
LIG_BRCT_BRCA1_1	481	485	PF00533	0.440
LIG_FHA_1	189	195	PF00498	0.716
LIG_FHA_1	199	205	PF00498	0.488
LIG_FHA_1	347	353	PF00498	0.345
LIG_FHA_1	366	372	PF00498	0.462
LIG_FHA_1	479	485	PF00498	0.481
LIG_FHA_1	501	507	PF00498	0.702
LIG_FHA_1	587	593	PF00498	0.548
LIG_FHA_1	739	745	PF00498	0.706
LIG_FHA_1	759	765	PF00498	0.727
LIG_FHA_1	823	829	PF00498	0.585
LIG_FHA_1	87	93	PF00498	0.492
LIG_FHA_2	137	143	PF00498	0.695
LIG_FHA_2	144	150	PF00498	0.616
LIG_FHA_2	151	157	PF00498	0.547
LIG_FHA_2	271	277	PF00498	0.782
LIG_FHA_2	331	337	PF00498	0.689
LIG_FHA_2	383	389	PF00498	0.488
LIG_FHA_2	503	509	PF00498	0.683
LIG_FHA_2	672	678	PF00498	0.572
LIG_FHA_2	856	862	PF00498	0.602
LIG_LIR_Apic_2	395	400	PF02991	0.496
LIG_LIR_Apic_2	664	669	PF02991	0.641
LIG_LIR_Gen_1	354	363	PF02991	0.362
LIG_LIR_Gen_1	482	492	PF02991	0.438
LIG_LIR_Gen_1	671	679	PF02991	0.631
LIG_LIR_Gen_1	866	876	PF02991	0.514
LIG_LIR_LC3C_4	422	426	PF02991	0.369
LIG_LIR_Nem_3	354	360	PF02991	0.355
LIG_LIR_Nem_3	482	488	PF02991	0.433
LIG_LIR_Nem_3	671	675	PF02991	0.601
LIG_LIR_Nem_3	840	846	PF02991	0.585
LIG_LIR_Nem_3	866	872	PF02991	0.523
LIG_PTB_Apo_2	356	363	PF02174	0.422
LIG_PTB_Apo_2	730	737	PF02174	0.613
LIG_PTB_Phospho_1	730	736	PF10480	0.614
LIG_Rb_pABgroove_1	406	414	PF01858	0.384
LIG_SH2_CRK	843	847	PF00017	0.546
LIG_SH2_NCK_1	618	622	PF00017	0.606
LIG_SH2_NCK_1	666	670	PF00017	0.649
LIG_SH2_PTP2	869	872	PF00017	0.524
LIG_SH2_SRC	666	669	PF00017	0.782
LIG_SH2_STAP1	722	726	PF00017	0.549
LIG_SH2_STAP1	738	742	PF00017	0.543
LIG_SH2_STAT5	713	716	PF00017	0.541
LIG_SH2_STAT5	835	838	PF00017	0.561
LIG_SH2_STAT5	869	872	PF00017	0.504
LIG_SH2_STAT5	9	12	PF00017	0.460
LIG_SH3_2	51	56	PF14604	0.543
LIG_SH3_3	119	125	PF00018	0.637
LIG_SH3_3	22	28	PF00018	0.468
LIG_SH3_3	308	314	PF00018	0.583
LIG_SH3_3	400	406	PF00018	0.485
LIG_SH3_3	443	449	PF00018	0.671
LIG_SH3_3	48	54	PF00018	0.479
LIG_SUMO_SIM_anti_2	331	339	PF11976	0.636
LIG_TRAF2_1	277	280	PF00917	0.591
LIG_TRAF2_1	453	456	PF00917	0.463
LIG_TRAF2_1	516	519	PF00917	0.518
LIG_TRAF2_1	579	582	PF00917	0.637
LIG_TRAF2_1	674	677	PF00917	0.635
LIG_TYR_ITIM	867	872	PF00017	0.466
LIG_WRC_WIRS_1	394	399	PF05994	0.510
LIG_WRC_WIRS_1	414	419	PF05994	0.414
MOD_CDK_SPxK_1	231	237	PF00069	0.500
MOD_CDK_SPxxK_3	166	173	PF00069	0.628
MOD_CDK_SPxxK_3	564	571	PF00069	0.559
MOD_CK1_1	151	157	PF00069	0.691
MOD_CK1_1	162	168	PF00069	0.709
MOD_CK1_1	198	204	PF00069	0.617
MOD_CK1_1	265	271	PF00069	0.669
MOD_CK1_1	274	280	PF00069	0.584
MOD_CK1_1	29	35	PF00069	0.582
MOD_CK1_1	304	310	PF00069	0.657
MOD_CK1_1	345	351	PF00069	0.456
MOD_CK1_1	358	364	PF00069	0.371
MOD_CK1_1	382	388	PF00069	0.453
MOD_CK1_1	390	396	PF00069	0.493
MOD_CK1_1	500	506	PF00069	0.656
MOD_CK1_1	520	526	PF00069	0.616
MOD_CK1_1	602	608	PF00069	0.777
MOD_CK1_1	671	677	PF00069	0.694
MOD_CK1_1	700	706	PF00069	0.676
MOD_CK1_1	732	738	PF00069	0.573
MOD_CK1_1	778	784	PF00069	0.623
MOD_CK1_1	785	791	PF00069	0.592
MOD_CK1_1	804	810	PF00069	0.485
MOD_CK1_1	98	104	PF00069	0.496
MOD_CK2_1	143	149	PF00069	0.626
MOD_CK2_1	150	156	PF00069	0.672
MOD_CK2_1	274	280	PF00069	0.646
MOD_CK2_1	330	336	PF00069	0.656
MOD_CK2_1	382	388	PF00069	0.453
MOD_CK2_1	413	419	PF00069	0.356
MOD_CK2_1	430	436	PF00069	0.296
MOD_CK2_1	575	581	PF00069	0.520
MOD_CK2_1	616	622	PF00069	0.603
MOD_CK2_1	651	657	PF00069	0.666
MOD_CK2_1	671	677	PF00069	0.641
MOD_CK2_1	857	863	PF00069	0.682
MOD_CK2_1	98	104	PF00069	0.476
MOD_GlcNHglycan	101	104	PF01048	0.684
MOD_GlcNHglycan	196	200	PF01048	0.583
MOD_GlcNHglycan	31	34	PF01048	0.578
MOD_GlcNHglycan	324	327	PF01048	0.723
MOD_GlcNHglycan	390	393	PF01048	0.563
MOD_GlcNHglycan	560	563	PF01048	0.541
MOD_GlcNHglycan	576	580	PF01048	0.688
MOD_GlcNHglycan	604	607	PF01048	0.558
MOD_GlcNHglycan	618	621	PF01048	0.599
MOD_GlcNHglycan	639	642	PF01048	0.657
MOD_GlcNHglycan	648	651	PF01048	0.735
MOD_GlcNHglycan	68	71	PF01048	0.587
MOD_GlcNHglycan	699	702	PF01048	0.679
MOD_GlcNHglycan	723	727	PF01048	0.640
MOD_GlcNHglycan	784	787	PF01048	0.626
MOD_GlcNHglycan	793	796	PF01048	0.601
MOD_GSK3_1	143	150	PF00069	0.613
MOD_GSK3_1	151	158	PF00069	0.620
MOD_GSK3_1	159	166	PF00069	0.620
MOD_GSK3_1	227	234	PF00069	0.648
MOD_GSK3_1	270	277	PF00069	0.639
MOD_GSK3_1	301	308	PF00069	0.726
MOD_GSK3_1	338	345	PF00069	0.608
MOD_GSK3_1	358	365	PF00069	0.317
MOD_GSK3_1	378	385	PF00069	0.472
MOD_GSK3_1	388	395	PF00069	0.595
MOD_GSK3_1	497	504	PF00069	0.771
MOD_GSK3_1	560	567	PF00069	0.682
MOD_GSK3_1	582	589	PF00069	0.585
MOD_GSK3_1	600	607	PF00069	0.740
MOD_GSK3_1	633	640	PF00069	0.699
MOD_GSK3_1	684	691	PF00069	0.683
MOD_GSK3_1	693	700	PF00069	0.713
MOD_GSK3_1	701	708	PF00069	0.509
MOD_GSK3_1	728	735	PF00069	0.577
MOD_GSK3_1	748	755	PF00069	0.462
MOD_GSK3_1	778	785	PF00069	0.616
MOD_GSK3_1	787	794	PF00069	0.589
MOD_GSK3_1	847	854	PF00069	0.535
MOD_GSK3_1	857	864	PF00069	0.590
MOD_GSK3_1	94	101	PF00069	0.539
MOD_N-GLC_1	265	270	PF02516	0.495
MOD_N-GLC_1	358	363	PF02516	0.433
MOD_N-GLC_1	600	605	PF02516	0.577
MOD_N-GLC_1	752	757	PF02516	0.607
MOD_NEK2_1	321	326	PF00069	0.794
MOD_NEK2_1	355	360	PF00069	0.394
MOD_NEK2_1	362	367	PF00069	0.494
MOD_NEK2_1	458	463	PF00069	0.409
MOD_NEK2_1	592	597	PF00069	0.550
MOD_NEK2_1	872	877	PF00069	0.515
MOD_NEK2_2	822	827	PF00069	0.580
MOD_OFUCOSY	819	826	PF10250	0.584
MOD_PIKK_1	592	598	PF00454	0.606
MOD_PK_1	651	657	PF00069	0.658
MOD_PKA_2	11	17	PF00069	0.530
MOD_PKA_2	129	135	PF00069	0.672
MOD_PKA_2	172	178	PF00069	0.617
MOD_PKA_2	322	328	PF00069	0.700
MOD_PKA_2	378	384	PF00069	0.400
MOD_PKA_2	466	472	PF00069	0.437
MOD_PKA_2	497	503	PF00069	0.618
MOD_PKA_2	66	72	PF00069	0.591
MOD_PKA_2	705	711	PF00069	0.654
MOD_PKA_2	804	810	PF00069	0.613
MOD_PKA_2	870	876	PF00069	0.446
MOD_PKA_2	98	104	PF00069	0.477
MOD_Plk_1	195	201	PF00069	0.541
MOD_Plk_1	358	364	PF00069	0.458
MOD_Plk_1	382	388	PF00069	0.434
MOD_Plk_1	581	587	PF00069	0.761
MOD_Plk_1	722	728	PF00069	0.547
MOD_Plk_1	738	744	PF00069	0.548
MOD_Plk_1	745	751	PF00069	0.668
MOD_Plk_1	79	85	PF00069	0.334
MOD_Plk_2-3	383	389	PF00069	0.493
MOD_Plk_2-3	413	419	PF00069	0.415
MOD_Plk_4	163	169	PF00069	0.621
MOD_Plk_4	393	399	PF00069	0.450
MOD_Plk_4	413	419	PF00069	0.420
MOD_Plk_4	458	464	PF00069	0.359
MOD_Plk_4	502	508	PF00069	0.739
MOD_Plk_4	668	674	PF00069	0.616
MOD_Plk_4	804	810	PF00069	0.704
MOD_ProDKin_1	13	19	PF00069	0.527
MOD_ProDKin_1	143	149	PF00069	0.570
MOD_ProDKin_1	159	165	PF00069	0.763
MOD_ProDKin_1	166	172	PF00069	0.814
MOD_ProDKin_1	231	237	PF00069	0.508
MOD_ProDKin_1	564	570	PF00069	0.613
MOD_ProDKin_1	847	853	PF00069	0.607
MOD_SUMO_for_1	453	456	PF00179	0.425
MOD_SUMO_rev_2	274	283	PF00179	0.599
TRG_DiLeu_BaEn_4	279	285	PF01217	0.570
TRG_DiLeu_BaEn_4	455	461	PF01217	0.421
TRG_ENDOCYTIC_2	429	432	PF00928	0.369
TRG_ENDOCYTIC_2	78	81	PF00928	0.459
TRG_ENDOCYTIC_2	842	845	PF00928	0.578
TRG_ENDOCYTIC_2	869	872	PF00928	0.465
TRG_ER_diArg_1	181	184	PF00400	0.662
TRG_ER_diArg_1	209	212	PF00400	0.487
TRG_ER_diArg_1	41	44	PF00400	0.486
TRG_ER_diArg_1	490	493	PF00400	0.482
TRG_ER_diArg_1	610	612	PF00400	0.664
TRG_ER_diArg_1	64	67	PF00400	0.549
TRG_NES_CRM1_1	370	383	PF08389	0.440
TRG_Pf-PMV_PEXEL_1	296	300	PF00026	0.618
TRG_Pf-PMV_PEXEL_1	653	657	PF00026	0.627

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I020	Leptomonas seymouri	44%	89%
A0A3S7X7U3	Leishmania donovani	89%	88%
A4H7T0	Leishmania braziliensis	72%	100%
A4I9V6	Leishmania infantum	89%	88%
C9ZMS6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	88%
Q4Q358	Leishmania major	91%	100%